Immunology - Hooper Lab

Research Output

29 Combining gnotobiotic mouse models with functional genomics to define the impact of the microflora on host physiology

Hooper, L. V., Mills, J. C., Roth, K. A., Stappenbeck, T. S., Wong, M. H. & Gordon, J. I., 2002, In : Methods in Microbiology. 31, p. 559-589 31 p.

Research output: Contribution to journalArticle

29 Scopus citations

A composite bacteriophage alters colonization by an intestinal commensal bacterium

Duerkop, B. A., Clements, C. V., Rollins, D., Rodrigues, J. L. M. & Hooper, L. V., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17621-17626 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V. & Koh, A., Jun 8 2015, In : Nature Medicine. 21, 7, p. 808-814 7 p.

Research output: Contribution to journalArticle

129 Scopus citations

A genomic view of the human-Bacteroides thetaiotaomicron symbiosis

Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V. & Gordon, J. I., Mar 28 2003, In : Science. 299, 5615, p. 2074-2076 3 p.

Research output: Contribution to journalArticle

854 Scopus citations

Alkaline Phosphatase: Keeping the Peace at the Gut Epithelial Surface

Vaishnava, S. & Hooper, L. V., Dec 13 2007, In : Cell Host and Microbe. 2, 6, p. 365-367 3 p.

Research output: Contribution to journalShort survey

44 Scopus citations

A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem

Hooper, L. V., Xu, J., Falk, P. G., Midtvedt, T. & Gordon, J. I., Aug 17 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 17, p. 9833-9838 6 p.

Research output: Contribution to journalArticle

317 Scopus citations

Analyzing the molecular foundations of commensalism in the mouse intestine

Hooper, L. V., Falk, P. G. & Gordon, J. I., Feb 1 2000, In : Current Opinion in Microbiology. 3, 1, p. 79-85 7 p.

Research output: Contribution to journalReview article

60 Scopus citations

Angiogenins: A new class of microbicidal proteins involved in innate immunity

Hooper, L. V., Stappenbeck, T. S., Hong, C. V. & Gordon, J. I., Mar 1 2003, In : Nature immunology. 4, 3, p. 269-273 5 p.

Research output: Contribution to journalArticle

630 Scopus citations

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate

Spiga, L., Winter, M. G., Furtado de Carvalho, T., Zhu, W., Hughes, E. R., Gillis, C. C., Behrendt, C. L., Kim, J., Chessa, D., Andrews-Polymenis, H. L., Beiting, D. P., Santos, R. L., Hooper, L. V. & Winter, S. E., Sep 13 2017, In : Cell Host and Microbe. 22, 3, p. 291-301.e6

Research output: Contribution to journalArticle

39 Scopus citations

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo-Rey, J., Grabe, M., Jiang, Q. X. & Hooper, L. V., 2014, In : Nature. 505, 7481, p. 103-107 5 p.

Research output: Contribution to journalArticle

142 Scopus citations

Antimicrobial Defense of the Intestine

Mukherjee, S. & Hooper, L. V., Jan 20 2015, In : Immunity. 42, 1, p. 28-39 12 p.

Research output: Contribution to journalReview article

113 Scopus citations

Bacteria Come into Focus: New Tools for Visualizing the Microbiota

Propheter, D. C. & Hooper, L. V., Oct 14 2015, In : Cell Host and Microbe. 18, 4, p. 392-394 3 p., 1348.

Research output: Contribution to journalArticle

5 Scopus citations

Bacterial contributions to mammalian gut development

Hooper, L. V., Mar 1 2004, In : Trends in Microbiology. 12, 3, p. 129-134 6 p.

Research output: Contribution to journalReview article

317 Scopus citations

Bacterial exposure induces and activates matrilysin in mucosal epithelial cells

López-Boado, Y. S., Wilson, C. L., Hooper, L. V., Gordon, J. I., Hultgren, S. J. & Parks, W. C., Mar 20 2000, In : Journal of Cell Biology. 148, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

137 Scopus citations

Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species

Chatzidaki-Livanis, M., Geva-Zatorsky, N., Comstock, L. E. & Hooper, L. V., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3627-3632 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance

Li, Y., Minor, N. T., Park, J. K., McKearin, D. M. & Maines, J. Z., Jun 9 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9304-9309 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis

Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V. & Koh, A. Y., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005129.

Research output: Contribution to journalArticle

53 Scopus citations

Characterization of a sulfotransferase responsible for the 4-O-sulfation of terminal β-N-acetyl-D-galactosamine on asparagine-linked oligosaccharides of glycoprotein hormones

Skelton, T. P., Hooper, L. V., Srivastava, V., Hindsgaul, O. & Baenziger, J. U., Nov 7 1991, In : Journal of Biological Chemistry. 266, 26, p. 17142-17150 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Clinical microbiology in the year 2025

Dunne, W. M., Pinckard, J. K. & Hooper, L. V., Nov 1 2002, In : Journal of clinical microbiology. 40, 11, p. 3889-3893 5 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

Commensal bacteria regulate toll-like receptor 3-dependent inflammation after skin injury

Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z. R., Hooper, L. V., Schmidt, R. R., Von Aulock, S., Radek, K. A., Huang, C. M., Ryan, A. F. & Gallo, R. L., Dec 2009, In : Nature medicine. 15, 12, p. 1377-1382 6 p.

Research output: Contribution to journalArticle

402 Scopus citations

Commensal bacteria shape intestinal immune system development

Cash, H. L. & Hooper, L. V., Feb 1 2005, In : ASM News. 71, 2, p. 77-83 7 p.

Research output: Contribution to journalReview article

27 Scopus citations

Commensal host-bacterial relationships in the gut

Hooper, L. V. & Gordon, J. I., May 11 2001, In : Science. 292, 5519, p. 1115-1118 4 p.

Research output: Contribution to journalReview article

1557 Scopus citations

Creating and maintaining the gastrointestinal ecosystem: What we know and need to know from gnotobiology

Falk, P. G., Hooper, L. V., Midtvedt, T. & Gordon, J. I., Dec 1 1998, In : Microbiology and Molecular Biology Reviews. 62, 4, p. 1157-1170 14 p.

Research output: Contribution to journalArticle

468 Scopus citations

Crystallization of hepatocyte nuclear factor 1β in complex with DNA

Lu, P., Li, Y., Gorman, A. & Chi, Y. I., Jun 2006, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62, 6, p. 525-529 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cutting edge: Developmental regulation of IFN-γ production by mouse neutrophil precursor cells

Sturge, C. R., Burger, E., Raetz, M., Hooper, L. V. & Yarovinsky, F., Jul 1 2015, In : Journal of Immunology. 195, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

Stappenbeck, T. S., Hooper, L. V. & Gordon, J. I., Nov 26 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 24, p. 15451-15455 5 p.

Research output: Contribution to journalArticle

687 Scopus citations

Differential expression of GalNAc-4-sulfotransferase and GalNAc-transferase results in distinct glycoforms of carbonic anhydrase VI in parotid and submaxillary glands

Hooper, L. V., Beranek, M. C., Manzella, S. M. & Baenziger, J. U., Mar 17 1995, In : Journal of Biological Chemistry. 270, 11, p. 5985-5993 9 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., Tang, Y. W., Hooper, L., Bordenstein, S. R., Das, S. R. & Weitkamp, J. H., Oct 2018, In : PloS one. 13, 10, e0206366.

Research output: Contribution to journalArticle

3 Scopus citations

Do symbiotic bacteria subvert host immunity?

Hooper, L. V., Apr 29 2009, In : Nature Reviews Microbiology. 7, 5, p. 367-374 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts

Tastan, Ö. Y., Maines, J. Z., Li, Y., Mckearin, D. M. & Buszczak, M., Oct 1 2010, In : Development. 137, 19, p. 3167-3176 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dynamics and cooperativity of Trp-cage folding

Hu, Z., Tang, Y., Wang, H., Zhang, X. & Lei, M., Jul 15 2008, In : Archives of Biochemistry and Biophysics. 475, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Jan 1 2017, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

34 Scopus citations

Eat your carrots! T cells are RARing to Go

Vaishnava, S. & Hooper, L. V., Mar 25 2011, In : Immunity. 34, 3, p. 290-292 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L. & Hooper, L. V., Jul 1 2012, In : Nature Reviews Immunology. 12, 7, p. 503-516 14 p.

Research output: Contribution to journalReview article

440 Scopus citations

Epithelial Cell Contributions to Intestinal Immunity

Hooper, L. V., 2015, In : Advances in Immunology. 126, p. 129-172 44 p.

Research output: Contribution to journalArticle

43 Scopus citations
99 Scopus citations
78 Scopus citations

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Erratum: Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth (Cell Host & Microbe (2018) 23(1) (54–64.e6) (S1931312817305000) (10.1016/j.chom.2017.11.006))

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Apr 11 2018, In : Cell Host and Microbe. 23, 4, p. 570 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
3 Scopus citations

Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes

Kleiner, M., Hooper, L. V. & Duerkop, B. A., Jan 22 2015, In : BMC Genomics. 16, 1, 7.

Research output: Contribution to journalArticle

66 Scopus citations

Fabrication of an oriented lectin microarray

Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 14 2010, In : ChemBioChem. 11, 9, p. 1203-1207+1157

Research output: Contribution to journalArticle

24 Scopus citations

From legumes to leukocytes: Biological roles for sulfated carbohydrates

Hooper, L. V., Manzella, S. M. & Baenziger, J. U., 1996, In : FASEB Journal. 10, 10, p. 1137-1146 10 p.

Research output: Contribution to journalReview article

81 Scopus citations

Glycans as legislators of host-microbial interactions: Spanning the spectrum from symbiosis to pathogenicity

Hooper, L. V. & Gordon, J. I., Jan 1 2001, In : Glycobiology. 11, 2, p. 1R-10R

Research output: Contribution to journalReview article

Open Access
187 Scopus citations

Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii

Benson, A., Pifer, R., Behrendt, C. L., Hooper, L. V. & Yarovinsky, F., Aug 20 2009, In : Cell Host and Microbe. 6, 2, p. 187-196 10 p.

Research output: Contribution to journalArticle

141 Scopus citations

Host-microbial symbiosis in the mammalian intestine: Exploring an internal ecosystem

Hooper, L. V., Bry, L., Falk, P. G. & Gordon, J. I., Apr 1998, In : BioEssays. 20, 4, p. 336-343 8 p.

Research output: Contribution to journalArticle

141 Scopus citations

How host-microbial interactions shape the nutrient environment of the mammalian intestine

Hooper, L. V., Midwedt, T. & Gordon, J. I., Nov 6 2002, In : Annual review of nutrition. 22, p. 283-307 25 p.

Research output: Contribution to journalReview article

983 Scopus citations

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

21 Scopus citations

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V. & MacPherson, A. J., Mar 2010, In : Nature Reviews Immunology. 10, 3, p. 159-169 11 p.

Research output: Contribution to journalReview article

747 Scopus citations

Immune control of the microbiota prevents obesity

Wang, Y. & Hooper, L. V., Jul 26 2019, In : Science (New York, N.Y.). 365, 6451, p. 316-317 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations