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2020

Chemotherapy Induces Cancer-Fighting B Cells

Liu, Z. & Fu, Y. X., Mar 19 2020, In : Cell. 180, 6, p. 1037-1039 3 p.

Research output: Contribution to journalArticle

Differential regulation of breast cancer bone metastasis by PARP1 and PARP2

Zuo, H., Yang, D., Yang, Q., Tang, H., Fu, Y. X. & Wan, Y., Dec 1 2020, In : Nature communications. 11, 1, 1578.

Research output: Contribution to journalArticle

Open Access

Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B

Wang, W., Zhou, X., Bian, Y., Wang, S., Chai, Q., Guo, Z., Wang, Z., Zhu, P., Peng, H., Yan, X., Li, W., Fu, Y. X. & Zhu, M., May 1 2020, In : Nature Nanotechnology. 15, 5, p. 406-416 11 p.

Research output: Contribution to journalArticle

Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development

Choi, J. H., Zhong, X., Zhang, Z., Su, L., McAlpine, W., Misawa, T., Liao, T. C., Zhan, X., Russell, J., Ludwig, S., Li, X., Tang, M., Anderton, P., Moresco, E. M. Y. & Beutler, B., Jan 1 2020, In : Journal of Experimental Medicine. 217, 4, e20190006.

Research output: Contribution to journalArticle

Open Access

Essential requirement for nicastrin in marginal zone and B-1 B cell development

Choi, J. H., Han, J., Theodoropoulos, P. C., Zhong, X., Wang, J., Medler, D., Ludwig, S., Zhan, X., Li, X., Tang, M., Gallagher, T., Yu, G. & Beutler, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4894-4901 8 p.

Research output: Contribution to journalArticle

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function

Zhong, X., Su, L., Yang, Y., Nair-Gill, E., Tang, M., Anderton, P., Li, X., Wang, J., Zhan, X., Tomchick, D. R., Brautigam, C. A., Moresco, E. M. Y., Choi, J. H. & Beutler, B., Apr 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 15, p. 8563-8572 10 p.

Research output: Contribution to journalArticle

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

Gao, X., Zhang, Z., Mashimo, T., Shen, B., Nyagilo, J., Wang, H., Wang, Y., Liu, Z., Mulgaonkar, A., Hu, X. L., Piccirillo, S. G. M., Eskiocak, U., Davé, D. P., Qin, S., Yang, Y., Sun, X., Fu, Y. X., Zong, H., Sun, W., Bachoo, R. M. & 1 others, Ge, W. P., Feb 25 2020, In : Cell Reports. 30, 8, p. 2489-2500.e5

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells

Pouzolles, M., Machado, A., Guilbaud, M., Irla, M., Gailhac, S., Barennes, P., Cesana, D., Calabria, A., Benedicenti, F., Sergé, A., Raman, I., Li, Q. Z., Montini, E., Klatzmann, D., Adjali, O., Taylor, N. & Zimmermann, V. S., Feb 2020, In : Journal of Allergy and Clinical Immunology. 145, 2, p. 679-697.e5

Research output: Contribution to journalArticle

1 Scopus citations

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

Shi, Y., Zheng, W., Yang, K., Harris, K. G., Ni, K., Xue, L., Lin, W., Chang, E. B., Weichselbaum, R. R. & Fu, Y. X., May 4 2020, In : The Journal of experimental medicine. 217, 5

Research output: Contribution to journalArticle

Open Access

Investigation of antigen-specific T-cell receptor clusters in human cancers

Zhang, H., Liu, L., Zhang, J., Chen, J., Ye, J., Shukla, S., Qiao, J., Zhan, X., Chen, H., Wu, C. J., Fu, Y. X. & Li, B., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1359-1371 13 p.

Research output: Contribution to journalArticle

Late-Onset Immunotherapy Toxicity and Delayed Autoantibody Changes: Checkpoint Inhibitor–Induced Raynaud's-Like Phenomenon

Khan, S., von Itzstein, M. S., Lu, R., Bermas, B. L., Karp, D. R., Khan, S. A., Fattah, F. J., Park, J. Y., Saltarski, J. M., Gloria-McCutchen, Y., Xie, Y., Li, Q. Z., Wakeland, E. K. & Gerber, D. E., May 1 2020, In : Oncologist. 25, 5, p. e753-e757

Research output: Contribution to journalArticle

Open Access

Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

Misawa, T., SoRelle, J. A., Choi, J. H., Yue, T., Wang, K. W., McAlpine, W., Wang, J., Liu, A., Tabeta, K., Turer, E. E., Evers, B., Nair-Gill, E., Poddar, S., Su, L., Ou, F., Yu, L., Russell, J., Ludwig, S., Zhan, X., Hildebrand, S. & 5 others, Li, X., Tang, M., Murray, A. R., Moresco, E. M. Y. & Beutler, B., Jan 24 2020, In : Science Immunology. 5, 43

Research output: Contribution to journalArticle

Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

Roy, C. J., Van Slyke, G., Ehrbar, D., Bornholdt, Z. A., Brennan, M. B., Campbell, L., Chen, M., Kim, D., Mlakar, N., Whaley, K. J., Froude, J. W., Torres-Velez, F. J., Vitetta, E., Didier, P. J., Doyle-Meyers, L., Zeitlin, L. & Mantis, N. J., Dec 1 2020, In : npj Vaccines. 5, 1, 13.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Pre-existing self-reactive IgA antibodies associated with primary graft dysfunction after lung transplantation

Kaza, V., Zhu, C., Feng, L., Torres, F., Bollineni, S., Mohanka, M., Banga, A., Joerns, J., Mohanakumar, T., Terada, L. S. & Li, Q. Z., Apr 2020, In : Transplant Immunology. 59, 101271.

Research output: Contribution to journalArticle

Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity

Mohammed, S., Vineetha, N. S., James, S., Aparna, J. S., Babu Lankadasari, M., Maeda, T., Ghosh, A., Saha, S., Li, Q. Z., Spiegel, S. & Harikumar, K. B., Mar 1 2020, In : FASEB Journal. 34, 3, p. 4329-4347 19 p.

Research output: Contribution to journalArticle

Open Access

Serum IL-6: A biomarker in childhood asthma?

Jackson, D. J., Bacharier, L. B., Calatroni, A., Gill, M. A., Hu, J., Liu, A. H., Wheatley, L. M., Gern, J. E., Gruchalla, R. S., Khurana Hershey, G. K., Kattan, M., Kercsmar, C. M., Kim, H., O'Connor, G. T., Patel, S., Pongracic, J. A., Wood, R. A. & Busse, W. W., Jan 1 2020, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access

Transcriptional profiling identifies caspase-1 as a T cell–intrinsic regulator of Th17 differentiation

Gao, Y., Deason, K., Jain, A., Irizarry-Caro, R. A., Dozmorov, I., Coughlin, L. A., Rauch, I., Evers, B. M., Koh, A. Y., Wakeland, E. K. & Pasare, C., Jan 1 2020, In : Journal of Experimental Medicine. 217, 4, e20190476.

Research output: Contribution to journalArticle

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

Han, C., Liu, Z., Zhang, Y., Shen, A., Dong, C., Zhang, A., Moore, C., Ren, Z., Lu, C., Cao, X., Zhang, C. L., Qiao, J. & Fu, Y. X., May 1 2020, In : Nature immunology. 21, 5, p. 546-554 9 p.

Research output: Contribution to journalArticle

Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity

Zhang, F., Manna, S., Pop, L. M., Chen, Z. J., Fu, Y. X. & Hannan, R., Apr 2020, In : Seminars in Radiation Oncology. 30, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis

Zhu, W., Winter, M. G., Spiga, L., Hughes, E. R., Chanin, R., Mulgaonkar, A., Pennington, J., Maas, M., Behrendt, C. L., Kim, J., Sun, X., Beiting, D. P., Hooper, L. V. & Winter, S. E., Mar 11 2020, In : Cell Host and Microbe. 27, 3, p. 376-388.e8

Research output: Contribution to journalArticle

2019

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Fermaintt, C. S., Sano, K., Liu, Z., Ishii, N., Seino, J., Dobbs, N., Suzuki, T., Fu, Y. X., Lehrman, M. A., Matsuo, I. & Yan, N., Dec 1 2019, In : Nature communications. 10, 1, 2377.

Research output: Contribution to journalArticle

Open Access

A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First-Degree Relatives of Systemic Lupus Erythematosus Patients

Ogunrinde, E., Zhou, Z., Luo, Z., Alekseyenko, A., Li, Q. Z., Macedo, D., Kamen, D. L., Oates, J. C., Gilkeson, G. S. & Jiang, W., Nov 1 2019, In : Arthritis and Rheumatology. 71, 11, p. 1858-1868 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians

Molineros, J. E., Looger, L. L., Kim, K., Okada, Y., Terao, C., Sun, C., Zhou, X. J., Raj, P., Kochi, Y., Suzuki, A., Akizuki, S., Nakabo, S., Bang, S. Y., Lee, H. S., Kang, Y. M., Suh, C. H., Chung, W. T., Park, Y. B., Choe, J. Y., Shim, S. C. & 13 others, Lee, S. S., Zuo, X., Yamamoto, K., Li, Q. Z., Shen, N., Porter, L. L., Harley, J. B., Chua, K. H., Zhang, H., Wakeland, E. K., Tsao, B. P., Bae, S. C. & Nath, S. K., Jan 1 2019, In : PLoS genetics. 15, 4, e1008092.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

Khan, A., Bakhru, P., Saikolappan, S., Das, K., Soudani, E., Singh, C. R., Estrella, J. L., Zhang, D., Pasare, C., Ma, Y., Sun, J., Wang, J., Hunter, R. L., Tony Eissa, N., Dhandayuthapani, S. & Jagannath, C., Dec 1 2019, In : npj Vaccines. 4, 1, 34.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

Sun, Z., Ren, Z., Yang, K., Liu, Z., Cao, S., Deng, S., Xu, L., Liang, Y., Guo, J., Bian, Y., Xu, H., Shi, J., Wang, F., Fu, Y-X. & Peng, H., Dec 1 2019, In : Nature communications. 10, 1, 3874.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud

Xu, C., Yang, X., Zhou, H., Li, Y., Xing, C., Zhou, T., Zhong, D., Lian, C., Yan, M., Chen, T., Liao, Z., Gao, B., Su, D., Wang, T., Sharma, S., Mohan, C., Ahituv, N., Malik, S., Li, Q. Z. & Su, P., Jan 1 2019, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

Lee, S., Liu, H., Wilen, C. B., Sychev, Z. E., Desai, C., Hykes, B. L., Orchard, R. C., McCune, B. T., Kim, K. W., Nice, T. J., Handley, S. A., Baldridge, M. T., Amarasinghe, G. K. & Virgin, H. W., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 845-857.e5

Research output: Contribution to journalArticle

6 Scopus citations

Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

Orvedahl, A., McAllaster, M. R., Sansone, A., Dunlap, B. F., Desai, C., Wang, Y. T., Balce, D. R., Luke, C. J., Lee, S., Orchard, R. C., Artyomov, M. N., Handley, S. A., Doench, J. G., Silverman, G. A. & Virgin, H. W., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16497-16506 10 p.

Research output: Contribution to journalArticle

Open Access

Body mass index drives changes in DNA methylation: A longitudinal study

Sun, D., Zhang, T., Su, S., Hao, G., Chen, T., Li, Q. Z., Bazzano, L., He, J., Wang, X., Li, S. & Chen, W., Oct 11 2019, In : Circulation research. 125, 9, p. 824-833 10 p.

Research output: Contribution to journalArticle

Open Access

CD160 serves as a negative regulator of NKT cells in acute hepatic injury

Kim, T. J., Park, G., Kim, J., Lim, S. A., Kim, J., Im, K., Shin, M. H., Fu, Y. X., Del Rio, M. L., Rodriguez-Barbosa, J. I., Yee, C., Suh, K. S., Kim, S. J., Ha, S. J. & Lee, K. M., Dec 1 2019, In : Nature communications. 10, 1, 3258.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

Sanchez-Lopez, E., Zhong, Z., Stubelius, A., Sweeney, S. R., Booshehri, L. M., Antonucci, L., Liu-Bryan, R., Lodi, A., Terkeltaub, R., Lacal, J. C., Murphy, A. N., Hoffman, H. M., Tiziani, S., Guma, M. & Karin, M., Jun 4 2019, In : Cell Metabolism. 29, 6, p. 1350-1362.e7

Research output: Contribution to journalArticle

10 Scopus citations

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

Chen, Y., Yu, M., Zheng, Y., Fu, G., Xin, G., Zhu, W., Luo, L., Burns, R., Li, Q. Z., Dent, A. L., Zhu, N., Cui, W., Malherbe, L., Wen, R. & Wang, D., Dec 1 2019, In : Nature communications. 10, 1, 4415.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma

National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium, Nov 2019, In : Journal of Allergy and Clinical Immunology. 144, 5, p. 1187-1197 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus

Mohammed, S., Vineetha, N. S., James, S., Aparna, J. S., Lankadasari, M. B., Allegood, J. C., Li, Q. Z., Spiegel, S. & Harikumar, K. B., Jun 1 2019, In : FASEB Journal. 33, 6, p. 7061-7071 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function

Zhao, X., Xie, H., Zhao, M., Ahsan, A., Li, X., Wang, F., Yi, J., Yang, Z., Wu, C., Raman, I., Li, Q. Z., Kim, T. J. & Liu, W., Jul 17 2019, In : Science Advances. 5, 7, eaaw0315.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans

Du, Q., Huynh, L. K., Coskun, F., Molina, E., King, M. A., Raj, P., Khan, S., Dozmorov, I., Seroogy, C. M., Wysocki, C. A., Padron, G. T., Yates, T. R., Louise Markert, M., Teresa de la Morena, M. & van Oers, N. S. C., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4724-4738 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Functional characterization of CD11c+ age-associated B cells as memory B cells

Du, S. W., Arkatkar, T., Al Qureshah, F., Jacobs, H. M., Thouvenel, C. D., Chiang, K., Largent, A. D., Li, Q. Z., Hou, B., Rawlings, D. J. & Jackson, S. W., Dec 1 2019, In : Journal of Immunology. 203, 11, p. 2817-2826 10 p.

Research output: Contribution to journalArticle

Global analysis of protein expression in muscle tissues of dermatomyositis/polymyosisits patients demonstrated an association between dysferlin and human leucocyte antigen A

Xiao, Y., Zhu, H., Li, L., Gao, S., Liu, D., Dai, B., Li, Q., Duan, H., Yang, H., Li, Q., Zhang, H., Luo, H. & Zuo, X., Aug 1 2019, In : Rheumatology (United Kingdom). 58, 8, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

High TLR7 expression drives the expansion of CD19+CD24HiCD38hi transitional B cells and autoantibody production in SLE patients

Wang, T., Marken, J., Chen, J., Tran, V. B., Li, Q., Li, M., Cerosaletti, K., Elkon, K. B., Zeng, X. & Giltiay, N. V., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1243.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity

Liu, Z., Han, C., Dong, C., Shen, A., Hsu, E., Ren, Z., Lu, C., Liu, L., Zhang, A., Timmerman, C., Pu, Y., Wang, Y., Chen, M., Qiao, J. & Fu, Y. X., Aug 9 2019, In : Science Immunology. 4, 38

Research output: Contribution to journalArticle

2 Scopus citations

Identification of antinorovirus genes in human cells using genome-wide CRISPR activation screening

Orchard, R. C., Sullender, M. E., Dunlap, B. F., Balce, D. R., Doench, J. G. & Virgin, H. W., Jan 1 2019, In : Journal of virology. 93, 1, e01324-18.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Increased serum matrix metalloproteinase-9 levels are associated with Anti-JO1 but not Anti-MDA5 in myositis patients

Liu, Y., Luo, H., Wang, L., Li, C., Liu, L., Huang, L., Liu, K., Liu, M., Gao, S., Xiao, Y., Zhu, H., Zuo, X., Zhang, H. & Li, Q., Jan 1 2019, In : Aging and Disease. 10, 4, p. 746-755 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma

Espinosa-Cotton, M., Rodman, S. N., Ross, K. A., Jensen, I. J., Sangodeyi-Miller, K., McLaren, A. J., Dahl, R. A., Gibson-Corley, K. N., Koch, A. T., Fu, Y. X., Badovinac, V. P., Laux, D., Narasimhan, B. & Simons, A. L., Mar 19 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, p. 1-16 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

Wang, Y., Du, X., Wei, J., Long, L., Tan, H., Guy, C., Dhungana, Y., Qian, C., Neale, G., Fu, Y. X., Yu, J., Peng, J. & Chi, H., May 1 2019, In : Cell Research. 29, 5, p. 391-405 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang, D., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

3 Scopus citations

Membrane-bound and soluble porcine CD83 functions antithetically in T cell activation and dendritic cell differentiation in vitro

Huo, S., Zhang, J., Liang, S., Wu, F., Zuo, Y., Cui, D., Zhang, Y., Zhong, Z. & Zhong, F., Oct 2019, In : Developmental and Comparative Immunology. 99, 103398.

Research output: Contribution to journalArticle

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T. C., de la Morena, M. T., Cleaver, O. B., Mendell, J. T. & van Oers, N. S. C., May 20 2019, In : Developmental cell. 49, 4, p. 618-631.e5

Research output: Contribution to journalArticle

4 Scopus citations

Molecular basis for retinol binding by serum amyloid A during infection

Hu, Z., Bang, Y. J., Ruhn, K. A. & Hooper, L. V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19077-19082 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations