Immunology - Administration

Research output

Research output per year 1975 1990 1996 2005 2007 2013 2019

• 198 Article
• 17 Conference contribution
• 16 Review article
• 7 Comment/debate
• 9 More
  • 4 Editorial
  • 3 Letter
  • 1 Chapter
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2019

  Immune dysregulation in cancer patients developing immune-related adverse events

  Khan, S., Khan, S., Luo, X., Fattah, F. J., Saltarski, J., Gloria-McCutchen, Y., Lu, R., Xie, Y., Li, Q., Wakeland, E. K. & Gerber, D. E., Jan 8 2019, In: British journal of cancer. 120, 1, p. 63-68 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasms 100%
  • Cytokines 72%
  • atezolizumab 61%
  • Therapeutics 38%
  • Interleukin-10 34%
  121 Scopus citations
• 2018

  A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

  Patel, Z. H., Lu, X., Miller, D., Forney, C. R., Lee, J., Lynch, A., Schroeder, C., Parks, L., Magnusen, A. F., Chen, X., Pujato, M., Maddox, A., Zoller, E. E., Namjou, B., Brunner, H. I., Henrickson, M., Huggins, J. L., Williams, A. H., Ziegler, J. T., Comeau, M. E., & 49 othersMarion, M. C., Glenn, S. B., Adler, A., Shen, N., Nath, S. K., Stevens, A. M., Freedman, B. I., Pons-Estel, B. A., Tsao, B. P., Jacob, C. O., Kamen, D. L., Brown, E. E., Gilkeson, G. S., Alarcón, G. S., Martin, J., Reveille, J. D., Anaya, J. M., James, J. A., Sivils, K. L., Criswell, L. A., Vilá, L. M., Petri, M., Scofield, R. H., Kimberly, R. P., Edberg, J. C., Ramsey-Goldman, R., Bang, S. Y., Lee, H. S., Bae, S. C., Boackle, S. A., Graham, D. C., Vyse, T. J., Merrill, J. T., Niewold, T. B., Ainsworth, H. C., Silverman, E. D., Weisman, M. H., Wallace, D. J., Raj, P., Guthridge, J. M., Gaffney, P. M., Kelly, J. A., Alarcón-Riquelme, M. E., Langefeld, C. D., Wakeland, E. K., Kaufman, K. M., Weirauch, M. T., Harley, J. B. & Kottyan, L. C., Jul 1 2018, In: Human molecular genetics. 27, 13, p. 2392-2404 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alleles 100%
  • AT-Hook Motifs 45%
  • B-Lymphocytes 42%
  • Transcription Factors 41%
  • Genetic Databases 35%
  28 Scopus citations

• Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012–2015

  Aroh, C., Liang, C., Raj, P., Wakeland, B., Yan, N. & Wakeland, E., Dec 1 2018, In: Infection, Genetics and Evolution. 66, p. 13-17 5 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus 100%
  • Satellite Viruses 90%
  • Disease Outbreaks 59%
  • persistence 56%
  • ecological niche 17%

• Drug-penetration gradients associated with acquired drug resistance in patients with tuberculosis

  Dheda, K., Lenders, L., Magombedze, G., Srivastava, S., Raj, P., Arning, E., Ashcraft, P., Bottiglieri, T., Wainwright, H., Pennel, T., Linegar, A., Moodley, L., Pooran, A., Pasipanodya, J. G., Sirgel, F. A., Van Helden, P. D., Wakeland, E. K., Warren, R. M. & Gumbo, T., Nov 1 2018, In: American journal of respiratory and critical care medicine. 198, 9, p. 1208-1219 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Resistance 100%
  • Tuberculosis 89%
  • Pharmaceutical Preparations 45%
  • Sputum 30%
  • Anti-Bacterial Agents 30%
  106 Scopus citations

• T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

  Jain, A., Song, R., Wakeland, E. K. & Pasare, C., Dec 1 2018, In: Nature communications. 9, 1, 3185.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • effectors 100%
  • Effector 71%
  • Licensure 71%
  • licensing 57%
  • Cytokines 40%
  70 Scopus citations

• The impact of Staphylococcus aureus genomic variation on clinical phenotype of children with acute hematogenous osteomyelitis

  Collins, A., Wakeland, E. K., Raj, P., Kim, M. S., Kim, J., Tareen, N. G. & Copley, L. A. B., Jun 2018, In: Heliyon. 4, 6, e00674.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteomyelitis 100%
  • Staphylococcus aureus 79%
  • Virulence 70%
  • Phenotype 55%
  • Child 40%
  7 Scopus citations

• Toll-Like Receptor 9 Deficiency Breaks Tolerance to RNA-Associated Antigens and Up-Regulates Toll-Like Receptor 7 Protein in Sle1 Mice

  Celhar, T., Yasuga, H., Lee, H. Y., Zharkova, O., Tripathi, S., Thornhill, S. I., Lu, H. K., Au, B., Lim, L. H. K., Thamboo, T. P., Akira, S., Wakeland, E. K., Connolly, J. E. & Fairhurst, A. M., Oct 2018, In: Arthritis and Rheumatology. 70, 10, p. 1597-1609 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toll-Like Receptor 7 100%
  • Toll-Like Receptor 9 94%
  • Up-Regulation 48%
  • RNA 46%
  • Antigens 42%
  13 Scopus citations
• 2017

  A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

  Zhao, J., Ma, J., Deng, Y., Kelly, J. A., Kim, K., Bang, S. Y., Lee, H. S., Li, Q. Z., Wakeland, E. K., Qiu, R., Liu, M., Guo, J., Li, Z., Tan, W., Rasmussen, A., Lessard, C. J., Sivils, K. L., Hahn, B. H., Grossman, J. M., Kamen, D. L., & 5 othersGilkeson, G. S., Bae, S. C., Gaffney, P. M., Shen, N. & Tsao, B. P., Mar 1 2017, In: Nature genetics. 49, 3, p. 433-437 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Autoimmune Diseases 100%
  • Odds Ratio 74%
  • Systemic Lupus Erythematosus 72%
  • Reactive Oxygen Species 30%
  • 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one 28%
  121 Scopus citations

• Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus

  Levitz, R., Gao, Y., Dozmorov, I., Song, R., Wakeland, E. K. & Kahn, J., Sep 2017, In: PloS one. 12, 9, e0184318.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Viruses 100%
  • Interleukin-6 32%
  • Cercopithecine Herpesvirus 1 28%
  • Viruses 28%
  • Macrophages 22%
  20 Scopus citations

• Dysregulated Lymphoid Cell Populations in Mouse Models of Systemic Lupus Erythematosus

  de Groof, A., Hémon, P., Mignen, O., Pers, J. O., Wakeland, E. K., Renaudineau, Y. & Lauwerys, B. R., Oct 1 2017, In: Clinical Reviews in Allergy and Immunology. 53, 2, p. 181-197 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Systemic Lupus Erythematosus 100%
  • Lymphocytes 73%
  • Antigen-Presenting Cells 67%
  • T-Lymphocytes 65%
  • B-Lymphocytes 65%
  18 Scopus citations

• Linezolid dose that maximizes sterilizing effect while minimizing toxicity and resistance emergence for tuberculosis

  Srivastava, S., Magombedze, G., Koeuth, T., Sherman, C., Pasipanodya, J. G., Raj, P., Wakeland, E., Deshpande, D. & Gumbo, T., Aug 2017, In: Antimicrobial agents and chemotherapy. 61, 8, e00751.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Linezolid 100%
  • Tuberculosis 64%
  • Whole Genome Sequencing 9%
  • RNA Sequence Analysis 8%
  • Pharmacokinetics 5%
  85 Scopus citations

• RAD51 interconnects between DNA replication, DNA repair and immunity

  Bhattacharya, S., Srinivasan, K., Abdisalaam, S., Su, F., Raj, P., Dozmorov, I., Mishra, R., Wakeland, E. K., Ghose, S., Mukherjee, S. & Asaithamby, A., May 5 2017, In: Nucleic acids research. 45, 8, p. 4590-4605 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Replication 100%
  • DNA Repair 92%
  • Innate Immunity 92%
  • Immunity 81%
  • Exonucleases 33%
  124 Scopus citations

• Transancestral mapping and genetic load in systemic lupus erythematosus

  Langefeld, C. D., Ainsworth, H. C., Graham, D. S. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bijl, M., Brown, E. E., & 88 othersBrunner, H. I., Cardiel, M. H., Catoggio, L., Cervera, R., Cucho-Venegas, J. M., Dahlqvist, S. R., D'Alfonso, S., Da Silva, B. M., De La RúaFigueroa, I., Doria, A., Edberg, J. C., Endreffy, E., Esquivel-Valerio, J. A., Fortin, P. R., Freedman, B. I., Frostegård, J., Garcýá, M. A., De La Torre, I. G., Gilkeson, G. S., Gladman, D. D., Gunnarsson, I., Guthridge, J. M., Huggins, J. L., James, J. A., Kallenberg, C. G. M., Kamen, D. L., Karp, D. R., Kaufman, K. M., Kottyan, L. C., Kovács, L., Laustrup, H., Lauwerys, B. R., Li, Q. Z., Maradiaga-Ceceną, M. A., Martín, J., McCune, J. M., McWilliams, D. R., Merrill, J. T., Miranda, P., Moctezuma, J. F., Nath, S. K., Niewold, T. B., Orozco, L., Ortego-Centeno, N., Petri, M., Pineau, C. A., Pons-Estel, B. A., Pope, J., Raj, P., Ramsey-Goldman, R., Reveille, J. D., Russell, L. P., Sabio, J. M., Aguilar-Salinas, C. A., Scherbarth, H. R., Scorza, R., Seldin, M. F., Sjöwall, C., Svenungsson, E., Thompson, S. D., Toloza, S. M. A., Truedsson, L., Tusié-Luna, T., Vasconcelos, C., Vilá, L. M., Wallace, D. J., Weisman, M. H., Wither, J. E., Bhangale, T., Oksenberg, J. R., Rioux, J. D., Gregersen, P. K., Syvänen, A. C., Rönnblom, L., Criswell, L. A., Jacob, C. O., Sivils, K. L., Tsao, B. P., Schanberg, L. E., Behrens, T. W., Silverman, E. D., Alarcón-Riquelme, M. E., Kimberly, R. P., Harley, J. B., Wakeland, E. K., Graham, R. R., Gaffney, P. M. & Vyse, T. J., Jul 17 2017, In: Nature communications. 8, 16021.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Load 100%
  • Systemic Lupus Erythematosus 56%
  • Hispanic Americans 19%
  • Autoimmune Diseases 17%
  • histories 16%
  267 Scopus citations
• 2016

  DNA polymerase-α regulates the activation of type i interferons through cytosolic RNA:DNA synthesis

  Starokadomskyy, P., Gemelli, T., Rios, J. J., Xing, C., Wang, R. C., Li, H., Pokatayev, V., Dozmorov, I., Khan, S., Miyata, N., Fraile, G., Raj, P., Xu, Z., Xu, Z., Ma, L., Lin, Z., Wang, H., Yang, Y., Ben-Amitai, D., Orenstein, N., & 11 othersMussaffi, H., Baselga, E., Tadini, G., Grunebaum, E., Sarajlija, A., Krzewski, K., Wakeland, E. K., Yan, N., De La Morena, M. T., Zinn, A. R. & Burstein, E., May 1 2016, In: Nature immunology. 17, 5, p. 495-504 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferon Type I 100%
  • DNA-Directed DNA Polymerase 94%
  • Nucleic Acids 82%
  • Interferons 77%
  • Catalytic DNA 62%
  110 Scopus citations

• Erratum: Personalized immunomonitoring uncovers molecular networks that stratify lupus patients ((Cell (2016) 165 (551-565))

  Banchereau, R., Hong, S., Cantarel, B., Baldwin, N., Baisch, J., Edens, M., Cepika, A. M., Acs, P., Turner, J., Anguiano, E., Vinod, P., Khan, S., Obermoser, G., Blankenship, D., Wakeland, E., Nassi, L., Gotte, A., Punaro, M., Liu, Y. J., Banchereau, J., & 3 othersRossello-Urgell, J., Wright, T. & Pascual, V., Jun 2 2016, In: Cell. 165, 6, p. 1548-1550 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  84 Scopus citations

• Fatty acid amide hydrolase regulates peripheral B cell receptor revision, polyreactivity, and B1 cells in lupus

  Pathak, S., Kumar, K. R., Kanta, H., Carr-Johnson, F., Han, J., Bashmakov, A., Faure, L., Ding, H., Vanarsa, K., Khan, S., Li, Q. Z., Chapman, K., Wakeland, E. K. & Mohan, C., Feb 15 2016, In: Journal of Immunology. 196, 4, p. 1507-1516 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fatty-acid amide hydrolase 100%
  • B-Lymphocytes 51%
  • Autoantibodies 31%
  • Central Tolerance 25%
  • Tissue Array Analysis 24%
  11 Scopus citations

• Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans

  Lessard, C. J., Sajuthi, S., Zhao, J., Kim, K., Ice, J. A., Li, H., Ainsworth, H., Rasmussen, A., Kelly, J. A., Marion, M., Bang, S. Y., Bin Joo, Y., Choi, J., Lee, H. S., Mo Kang, Y., Suh, C. H., Tae Chung, W., Lee, S. K., Choe, J. Y., Cheol Shim, S., & 19 othersHee Oh, J., Jin Kim, Y., Han, B. G., Shen, N., Siew Howe, H., Wakeland, E. K., Li, Q. Z., Wook Song, Y., Gaffney, P. M., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Vyse, T. J., Harley, J. B., Sivils, K. L., Bae, S. C., Langefeld, C. D. & Tsao, B. P., May 1 2016, In: Arthritis and Rheumatology. 68, 5, p. 1197-1209 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Lupus Erythematosus 100%
  • Single Nucleotide Polymorphism 37%
  • Population Control 21%
  • Genome-Wide Association Study 18%
  • Korea 18%
  74 Scopus citations

• Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

  Banchereau, R., Hong, S., Cantarel, B., Baldwin, N., Baisch, J., Edens, M., Cepika, A. M., Acs, P., Turner, J., Anguiano, E., Vinod, P., Kahn, S., Obermoser, G., Blankenship, D., Wakeland, E., Nassi, L., Gotte, A., Punaro, M., Liu, Y. J., Banchereau, J., & 3 othersRossello-Urgell, J., Wright, T. & Pascual, V., Apr 21 2016, In: Cell. 165, 3, p. 551-565 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nephritis 100%
  • Heterogeneity 77%
  • Systemic Lupus Erythematosus 52%
  • Autoimmune Diseases 48%
  • Biological Marker 37%
  424 Scopus citations

• Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

  Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B., & 9 othersNath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In: eLife. 5, FEBRUARY2016, e12089.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Autoimmunity 100%
  • Systemic Lupus Erythematosus 96%
  • Binding Site 72%
  • HLA-DQA1 antigen 39%
  • HLA-D Antigens 37%
  97 Scopus citations

• RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8

  Khan, S., Kuruvilla, M., Hagin, D., Wakeland, B., Liang, C., Vishwanathan, K., Gatti, R. A., Torgersen, T. R., Abraham, R. S., Wakeland, E. K., van Oers, N. S. C. & de la Morena, M. T., Jul 1 2016, In: Journal of Allergy and Clinical Immunology. 138, 1, p. 289-292.e6

  Research output: Contribution to journal › Article › peer-review
  5 Scopus citations
• 2015

  Autoimmune Diseases in the Bioinformatics Paradigm

  Li, Q. Z. & Wakeland, E. K., Aug 2015, In: Genomics, Proteomics and Bioinformatics. 13, 4, p. 205-207 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance

  Wong, E. B., Soni, C., Chan, A. Y., Domeier, P. P., Shwetank, Abraham, T., Limaye, N., Khan, T. N., Elias, M. J., Chodisetti, S. B., Wakeland, E. K. & Rahman, Z. S. M., May 1 2015, In: Journal of Immunology. 194, 9, p. 4130-4143 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Germinal Center 100%
  • B-Lymphocytes 65%
  • Lymphocyte Activation 40%
  • Autoantibodies 25%
  • Alleles 13%
  32 Scopus citations

• Cutting edge: Inhibiting TBK1 by compound II ameliorates autoimmune disease in mice

  Hasan, M., Dobbs, N., Khan, S., White, M. A., Wakeland, E. K., Li, Q. Z. & Yan, N., Nov 15 2015, In: Journal of Immunology. 195, 10, p. 4573-4577 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Autoimmune Diseases 100%
  • Phosphotransferases 89%
  • Systemic Lupus Erythematosus 31%
  • Poly I-C 21%
  • Protein-Serine-Threonine Kinases 18%
  60 Scopus citations

• Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation

  Hu, W., Jain, A., Gao, Y., Dozmorov, I. M., Mandraju, R., Wakeland, E. K. & Pasare, C., Nov 10 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 13994-13999 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dendritic Cells 100%
  • Interferon Regulatory Factor-3 41%
  • Myeloid Differentiation Factor 88 20%
  • Toll-Like Receptor 3 19%
  • Pathogen-Associated Molecular Pattern Molecules 18%
  52 Scopus citations

• Genomic heterogeneity of Methicillin resistant Staphylococcus aureus associated with variation in severity of illness among children with acute hematogenous osteomyelitis

  Gaviria-Agudelo, C., Aroh, C., Tareen, N., Wakeland, E. K., Kim, M. & Copley, L. A., Jun 18 2015, In: PloS one. 10, 6, e0130415.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • osteomyelitis 100%
  • Methicillin 96%
  • methicillin-resistant Staphylococcus aureus 80%
  • Osteomyelitis 69%
  • Methicillin-Resistant Staphylococcus aureus 65%
  17 Scopus citations

• Polygenic control of susceptibility to murine systemic lupus erythematosus

  Morel, L., Rudofsky, U. H., Longmate, J. A., Schiffenbauer, J. & Wakeland, E. K., Nov 2015, In: Journal of Immunology. 195, 9, p. 4047-4057 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glomerulonephritis 100%
  • Systemic Lupus Erythematosus 88%
  • Alleles 46%
  • Chromosomes, Human, Pair 7 40%
  • Chromosomes, Human, Pair 1 38%
  1 Scopus citations

• RNA sensing by conventional dendritic cells is central to the development of lupus nephritis

  Celhar, T., Hopkins, R., Thornhill, S. I., De Magalhaes, R., Hwang, S. H., Lee, H. Y., Yasuga, H., Jones, L. A., Casco, J., Lee, B., Thamboo, T. P., Zhou, X. J., Poidinger, M., Connolly, J. E., Wakeland, E. K. & Fairhurst, A. M., Nov 10 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. E6195-E6204

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toll-Like Receptor 7 100%
  • Lupus Nephritis 82%
  • Dendritic Cells 60%
  • RNA 46%
  • Systemic Lupus Erythematosus 38%
  44 Scopus citations
• 2014

  Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations

  Kim-Howard, X., Sun, C., Molineros, J. E., Maiti, A. K., Chandru, H., Adler, A., Wiley, G. B., Kaufman, K. M., Kottyan, L., Guthridge, J. M., Rasmussen, A., Kelly, J., Sánchez, E., Raj, P., Li, Q. Z., Bang, S. Y., Lee, H. S., Kim, T. H., Kang, Y. M., Suh, C. H., & 35 othersChung, W. T., Park, Y. B., Choe, J. Y., Shim, S. C., Lee Shin-Seok, S. S., Han, B. G., Olsen, N. J., Karp, D. R., Moser, K., Pons-Estel, B. A., Wakeland, E. K., James, J. A., Harley, J. B., Bae, S. C., Gaffney, P. M., Alarcón-Riquelme, M., Acevedo, E., La Torre, I. G. D., Maradiaga-Ceceña, M. A., Cardiel, M. H., Esquivel-Valerio, J. A., Rodriguez-Amado, J., Moctezuma, J. F., Miranda, P., Perandones, C., Castel, C., Laborde, H. A., Alba, P., Musuruana, J., Goecke, A., Foster, C., Orozco, L., Baca, V., Looger, L. L. & Nath, S. K., Mar 2014, In: Human molecular genetics. 23, 6, p. 1656-1668 13 p., ddt532.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Lupus Erythematosus 100%
  • Single Nucleotide Polymorphism 89%
  • Hispanic Americans 81%
  • African Americans 59%
  • NADPH Oxidases 48%
  62 Scopus citations

• Hunting autoimmune disease genes in NOD: Early steps on a long road to somewhere important (hopefully)

  Wakeland, E. K., Jul 1 2014, In: Journal of Immunology. 193, 1, p. 3-6 4 p.

  Research output: Contribution to journal › Article › peer-review
  4 Scopus citations

• T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice

  Sinai, P., Dozmorov, I. M., Song, R., Schwartzberg, P. L., Wakeland, E. K. & Wülfing, C., Dec 2014, In: European Journal of Immunology. 44, 12, p. 3522-3531 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Lupus Erythematosus 100%
  • Cell Communication 99%
  • B-Lymphocytes 81%
  • T-Lymphocytes 43%
  • Antinuclear Antibodies 20%
  17 Scopus citations

• Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription

  Guthridge, J. M., Lu, R., Sun, H., Sun, C., Wiley, G. B., Dominguez, N., MacWana, S. R., Lessard, C. J., Kim-Howard, X., Cobb, B. L., Kaufman, K. M., Kelly, J. A., Langefeld, C. D., Adler, A. J., Harley, I. T. W., Merrill, J. T., Gilkeson, G. S., Kamen, D. L., Niewold, T. B., Brown, E. E., & 31 othersEdberg, J. C., Petri, M. A., Ramsey-Goldman, R., Reveille, J. D., Vilá, L. M., Kimberly, R. P., Freedman, B. I., Stevens, A. M., Boackle, S. A., Criswell, L. A., Vyse, T. J., Behrens, T. W., Jacob, C. O., Alarcón-Riquelme, M. E., Sivils, K. L., Choi, J., Joo, Y. B., Bang, S. Y., Lee, H. S., Bae, S. C., Shen, N., Qian, X., Tsao, B. P., Hal Scofield, R., Harley, J. B., Webb, C. F., Wakeland, E. K., James, J. A., Nath, S. K., Graham, R. R. & Gaffney, P. M., Apr 3 2014, In: American Journal of Human Genetics. 94, 4, p. 586-598 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Lupus Erythematosus 100%
  • Autoimmune Diseases 92%
  • B-Lymphocytes 81%
  • Alleles 77%
  • Cell Line 62%
  52 Scopus citations

• Whole transcriptome RNA-seq analysis: Tumorigenesis and metastasis of melanoma

  Zhao, H., Li, Y., Wang, S., Yang, Y., Wang, J., Ruan, X., Yang, Y., Cai, K., Zhang, B., Cui, P., Yan, J., Zhao, Y., Wakeland, E. K., Li, Q., Hu, S. & Fang, X., Sep 15 2014, In: Gene. 548, 2, p. 234-243 10 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA-Seq 100%
  • Transcriptome 78%
  • Melanoma 71%
  • Carcinogenesis 65%
  • Neoplasm Metastasis 52%
  22 Scopus citations
• 2013

  A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes

  Dutta, M., Kraus, Z. J., Gomez-Rodriguez, J., Hwang, S. H., Cannons, J. L., Cheng, J., Lee, S. Y., Wiest, D. L., Wakeland, E. K. & Schwartzberg, P. L., Mar 1 2013, In: Journal of Immunology. 190, 5, p. 2121-2128 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zinc Fingers 100%
  • Thymocytes 95%
  • Transcription Factors 66%
  • Early Growth Response Protein 2 63%
  • Protein Binding 22%
  42 Scopus citations

• Complete Genome Analysis of Three Acinetobacter baumannii Clinical Isolates in China for Insight into the Diversification of Drug Resistance Elements

  Zhu, L., Yan, Z., Zhang, Z., Zhou, Q., Zhou, J., Wakeland, E. K., Fang, X., Xuan, Z., Shen, D. & Li, Q. Z., Jun 24 2013, In: PloS one. 8, 6, e66584.

  Research output: Contribution to journal › Article › peer-review

  • Acinetobacter baumannii 100%
  • drug resistance 87%
  • Drug Resistance 67%
  • China 59%
  • Strain 51%
  62 Scopus citations

• Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

  Hinks, A., Cobb, J., Marion, M. C., Prahalad, S., Sudman, M., Bowes, J., Martin, P., Comeau, M. E., Sajuthi, S., Andrews, R., Brown, M., Chen, W. M., Concannon, P., Deloukas, P., Edkins, S., Eyre, S., Gaffney, P. M., Guthery, S. L., Guthridge, J. M., Hunt, S. E., & 19 othersJames, J. A., Keddache, M., Moser, K. L., Nigrovic, P. A., Onengut-Gumuscu, S., Onslow, M. L., Rosé, C. D., Rich, S. S., Steel, K. J. A., Wakeland, E. K., Wallace, C. A., Wedderburn, L. R., Woo, P., Bohnsack, J. F., Haas, J. P., Glass, D. N., Langefeld, C. D., Thomson, W. & Thompson, S. D., Jun 2013, In: Nature genetics. 45, 6, p. 664-669 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Juvenile Arthritis 100%
  • Immune System Diseases 89%
  • HLA Antigens 24%
  • Rheumatoid Factor 13%
  • Computational Biology 11%
  293 Scopus citations

• DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN

  Ozaltin, F., Li, B., Rauhauser, A., An, S. W., Soylemezoglu, O., Gonul, I. I., Taskiran, E. Z., Ibsirlioglu, T., Korkmaz, E., Bilginer, Y., Duzova, A., Ozen, S., Topaloglu, R., Besbas, N., Ashraf, S., Du, Y., Liang, C., Chen, P., Lu, D., Vadnagara, K., & 13 othersArbuckle, S., Lewis, D., Wakeland, B., Quigg, R. J., Ransom, R. F., Wakeland, E. K., Topham, M. K., Bazan, N. G., Mohan, C., Hildebrandt, F., Bakkaloglu, A., Huang, C. L. & Attanasio, M., Feb 28 2013, In: Journal of the American Society of Nephrology. 24, 3, p. 377-384 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Diacylglycerol Kinase 100%
  • Podocytes 83%
  • Phosphatidic Acids 45%
  • Diglycerides 40%
  • Whole Exome Sequencing 40%
  121 Scopus citations

• Dynamic transcriptomes of human myeloid leukemia cells

  Wang, H., Hu, H., Zhang, Q., Yang, Y., Li, Y., Hu, Y., Ruan, X., Yang, Y., Zhang, Z., Shu, C., Yan, J., Wakeland, E. K., Li, Q., Hu, S. & Fang, X., Oct 2013, In: Genomics. 102, 4, p. 250-256 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Myeloid Leukemia 100%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 85%
  • Myeloid Cells 83%
  • Acute Myeloid Leukemia 77%
  • Transcriptome 75%
  27 Scopus citations

• Few Single Nucleotide Variations in Exomes of Human Cord Blood Induced Pluripotent Stem Cells

  Su, R. J., Yang, Y., Neises, A., Payne, K. J., Wang, J., Viswanathan, K., Wakeland, E. K., Fang, X. & Zhang, X. B., Apr 1 2013, In: PloS one. 8, 4, e59908.

  Research output: Contribution to journal › Article › peer-review

  • induced pluripotent stem cells 100%
  • Cord 79%
  • Exome 77%
  • Induced Pluripotent Stem Cells 72%
  • Fetal Blood 63%
  25 Scopus citations

• Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

  Arai, S., Maehara, N., Iwamura, Y., Honda, S. I., Nakashima, K., Kai, T., Ogishi, M., Morita, K., Kurokawa, J., Mori, M., Motoi, Y., Miyake, K., Matsuhashi, N., Yamamura, K. I., Ohara, O., Shibuya, A., Wakeland, E. K., Li, Q. Z. & Miyazaki, T., Apr 25 2013, In: Cell Reports. 3, 4, p. 1187-1198 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis Inhibitor 100%
  • Follicular Dendritic Cells 73%
  • Antigen-Antibody Complex 53%
  • Autoantibodies 47%
  • Immunoglobulin M 45%
  87 Scopus citations

• Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians

  Kaiser, R., Taylor, K. E., Deng, Y., Zhao, J., Li, Y., Nititham, J., Chang, M., Catanese, J., Begovich, A. B., Brown, E. E., Edberg, J. C., McGwin, G., Alarcón, G. S., Ramsey-Goldman, R., Reveille, J. D., Vila, L. M., Petri, M., Kimberly, R. P., Feng, X., Sun, L., & 13 othersShen, N., Li, W., Lu, J. X., Wakeland, E. K., Li, Q. Z., Yang, W., Lau, Y. L., Liu, F. L., Chang, D. M., Yu, C. Y., Song, Y. W., Tsao, B. P. & Criswell, L. A., Jan 2013, In: Arthritis and rheumatism. 65, 1, p. 211-215 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Lupus Erythematosus 100%
  • Single Nucleotide Polymorphism 89%
  • Odds Ratio 58%
  • Thrombosis 35%
  • Venous Thrombosis 29%
  9 Scopus citations

• SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

  Becker, A. M., Dao, K. H., Han, B. K., Kornu, R., Lakhanpal, S., Mobley, A. B., Li, Q. Z., Lian, Y., Wu, T., Reimold, A. M., Olsen, N. J., Karp, D. R., Chowdhury, F. Z., Farrar, J. D., Satterthwaite, A. B., Mohan, C., Lipsky, P. E., Wakeland, E. K. & Davis, L. S., Jun 24 2013, In: PloS one. 8, 6, e67003.

  Research output: Contribution to journal › Article › peer-review

  • lupus erythematosus 100%
  • interferons 73%
  • Effector 70%
  • Myeloid Cells 66%
  • B-lymphocytes 64%
  150 Scopus citations

• Transcriptome dynamics during human erythroid differentiation and development

  Yang, Y., Wang, H., Chang, K. H., Qu, H., Zhang, Z., Xiong, Q., Qi, H., Cui, P., Lin, Q., Ruan, X., Yang, Y., Li, Y., Shu, C., Li, Q., Wakeland, E. K., Yan, J., Hu, S. & Fang, X., Nov 2013, In: Genomics. 102, 5-6, p. 431-441 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Embryonic Stem Cells 100%
  • Transcriptome 76%
  • Erythroid Cells 34%
  • Erythropoiesis 32%
  • Cell Communication 25%
  20 Scopus citations

• Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

  Hasan, M., Koch, J., Rakheja, D., Pattnaik, A. K., Brugarolas, J. B., Dozmorov, I., Levine, B., Wakeland, E. K., Lee-Kirsch, M. A. & Yan, N., Jan 2013, In: Nature immunology. 14, 1, p. 61-71 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferons 100%
  • Transcriptional Activation 99%
  • Antiviral Agents 93%
  • three prime repair exonuclease 1 32%
  • Genes 25%
  119 Scopus citations
• 2012

  A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

  Wang, S., Adrianto, I., Wiley, G. B., Lessard, C. J., Kelly, J. A., Adler, A. J., Glenn, S. B., Williams, A. H., Ziegler, J. T., Comeau, M. E., Marion, M. C., Wakeland, B. E., Liang, C., Kaufman, K. M., Guthridge, J. M., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Bae, S. C., Kim, J. H., & 29 othersJoo, Y. B., Boackle, S. A., Brown, E. E., Petri, M. A., Ramsey-Goldman, R., Reveille, J. D., Vilá, L. M., Criswell, L. A., Edberg, J. C., Freedman, B. I., Gilkeson, G. S., Jacob, C. O., James, J. A., Kamen, D. L., Kimberly, R. P., Martin, J., Merrill, J. T., Niewold, T. B., Pons-Estel, B. A., Scofield, R. H., Stevens, A. M., Tsao, B. P., Vyse, T. J., Langefeld, C. D., Harley, J. B., Wakeland, E. K., Moser, K. L., Montgomery, C. G. & Gaffney, P. M., Jul 2012, In: Genes and Immunity. 13, 5, p. 380-387 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Lupus Erythematosus 100%
  • Haplotypes 99%
  • Ubiquitin-Conjugating Enzymes 38%
  • Genome-Wide Association Study 27%
  • Autoimmunity 25%
  49 Scopus citations

• Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus

  Adrianto, I., Wang, S., Wiley, G. B., Lessard, C. J., Kelly, J. A., Adler, A. J., Glenn, S. B., Williams, A. H., Ziegler, J. T., Comeau, M. E., Marion, M. C., Wakeland, B. E., Liang, C., Kaufman, K. M., Guthridge, J. M., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Bae, S. C., Kim, J. H., & 29 othersJoo, Y. B., Boackle, S. A., Brown, E. E., Petri, M. A., Ramsey-Goldman, R., Reveille, J. D., Vilá, L. M., Criswell, L. A., Edberg, J. C., Freedman, B. I., Gilkeson, G. S., Jacob, C. O., James, J. A., Kamen, D. L., Kimberly, R. P., Martín, J., Merrill, J. T., Niewold, T. B., Pons-Estel, B. A., Scofield, R. H., Stevens, A. M., Tsao, B. P., Vyse, T. J., Langefeld, C. D., Harley, J. B., Wakeland, E. K., Moser, K. L., Montgomery, C. G. & Gaffney, P. M., Nov 2012, In: Arthritis and rheumatism. 64, 11, p. 3695-3705 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Lupus Erythematosus 100%
  • Haplotypes 99%
  • African Americans 37%
  • Hispanic Americans 25%
  • Population 20%
  70 Scopus citations

• Autoimmunity

  Crow, Y. J. & Wakeland, E. K., Dec 2012, In: Current Opinion in Immunology. 24, 6, p. 649-650 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Scopus citations

• B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus - Prone mice

  Hwang, S. H., Lee, H., Yamamoto, M., Jones, L. A., Dayalan, J., Hopkins, R., Zhou, X. J., Yarovinsky, F., Connolly, J. E., Curotto De Lafaille, M. A., Wakeland, E. K. & Fairhurst, A. M., Dec 15 2012, In: Journal of Immunology. 189, 12, p. 5786-5796 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Lupus Erythematosus 100%
  • Autoantibodies 98%
  • B-Lymphocytes 81%
  • RNA 73%
  • Recombinases 28%
  94 Scopus citations

• Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

  Lessard, C. J., Adrianto, I., Ice, J. A., Wiley, G. B., Kelly, J. A., Glenn, S. B., Adler, A. J., Li, H., Rasmussen, A., Williams, A. H., Ziegler, J., Comeau, M. E., Marion, M., Wakeland, B. E., Liang, C., Ramos, P. S., Grundahl, K. M., Gallant, C. J., Alarcón, G. S., Anaya, J. M., & 37 othersBae, S. C., Boackle, S. A., Brown, E. E., Chang, D. M., Cho, S. K., Criswell, L. A., Edberg, J. C., Freedman, B. I., Gilkeson, G. S., Jacob, C. O., James, J. A., Kamen, D. L., Kimberly, R. P., Kim, J. H., Martin, J., Merrill, J. T., Niewold, T. B., Park, S. Y., Petri, M. A., Pons-Estel, B. A., Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Song, Y. W., Stevens, A. M., Tsao, B. P., Vila, L. M., Vyse, T. J., Yu, C. Y., Guthridge, J. M., Kaufman, K. M., Harley, J. B., Wakeland, E. K., Langefeld, C. D., Gaffney, P. M., Montgomery, C. G. & Moser, K. L., Apr 6 2012, In: American Journal of Human Genetics. 90, 4, p. 648-660 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Zona Pellucida 100%
  • Systemic Lupus Erythematosus 68%
  • Carrier Proteins 62%
  • Genome-Wide Association Study 25%
  • interferon regulatory factor-8 20%
  153 Scopus citations

• Identification of novel coding mutation in C1qA gene in an African-American pedigree with lupus and C1q deficiency

  Namjou, B., Keddache, M., Fletcher, D., Dillon, S., Kottyan, L., Wiley, G., Gaffney, P. M., Wakeland, B. E., Liang, C., Wakeland, E. K., Scofield, R. H., Kaufman, K. & Harley, J. B., Sep 2012, In: Lupus. 21, 10, p. 1113-1118 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pedigree 100%
  • African Americans 85%
  • Mutation 51%
  • Initiator Codon 37%
  • Genes 36%
  10 Scopus citations

• Influence of carbon monoxide on growth and apop-tosis of human umbilical artery smooth muscle cells and vein endothelial cells

  Li, Y., Wang, H., Yang, B., Yang, J., Ruan, X., Yang, Y., Wakeland, E., Li, Q. & Fang, X., Nov 17 2012, In: International Journal of Biological Sciences. 8, 10, p. 1431-1446 16 p.

  Research output: Contribution to journal › Article › peer-review

  • umbilical arteries 100%
  • human umbilical vein endothelial cells 80%
  • Umbilical Arteries 80%
  • carbon monoxide 76%
  • endothelial cells 67%
  17 Scopus citations