Hamon Center for Therapeutic Oncology - Brekken Lab

Research output

Research output per year 1997 1998 2005 2015 2016 2017

• 17 Article
• 1 Review article

Research output per year

Research output per year

Search results

• 2017

  Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies

  Sharma, R., Huang, X., Brekken, R. A. & Schroit, A. J., Aug 8 2017, In: British journal of cancer. 117, 4, p. 545-552 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exosomes 100%
  • Phosphatidylserines 97%
  • Neoplasms 27%
  • Phospholipids 8%
  • Enzyme-Linked Immunosorbent Assay 7%
  100 Scopus citations
• 2016

  Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts

  Cheng, X., Li, L., Thorpe, P. E., Yopp, A. C., Brekken, R. A. & Huang, X., Dec 1 2016, In: Annals of Surgical Oncology. 23, p. 583-591 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sorafenib 100%
  • Phosphatidylserines 93%
  • Heterografts 73%
  • Hepatocellular Carcinoma 65%
  • bavituximab 64%
  17 Scopus citations

• Antibody-Mediated phosphatidylserine blockade enhances the antitumor responses to CTLA-4 and PD-1 antibodies in melanoma

  Freimark, B. D., Gong, J., Ye, D., Gray, M. J., Nguyen, V., Yin, S., Hatch, M. M. S., Hughes, C. C. W., Schroit, A. J., Hutchins, J. T., Brekken, R. A. & Huang, X., Jun 2016, In: Cancer Immunology Research. 4, 6, p. 531-540 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphatidylserines 100%
  • Melanoma 72%
  • Antibodies 48%
  • Myeloid-Derived Suppressor Cells 23%
  • Tumor-Infiltrating Lymphocytes 22%
  17 Scopus citations

• Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis

  Mineo, C., Lanier, L., Jung, E., Sengupta, S., Ulrich, V., Sacharidou, A., Tarango, C., Osunbunmi, O., Shen, Y. M., Salmon, J. E., Brekken, R. A., Huang, X., Thorpe, P. E. & Shaul, P. W., Jul 2016, In: PloS one. 11, 7, e0158757.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • pregnancy complications 100%
  • Antiphospholipid Antibodies 72%
  • thrombosis 69%
  • Antiphospholipid Syndrome 69%
  • Pregnancy Complications 65%
  21 Scopus citations

• Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

  Birge, R. B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J., Calianese, D., Barcinski, M., Brekken, R. A., Huang, X., Hutchins, J. T., Freimark, B., Empig, C., Mercer, J., Schroit, A. J., Schett, G. & Herrmann, M., Jun 1 2016, In: Cell Death and Differentiation. 23, 6, p. 962-978 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Phosphatidylserines 100%
  • Communicable Diseases 74%
  • Immunosuppressive Agents 72%
  • Neoplasms 28%
  • Regulated Cell Death 19%
  454 Scopus citations
• 2015

  Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

  Jiang, L., Xiao, L., Sugiura, H., Huang, X., Ali, A., Kuro-O, M., DeBerardinis, R. J. & Boothman, D. A., Jul 23 2015, In: Oncogene. 34, 30, p. 3908-3916 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epithelial-Mesenchymal Transition 100%
  • Fatty Acid Synthases 94%
  • Transforming Growth Factor beta 88%
  • Lipogenesis 59%
  • Neoplasm Metastasis 29%
  163 Scopus citations

• Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium: PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo

  Li, T., Aredo, B., Zhang, K., Zhong, X., Pulido, J. S., Wang, S., He, Y. G., Huang, X., Brekken, R. A. & Ufret-Vincenty, R. L., Nov 1 2015, In: Investigative Ophthalmology and Visual Science. 56, 12, p. 7137-7145 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Choroidal Neovascularization 100%
  • Phosphatidylserines 92%
  • Endothelium 71%
  • Antibodies 44%
  • Cell Adhesion Molecules 17%
  9 Scopus citations
• 2013

  Phosphatidylserine-targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation

  Yin, Y., Huang, X., Lynn, K. D. & Thorpe, P. E., Oct 1 2013, In: Cancer Immunology Research. 1, 4, p. 256-268 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid-Derived Suppressor Cells 100%
  • Phosphatidylserines 86%
  • Cell Differentiation 60%
  • Macrophages 52%
  • Antibodies 41%
  118 Scopus citations
• 2011

  Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine

  Huang, X., Ye, D. & Thorpe, P. E., Jun 24 2011, In: Vaccine. 29, 29-30, p. 4785-4793 9 p.

  Research output: Contribution to journal › Article › peer-review

  • cancer vaccines 100%
  • Cancer Vaccines 65%
  • phosphatidylserines 63%
  • Phosphatidylserines 61%
  • interleukin-2 61%
  28 Scopus citations
• 2006

  Plasma protein β-2-glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3G4 and anionic phospholipids on endothelial cells

  Luster, T. A., He, J., Huang, X., Maiti, S. N., Schroit, A. J., De Groot, P. G. & Thorpe, P. E., Oct 6 2006, In: Journal of Biological Chemistry. 281, 40, p. 29863-29871 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Anionic Phospholipid 100%
  • Neoplasm Antibodies 96%
  • Phosphatidylserines 71%
  • Phospholipids 62%
  • Blood Proteins 62%
  60 Scopus citations
• 2005

  A monoclonal antibody that binds anionic phospholipids on tumor blood vessels enhances the antitumor effect of docetaxel on human breast tumors in mice

  Huang, X., Bennett, M. & Thorpe, P. E., May 15 2005, In: Cancer research. 65, 10, p. 4408-4416 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Tissue Neoplasms 100%
  • Docetaxel 80%
  • Phospholipids 64%
  • Monoclonal Antibodies 52%
  • Breast Neoplasms 46%
  123 Scopus citations

• Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice

  Ran, S., He, J., Huang, X., Soares, M., Scothorn, D. & Thorpe, P. E., Feb 15 2005, In: Clinical Cancer Research. 11, 4, p. 1551-1562 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Tissue Neoplasms 100%
  • Phospholipids 64%
  • Monoclonal Antibodies 52%
  • Neoplasms 23%
  • Endothelial Cells 12%
  130 Scopus citations
• 2004

  Anti-tumor effects and lack of side effects in mice of an immunotoxin directed against human and mouse prostate-specific membrane antigen

  Huang, X., Bennett, M. & Thorpe, P. E., Sep 15 2004, In: Prostate. 61, 1, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • mouse PSMA protein 100%
  • human FOLH1 protein 91%
  • Immunotoxins 65%
  • Prostate-Specific Antigen 25%
  • Neoplasms 15%
  56 Scopus citations
• 2003

  Evaluation of novel antimouse VEGFR2 antibodies as potential antiangiogenic or vascular targeting agents for tumor therapy

  Ran, S., Huang, X., Downes, A. & Thorpe, P. E., 2003, In: Neoplasia. 5, 4, p. 297-307 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Blood Vessels 100%
  • Antibodies 94%
  • Vascular Endothelium 62%
  • Neoplasms 54%
  • Kidney Glomerulus 42%
  44 Scopus citations
• 2002

  A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model

  Zhang, W., Ran, S., Sambade, M., Huang, X. & Thorpe, P. E., 2002, In: Angiogenesis. 5, 1-2, p. 35-44 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Vascular Endothelial Growth Factor A 100%
  • Monoclonal Antibodies 84%
  • Block Like Crystal 78%
  • Breast Neoplasms 74%
  • Blood Vessels 68%
  102 Scopus citations
• 1998

  Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonance

  Huang, X., Gottstein, C., Brekken, R. A. & Thorpe, P. E., Nov 27 1998, In: Biochemical and Biophysical Research Communications. 252, 3, p. 643-648 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Surface Plasmon Resonance 100%
  • Vascular Endothelial Growth Factor Receptor-2 99%
  • Vascular Endothelial Growth Factor A 68%
  • Vascular Endothelial Growth Factor Receptor 63%
  • human VEGFA protein 37%
  28 Scopus citations

• Vascular endothelial growth factor as a marker of tumor endothelium

  Brekken, R. A., Huang, X., King, S. W. & Thorpe, P. E., May 1 1998, In: Cancer research. 58, 9, p. 1952-1959 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Biomarkers 100%
  • Endothelium 90%
  • Vascular Endothelial Growth Factor A 88%
  • Neoplasms 33%
  • Vascular Endothelial Growth Factor Receptor 24%
  169 Scopus citations
• 1997

  Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature

  Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S. & Thorpe, P. E., Jan 24 1997, In: Science. 275, 5299, p. 547-550 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Thromboplastin 100%
  • Infarction 75%
  • Antibodies 49%
  • Thrombosis 41%
  • Thrombogen 39%
  474 Scopus citations