Research Output 1954 2019

2019

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Fermaintt, C. S., Sano, K., Liu, Z., Ishii, N., Seino, J., Dobbs, N., Suzuki, T., Fu, Y-X., Lehrman, M. A., Matsuo, I. & Yan, N., Dec 1 2019, In : Nature communications. 10, 1, 2377.

Research output: Contribution to journalArticle

Open Access
Disaccharides
activity (biology)
Autoimmunity
Autoimmune Diseases
Polysaccharides

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians

Molineros, J. E., Looger, L. L., Kim, K., Okada, Y., Terao, C., Sun, C., Zhou, X. J., Raj, P., Kochi, Y., Suzuki, A., Akizuki, S., Nakabo, S., Bang, S. Y., Lee, H. S., Kang, Y. M., Suh, C. H., Chung, W. T., Park, Y. B., Choe, J. Y., Shim, S. C. & 13 othersLee, S. S., Zuo, X., Yamamoto, K., Li, Q., Shen, N., Porter, L. L., Harley, J. B., Chua, K. H., Zhang, H., Wakeland, E. K., Tsao, B. P., Bae, S. C. & Nath, S. K., Apr 1 2019, In : PLoS genetics. 15, 4, p. e1008092

Research output: Contribution to journalArticle

Open Access
lupus erythematosus
antibody formation
HLA Antigens
antigen
Systemic Lupus Erythematosus

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H-X., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J. L., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B. A., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
Serum Amyloid A Protein
Retinoic Acid Receptors
Vitamin A
Immunity
Th17 Cells

Erratum: Targeting CD137 enhances the efficacy of cetuximab(J Clin Invest. (2019)129:6 (2595-2595) DOI: 10.1172/JCI129689)

Kohrt, H. E., Colevas, A. D., Houot, R., Weiskopf, K., Goldstein, M. J., Lund, P., Mueller, A., Sagiv-Barfi, I., Marabelle, A., Lira, R., Troutner, E., Richards, L., Rajapaska, A., Hebb, J., Chester, C., Waller, E., Ostashko, A., Weng, W. K., Chen, L., Czerwinski, D. & 3 othersFu, Y-X., Sunwoo, J. & Levy, R., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Information Storage and Retrieval
Medicine
Cetuximab

Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma

Espinosa-Cotton, M., Rodman, S. N., Ross, K. A., Jensen, I. J., Sangodeyi-Miller, K., McLaren, A. J., Dahl, R. A., Gibson-Corley, K. N., Koch, A. T., Fu, Y-X., Badovinac, V. P., Laux, D., Narasimhan, B. & Simons, A. L., Mar 19 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, p. 1-16 16 p.

Research output: Contribution to journalArticle

Interleukin-1alpha
Interleukin-1
Neoplasms
Epidermal Growth Factor Receptor
Polyanhydrides
1 Citation (Scopus)

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

Wang, Y., Du, X., Wei, J., Long, L., Tan, H., Guy, C., Dhungana, Y., Qian, C., Neale, G., Fu, Y-X., Yu, J., Peng, J. & Chi, H., May 1 2019, In : Cell Research. 29, 5, p. 391-405 15 p.

Research output: Contribution to journalArticle

Dendritic Cells
Immunity
Neoplasms
Regulatory T-Lymphocytes
Homeostasis

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang Ph.D., D-W., Fang, B., Russell, J. L., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 othersMoresco, E. Y. & Beutler, B. A., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

Lymphopoiesis
Catenins
Wnt2 Protein
Ethylnitrosourea
Wnt Signaling Pathway
Long Noncoding RNA
Prolactin
Growth Hormone
MicroRNAs
Genes
1 Citation (Scopus)

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Harris-Tryon, T., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 777-788.e8

Research output: Contribution to journalArticle

Resistin
Vitamin A
Skin
Cell Shape
Infection

Single-cell RNA-sequencing of peripheral blood mononuclear cells with ddSEQ

Khan, S. & Kaihara, K. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 155-176 22 p. (Methods in Molecular Biology; vol. 1979).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Sequence Analysis
Blood Cells
Immune System
Gene Expression
Infection
1 Citation (Scopus)

Sputum antineutrophil cytoplasmic antibodies in serum antineutrophil cytoplasmic antibody–negative eosinophilic granulomatosis with polyangiitis

Mukherjee, M., Thomas, S. R., Radford, K., Dvorkin-Gheva, A., Davydchenko, S., Kjarsgaard, M., Svenningsen, S., Almas, S., Felix, L. C., Stearns, J., Li, Q., Khalidi, N., Lacy, P. & Nair, P. K., Jan 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 2, p. 158-170 13 p.

Research output: Contribution to journalArticle

Antineutrophil Cytoplasmic Antibodies
Granulomatosis with Polyangiitis
Sputum
Serum
Eosinophils

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B. A. & Zhang, H., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2938-2949 12 p.

Research output: Contribution to journalArticle

Ligands
Lipopeptides
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Melanoma

Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy

Luo, M., Liu, Z., Zhang, X., Han, C., Samandi, L. Z., Dong, C., Sumer, B. D., Lea, J. S., Fu, Y-X. & Gao, J., Apr 28 2019, In : Journal of Controlled Release. 300, p. 154-160 7 p.

Research output: Contribution to journalArticle

Ionizing Radiation
Immunotherapy
Interferons
Transcriptional Activation
Neoplasms
B-Lymphocyte Subsets
T-Lymphocyte Subsets
Amyloid
Exercise
Cognition

Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis

Qiao, J., Liu, Z., Dong, C., Luan, Y., Zhang, A., Moore, C., Fu, K., Peng, J., Wang, Y., Ren, Z., Han, C., Xu, T. & Fu, Y-X., Jun 10 2019, In : Cancer Cell. 35, 6, p. 901-915.e4

Research output: Contribution to journalArticle

Interleukin-10
Dendritic Cells
Apoptosis
T-Lymphocytes
Neoplasms
2 Citations (Scopus)

The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Wang, G. Z., Zhang, L., Zhao, X. C., Gao, S. H., Qu, L. W., Yu, H., Fang, W. F., Zhou, Y. C., Liang, F., Zhang, C., Huang, Y. C., Liu, Z., Fu, Y-X. & Zhou, G. B., Dec 1 2019, In : Nature communications. 10, 1, 1125.

Research output: Contribution to journalArticle

Open Access
tobacco
Aryl Hydrocarbon Receptors
Tobacco
Immunotherapy
hydrocarbons
2 Citations (Scopus)

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children

Altman, M. C., Gill, M. A., Whalen, E., Babineau, D. C., Shao, B., Liu, A. H., Jepson, B., Gruchalla, R. S., O’Connor, G. T., Pongracic, J. A., Kercsmar, C. M., Khurana Hershey, G. K., Zoratti, E. M., Johnson, C. C., Teach, S. J., Kattan, M., Bacharier, L. B., Beigelman, A., Sigelman, S. M., Presnell, S. & 6 othersGern, J. E., Gergen, P. J., Wheatley, L. M., Togias, A., Busse, W. W. & Jackson, D. J., May 1 2019, In : Nature Immunology. 20, 5, p. 637-651 15 p.

Research output: Contribution to journalArticle

Transcriptome
Asthma
Viruses
Mucus
Epidermal Growth Factor Receptor
1 Citation (Scopus)

Yersinia pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection

He, Y. X., Ye, C. L., Zhang, P., Li, Q., Park, C. G., Yang, K., Jiang, L. Y., Lv, Y., Ying, X. L., Ding, H. H., Huang, H. P., Mambwe Tembo, J., Li, A. Y., Cheng, B., Zhang, S. S., Zheng, G. X., Chen, S. Y., Li, W., Xia, L. X., Kan, B. & 8 othersWang, X., Jing, H. Q., Yang, R. F., Peng, H., Fu, Y-X., Klena, J. D., Skurnik, M. & Chen, T., Jan 1 2019, In : Infection and Immunity. 87, 1

Research output: Contribution to journalArticle

Yersinia pseudotuberculosis
Infection
Peyer's Patches
Spleen
Lymph Nodes
2018
1 Citation (Scopus)

A Critical Role of the IL-1β–IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis

Cai, Y., Xue, F., Quan, C., Qu, M., Liu, N., Zhang, Y., Fleming, C., Hu, X., Zhang, H. G., Weichselbaum, R., Fu, Y-X., Tieri, D., Rouchka, E. C., Zheng, J. & Yan, J., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Psoriasis
Interleukin-1
Skin
Inflammation
T-cells
7 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
2 Citations (Scopus)

Adrenergic signaling at the interface of allergic asthma and viral infections

Agaç, D., Gill, M. A. & Farrar, J. D., Apr 11 2018, In : Frontiers in Immunology. 9, APR, 736.

Research output: Contribution to journalArticle

Virus Diseases
Adrenergic Agents
Asthma
Rhinovirus
Norepinephrine
1 Citation (Scopus)

Altered Marginal Zone B Cell Selection in the Absence of i κbNS

Ádori, M., Pedersen, G. K., Ádori, C., Erikson, E., Khoenkhoen, S., Stark, J. M., Choi, J. H., Dosenovic, P., Karlsson, M. C. I., Beutler, B. & Hedestam, G. B. K., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 775-787 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Blood-Borne Pathogens
B-Lymphocyte Subsets
Ficoll
B-Lymphoid Precursor Cells
1 Citation (Scopus)

Another way to not get eaten news-and-views

Zhang, C. & Fu, Y-X., Jan 1 2018, In : Nature Immunology. 19, 1, p. 6-7 2 p.

Research output: Contribution to journalShort survey

1 Citation (Scopus)

A PI3K p110α-selective inhibitor enhances the efficacy of anti-HER2/neu antibody therapy against breast cancer in mice

Choi, J. H., Kim, K. H., Roh, K. H., Jung, H., Lee, A., Lee, J. Y., Song, J. Y., Park, S. J., Kim, I., Lee, W. S., Seo, S. K., Choi, I. W., Fu, Y. X., Yea, S. S. & Park, S. G., Jan 12 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Breast Neoplasms
Antibodies
Anti-Idiotypic Antibodies
Neoplasms

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

Patel, Z. H., Lu, X., Miller, D., Forney, C. R., Lee, J., Lynch, A., Schroeder, C., Parks, L., Magnusen, A. F., Chen, X., Pujato, M., Maddox, A., Zoller, E. E., Namjou, B., Brunner, H. I., Henrickson, M., Huggins, J. L., Williams, A. H., Ziegler, J. T., Comeau, M. E. & 49 othersMarion, M. C., Glenn, S. B., Adler, A., Shen, N., Nath, S. K., Stevens, A. M., Freedman, B. I., Pons-Estel, B. A., Tsao, B. P., Jacob, C. O., Kamen, D. L., Brown, E. E., Gilkeson, G. S., Alarcón, G. S., Martin, J., Reveille, J. D., Anaya, J. M., James, J. A., Sivils, K. L., Criswell, L. A., Vilá, L. M., Petri, M., Scofield, R. H., Kimberly, R. P., Edberg, J. C., Ramsey-Goldman, R., Bang, S. Y., Lee, H. S., Bae, S. C., Boackle, S. A., Graham, D. C., Vyse, T. J., Merrill, J. T., Niewold, T. B., Ainsworth, H. C., Silverman, E. D., Weisman, M. H., Wallace, D. J., Raj, P., Guthridge, J. M., Gaffney, P. M., Kelly, J. A., Alarcón-Riquelme, M. E., Langefeld, C. D., Wakeland, E. K., Kaufman, K. M., Weirauch, M. T., Harley, J. B. & Kottyan, L. C., Jul 1 2018, In : Human Molecular Genetics. 27, 13, p. 2392-2404 13 p.

Research output: Contribution to journalArticle

Alleles
AT-Hook Motifs
B-Lymphocytes
Transcription Factors
Genetic Databases
2 Citations (Scopus)

A role for retrotransposons in chromothripsis

Hancks, D. C., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 169-181 13 p. (Methods in Molecular Biology; vol. 1769).

Research output: Chapter in Book/Report/Conference proceedingChapter

Retroelements
Double-Stranded DNA Breaks
Chromosomes
Genome
Sequence Inversion
1 Citation (Scopus)

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Medical problems
Clustered Regularly Interspaced Short Palindromic Repeats
Obesity
Mutation

B-1a Cell Development in Splenectomized Neonatal Mice

Pedersen, G. K., Li, X., Khoenkhoen, S., Ádori, M., Beutler, B. A. & Karlsson Hedestam, G. B., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Open Access
Spleen
Splenectomy
Bone Marrow
B-Lymphocyte Subsets
B-Lymphoid Precursor Cells
6 Citations (Scopus)

BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation

Deason, K., Troutman, T. D., Jain, A., Challa, D. K., Mandraju, R., Brewer, T., Ward, E. S. & Pasare, C., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2413-2428 16 p.

Research output: Contribution to journalArticle

Th17 Cells
1-Phosphatidylinositol 4-Kinase
Interleukins
Sirolimus
Phosphatidylinositol 3-Kinases
1 Citation (Scopus)
B-Lymphocytes
Autoantibodies
Systemic Lupus Erythematosus
Myeloid Cells
Antigen-Antibody Complex

Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012–2015

Aroh, C., Liang, C., Raj, P., Wakeland, B., Yan, N. & Wakeland, E., Dec 1 2018, In : Infection, Genetics and Evolution. 66, p. 13-17 5 p.

Research output: Contribution to journalArticle

West Nile virus
Satellite Viruses
Disease Outbreaks
persistence
West Nile Fever
2 Citations (Scopus)

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Dimerization
Toll-Like Receptors
Screening
Toll-Like Receptor 2
Macrophages

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., Tang, Y. W., Hooper, L. V., Bordenstein, S. R., Das, S. R. & Weitkamp, J. H., Oct 1 2018, In : PLoS One. 13, 10, e0206366.

Research output: Contribution to journalArticle

enterocolitis
Necrotizing Enterocolitis
microbial communities
Microbiota
antibiotics
8 Citations (Scopus)

Drug-penetration gradients associated with acquired drug resistance in patients with tuberculosis

Dheda, K., Lenders, L., Magombedze, G., Srivastava, S., Raj, P., Arning, E., Ashcraft, P., Bottiglieri, T., Wainwright, H., Pennel, T., Linegar, A., Moodley, L., Pooran, A., Pasipanodya, J. G., Sirgel, F. A., Van Helden, P. D., Wakeland, E. K., Warren, R. M. & Gumbo, T., Nov 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 9, p. 1208-1219 12 p.

Research output: Contribution to journalArticle

Drug Resistance
Tuberculosis
Pharmaceutical Preparations
Anti-Bacterial Agents
Sputum
6 Citations (Scopus)

Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion

Liu, X., Liu, L., Ren, Z., Yang, K., Xu, H., Luan, Y., Fu, K., Guo, J., Peng, H., Zhu, M. & Fu, Y. X., Aug 21 2018, In : Cell Reports. 24, 8, p. 2101-2111 11 p.

Research output: Contribution to journalArticle

Immune Evasion
Tumors
Cells
Neoplasms
T-cells

Erratum: Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth (Cell Host & Microbe (2018) 23(1) (54–64.e6) (S1931312817305000) (10.1016/j.chom.2017.11.006))

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Apr 11 2018, In : Cell Host and Microbe. 23, 4, 1 p.

Research output: Contribution to journalComment/debate

Dysbiosis
Salmonella
Publications
Lactic Acid
Growth
1 Citation (Scopus)

Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function

McAlpine, W., Sun, L., Wang, K. W., Liu, A., Jain, R., Miguel, M. S., Wang, J., Zhang, Z., Hayse, B., McAlpine, S. G., Choi, J. H., Zhong, X., Ludwig, S., Russell, J. L., Zhan, X., Choi, M., Li, X., Tang, M., Moresco, E. M. Y., Beutler, B. A. & 1 othersTurer, E. E., Dec 4 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 49, p. E11523-E11531

Research output: Contribution to journalArticle

Toll-Like Receptors
Autoimmunity
Ligands
Phagosomes
Dextran Sulfate
3 Citations (Scopus)

Expression of corticosteroid-regulated genes by PBMCs in children with asthma

Goleva, E., Babineau, D. C., Gill, M. A., Jackson, L. P., Shao, B., Hu, Z., Liu, A. H., Visness, C. M., Sorkness, C. A., Leung, D. Y. M., Togias, A. & Busse, W. W., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Adrenal Cortex Hormones
Asthma
Genes
Interleukin-8
Glucocorticoid Receptors

Foxo3 promotes apoptosis of B cell receptor-stimulated immature B cells, thus limiting the window for receptor editing

Ottens, K., Hinman, R. M., Barrios, E., Skaug, B., Davis, L. S., Li, Q. Z., Castrillon, D. H. & Satterthwaite, A. B., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 940-949 10 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
B-Lymphocytes
Apoptosis
Systemic Lupus Erythematosus
Autoantibodies
11 Citations (Scopus)

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

Preite, S., Cannons, J. L., Radtke, A. J., Vujkovic-Cvijin, I., Gomez-Rodriguez, J., Volpi, S., Huang, B., Cheng, J., Collins, N., Reilley, J., Handon, R., Dobbs, K., Huq, L., Raman, I., Zhu, C., Li, Q. Z., Li, M. O., Pittaluga, S., Uzel, G., Notarangelo, L. D. & 3 othersBelkaid, Y., Germain, R. N. & Schwartzberg, P. L., Sep 1 2018, In : Nature Immunology. 19, 9, p. 986-1000 15 p.

Research output: Contribution to journalArticle

Humoral Immunity
Phosphatidylinositol 3-Kinases
Germinal Center
Microbiota
Helper-Inducer T-Lymphocytes
7 Citations (Scopus)

IgM and igD b cell receptors differentially respond to endogenous antigens and control B cell fate

Noviski, M., Mueller, J. L., Satterthwaite, A., Garrett-Sinha, L. A., Brombacher, F. & Zikherman, J., Mar 9 2018, In : eLife. 7, e35074.

Research output: Contribution to journalArticle

Immunoglobulin D
Immunoglobulin M
B-Lymphocytes
Cells
Antigens

IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1

Palmer, V. L., Worth, A. N., Scott, R. L., Perry, G. A., Yan, M., Li, Q. Z. & Swanson, P. C., Sep 1 2018, In : Cellular Immunology. 331, p. 110-120 11 p.

Research output: Contribution to journalArticle

Interleukin-10
Transgenic Mice
B-Lymphocytes
Autoantibodies
Immunoglobulin M
2 Citations (Scopus)

Immune dysregulation in cancer patients developing immune-related adverse events

Khan, S., Khan, S., Luo, X., Fattah, F. J., Saltarski, J., Gloria-McCutchen, Y., Lu, R., Xie, Y., Li, Q., Wakeland, E. K. & Gerber, D. E., Jan 1 2018, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

Neoplasms
Cytokines
Therapeutics
Interleukin-10
Serum
3 Citations (Scopus)

Immune Evasion in Tumor's Own Sweet Way

Tang, H. & Fu, Y. X., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Tumor Escape
Neoplasms
Tumor Microenvironment
Glycolysis
Immunity
Systemic Scleroderma
DNA Methylation
Methylation
Blood Cells
Genome
7 Citations (Scopus)

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

Ye, R., Gordillo, R., Shao, M., Onodera, T., Chen, Z., Chen, S., Lin, X., SoRelle, J. A., Li, X., Tang, M., Keller, M. P., Kuliawat, R., Attie, A. D., Gupta, R. K., Holland, W. L., Beutler, B. A., Herz, J. & Scherer, P. E., Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Lipid Metabolism
Obesity
Insulin
Diet
3 Citations (Scopus)

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 othersCao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature Communications. 9, 1, 4324.

Research output: Contribution to journalArticle

fear
Instinct
odors
predators
Genetic Testing
19 Citations (Scopus)

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Paneth Cells
Autophagy
Toxoplasma
Inflammation
Microbiota
40 Citations (Scopus)

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

Lu, K., He, C., Guo, N., Chan, C., Ni, K., Lan, G., Tang, H., Pelizzari, C., Fu, Y. X., Spiotto, M. T., Weichselbaum, R. R. & Lin, W., Mar 26 2018, (Accepted/In press) In : Nature Biomedical Engineering. p. 1-11 11 p.

Research output: Contribution to journalArticle

X-Ray Therapy
Immunotherapy
Dosimetry
Tumors
X rays