Immunology - Hooper Lab

Research Output

2012

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L. & Hooper, L. V., Jul 1 2012, In : Nature Reviews Immunology. 12, 7, p. 503-516 14 p.

Research output: Contribution to journalReview article

440 Scopus citations

Interactions between the microbiota and the immune system

Hooper, L. V., Littman, D. R. & Macpherson, A. J., Jun 8 2012, In : Science. 336, 6086, p. 1268-1273 6 p.

Research output: Contribution to journalReview article

1932 Scopus citations

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 2012, In : Genes and Development. 26, 12, p. 1306-1311 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling

Li, Y., Maines, J. Z., Tastan, Ö. Y., McKearin, D. M. & Buszczak, M., May 1 2012, In : Development. 139, 9, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Molecular dynamics studies of the antimicrobial peptides piscidin 1 and its mutants with a DOPC lipid bilayer

Yuan, T., Zhang, X., Hu, Z., Wang, F. & Lei, M., Dec 2012, In : Biopolymers. 97, 12, p. 998-1009 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Eat your carrots! T cells are RARing to Go

Vaishnava, S. & Hooper, L. V., Mar 25 2011, In : Immunity. 34, 3, p. 290-292 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Intestinal microbiota promote enteric virus replication and systemic pathogenesis

Kuss, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J., Frierson, J. M., Hooper, L. V., Dermody, T. S. & Pfeiffer, J. K., Oct 14 2011, In : Science. 334, 6053, p. 249-252 4 p.

Research output: Contribution to journalArticle

309 Scopus citations

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

Li, X. D., Chiu, Y. H., Ismail, A. S., Behrendt, C. L., Wight-Carter, M., Hooper, L. V. & Chen, Z. J., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17390-17395 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Orientation of GST-tagged lectins via in situ surface modification to create an expanded lectin microarray for glycomic analysis

Propheter, D. C. & Mahal, L. K., Jul 1 2011, In : Molecular BioSystems. 7, 7, p. 2114-2117 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Recombinant lectin microarrays for glycomic analysis.

Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 15 2011, In : Methods in molecular biology (Clifton, N.J.). 723, p. 67-77 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K. & Hooper, L. V., Oct 14 2011, In : Science. 334, 6053, p. 255-258 4 p.

Research output: Contribution to journalArticle

743 Scopus citations

You AhR what you eat: Linking diet and immunity

Hooper, L. V., Oct 28 2011, In : Cell. 147, 3, p. 489-491 3 p.

Research output: Contribution to journalShort survey

21 Scopus citations

γδ intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface

Ismail, A. S., Severson, K. M., Vaishnava, S., Behrendt, C. L., Yu, X., Benjamin, J. L., Ruhn, K. A., Hou, B., DeFranco, A. L., Yarovinsky, F. & Hooper, L. V., May 24 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 21, p. 8743-8748 6 p.

Research output: Contribution to journalArticle

163 Scopus citations
2010

Drosophila ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts

Tastan, Ö. Y., Maines, J. Z., Li, Y., Mckearin, D. M. & Buszczak, M., Oct 1 2010, In : Development. 137, 19, p. 3167-3176 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Fabrication of an oriented lectin microarray

Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 14 2010, In : ChemBioChem. 11, 9, p. 1203-1207+1157

Research output: Contribution to journalArticle

24 Scopus citations

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V. & MacPherson, A. J., Mar 2010, In : Nature Reviews Immunology. 10, 3, p. 159-169 11 p.

Research output: Contribution to journalReview article

747 Scopus citations

Molecular basis for peptidoglycan recognition by a bactericidal lectin

Lehotzkya, R. E., Partchb, C. L., Mukherjeea, S., Casha, H. L., Goldman, W. E., Gardner, K. H. & Hooper, L. V., Apr 27 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7722-7727 6 p.

Research output: Contribution to journalArticle

87 Scopus citations
2009

Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance

Li, Y., Minor, N. T., Park, J. K., McKearin, D. M. & Maines, J. Z., Jun 9 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 23, p. 9304-9309 6 p.

Research output: Contribution to journalArticle

93 Scopus citations

Commensal bacteria regulate toll-like receptor 3-dependent inflammation after skin injury

Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z. R., Hooper, L. V., Schmidt, R. R., Von Aulock, S., Radek, K. A., Huang, C. M., Ryan, A. F. & Gallo, R. L., Dec 2009, In : Nature medicine. 15, 12, p. 1377-1382 6 p.

Research output: Contribution to journalArticle

402 Scopus citations

Do symbiotic bacteria subvert host immunity?

Hooper, L. V., Apr 29 2009, In : Nature Reviews Microbiology. 7, 5, p. 367-374 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii

Benson, A., Pifer, R., Behrendt, C. L., Hooper, L. V. & Yarovinsky, F., Aug 20 2009, In : Cell Host and Microbe. 6, 2, p. 187-196 10 p.

Research output: Contribution to journalArticle

141 Scopus citations

Immune Responses to the Microbiota at the Intestinal Mucosal Surface

Duerkop, B. A., Vaishnava, S. & Hooper, L. V., Sep 18 2009, In : Immunity. 31, 3, p. 368-376 9 p.

Research output: Contribution to journalReview article

261 Scopus citations

Reciprocal interactions between commensal bacteria and γδ intraepithelial lymphocytes during mucosal injury

Ismail, A. S., Behrendt, C. L. & Hooper, L. V., Mar 1 2009, In : Journal of Immunology. 182, 5, p. 3047-3054 8 p.

Research output: Contribution to journalArticle

136 Scopus citations

Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment

Mukherjee, S., Partch, C. L., Lehotzky, R. E., Whitham, C. V., Chu, H., Bevins, C. L., Gardner, K. H. & Hooper, L. V., Feb 20 2009, In : Journal of Biological Chemistry. 284, 8, p. 4881-4888 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
2008

Dynamics and cooperativity of Trp-cage folding

Hu, Z., Tang, Y., Wang, H., Zhang, X. & Lei, M., Jul 15 2008, In : Archives of Biochemistry and Biophysics. 475, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Innate immune responses to commensal bacteria in the gut epithelium.

Vaishnava, S., Behrendt, C. L. & Hooper, L. V., Apr 2008, In : Journal of pediatric gastroenterology and nutrition. 46 Suppl 1, p. E10-11

Research output: Contribution to journalReview article

15 Scopus citations

Multi-layered regulation of intestinal antimicrobial defense

Mukherjee, S., Vaishnava, S. & Hooper, L. V., Oct 1 2008, In : Cellular and Molecular Life Sciences. 65, 19, p. 3019-3027 9 p.

Research output: Contribution to journalReview article

91 Scopus citations

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L. & Hooper, L. V., Dec 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20858-20863 6 p.

Research output: Contribution to journalArticle

608 Scopus citations
2007

Alkaline Phosphatase: Keeping the Peace at the Gut Epithelial Surface

Vaishnava, S. & Hooper, L. V., Dec 13 2007, In : Cell Host and Microbe. 2, 6, p. 365-367 3 p.

Research output: Contribution to journalShort survey

44 Scopus citations
2006

Crystallization of hepatocyte nuclear factor 1β in complex with DNA

Lu, P., Li, Y., Gorman, A. & Chi, Y. I., Jun 2006, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 62, 6, p. 525-529 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli

Cash, H. L., Whitham, C. V. & Hooper, L. V., Jul 1 2006, In : Protein Expression and Purification. 48, 1, p. 151-159 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L. & Hooper, L. V., Aug 25 2006, In : Science. 313, 5790, p. 1126-1130 5 p.

Research output: Contribution to journalArticle

882 Scopus citations
2005

Commensal bacteria shape intestinal immune system development

Cash, H. L. & Hooper, L. V., Feb 1 2005, In : ASM News. 71, 2, p. 77-83 7 p.

Research output: Contribution to journalReview article

27 Scopus citations
78 Scopus citations
2004

Bacterial contributions to mammalian gut development

Hooper, L. V., Mar 1 2004, In : Trends in Microbiology. 12, 3, p. 129-134 6 p.

Research output: Contribution to journalReview article

317 Scopus citations

Laser microdissection: Exploring host-bacterial encounters at the front lines

Hooper, L. V., Jun 1 2004, In : Current Opinion in Microbiology. 7, 3, p. 290-295 6 p.

Research output: Contribution to journalReview article

14 Scopus citations

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Gou, Y. K., Nagy, A., Semenkovich, C. F. & Gordon, J. I., Nov 2 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 44, p. 15718-15723 6 p.

Research output: Contribution to journalArticle

3256 Scopus citations
2003

A genomic view of the human-Bacteroides thetaiotaomicron symbiosis

Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V. & Gordon, J. I., Mar 28 2003, In : Science. 299, 5615, p. 2074-2076 3 p.

Research output: Contribution to journalArticle

854 Scopus citations

Angiogenins: A new class of microbicidal proteins involved in innate immunity

Hooper, L. V., Stappenbeck, T. S., Hong, C. V. & Gordon, J. I., Mar 1 2003, In : Nature immunology. 4, 3, p. 269-273 5 p.

Research output: Contribution to journalArticle

630 Scopus citations

Response from Jeffrey I. Gordon et al. Commensal bacteria make a difference

Gordon, J. I., Stappenbeck, T. S. & Hooper, L. V., Apr 1 2003, In : Trends in Microbiology. 11, 4, p. 150-151 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations
2002

29 Combining gnotobiotic mouse models with functional genomics to define the impact of the microflora on host physiology

Hooper, L. V., Mills, J. C., Roth, K. A., Stappenbeck, T. S., Wong, M. H. & Gordon, J. I., 2002, In : Methods in Microbiology. 31, p. 559-589 31 p.

Research output: Contribution to journalArticle

29 Scopus citations

Clinical microbiology in the year 2025

Dunne, W. M., Pinckard, J. K. & Hooper, L. V., Nov 1 2002, In : Journal of clinical microbiology. 40, 11, p. 3889-3893 5 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

Stappenbeck, T. S., Hooper, L. V. & Gordon, J. I., Nov 26 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 24, p. 15451-15455 5 p.

Research output: Contribution to journalArticle

687 Scopus citations

How host-microbial interactions shape the nutrient environment of the mammalian intestine

Hooper, L. V., Midwedt, T. & Gordon, J. I., Nov 6 2002, In : Annual review of nutrition. 22, p. 283-307 25 p.

Research output: Contribution to journalReview article

983 Scopus citations

Laser capture microdissection of mouse intestine: Characterizing mRNA and protein expression, and profiling intermediary metabolism in specified cell populations

Stappenbeck, T. S., Hooper, L. V., Manchester, J. K., Wong, M. H. & Gordon, J. I., Jan 1 2002, In : Methods in Enzymology. 356, p. 167-196 30 p.

Research output: Contribution to journalArticle

47 Scopus citations
2001

Commensal host-bacterial relationships in the gut

Hooper, L. V. & Gordon, J. I., May 11 2001, In : Science. 292, 5519, p. 1115-1118 4 p.

Research output: Contribution to journalReview article

1557 Scopus citations

Glycans as legislators of host-microbial interactions: Spanning the spectrum from symbiosis to pathogenicity

Hooper, L. V. & Gordon, J. I., Jan 1 2001, In : Glycobiology. 11, 2, p. 1R-10R

Research output: Contribution to journalReview article

Open Access
187 Scopus citations

Molecular analysis of commensal host-microbial relationships in the intestine

Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G. & Gordon, J. I., Feb 2 2001, In : Science. 291, 5505, p. 881-884 4 p.

Research output: Contribution to journalArticle

1469 Scopus citations
2000

Analyzing the molecular foundations of commensalism in the mouse intestine

Hooper, L. V., Falk, P. G. & Gordon, J. I., Feb 1 2000, In : Current Opinion in Microbiology. 3, 1, p. 79-85 7 p.

Research output: Contribution to journalReview article

60 Scopus citations

Bacterial exposure induces and activates matrilysin in mucosal epithelial cells

López-Boado, Y. S., Wilson, C. L., Hooper, L. V., Gordon, J. I., Hultgren, S. J. & Parks, W. C., Mar 20 2000, In : Journal of Cell Biology. 148, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

137 Scopus citations