Hamon Center for Therapeutic Oncology - Brekken Lab

Research Output

2017

Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies

Sharma, R., Huang, X., Brekken, R. A. & Schroit, A. J., Aug 8 2017, In : British Journal of Cancer. 117, 4, p. 545-552 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts

Cheng, X., Li, L., Thorpe, P. E., Yopp, A. C., Brekken, R. A. & Huang, X., Feb 4 2016, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Antibody-Mediated phosphatidylserine blockade enhances the antitumor responses to CTLA-4 and PD-1 antibodies in melanoma

Freimark, B. D., Gong, J., Ye, D., Gray, M. J., Nguyen, V., Yin, S., Hatch, M. M. S., Hughes, C. C. W., Schroit, A. J., Hutchins, J. T., Brekken, R. A. & Huang, X., Jun 1 2016, In : Cancer immunology research. 4, 6, p. 531-540 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis

Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y. M., Salmon, J. E., Brekken, R. A., Huang, X., Thorpe, P. E. & Shaul, P. W., Jul 2016, In : PloS one. 11, 7, e0158757.

Research output: Contribution to journalArticle

11 Scopus citations

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

Birge, R. B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J., Calianese, D., Barcinski, M., Brekken, R. A., Huang, X., Hutchins, J. T., Freimark, B., Empig, C., Mercer, J., Schroit, A. J., Schett, G. & Herrmann, M., Feb 26 2016, (Accepted/In press) In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

160 Scopus citations
2015

Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium: PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo

Li, T., Aredo, B., Zhang, K., Zhong, X., Pulido, J. S., Wang, S., He, Y. G., Huang, X., Brekken, R. A. & Ufret-Vincenty, R. L., Nov 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 12, p. 7137-7145 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

Jiang, L., Xiao, L., Sugiura, H., Huang, X., Ali, A., Kuro-O, M., DeBerardinis, R. J. & Boothman, D. A., Oct 6 2014, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

83 Scopus citations
2013

Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation

Yin, Y., Huang, X., Lynn, K. D. & Thorpe, P. E., Oct 1 2013, In : Cancer Immunology Research. 1, 4, p. 256-268 13 p.

Research output: Contribution to journalArticle

70 Scopus citations
2011

Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine

Huang, X., Ye, D. & Thorpe, P. E., Jun 24 2011, In : Vaccine. 29, 29-30, p. 4785-4793 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2006

Plasma protein β-2-glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cells

Luster, T. A., He, J., Huang, X., Maiti, S. N., Schroit, A. J., De Groot, P. G. & Thorpe, P. E., Oct 6 2006, In : Journal of Biological Chemistry. 281, 40, p. 29863-29871 9 p.

Research output: Contribution to journalArticle

50 Scopus citations
2005

A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice

Huang, X., Bennett, M. & Thorpe, P. E., May 15 2005, In : Cancer Research. 65, 10, p. 4408-4416 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice

Ran, S., He, J., Huang, X., Soares, M., Scothorn, D. & Thorpe, P. E., Feb 15 2005, In : Clinical Cancer Research. 11, 4, p. 1551-1562 12 p.

Research output: Contribution to journalArticle

116 Scopus citations
2004

Anti-tumor effects and lack of side effects in mice of an immunotoxin directed against human and mouse prostate-specific membrane antigen

Huang, X., Bennett, M. & Thorpe, P. E., Sep 15 2004, In : Prostate. 61, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

48 Scopus citations
2003

Evaluation of novel antimouse VEGFR2 antibodies as potential antiangiogenic or vascular targeting agents for tumor therapy

Ran, S., Huang, X., Downes, A. & Thorpe, P. E., Jul 1 2003, In : Neoplasia. 5, 4, p. 297-307 11 p.

Research output: Contribution to journalArticle

39 Scopus citations
2002

A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model

Zhang, W., Ran, S., Sambade, M., Huang, X. & Thorpe, P. E., Dec 1 2002, In : Angiogenesis. 5, 1-2, p. 35-44 10 p.

Research output: Contribution to journalArticle

97 Scopus citations
1998

Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonance

Huang, X., Gottstein, C., Brekken, R. A. & Thorpe, P. E., Nov 27 1998, In : Biochemical and Biophysical Research Communications. 252, 3, p. 643-648 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Vascular endothelial growth factor as a marker of tumor endothelium

Brekken, R. A., Huang, X., King, S. W. & Thorpe, P. E., May 1 1998, In : Cancer Research. 58, 9, p. 1952-1959 8 p.

Research output: Contribution to journalArticle

161 Scopus citations
1997

Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature

Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S. & Thorpe, P. E., Jan 24 1997, In : Science. 275, 5299, p. 547-550 4 p.

Research output: Contribution to journalArticle

430 Scopus citations