Immunology - Hooper Lab

Research Output

Article

29 Combining gnotobiotic mouse models with functional genomics to define the impact of the microflora on host physiology

Hooper, L. V., Mills, J. C., Roth, K. A., Stappenbeck, T. S., Wong, M. H. & Gordon, J. I., 2002, In : Methods in Microbiology. 31, p. 559-589 31 p.

Research output: Contribution to journalArticle

29 Scopus citations

A composite bacteriophage alters colonization by an intestinal commensal bacterium

Duerkop, B. A., Clements, C. V., Rollins, D., Rodrigues, J. L. M. & Hooper, L. V., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17621-17626 6 p.

Research output: Contribution to journalArticle

115 Scopus citations

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V. & Koh, A., Jun 8 2015, In : Nature Medicine. 21, 7, p. 808-814 7 p.

Research output: Contribution to journalArticle

129 Scopus citations

A genomic view of the human-Bacteroides thetaiotaomicron symbiosis

Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V. & Gordon, J. I., Mar 28 2003, In : Science. 299, 5615, p. 2074-2076 3 p.

Research output: Contribution to journalArticle

854 Scopus citations

A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem

Hooper, L. V., Xu, J., Falk, P. G., Midtvedt, T. & Gordon, J. I., Aug 17 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 17, p. 9833-9838 6 p.

Research output: Contribution to journalArticle

317 Scopus citations

Angiogenins: A new class of microbicidal proteins involved in innate immunity

Hooper, L. V., Stappenbeck, T. S., Hong, C. V. & Gordon, J. I., Mar 1 2003, In : Nature immunology. 4, 3, p. 269-273 5 p.

Research output: Contribution to journalArticle

630 Scopus citations

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate

Spiga, L., Winter, M. G., Furtado de Carvalho, T., Zhu, W., Hughes, E. R., Gillis, C. C., Behrendt, C. L., Kim, J., Chessa, D., Andrews-Polymenis, H. L., Beiting, D. P., Santos, R. L., Hooper, L. V. & Winter, S. E., Sep 13 2017, In : Cell Host and Microbe. 22, 3, p. 291-301.e6

Research output: Contribution to journalArticle

39 Scopus citations

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo-Rey, J., Grabe, M., Jiang, Q. X. & Hooper, L. V., 2014, In : Nature. 505, 7481, p. 103-107 5 p.

Research output: Contribution to journalArticle

142 Scopus citations

Bacteria Come into Focus: New Tools for Visualizing the Microbiota

Propheter, D. C. & Hooper, L. V., Oct 14 2015, In : Cell Host and Microbe. 18, 4, p. 392-394 3 p., 1348.

Research output: Contribution to journalArticle

5 Scopus citations

Bacterial exposure induces and activates matrilysin in mucosal epithelial cells

López-Boado, Y. S., Wilson, C. L., Hooper, L. V., Gordon, J. I., Hultgren, S. J. & Parks, W. C., Mar 20 2000, In : Journal of Cell Biology. 148, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

137 Scopus citations

Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species

Chatzidaki-Livanis, M., Geva-Zatorsky, N., Comstock, L. E. & Hooper, L. V., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3627-3632 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance

Li, Y., Minor, N. T., Park, J. K., McKearin, D. M. & Maines, J. Z., Jun 9 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9304-9309 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis

Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V. & Koh, A. Y., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005129.

Research output: Contribution to journalArticle

53 Scopus citations

Characterization of a sulfotransferase responsible for the 4-O-sulfation of terminal β-N-acetyl-D-galactosamine on asparagine-linked oligosaccharides of glycoprotein hormones

Skelton, T. P., Hooper, L. V., Srivastava, V., Hindsgaul, O. & Baenziger, J. U., Nov 7 1991, In : Journal of Biological Chemistry. 266, 26, p. 17142-17150 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Commensal bacteria regulate toll-like receptor 3-dependent inflammation after skin injury

Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z. R., Hooper, L. V., Schmidt, R. R., Von Aulock, S., Radek, K. A., Huang, C. M., Ryan, A. F. & Gallo, R. L., Dec 2009, In : Nature medicine. 15, 12, p. 1377-1382 6 p.

Research output: Contribution to journalArticle

402 Scopus citations

Creating and maintaining the gastrointestinal ecosystem: What we know and need to know from gnotobiology

Falk, P. G., Hooper, L. V., Midtvedt, T. & Gordon, J. I., Dec 1 1998, In : Microbiology and Molecular Biology Reviews. 62, 4, p. 1157-1170 14 p.

Research output: Contribution to journalArticle

468 Scopus citations

Crystallization of hepatocyte nuclear factor 1β in complex with DNA

Lu, P., Li, Y., Gorman, A. & Chi, Y. I., Jun 2006, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62, 6, p. 525-529 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cutting edge: Developmental regulation of IFN-γ production by mouse neutrophil precursor cells

Sturge, C. R., Burger, E., Raetz, M., Hooper, L. V. & Yarovinsky, F., Jul 1 2015, In : Journal of Immunology. 195, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

Stappenbeck, T. S., Hooper, L. V. & Gordon, J. I., Nov 26 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 24, p. 15451-15455 5 p.

Research output: Contribution to journalArticle

687 Scopus citations

Differential expression of GalNAc-4-sulfotransferase and GalNAc-transferase results in distinct glycoforms of carbonic anhydrase VI in parotid and submaxillary glands

Hooper, L. V., Beranek, M. C., Manzella, S. M. & Baenziger, J. U., Mar 17 1995, In : Journal of Biological Chemistry. 270, 11, p. 5985-5993 9 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., Tang, Y. W., Hooper, L., Bordenstein, S. R., Das, S. R. & Weitkamp, J. H., Oct 2018, In : PloS one. 13, 10, e0206366.

Research output: Contribution to journalArticle

3 Scopus citations

Do symbiotic bacteria subvert host immunity?

Hooper, L. V., Apr 29 2009, In : Nature Reviews Microbiology. 7, 5, p. 367-374 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts

Tastan, Ö. Y., Maines, J. Z., Li, Y., Mckearin, D. M. & Buszczak, M., Oct 1 2010, In : Development. 137, 19, p. 3167-3176 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dynamics and cooperativity of Trp-cage folding

Hu, Z., Tang, Y., Wang, H., Zhang, X. & Lei, M., Jul 15 2008, In : Archives of Biochemistry and Biophysics. 475, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Jan 1 2017, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

34 Scopus citations

Epithelial Cell Contributions to Intestinal Immunity

Hooper, L. V., 2015, In : Advances in Immunology. 126, p. 129-172 44 p.

Research output: Contribution to journalArticle

43 Scopus citations

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
3 Scopus citations

Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes

Kleiner, M., Hooper, L. V. & Duerkop, B. A., Jan 22 2015, In : BMC Genomics. 16, 1, 7.

Research output: Contribution to journalArticle

66 Scopus citations

Fabrication of an oriented lectin microarray

Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 14 2010, In : ChemBioChem. 11, 9, p. 1203-1207+1157

Research output: Contribution to journalArticle

24 Scopus citations

Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii

Benson, A., Pifer, R., Behrendt, C. L., Hooper, L. V. & Yarovinsky, F., Aug 20 2009, In : Cell Host and Microbe. 6, 2, p. 187-196 10 p.

Research output: Contribution to journalArticle

141 Scopus citations

Host-microbial symbiosis in the mammalian intestine: Exploring an internal ecosystem

Hooper, L. V., Bry, L., Falk, P. G. & Gordon, J. I., Apr 1998, In : BioEssays. 20, 4, p. 336-343 8 p.

Research output: Contribution to journalArticle

141 Scopus citations

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

21 Scopus citations

Immunology: A bacterial nudge to T-cell function

Bel, S. & Hooper, L. V., Oct 15 2015, In : Nature. 526, 7573, p. 328-330 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Integrin-associated protein: A 50-kD plasma membrane antigen physically and functionally associated with integrins

Brown, E., Hooper, L., Ho, T. & Gresham, H., 1990, In : Journal of Cell Biology. 111, 6 I, p. 2785-2794 10 p.

Research output: Contribution to journalArticle

Open Access
285 Scopus citations

Intestinal epithelial autophagy is essential for host defense against invasive bacteria

Benjamin, J. L., Sumpter, R., Levine, B. & Hooper, L. V., Jun 12 2013, In : Cell Host and Microbe. 13, 6, p. 723-734 12 p.

Research output: Contribution to journalArticle

161 Scopus citations

Intestinal microbiota promote enteric virus replication and systemic pathogenesis

Kuss, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J., Frierson, J. M., Hooper, L. V., Dermody, T. S. & Pfeiffer, J. K., Oct 14 2011, In : Science. 334, 6053, p. 249-252 4 p.

Research output: Contribution to journalArticle

309 Scopus citations

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

Wang, L., Fouts, D. E., Stärkel, P., Hartmann, P., Chen, P., Llorente, C., DePew, J., Moncera, K., Ho, S. B., Brenner, D. A., Hooper, L. V. & Schnabl, B., 2016, In : Cell Host and Microbe. 19, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

123 Scopus citations

Laser capture microdissection of mouse intestine: Characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations

Stappenbeck, T. S., Hooper, L. V., Manchester, J. K., Wong, M. H. & Gordon, J. I., Jan 1 2002, In : Methods in Enzymology. 356, p. 167-196 30 p.

Research output: Contribution to journalArticle

47 Scopus citations

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Feb 14 2018, In : Cell Host and Microbe. 23, 2, p. 177-190.e4

Research output: Contribution to journalArticle

32 Scopus citations

Maternal high-fat diet results in microbiota-dependent expansion of ILC3s in mice offspring

Babu, S. T., Niu, X., Raetz, M., Savani, R. C., Hooper, L. V. & Mirpuri Hathiramani, J., Oct 4 2018, In : JCI insight. 3, 19

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 2012, In : Genes and Development. 26, 12, p. 1306-1311 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary

Li, Y., Zhang, Q., Carreira-Rosario, A., Maines, J. Z., McKearin, D. M. & Buszczak, M., Mar 20 2013, In : PloS one. 8, 3, e58301.

Research output: Contribution to journalArticle

37 Scopus citations

Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling

Li, Y., Maines, J. Z., Tastan, Ö. Y., McKearin, D. M. & Buszczak, M., May 1 2012, In : Development. 139, 9, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis

Hughes, E. R., Winter, M. G., Duerkop, B. A., Spiga, L., Furtado de Carvalho, T., Zhu, W., Gillis, C. C., Büttner, L., Smoot, M. P., Behrendt, C. L., Cherry, S., Santos, R. L., Hooper, L. V. & Winter, S. E., Feb 8 2017, In : Cell Host and Microbe. 21, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

Li, X. D., Chiu, Y. H., Ismail, A. S., Behrendt, C. L., Wight-Carter, M., Hooper, L. V. & Chen, Z. J., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17390-17395 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Molecular analysis of commensal host-microbial relationships in the intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G. & Gordon, J. I., Feb 2 2001, In : Science. 291, 5505, p. 881-884 4 p.

Research output: Contribution to journalArticle

1469 Scopus citations

Molecular basis for lytic bacteriophage resistance in enterococci

Duerkop, B. A., Huo, W., Bhardwaj, P., Palmer, K. L. & Hooper, L. V., Jul 1 2016, In : mBio. 7, 4, e01304-16.

Research output: Contribution to journalArticle

28 Scopus citations

Molecular basis for peptidoglycan recognition by a bactericidal lectin

Lehotzkya, R. E., Partchb, C. L., Mukherjeea, S., Casha, H. L., Goldman, W. E., Gardner, K. H. & Hooper, L. V., Apr 27 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7722-7727 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Molecular basis for retinol binding by serum amyloid A during infection

Hu, Z., Bang, Y. J., Ruhn, K. A. & Hooper, L. V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19077-19082 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations