Hamon Center Therapeutic Oncology - Minna Lab

Research Output 1986 2019

2019

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & DeBerardinis, R. J., May 16 2019, In : Nature. 569, 7756, p. E4

Research output: Contribution to journalComment/debate

Open Access
Carbamyl Phosphate
Lung Neoplasms
DNA
pyrimidine
phosphorylethanolamine

Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer (Oncogene, (2019), 38, 14, (2551-2564), 10.1038/s41388-018-0588-2)

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A. F., Heymach, J., Wistuba, I., Xiao, G., Minna, J. & Xie, Y., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalComment/debate

Oncogenes
Publications
Lung Neoplasms
Gene Expression
8 Citations (Scopus)

Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis

Yan, X., Zhang, X., Wang, L., Zhang, R., Pu, X., Wu, S., Li, L., Tong, P., Wang, J., Meng, Q. H., Jensen, V. B., Girard, L., Minna, J. D., Roth, J. A., Swisher, S. G., Heymach, J. V. & Fang, B., Jan 1 2019, In : Cancer Research. 79, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Thioredoxins
Glutathione
Lung Neoplasms
Oxidoreductases
1 Citation (Scopus)

Systematic analysis of gene expression in lung adenocarcinoma and squamous cell carcinoma with a case study of FAM83A and FAM83B

Cai, L., Luo, D., Yao, B., Yang, D. M., Lin, S., Girard, L., Deberardinis, R. J., Minna, J. D., Xie, Y. & Xiao, G., Jun 1 2019, In : Cancers. 11, 6, 886.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Gene Expression
Databases
Neoplasm Genes

Unbiased peptoid combinatorial cell screen identifies plectin protein as a potential biomarker for lung cancer stem cells

Raymond, A. C., Gao, B., Girard, L., Minna, J. D. & Gomika Udugamasooriya, D., Dec 1 2019, In : Scientific reports. 9, 1, 14954.

Research output: Contribution to journalArticle

Open Access
Plectin
Peptoids
Neoplastic Stem Cells
Lung Neoplasms
Biomarkers
2018
1 Citation (Scopus)

A quantitative method for assessing smoke associated molecular damage in lung cancers

Song, K., Bi, J. H., Qiu, Z. W., Felizardo, R., Girard, L., Minna, J. D. & Gazdar, A. F., Jan 1 2018, In : Translational Lung Cancer Research. 7, 4, p. 439-449 11 p.

Research output: Contribution to journalArticle

Smoke
Tobacco
Lung Neoplasms
Mutation
Small Cell Lung Carcinoma
17 Citations (Scopus)

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Oncology
Biosynthesis
Small Molecule Libraries
2 Citations (Scopus)

Concomitant targeting of the mTOR/MAPK pathways: Novel therapeutic strategy in subsets of RICTOR/KRAS-altered non-small cell lung cancer

Ruder, D., Papadimitrakopoulou, V., Shien, K., Behrens, C., Kalhor, N., Chen, H., Shen, L., Jack Lee, J., Hong, W. K., Tang, X., Girard, L., Minna, J. D., Diao, L., Wang, J., Mino, B., Villalobos, P., Rodriguez-Canales, J., Hanson, N. E., Sun, J., Miller, V. & 6 others, Greenbowe, J., Frampton, G., Herbst, R. S., Baladandayuthapani, V., Wistuba, I. I. & Izzo, J. G., Sep 1 2018, In : Oncotarget. 9, 74, p. 33995-34008 14 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Biodiversity
Therapeutics
Lung Neoplasms
Clinical Trials

eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer

Tanaka, I., Sato, M., Kato, T., Goto, D., Kakumu, T., Miyazawa, A., Yogo, N., Hase, T., Morise, M., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Jan 1 2018, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Peptide Initiation Factors
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Small Interfering RNA

Kub5-HeraRPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers

Motea, E. A., Fattah, F. J., Xiao, L., Girard, L., Rommel, A., Morales, J. C., Patidar, P., Zhou, Y., Porter, A., Xie, Y., Minna, J. D. & Boothman, D. A., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6459-6470 12 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Precision Medicine
Breast Neoplasms
DNA Damage
CDC2 Protein Kinase
3 Citations (Scopus)

LCE: an open web portal to explore gene expression and clinical associations in lung cancer

Cai, L., Lin, S. Y., Girard, L., Zhou, Y., Yang, L., Ci, B., Zhou, Q., Luo, D., Yao, B., Tang, H., Allen, J., Huffman, K., Gazdar, A. F., Heymach, J., Wistuba, I., Xiao, G., Minna, J. D. & Xie, Y., Jan 1 2018, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Lung Neoplasms
Gene Expression
Databases
Survival Analysis
Meta-Analysis
14 Citations (Scopus)

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes

Zhang, W., Girard, L., Zhang, Y. A., Haruki, T., Papari-Zareei, M., Stastny, V., Ghayee, H. K., Pacak, K., Oliver, T. G., Minna, J. D. & Gazdar, A. F., Feb 1 2018, In : Translational Lung Cancer Research. 7, 1, p. 32-49 18 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Phenotype
Neoplasms
Tumor Cell Line
Cell Line
4 Citations (Scopus)

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 1 2018, In : Neoplasia (United States). 20, 8, p. 826-837 12 p.

Research output: Contribution to journalArticle

alpha-2'-deoxythioguanosine
Telomerase
Non-Small Cell Lung Carcinoma
Drug Therapy
Lung Neoplasms
2 Citations (Scopus)
Merkel cell polyomavirus
Merkel Cell Carcinoma
Needles
Pancreas
Immunohistochemistry
5 Citations (Scopus)

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M. D., Girard, L., Gazdar, A. F., Minna, J. D., Johnson, J. E. & Cobb, M. H., Apr 1 2018, In : Translational Oncology. 11, 2, p. 292-299 8 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Neuroendocrine Tumors
Small Cell Lung Carcinoma
Lung
Lung Neoplasms
10 Citations (Scopus)

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

Gong, K., Guo, G., Gerber, D. E., Gao, B., Peyton, M., Huang, C., Minna, J. D., Hatanpaa, K. J., Kernstine, K., Cai, L., Xie, Y., Zhu, H., Fattah, F. J., Zhang, S., Takahashi, M., Mukherjee, B., Burma, S., Dowell, J., Dao, K., Papadimitrakopoulou, V. A. & 4 others, Olivas, V., Bivona, T. G., Zhao, D. & Habib, A. A., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2500-2518 19 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
RNA Stability
Inflammation Mediators
Oncogenes
3 Citations (Scopus)

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P. H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J. D., Mishra, P., DeBerardinis, R. J. & O'Donnell-Mendell, K. A., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

CD147 Antigens
Metabolism
Lactic Acid
Lung Neoplasms
Peptide Hydrolases
2017
2 Citations (Scopus)

12-O-tetradecanoylphorbol-13-acetate (TPA) increases murine intestinal crypt stem cell survival following radiation injury

Liang, Y., Zhou, H., Yao, Y., Deng, A., Wang, Z., Gao, B., Zhou, M., Cui, Y., Wang, L., Zhou, L., Wang, B., Wang, L., Liu, A., Qiu, L., Qian, K., Lu, Y., Deng, W., Zheng, X., Han, Z., Li, Y. & 1 others, Sun, J., 2017, In : Oncotarget. 8, 28, p. 45566-45576 11 p.

Research output: Contribution to journalArticle

Radiation Injuries
Tetradecanoylphorbol Acetate
Cell Survival
Stem Cells
Ionizing Radiation
11 Citations (Scopus)

Combination therapy targeting BCL6 and phospho-STAT3 defeats intratumor heterogeneity in a subset of non-small cell lung cancers

Deb, D., Rajaram, S., Larsen, J. E., Dospoy, P. D., Marullo, R., Li, L. S., Avila, K., Xue, F., Cerchietti, L., Minna, J. D., Altschuler, S. J. & Wu, L. F., Jun 1 2017, In : Cancer Research. 77, 11, p. 3070-3081 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Oncogenes
Down-Regulation
Neoplasms
MAP Kinase Signaling System
54 Citations (Scopus)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y. F., Ni, M., Huffman, K. E., Girard, L., Byers, L. A., Unsal-Kacmaz, K., Peña, C. G., Heymach, J. V., Wauters, E., Vansteenkiste, J., Castrillon, D. H. & 6 others, Chen, B. P. C., Wistuba, I., Lambrechts, D., Xu, J., Minna, J. D. & Deberardinis, R. J., Jun 1 2017, In : Nature. 546, 7656, p. 168-172 5 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
Ligases
Lung Neoplasms
DNA
Ammonia
6 Citations (Scopus)

GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma

Kasiri, S., Shao, C., Chen, B., Wilson, A. N., Yenerall, P., Timmons, B. C., Girard, L., Tian, H., Behrens, C., Wistuba, I. I., Gazdar, A. F. & Kim, J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4448-4459 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Squamous Cell Carcinoma
Lung
Gene Amplification
Tumor Cell Line
3 Citations (Scopus)

Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer

Kakumu, T., Sato, M., Goto, D., Kato, T., Yogo, N., Hase, T., Morise, M., Fukui, T., Yokoi, K., Sekido, Y., Girard, L., Minna, J. D., Byers, L. A., Heymach, J. V., Coombes, K. R., Kondo, M. & Hasegawa, Y., Apr 1 2017, In : Cancer Science. 108, 4, p. 732-743 12 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Catalytic Domain
Proteasome Endopeptidase Complex
Cell Line
Small Interfering RNA
15 Citations (Scopus)

JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non–small cell lung cancer

Shien, K., Papadimitrakopoulou, V. A., Ruder, D., Behrens, C., Shen, L., Kalhor, N., Song, J., Lee, J. J., Wang, J., Tang, X., Herbst, R. S., Toyooka, S., Girard, L., Minna, J. D., Kurie, J. M., Wistuba, I. I. & Izzo, J. G., Oct 1 2017, In : Molecular Cancer Therapeutics. 16, 10, p. 2234-2245 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cytokines
Interleukin-6
Pharmaceutical Preparations
Oncostatin M
5 Citations (Scopus)

Mortalin expression in pancreatic cancer and its clinical and prognostic significance

Cui, X., Li, Z., Piao, J., Li, J., Li, L., Lin, Z. & Jin, A., Jun 1 2017, In : Human Pathology. 64, p. 171-178 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Fluorescent Antibody Technique
Survival
Immunohistochemistry
5 Citations (Scopus)

Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions

Gao, B., Huang, C., Kernstine, K., Pelekanou, V., Kluger, Y., Jiang, T., Peters-Hall, J. R., Coquelin, M., Girard, L., Zhang, W., Huffman, K., Oliver, D., Kinose, F., Haura, E., Teer, J. K., Rix, U., Le, A. T., Aisner, D. L., Varella-Garcia, M., Doebele, R. C. & 10 others, Covington, K. R., Hampton, O. A., Doddapaneni, H. V., Jayaseelan, J. C., Hu, J., Wheeler, D. A., Shay, J. W., Rimm, D. L., Gazdar, A. & Minna, J. D., 2017, In : Oncotarget. 8, 7, p. 11114-11126 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epithelial Cells
Cell Culture Techniques
Neoplasms
Lung
21 Citations (Scopus)

Platelet distribution width correlates with prognosis of non-small cell lung cancer

Cui, M. M., Li, N., Liu, X., Yun, Z. Y., Niu, Y., Zhang, Y., Gao, B., Liu, T. & Wang, R. T., Dec 1 2017, In : Scientific Reports. 7, 1, 3456.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Blood Platelets
Hematologic Tests
Proportional Hazards Models
Survival
15 Citations (Scopus)

PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by EGFR and KRAS during lung tumorigenesis

Zhou, X., Updegraff, B. L., Guo, Y., Peyton, M., Girard, L., Larsen, J. E., Xie, X-J., Zhou, Y., Hwang, T. H., Xie, Y., Rodriguez-Canales, J., Villalobos, P., Behrens, C., Wistuba, I. I., Minna, J. D. & O'Donnell-Mendell, K. A., Jan 1 2017, In : Cancer Research. 77, 1, p. 187-197 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Non-Small Cell Lung Carcinoma
Lung
Neoplasms
Phosphoprotein Phosphatases
6 Citations (Scopus)

Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer

Zhao, X., Huffman, K. E., Fujimoto, J., Canales, J. R., Girard, L., Nie, G., Heymach, J. V., Wistuba, I. I., Minna, J. D. & Yu, Y., Oct 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 10, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Large-Core Needle Biopsy
Biopsy
Needles
Proteomics
Lung Neoplasms
23 Citations (Scopus)

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Tagal, V., Wei, S., Zhang, W., Brekken, R. A., Posner, B. A., Peyton, M., Girard, L., Hwang, T., Wheeler, D. A., Minna, J. D., White, M. A., Gazdar, A. F. & Roth, M. G., Jan 19 2017, In : Nature Communications. 8, 14098.

Research output: Contribution to journalArticle

Aurora Kinase A
mutations
Non-Small Cell Lung Carcinoma
lungs
inhibitors
28 Citations (Scopus)

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

Dalvi, M. P., Wang, L., Zhong, R., Kollipara, R. K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B. C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E. R., Suraokar, M., Pataer, A., Swisher, S. G., Kalhor, N., Bhanu, N. V., Garcia, B. A. & 9 others, Heymach, J. V., Coombes, K., Xie, Y., Girard, L., Gazdar, A. F., Kittler, R., Wistuba, I. I., Minna, J. D. & Martinez, E. D., May 23 2017, In : Cell Reports. 19, 8, p. 1669-1684 16 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Hypersensitivity
Chemotherapy
Cells
Non-Small Cell Lung Carcinoma
2016
41 Citations (Scopus)

An expression signature as an aid to the histologic classification of non-small cell lung cancer

Girard, L., Rodriguez-Canales, J., Behrens, C., Thompson, D. M., Botros, I. W., Tang, H., Xie, Y., Rekhtman, N., Travis, W. D., Wistuba, I. I., Minna, J. D. & Gazdar, A. F., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4880-4889 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Atlases
Lung
77 Citations (Scopus)

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In : Cell Reports. 16, 5, p. 1259-1272 14 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Small Cell Lung Carcinoma
Tumors
Genes
Lung
25 Citations (Scopus)

Epithelial-mesenchymal transition predicts polo-like kinase 1 inhibitor-mediated apoptosis in non-small cell lung cancer

Ferrarotto, R., Goonatilake, R., Yoo, S. Y., Tong, P., Giri, U., Peng, S., Minna, J., Girard, L., Wang, Y., Wang, L., Li, L., Diao, L., Peng, D. H., Gibbons, D. L., Glisson, B. S., Heymach, J. V., Wang, J., Byers, L. A. & Johnson, F. M., Apr 1 2016, In : Clinical Cancer Research. 22, 7, p. 1674-1686 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Non-Small Cell Lung Carcinoma
Apoptosis
Cell Line
polo-like kinase 1
7 Citations (Scopus)

Identification of gene expression differences between lymphangiogenic and non-lymphangiogenic non-small cell lung cancer cell lines

Regan, E., Sibley, R. C., Cenik, B. K., Silva, A., Girard, L., Minna, J. D. & Dellinger, M. T., Mar 1 2016, In : PLoS One. 11, 3, e150963.

Research output: Contribution to journalArticle

Lymphangiogenesis
lung neoplasms
Gene expression
Non-Small Cell Lung Carcinoma
Tumors
15 Citations (Scopus)

ITPKA gene body methylation regulates gene expression and serves as an early diagnostic marker in lung and other cancers

Wang, Y. W., Ma, X., Zhang, Y. A., Wang, M. J., Yatabe, Y., Lam, S., Girard, L., Chen, J. Y. & Gazdar, A. F., 2016, In : Journal of Thoracic Oncology. 11, 9, p. 1469-1481 13 p.

Research output: Contribution to journalArticle

Inositol
Methylation
Lung Neoplasms
Phosphotransferases
Gene Expression
14 Citations (Scopus)

Nicotinic acetylcholine receptor expression in human airway correlates with lung function

Lam, D. C. L., Luo, S. Y., Fu, K. H., Lui, M. M. S., Chan, K. H., Wistuba, I. I., Gao, B., Tsao, S. W., Ip, M. S. M. & Minna, J. D., Feb 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 3, p. L232-L239

Research output: Contribution to journalArticle

Nicotinic Receptors
Nicotine
Lung
Epithelial Cells
Cell Line
1 Citation (Scopus)

NQO1 bioactivatable drugs enhance radiation responses

Bey, E. A., Meade, J. C., Silvers, M. A., Motea, E. A., Patidar, P. L., Brekken, R., Deja, S., Merritt, M. E., Kilgore, J. A., Liu, Y., Huang, X., Li, L., Yordy, J., Williams, N. S., Gao, J. & Boothman, D. A., Jan 1 2016, Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Springer International Publishing, p. 225-252 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Radiation
Pharmaceutical Preparations
Neoplasms
Catalase
NAD
18 Citations (Scopus)

NQO1-Mediated tumor-selective lethality and radiosensitization for head and neck cancer

Li, L. S., Reddy, S., Lin, Z. H., Liu, S., Park, H., Chun, S. G., Bornmann, W. G., Thibodeaux, J., Yan, J., Chakrabarti, G., Xie, X. J., Sumer, B. D., Boothman, D. A. & Yordy, J. S., Jul 1 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1757-1767 11 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Ionizing Radiation
Neoplasms
NAD
Reactive Oxygen Species
1 Citation (Scopus)

Selecting reliable mRNA expression measurements across platforms improves downstream analysis

Tong, P., Diao, L., Shen, L., Li, L., Heymach, J. V., Girard, L., Minna, J. D., Coombes, K. R., Byers, L. A. & Wang, J., 2016, In : Cancer Informatics. 15, p. 81-89 9 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Messenger RNA
Genes
Gene Expression
Technology
6 Citations (Scopus)

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas

Zhang, Y. A., Zhou, Y., Luo, X., Song, K., Ma, X., Sathe, A., Girard, L., Xiao, G. & Gazdar, A. F., Nov 1 2016, In : EBioMedicine. 13, p. 80-89 10 p.

Research output: Contribution to journalArticle

Methylation
Biomarkers
Glioma
Survival
Genes
18 Citations (Scopus)

Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC

Piao, J., Chen, L., Quan, T., Li, L., Quan, C., Piao, Y., Jin, T. & Lin, Z., 2016, In : Oncotarget. 7, 37, p. 60169-60180 12 p.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Phosphatidylinositol 3-Kinases
Non-Small Cell Lung Carcinoma
Histone Deacetylases
9 Citations (Scopus)

Validation of SCT methylation as a hallmark biomarker for lung cancers

Zhang, Y. A., Ma, X., Sathe, A., Fujimoto, J., Wistuba, I. I., Lam, S., Yatabe, Y., Wang, Y. W., Stastny, V., Gao, B., Larsen, J. E., Girard, L., Liu, X., Song, K., Behrens, C., Kalhor, N., Xie, Y., Zhang, M. Q., Minna, J. D. & Gazdar, A. F., Mar 23 2016, In : Journal of Thoracic Oncology. 11, 3, p. 346-360 15 p.

Research output: Contribution to journalArticle

Secretin
Methylation
Lung Neoplasms
Biomarkers
Genes
79 Citations (Scopus)

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Kim, J., McMillan, E., Kim, H. S., Venkateswaran, N., Makkar, G., Rodriguez-Canales, A., Villalobos, P., Neggers, J. E., Mendiratta, S., Wei, S., Landesman, Y., Senapedis, W., Baloglu, E., Chow, C. W. B., Frink, R. E., Gao, B., Roth, M., Minna, J. D., Daelemans, D., Wistuba, I. I. & 3 others, Posner, B. A., Scaglioni, P. P. & White, M. A., Sep 28 2016, In : Nature. 538, 7623, p. 114-117 4 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Biological Phenomena
Cytoplasmic and Nuclear Receptors
88 Citations (Scopus)

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

Larsen, J. E., Nathan, V., Osborne, J. K., Farrow, R. K., Deb, D., Sullivan, J. P., Dospoy, P. D., Augustyn, A., Hight, S. K., Sato, M., Girard, L., Behrens, C., Wistuba, I. I., Gazdar, A. F., Hayward, N. K. & Minna, J. D., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3219-3235 17 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Lung Neoplasms
Epithelial Cells
Non-Small Cell Lung Carcinoma
Protein Splicing
2015
238 Citations (Scopus)

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

Skoulidis, F., Byers, L. A., Diao, L., Papadimitrakopoulou, V. A., Tong, P., Izzo, J., Behrens, C., Kadara, H., Parra, E. R., Canales, J. R., Zhang, J., Giri, U., Gudikote, J., Cortez, M. A., Yang, C., Fan, Y., Peyton, M., Girard, L., Coombes, K. R., Toniatti, C. & 17 others, Heffernan, T. P., Choi, M., Frampton, G. M., Miller, V., Weinstein, J. N., Herbst, R. S., Wong, K. K., Zhang, J., Sharma, P., Mills, G. B., Hong, W. K., Minna, J. D., Allison, J. P., Futrea, A., Wang, J., Wistuba, I. I. & Heymach, J. V., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 861-878 18 p.

Research output: Contribution to journalArticle

Biomarkers
Therapeutics
Neoplasms
Proteomics
Immune System
5 Citations (Scopus)
Linear Energy Transfer
Epithelial Cells
Radiation
Agar
Lung Neoplasms
12 Citations (Scopus)

LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells

Wei, Q., Chen, Z. H., Wang, L., Zhang, T., Duan, L., Behrens, C., Wistuba, I. I., Minna, J. D., Gao, B., Luo, J. H. & Liu, Z. P., Sep 14 2015, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Leucine Zippers
Carcinogenesis
Transcription Factors
Epithelial Cells
Lung
9 Citations (Scopus)

On comparing heterogeneity across biomarkers

Steininger, R. J., Rajaram, S., Girard, L., Minna, J. D., Wu, L. F. & Altschuler, S. J., Jun 1 2015, In : Cytometry Part A. 87, 6, p. 558-567 10 p.

Research output: Contribution to journalArticle

Biomarkers
Microscopy
Cell Line
Lung Neoplasms
Staining and Labeling
1 Citation (Scopus)

Significance of NAD (P) H: quinone oxidoreductase 1 overexpression in prognostic evaluation of thyroid medullary carcinoma

Jin, Z., Cui, X., Zhang, Y., Yang, Y., Li, L., Lin, Z. & Chen, L., Feb 1 2015, In : Zhonghua bing li xue za zhi Chinese journal of pathology. 44, 2, p. 128-129 2 p.

Research output: Contribution to journalArticle

Neoplasm Proteins
NAD(P)H Dehydrogenase (Quinone)
Medullary Carcinoma
NADP
Thyroid Neoplasms
12 Citations (Scopus)

Systematic siRNA screen unmasks NSCLC growth dependence by palmitoyltransferase DHHC5

Tian, H., Lu, J. Y., Shao, C., Huffman, K. E., Carstens, R. M., Larsen, J. E., Girard, L., Liu, H., Rodriguez-Canales, J., Frenkel, E. P., Wistuba, I. I., Minna, J. D. & Hofmann, S. L., Apr 1 2015, In : Molecular Cancer Research. 13, 4, p. 784-794 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Small Interfering RNA
Lipoylation
Growth
Neoplasms