Immunology - Hooper Lab

Research Output

Article

Molecular dynamics studies of the antimicrobial peptides piscidin 1 and its mutants with a DOPC lipid bilayer

Yuan, T., Zhang, X., Hu, Z., Wang, F. & Lei, M., Dec 2012, In : Biopolymers. 97, 12, p. 998-1009 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Murine colitis reveals a disease-associated bacteriophage community

Duerkop, B. A., Kleiner, M., Paez-Espino, D., Zhu, W., Bushnell, B., Hassell, B., Winter, S. E., Kyrpides, N. C. & Hooper, L. V., Sep 1 2018, In : Nature microbiology. 3, 9, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways

Udden, S. M. N., Peng, L., Gan, J. L., Shelton, J. M., Malter, J. S., Hooper, L. V. & Zaki, M. H., Jun 27 2017, In : Cell Reports. 19, 13, p. 2756-2770 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Oligosaccharides containing β1,4-linked N-acetylgalactosamine, a paradigm for protein-specific glycosylation

Manzella, S. M., Hooper, L. V. & Baenziger, J. U., Jan 1 1996, In : Journal of Biological Chemistry. 271, 21, p. 12117-12120 4 p.

Research output: Contribution to journalArticle

Open Access
84 Scopus citations

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L. & Hooper, L. V., Dec 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20858-20863 6 p.

Research output: Contribution to journalArticle

612 Scopus citations

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Bel, S., Pendse, M., Wang, Y., Ii, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J. & Hooper, L. V., Sep 8 2017, In : Science. 357, 6355, p. 1047-1052 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

Raetz, M., Hwang, S. H., Wilhelm, C. L., Kirkland, D., Benson, A., Sturge, C. R., Mirpuri, J., Vaishnava, S., Hou, B., Defranco, A. L., Gilpin, C. J., Hooper, L. V. & Yarovinsky, F., Feb 1 2013, In : Nature immunology. 14, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

112 Scopus citations

Precision editing of the gut microbiota ameliorates colitis

Zhu, W., Winter, M. G., Byndloss, M. X., Spiga, L., Duerkop, B. A., Hughes, E. R., Büttner, L., De Lima Romão, E., Behrendt, C. L., Lopez, C. A., Sifuentes-Dominguez, L., Huff-Hardy, K., Wilson, R. P., Gillis, C. C., Tükel, Ç., Koh, A. Y., Burstein, E., Hooper, L. V., Bäumler, A. J. & Winter, S. E., Jan 11 2018, In : Nature. 553, 7687, p. 208-211 4 p.

Research output: Contribution to journalArticle

138 Scopus citations

Proteobacteria-specific IgA regulates maturation of the intestinal microbiota

Mirpuri, J., Raetz, M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V. & Yarovinsky, F., Sep 25 2013, In : Gut Microbes. 5, 1

Research output: Contribution to journalArticle

99 Scopus citations

Pulmonary Th17 antifungal immunity is regulated by the gut microbiome

McAleer, J. P., Nguyen, N. L. H., Chen, K., Kumar, P., Ricks, D. M., Binnie, M., Armentrout, R. A., Pociask, D. A., Hein, A., Yu, A., Vikram, A., Bibby, K., Umesaki, Y., Rivera, A., Sheppard, D., Ouyang, W., Hooper, L. V. & Kolls, J. K., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 97-107 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Purification and characterization of the GalNAc-4-sulfotransferase responsible for sulfation of GalNAcβ1,4GlcNAc-bearing oligosaccharides

Hooper, L. V., Hindsgaul, O. & Baenziger, J. U., Jan 1 1995, In : Journal of Biological Chemistry. 270, 27, p. 16327-16332 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Reciprocal interactions between commensal bacteria and γδ intraepithelial lymphocytes during mucosal injury

Ismail, A. S., Behrendt, C. L. & Hooper, L. V., Mar 1 2009, In : Journal of Immunology. 182, 5, p. 3047-3054 8 p.

Research output: Contribution to journalArticle

136 Scopus citations

Recombinant lectin microarrays for glycomic analysis.

Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 15 2011, In : Methods in molecular biology (Clifton, N.J.). 723, p. 67-77 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli

Cash, H. L., Whitham, C. V. & Hooper, L. V., Jul 1 2006, In : Protein Expression and Purification. 48, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment

Mukherjee, S., Partch, C. L., Lehotzky, R. E., Whitham, C. V., Chu, H., Bevins, C. L., Gardner, K. H. & Hooper, L. V., Feb 20 2009, In : Journal of Biological Chemistry. 284, 8, p. 4881-4888 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Harris, T. A., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 777-788.e8

Research output: Contribution to journalArticle

10 Scopus citations
33 Scopus citations

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S. & Hooper, L. V., Jul 29 2014, In : eLife. 3, July2014, p. 1-18 18 p., e03206.

Research output: Contribution to journalArticle

68 Scopus citations

Sulfotransferase and glycosyltransferase analyses using a 96-well filtration plate

Hooper, L. V. & Baenziger, J. U., Jul 1993, In : Analytical biochemistry. 212, 1, p. 128-133 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

Zhao, D., Kim, Y. H., Jeong, S., Greenson, J. K., Chaudhry, M. S., Hoepting, M., Anderson, E. R., van den Brink, M. R., Peled, J. U., Gomes, A. L., Slingerland, A. E., Donovan, M. J., Harris, A. C., Levine, J. E., Ozbek, U., Hooper, L. V., Stappenbeck, T. S., Ver Heul, A., Liu, T. C., Reddy, P. & 1 others, Ferrara, J. L., Nov 1 2018, In : Journal of Clinical Investigation. 128, 11, p. 4970-4979 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L. & Hooper, L. V., Aug 25 2006, In : Science. 313, 5790, p. 1126-1130 5 p.

Research output: Contribution to journalArticle

891 Scopus citations

TH17 cell differentiation is regulated by the circadian clock

Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S. & Hooper, L. V., 2013, In : Science. 342, 6159, p. 727-730 4 p.

Research output: Contribution to journalArticle

193 Scopus citations

The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K. & Hooper, L. V., Oct 14 2011, In : Science. 334, 6053, p. 255-258 4 p.

Research output: Contribution to journalArticle

747 Scopus citations

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

Yu, X., Wang, Y., Deng Ph.D., M., Li, Y., Ruhn, K. A., Zhang, C. & Hooper, L. V., Oct 13 2014, In : eLife. 3, e04406.

Research output: Contribution to journalArticle

140 Scopus citations

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Hu, S., Peng, L., Kwak, Y. T., Tekippe, E. M., Pasare, C., Malter, J. S., Hooper, L. V. & Zaki, M. H., Apr 3 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

55 Scopus citations

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Gou, Y. K., Nagy, A., Semenkovich, C. F. & Gordon, J. I., Nov 2 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 44, p. 15718-15723 6 p.

Research output: Contribution to journalArticle

3301 Scopus citations

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

Kuang, Z., Wang, Y., Li, Y., Ye, C., Ruhn, K. A., Behrendt, C. L., Olson, E. N. & Hooper, L. V., Sep 27 2019, In : Science. 365, 6460, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M. & Hooper, L. V., Sep 1 2017, In : Science. 357, 6354, p. 912-916 5 p.

Research output: Contribution to journalArticle

107 Scopus citations

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V. & Farrar, J. D., Nov 2018, In : Brain, Behavior, and Immunity. 74, p. 176-185 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Understanding the microbiota in the midst of Renaissance architecture and olive groves

Guarner, F., Hooper, L. V. & Núñez, G., Feb 1 2013, In : Nature immunology. 14, 2, p. 101-105 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis

Zhu, W., Winter, M. G., Spiga, L., Hughes, E. R., Chanin, R., Mulgaonkar, A., Pennington, J., Maas, M., Behrendt, C. L., Kim, J., Sun, X., Beiting, D. P., Hooper, L. V. & Winter, S. E., Mar 11 2020, In : Cell Host and Microbe. 27, 3, p. 376-388.e8

Research output: Contribution to journalArticle

2 Scopus citations

γδ intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface

Ismail, A. S., Severson, K. M., Vaishnava, S., Behrendt, C. L., Yu, X., Benjamin, J. L., Ruhn, K. A., Hou, B., DeFranco, A. L., Yarovinsky, F. & Hooper, L. V., May 24 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 21, p. 8743-8748 6 p.

Research output: Contribution to journalArticle

163 Scopus citations
Comment/debate

Clinical microbiology in the year 2025

Dunne, W. M., Pinckard, J. K. & Hooper, L. V., Nov 1 2002, In : Journal of clinical microbiology. 40, 11, p. 3889-3893 5 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

Erratum: Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth (Cell Host & Microbe (2018) 23(1) (54–64.e6) (S1931312817305000) (10.1016/j.chom.2017.11.006))

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Apr 11 2018, In : Cell Host and Microbe. 23, 4, p. 570 1 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Immune control of the microbiota prevents obesity

Wang, Y. & Hooper, L. V., Jul 26 2019, In : Science (New York, N.Y.). 365, 6451, p. 316-317 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Innate lymphoid cells sweeten the pot: Immune cells prompt gut epithelial cells to produce carbohydrate nutrients for resident bacteria

Hooper, L. V., Sep 12 2014, In : Science. 345, 6202, p. 1248-1249 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Interactions between epithelial cells and bacteria, normal and pathogenic

Umesaki, Y., Okada, Y., Imaoka, A., Setoyama, H., Matsumoto, S., Gordon, J. I., Hooper, L. V., Bry, L., Midtvedt, T. & Falk, P. G., May 28 1997, In : Science. 276, 5314, p. 964-965 2 p.

Research output: Contribution to journalComment/debate

32 Scopus citations

Secretory autophagy of lysozyme in Paneth cells

Bel, S. & Hooper, L. V., Apr 3 2018, In : Autophagy. 14, 4, p. 719-721 3 p.

Research output: Contribution to journalComment/debate

10 Scopus citations
Review article

Analyzing the molecular foundations of commensalism in the mouse intestine

Hooper, L. V., Falk, P. G. & Gordon, J. I., Feb 1 2000, In : Current Opinion in Microbiology. 3, 1, p. 79-85 7 p.

Research output: Contribution to journalReview article

60 Scopus citations

Antimicrobial Defense of the Intestine

Mukherjee, S. & Hooper, L. V., Jan 20 2015, In : Immunity. 42, 1, p. 28-39 12 p.

Research output: Contribution to journalReview article

119 Scopus citations

Bacterial contributions to mammalian gut development

Hooper, L. V., Mar 1 2004, In : Trends in Microbiology. 12, 3, p. 129-134 6 p.

Research output: Contribution to journalReview article

318 Scopus citations

Commensal bacteria shape intestinal immune system development

Cash, H. L. & Hooper, L. V., Feb 1 2005, In : ASM News. 71, 2, p. 77-83 7 p.

Research output: Contribution to journalReview article

27 Scopus citations

Commensal host-bacterial relationships in the gut

Hooper, L. V. & Gordon, J. I., May 11 2001, In : Science. 292, 5519, p. 1115-1118 4 p.

Research output: Contribution to journalReview article

1572 Scopus citations

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L. & Hooper, L. V., Jul 1 2012, In : Nature Reviews Immunology. 12, 7, p. 503-516 14 p.

Research output: Contribution to journalReview article

447 Scopus citations
99 Scopus citations
78 Scopus citations

From legumes to leukocytes: Biological roles for sulfated carbohydrates

Hooper, L. V., Manzella, S. M. & Baenziger, J. U., 1996, In : FASEB Journal. 10, 10, p. 1137-1146 10 p.

Research output: Contribution to journalReview article

81 Scopus citations

Glycans as legislators of host-microbial interactions: Spanning the spectrum from symbiosis to pathogenicity

Hooper, L. V. & Gordon, J. I., Jan 1 2001, In : Glycobiology. 11, 2, p. 1R-10R

Research output: Contribution to journalReview article

Open Access
188 Scopus citations

How host-microbial interactions shape the nutrient environment of the mammalian intestine

Hooper, L. V., Midwedt, T. & Gordon, J. I., Nov 6 2002, In : Annual review of nutrition. 22, p. 283-307 25 p.

Research output: Contribution to journalReview article

988 Scopus citations

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V. & MacPherson, A. J., Mar 2010, In : Nature Reviews Immunology. 10, 3, p. 159-169 11 p.

Research output: Contribution to journalReview article

755 Scopus citations