Hematology & Oncology

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2020

A Phase I Study of Alpha-1,3-Galactosyltransferase-Expressing Allogeneic Renal Cell Carcinoma Immunotherapy in Patients with Refractory Metastatic Renal Cell Carcinoma

Hahn, A. W., Drake, C., Denmeade, S. R., Zakharia, Y., Maughan, B. L., Kennedy, E., Link, C., Vahanian, N., Hammers, H. & Agarwal, N., Feb 1 2020, In : Oncologist. 25, 2, p. 121-e213

Research output: Contribution to journalArticle

Open Access

A randomized, phase 2 study of deoxyuridine triphosphatase inhibitor, TAS-114, in combination with S-1 versus S-1 alone in patients with advanced non-small-cell lung cancer

Yamamoto, N., Hayashi, H., Planchard, D., Morán, T., Gregorc, V., Dowell, J., Sakai, H., Yoh, K., Nishio, M., Cortot, A. B., Benhadji, K. A., Soni, N., Huang, J., Makris, L. & Cedres, S., Jan 1 2020, (Accepted/In press) In : Investigational New Drugs.

Research output: Contribution to journalArticle

Open Access

B cells and tertiary lymphoid structures promote immunotherapy response

Helmink, B. A., Reddy, S. M., Gao, J., Zhang, S., Basar, R., Thakur, R., Yizhak, K., Sade-Feldman, M., Blando, J., Han, G., Gopalakrishnan, V., Xi, Y., Zhao, H., Amaria, R. N., Tawbi, H. A., Cogdill, A. P., Liu, W., LeBleu, V. S., Kugeratski, F. G., Patel, S. & 40 others, Davies, M. A., Hwu, P., Lee, J. E., Gershenwald, J. E., Lucci, A., Arora, R., Woodman, S., Keung, E. Z., Gaudreau, P. O., Reuben, A., Spencer, C. N., Burton, E. M., Haydu, L. E., Lazar, A. J., Zapassodi, R., Hudgens, C. W., Ledesma, D. A., Ong, S. F., Bailey, M., Warren, S., Rao, D., Krijgsman, O., Rozeman, E. A., Peeper, D., Blank, C. U., Schumacher, T. N., Butterfield, L. H., Zelazowska, M. A., McBride, K. M., Kalluri, R., Allison, J., Petitprez, F., Fridman, W. H., Sautès-Fridman, C., Hacohen, N., Rezvani, K., Sharma, P., Tetzlaff, M. T., Wang, L. & Wargo, J. A., Jan 23 2020, In : Nature. 577, 7791, p. 549-555 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Closing the gap: Contribution of surgical best practices to outcome differences between high- and low-volume centers for lung cancer resection

von Itzstein, M. S., Lu, R., Kernstine, K. H., Halm, E. A., Wang, S., Xie, Y. & Gerber, D. E., Jan 1 2020, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Open Access

Definition and coordination of roles and responsibilities among cancer center clinic and research personnel

Craddock Lee, S. J., Reimer, T., Garcia, S., Williams, E. L., West, M., Stuart, T. & Gerber, D. E., Jan 1 2020, In : Journal of oncology practice. 16, 1, p. E64-E74

Research output: Contribution to journalArticle

Enasidenib in patients with mutant IDH2 myelodysplastic syndromes: a phase 1 subgroup analysis of the multicentre, AG221-C-001 trial

Stein, E. M., Fathi, A. T., DiNardo, C. D., Pollyea, D. A., Roboz, G. J., Collins, R., Sekeres, M. A., Stone, R. M., Attar, E. C., Frattini, M. G., Tosolini, A., Xu, Q., See, W. L., MacBeth, K. J., de Botton, S., Tallman, M. S. & Kantarjian, H. M., Apr 2020, In : The Lancet Haematology. 7, 4, p. e309-e319

Research output: Contribution to journalArticle

1 Scopus citations

Final analysis of a phase 1/2b study of ibrutinib combined with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma

Chari, A., Cornell, R. F., Gasparetto, C., Karanes, C., Matous, J. V., Niesvizky, R., Lunning, M., Usmani, S. Z., Anderson, L. D., Chhabra, S., Girnius, S., Shustik, C., Stuart, R., Lee, Y., Salman, Z., Liu, E. & Valent, J., Jan 1 2020, (Accepted/In press) In : Hematological Oncology.

Research output: Contribution to journalArticle

Open Access

Improving the time to activation of new clinical trials at a national cancer institute-designated comprehensive cancer center

Williams, E., Brown, T. J., Griffith, P., Rahimi, A., Oilepo, R., Hammers, H., Laetsch, T. W., Currykosky, P., Partridge, S. & Beg, M. S., Apr 1 2020, In : Journal of oncology practice. 16, 4, p. E324-E332

Research output: Contribution to journalArticle

Increased reporting but decreased mortality associated with adverse events in patients undergoing lung cancer surgery: Competing forces in an era of heightened focus on care quality?

Von Itzstein, M. S., Gupta, A., Kernstine, K. H., Mara, K. C., Khanna, S. & Gerber, D. E., Apr 2020, In : PloS one. 15, 4, e0231258.

Research output: Contribution to journalArticle

Open Access

In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients

Tiwari, V., Mashimo, T., An, Z., Vemireddy, V., Piccirillo, S., Askari, P., Hulsey, K. M., Zhang, S., de Graaf, R. A., Patel, T. R., Pan, E., Mickey, B. E., Maher, E. A., Bachoo, R. M. & Choi, C., Jan 1 2020, (Accepted/In press) In : Magnetic resonance in medicine.

Research output: Contribution to journalArticle

Lack of Association Between Radiographic Tumor Burden and Efficacy of Immune Checkpoint Inhibitors in Advanced Lung Cancer

Popat, V., Lu, R., Ahmed, M., Park, J. Y., Xie, Y. & Gerber, D. E., Jan 1 2020, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access

Novel hyaluronan formulation for preventing acute skin reactions in breast during radiotherapy: a randomized clinical trial

Rahimi, A., Mohamad, O., Albuquerque, K., Kim, D. W. N., Chen, D., Thomas, K., Wooldridge, R., Rivers, A., Leitch, M., Rao, R., Haley, B., Ahn, C., Garwood, D. & Spangler, A., Mar 1 2020, In : Supportive Care in Cancer. 28, 3, p. 1481-1489 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Osimertinib in pulmonary manifestations: Two case reports and review of the literature

Lu, H. & Dowell, J., Jan 1 2020, In : In Vivo. 34, 1, p. 315-319 5 p.

Research output: Contribution to journalArticle

Open Access

Patient familiarity with, understanding of, and preferences for clinical trial endpoints and terminology

von Itzstein, M. S., Railey, E., Smith, M. L., White, C. B., Sledge, G. W., Howell, J. R., Lawton, W., Marinucci, D. M., Unni, N. & Gerber, D. E., Apr 15 2020, In : Cancer. 126, 8, p. 1605-1613 9 p.

Research output: Contribution to journalArticle

Patterns of Care for Stage II-III Rectosigmoid Cancers in the United States, 2004-2015

Sanford, N. N., Aguilera, T. A., Beg, M. S., Sanjeevaiah, A., Hong, T. S., Wo, J. Y. & Folkert, M. R., Jan 1 2020, (Accepted/In press) In : American Journal of Clinical Oncology: Cancer Clinical Trials. 674.

Research output: Contribution to journalArticle

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

Hong, D. S., Kang, Y. K., Borad, M., Sachdev, J., Ejadi, S., Lim, H. Y., Brenner, A. J., Park, K., Lee, J. L., Kim, T. Y., Shin, S., Becerra, C. R., Falchook, G., Stoudemire, J., Martin, D., Kelnar, K., Peltier, H., Bonato, V., Bader, A. G., Smith, S. & 3 others, Kim, S., O’Neill, V. & Beg, M. S., Jan 1 2020, (Accepted/In press) In : British journal of cancer.

Research output: Contribution to journalArticle

Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer

Gerber, D. E., Camidge, D. R., Morgensztern, D., Cetnar, J., Kelly, R. J., Ramalingam, S. S., Spigel, D. R., Jeong, W., Scaglioni, P. P., Zhang, S., Li, M., Weaver, D. T., Vaikus, L., Keegan, M., Horobin, J. C. & Burns, T. F., Jan 2020, In : Lung Cancer. 139, p. 60-67 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phase Ia study of anti-NAPI2B antibody–drug conjugate lifastuzumab vedotin DNIB0600A in patients with non–small cell lung cancer and platinum-resistant ovarian cancer

Gerber, D. E., Infante, J. R., Gordon, M. S., Goldberg, S. B., Martín, M., Felip, E., Garcia, M. M., Schiller, J. H., Spigel, D. R., Cordova, J., Westcott, V., Wang, Y., Shames, D. S., Choi, Y. J., Kahn, R., Dere, R. C., Samineni, D., Xu, J., Lin, K., Wood, K. & 7 others, Royer-Joo, S., Lemahieu, V., Schuth, E., Vaze, A., Maslyar, D., Humke, E. W. & Burris, H. A., Jan 15 2020, In : Clinical Cancer Research. 26, 2, p. 364-372 9 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Stakeholder engagement to initiate lung cancer screening in an urban safety-net health system

Lee, S. J. C., Hamann, H. A., Browning, T., Santini, N. O., Abbara, S., Balis, D. S., Chiu, H., Moran, B. A., McGuire, M. & Gerber, D. E., Mar 2020, In : Healthcare. 8, 1, 100370.

Research output: Contribution to journalArticle

Target discovery of selective non-small-cell lung cancer toxins reveals inhibitors of mitochondrial complex i

Madhusudhan, N., Hu, B., Mishra, P., Calva-Moreno, J. F., Patel, K., Boriack, R., Ready, J. M. & Nijhawan, D., Jan 17 2020, In : ACS chemical biology. 15, 1, p. 158-170 13 p.

Research output: Contribution to journalArticle

The association of lymphotoxin-beta receptor with the subsequent diagnosis of incident gastrointestinal cancer: Results from the Dallas Heart Study

Bergstrom, C. P., Beg, M. S., Ayers, C., Gupta, A. & Neeland, I. J., Feb 1 2020, In : Journal of Gastrointestinal Oncology. 11, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Open Access

Timing, Sites, and Correlates of Lung Cancer Recurrence

Karacz, C. M., Yan, J., Zhu, H. & Gerber, D. E., Mar 2020, In : Clinical lung cancer. 21, 2, p. 127-135.e3

Research output: Contribution to journalArticle

2019

Allogeneic hematopoietic cell transplantation provides effective salvage despite refractory disease or failed prior autologous transplant in angioimmunoblastic T-cell lymphoma: A CIBMTR analysis

Epperla, N., Ahn, K. W., Litovich, C., Ahmed, S., Battiwalla, M., Cohen, J. B., Dahi, P., Farhadfar, N., Farooq, U., Freytes, C. O., Ghosh, N., Haverkos, B., Herrera, A., Hertzberg, M., Hildebrandt, G., Inwards, D., Kharfan-Dabaja, M. A., Khimani, F., Lazarus, H., Lazaryan, A. & 13 others, Lekakis, L., Murthy, H., Nathan, S., Nishihori, T., Pawarode, A., Prestidge, T., Ramakrishnan, P., Rezvani, A. R., Romee, R., Shah, N. N., Sureda, A., Fenske, T. S. & Hamadani, M., Jan 10 2019, In : Journal of Hematology and Oncology. 12, 1, 6.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

An evaluation of fulvestrant for the treatment of metastatic breast cancer

Soleja, M., Raj, G. V. & Unni, N., Oct 13 2019, In : Expert Opinion on Pharmacotherapy. 20, 15, p. 1819-1829 11 p.

Research output: Contribution to journalArticle

A non-hierarchical organization of tumorigenic ng2 cells in glioblastoma promoted by egfr

Al-Mayhani, T. F., Heywood, R. M., Vemireddy, V., Lathia, J. D., Piccirillo, S. G. M. & Watts, C., Jun 10 2019, In : Neuro-oncology. 21, 6, p. 719-729 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A phase II study of addition of pracinostat to a hypomethylating agent in patients with myelodysplastic syndromes who have not responded to previous hypomethylating agent therapy

Yalniz, F. F., Berdeja, J. G., Maris, M. B., Lyons, R. M., Reeves, J. A., Essell, J. H., Patel, P., Sekeres, M., Hughes, A., Mappa, S. & Garcia-Manero, G., Jan 1 2019, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15

Ting, T. C., Goralski, M., Klein, K., Wang, B., Kim, J., Xie, Y. & Nijhawan, D., Nov 5 2019, In : Cell Reports. 29, 6, p. 1499-1510.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Bleeding due to acquired dysfibrinogenemia as the initial presentation of multiple myeloma

Siddiq, N., Bergstrom, C., Anderson, L. D. & Nagalla, S., Jul 1 2019, In : BMJ Case Reports. 12, 7, e229312.

Research output: Contribution to journalArticle

Blocking monocytic myeloid-derived suppressor cell function via anti-DC-HIL/GpNMB antibody restores the in vitro integrity of T cells from cancer patients

Kobayashi, M., Chung, J. S., Beg, M., Arriaga, Y., Verma, U., Courtney, K., Mansour, J., Haley, B., Khan, S., Horiuchi, Y., Ramani, V., Harker, D., Gopal, P., Araghizadeh, F., Cruz, P. D. & Ariizumi, K., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 828-838 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Breast Implant-associated Plasmablastic Lymphoma: A Case Report and Discussion of the Literature

Geethakumari, P. R., Markantonis, J., Shah, J. L., Alsuwaidan, A., Shahab, I., Chen, W. & Jaso, J. M., Oct 2019, In : Clinical Lymphoma, Myeloma and Leukemia. 19, 10, p. e568-e572

Research output: Contribution to journalArticle

2 Scopus citations

Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study

Martínez Chanzá, N., Xie, W., Asim Bilen, M., Dzimitrowicz, H., Burkart, J., Geynisman, D. M., Balakrishnan, A., Bowman, I. A., Jain, R., Stadler, W., Zakharia, Y., Narayan, V., Beuselinck, B., McKay, R. R., Tripathi, A., Pachynski, R., Hahn, A. W., Hsu, J. A., Shah, S. A., Lam, E. T. & 18 others, Rose, T. L., Mega, A. E., Vogelzang, N., Harrison, M. R., Mortazavi, A., Plimack, E. R., Vaishampayan, U., Hammers, H., George, S., Haas, N., Agarwal, N., Pal, S. K., Srinivas, S., Carneiro, B. A., Heng, D. Y. C., Bosse, D., Choueiri, T. K. & Harshman, L. C., Apr 2019, In : The Lancet Oncology. 20, 4, p. 581-590 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E. N., Verma, U. & Brekken, R. A., Jul 23 2019, In : JCI Insight. 4, 16, e129212.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Classification of brain tumor isocitrate dehydrogenase status using MRI and deep learning

Nalawade, S., Murugesan, G. K., Vejdani-Jahromi, M., Fisicaro, R. A., Bangalore Yogananda, C. G., Wagner, B., Mickey, B., Maher, E., Pinho, M. C., Fei, B., Madhuranthakam, A. J. & Maldjian, J. A., Oct 1 2019, In : Journal of Medical Imaging. 6, 4, 046003.

Research output: Contribution to journalArticle

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S. K., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R. H., Buelow, D. R., Baker, S. D., Druker, B. J. & Tyner, J. W., Dec 1 2019, In : Nature communications. 10, 1, 244.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Combined targeting of estrogen receptor alpha and XPO1 prevent AKT activation, remodel metabolic pathways and induce autophagy to overcome tamoxifen resistance

Kulkoyluoglu-Cotul, E., Smith, B. P., Wrobel, K., Zhao, Y. C., Chen, K. L. A., Hieronymi, K., Imir, O. B., Duong, K., O’Callaghan, C., Mehta, A., Sahoo, S., Haley, B. B., Chang, H., Landesman, Y. & Madak-Erdogan, Z., Apr 1 2019, In : Cancers. 11, 4, 479.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation

Tuladhar, R., Yeu, Y., Tyler Piazza, J., Tan, Z., Rene Clemenceau, J., Wu, X., Barrett, Q., Herbert, J., Mathews, D. H., Kim, J., Hyun Hwang, T. & Lum, L., Dec 1 2019, In : Nature communications. 10, 1, 4056.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Cytoreductive Nephrectomy in Metastatic Papillary Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium

Graham, J., Wells, J. C., Donskov, F., Lee, J. L., Fraccon, A., Pasini, F., Porta, C., Bowman, I. A., Bjarnason, G. A., Ernst, D. S., Rha, S. Y., Beuselinck, B., Hansen, A., North, S. A., Kollmannsberger, C. K., Wood, L. A., Vaishampayan, U. N., Pal, S. K., Choueiri, T. K. & Heng, D. Y. C., Nov 1 2019, In : European Urology Oncology. 2, 6, p. 643-648 6 p.

Research output: Contribution to journalArticle

Decreasing Inappropriate Use of Rasburicase to Promote Cost-Effective Care

Patel, K. K., Brown, T. J., Gupta, A., Roberts, T., Marley, E., Li, H. C. & Sadeghi, N., Feb 1 2019, In : Journal of oncology practice. 15, 2, p. e178-e186

Research output: Contribution to journalArticle

1 Scopus citations

DEFOR: Depth- and frequency-based somatic copy number alteration detector

Zhang, H., Zhan, X., Brugarolas, J. & Xie, Y., Oct 1 2019, In : Bioinformatics. 35, 19, p. 3824-3825 2 p.

Research output: Contribution to journalArticle

Open Access

Development and Validation of a Nomogram Prognostic Model for Patients With Advanced Non-Small-Cell Lung Cancer

Wang, T., Lu, R., Lai, S., Schiller, J. H., Zhou, F. L., Ci, B., Wang, S., Gao, X., Yao, B., Gerber, D. E., Johnson, D. H., Xiao, G. & Xie, Y., Apr 1 2019, In : Cancer Informatics. 18

Research output: Contribution to journalArticle

Open Access

Downregulation of human DAB2IP gene expression in renal cell carcinoma results in resistance to ionizing radiation

Yun, E. J., Lin, C. J., Dang, A., Hernandez, E., Guo, J., Chen, W. M., Allison, J., Kim, N., Kapur, P., Brugarolas, J., Wu, K., He, D., Lai, C. H., Lin, H., Saha, D., Baek, S. T., Chen, B. P. C. & Hsieh, J. T., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4542-4551 10 p.

Research output: Contribution to journalArticle

Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study

Pulsipher, M. A., Logan, B. R., Chitphakdithai, P., Kiefer, D. M., Riches, M. L., Rizzo, J. D., Anderlini, P., Leitman, S. F., Varni, J. W., Kobusingye, H., Besser, R. A. M., Miller, J. P., Drexler, R. J., Abdel-Mageed, A., Ahmed, I. A., Akard, L. P., Artz, A. S., Ball, E. D., Bayer, R. L., Bigelow, C. & 42 others, Bolwell, B. J., Broun, E. R., Bunin, N. J., Delgado, D. C., Duckworth, K., Dvorak, C. C., Hahn, T. E., Haight, A. E., Hari, P. N., Hayes-Lattin, B. M., Jacobsohn, D. A., Jakubowski, A. A., Kasow, K. A., Lazarus, H. M., Liesveld, J. L., Linenberger, M., Litzow, M. R., Longo, W., Magalhaes-Silverman, M., McCarty, J. M., McGuirk, J. P., Mori, S., Prasad, V. K., Rowley, S. D., Rybka, W. B., Sahdev, I., Schriber, J. R., Selby, G. B., Shaughnessy, P. J., Shenoy, S., Spitzer, T., Tse, W. T., Uberti, J. P., Vusirikala, M., Waller, E. K., Weisdorf, D. J., Yanik, G. A., Navarro, W. H., Horowitz, M. M., Switzer, G. E., Shaw, B. E. & Confer, D. L., Apr 2019, In : Biology of Blood and Marrow Transplantation. 25, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of public deliberation on patient attitudes regarding consent and data use in a learning health care system for oncology

Jagsi, R., Griffith, K. A., Jones, R. D., Krenz, C., Gornick, M., Spence, R., De Vries, R., Hawley, S. T., Zon, R., Bolte, S., Sadeghi, N., Schilsky, R. L. & Bradbury, A. R., Jan 1 2019, In : Journal of Clinical Oncology. 37, 34, p. 3203-3211 9 p.

Research output: Contribution to journalArticle

1 Scopus citations