Immunology - Hooper Lab

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2020

Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis

Zhu, W., Winter, M. G., Spiga, L., Hughes, E. R., Chanin, R., Mulgaonkar, A., Pennington, J., Maas, M., Behrendt, C. L., Kim, J., Sun, X., Beiting, D. P., Hooper, L. V. & Winter, S. E., Mar 11 2020, In : Cell Host and Microbe. 27, 3, p. 376-388.e8

Research output: Contribution to journalArticle

2 Scopus citations
2019

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Molecular basis for retinol binding by serum amyloid A during infection

Hu, Z., Bang, Y. J., Ruhn, K. A. & Hooper, L. V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19077-19082 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Harris, T. A., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 777-788.e8

Research output: Contribution to journalArticle

10 Scopus citations

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

Kuang, Z., Wang, Y., Li, Y., Ye, C., Ruhn, K. A., Behrendt, C. L., Olson, E. N. & Hooper, L. V., Sep 27 2019, In : Science. 365, 6460, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
2018

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., Tang, Y. W., Hooper, L., Bordenstein, S. R., Das, S. R. & Weitkamp, J. H., Oct 2018, In : PloS one. 13, 10, e0206366.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Feb 14 2018, In : Cell Host and Microbe. 23, 2, p. 177-190.e4

Research output: Contribution to journalArticle

33 Scopus citations

Maternal high-fat diet results in microbiota-dependent expansion of ILC3s in mice offspring

Babu, S. T., Niu, X., Raetz, M., Savani, R. C., Hooper, L. V. & Mirpuri Hathiramani, J., Oct 4 2018, In : JCI insight. 3, 19

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Murine colitis reveals a disease-associated bacteriophage community

Duerkop, B. A., Kleiner, M., Paez-Espino, D., Zhu, W., Bushnell, B., Hassell, B., Winter, S. E., Kyrpides, N. C. & Hooper, L. V., Sep 1 2018, In : Nature microbiology. 3, 9, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Precision editing of the gut microbiota ameliorates colitis

Zhu, W., Winter, M. G., Byndloss, M. X., Spiga, L., Duerkop, B. A., Hughes, E. R., Büttner, L., De Lima Romão, E., Behrendt, C. L., Lopez, C. A., Sifuentes-Dominguez, L., Huff-Hardy, K., Wilson, R. P., Gillis, C. C., Tükel, Ç., Koh, A. Y., Burstein, E., Hooper, L. V., Bäumler, A. J. & Winter, S. E., Jan 11 2018, In : Nature. 553, 7687, p. 208-211 4 p.

Research output: Contribution to journalArticle

138 Scopus citations

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

Zhao, D., Kim, Y. H., Jeong, S., Greenson, J. K., Chaudhry, M. S., Hoepting, M., Anderson, E. R., van den Brink, M. R., Peled, J. U., Gomes, A. L., Slingerland, A. E., Donovan, M. J., Harris, A. C., Levine, J. E., Ozbek, U., Hooper, L. V., Stappenbeck, T. S., Ver Heul, A., Liu, T. C., Reddy, P. & 1 others, Ferrara, J. L., Nov 1 2018, In : Journal of Clinical Investigation. 128, 11, p. 4970-4979 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V. & Farrar, J. D., Nov 2018, In : Brain, Behavior, and Immunity. 74, p. 176-185 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2017

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate

Spiga, L., Winter, M. G., Furtado de Carvalho, T., Zhu, W., Hughes, E. R., Gillis, C. C., Behrendt, C. L., Kim, J., Chessa, D., Andrews-Polymenis, H. L., Beiting, D. P., Santos, R. L., Hooper, L. V. & Winter, S. E., Sep 13 2017, In : Cell Host and Microbe. 22, 3, p. 291-301.e6

Research output: Contribution to journalArticle

40 Scopus citations

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Jan 1 2017, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

34 Scopus citations

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

21 Scopus citations

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis

Hughes, E. R., Winter, M. G., Duerkop, B. A., Spiga, L., Furtado de Carvalho, T., Zhu, W., Gillis, C. C., Büttner, L., Smoot, M. P., Behrendt, C. L., Cherry, S., Santos, R. L., Hooper, L. V. & Winter, S. E., Feb 8 2017, In : Cell Host and Microbe. 21, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways

Udden, S. M. N., Peng, L., Gan, J. L., Shelton, J. M., Malter, J. S., Hooper, L. V. & Zaki, M. H., Jun 27 2017, In : Cell Reports. 19, 13, p. 2756-2770 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Bel, S., Pendse, M., Wang, Y., Ii, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J. & Hooper, L. V., Sep 8 2017, In : Science. 357, 6355, p. 1047-1052 6 p.

Research output: Contribution to journalArticle

103 Scopus citations
33 Scopus citations

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M. & Hooper, L. V., Sep 1 2017, In : Science. 357, 6354, p. 912-916 5 p.

Research output: Contribution to journalArticle

107 Scopus citations
2016

Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species

Chatzidaki-Livanis, M., Geva-Zatorsky, N., Comstock, L. E. & Hooper, L. V., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3627-3632 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

Wang, L., Fouts, D. E., Stärkel, P., Hartmann, P., Chen, P., Llorente, C., DePew, J., Moncera, K., Ho, S. B., Brenner, D. A., Hooper, L. V. & Schnabl, B., 2016, In : Cell Host and Microbe. 19, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

128 Scopus citations

Molecular basis for lytic bacteriophage resistance in enterococci

Duerkop, B. A., Huo, W., Bhardwaj, P., Palmer, K. L. & Hooper, L. V., Jul 1 2016, In : mBio. 7, 4, e01304-16.

Research output: Contribution to journalArticle

29 Scopus citations

Pulmonary Th17 antifungal immunity is regulated by the gut microbiome

McAleer, J. P., Nguyen, N. L. H., Chen, K., Kumar, P., Ricks, D. M., Binnie, M., Armentrout, R. A., Pociask, D. A., Hein, A., Yu, A., Vikram, A., Bibby, K., Umesaki, Y., Rivera, A., Sheppard, D., Ouyang, W., Hooper, L. V. & Kolls, J. K., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 97-107 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2015

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V. & Koh, A., Jun 8 2015, In : Nature Medicine. 21, 7, p. 808-814 7 p.

Research output: Contribution to journalArticle

131 Scopus citations

Bacteria Come into Focus: New Tools for Visualizing the Microbiota

Propheter, D. C. & Hooper, L. V., Oct 14 2015, In : Cell Host and Microbe. 18, 4, p. 392-394 3 p., 1348.

Research output: Contribution to journalArticle

6 Scopus citations

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis

Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V. & Koh, A. Y., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005129.

Research output: Contribution to journalArticle

56 Scopus citations

Cutting edge: Developmental regulation of IFN-γ production by mouse neutrophil precursor cells

Sturge, C. R., Burger, E., Raetz, M., Hooper, L. V. & Yarovinsky, F., Jul 1 2015, In : Journal of Immunology. 195, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Epithelial Cell Contributions to Intestinal Immunity

Hooper, L. V., 2015, In : Advances in Immunology. 126, p. 129-172 44 p.

Research output: Contribution to journalArticle

43 Scopus citations
3 Scopus citations

Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes

Kleiner, M., Hooper, L. V. & Duerkop, B. A., Jan 22 2015, In : BMC Genomics. 16, 1, 7.

Research output: Contribution to journalArticle

68 Scopus citations

Immunology: A bacterial nudge to T-cell function

Bel, S. & Hooper, L. V., Oct 15 2015, In : Nature. 526, 7573, p. 328-330 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Hu, S., Peng, L., Kwak, Y. T., Tekippe, E. M., Pasare, C., Malter, J. S., Hooper, L. V. & Zaki, M. H., Apr 3 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

55 Scopus citations
2014

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo-Rey, J., Grabe, M., Jiang, Q. X. & Hooper, L. V., 2014, In : Nature. 505, 7481, p. 103-107 5 p.

Research output: Contribution to journalArticle

147 Scopus citations

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S. & Hooper, L. V., Jul 29 2014, In : eLife. 3, July2014, p. 1-18 18 p., e03206.

Research output: Contribution to journalArticle

68 Scopus citations

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

Yu, X., Wang, Y., Deng Ph.D., M., Li, Y., Ruhn, K. A., Zhang, C. & Hooper, L. V., Oct 13 2014, In : eLife. 3, e04406.

Research output: Contribution to journalArticle

140 Scopus citations
2013

Intestinal epithelial autophagy is essential for host defense against invasive bacteria

Benjamin, J. L., Sumpter, R., Levine, B. & Hooper, L. V., Jun 12 2013, In : Cell Host and Microbe. 13, 6, p. 723-734 12 p.

Research output: Contribution to journalArticle

164 Scopus citations

Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary

Li, Y., Zhang, Q., Carreira-Rosario, A., Maines, J. Z., McKearin, D. M. & Buszczak, M., Mar 20 2013, In : PloS one. 8, 3, e58301.

Research output: Contribution to journalArticle

37 Scopus citations

Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

Raetz, M., Hwang, S. H., Wilhelm, C. L., Kirkland, D., Benson, A., Sturge, C. R., Mirpuri, J., Vaishnava, S., Hou, B., Defranco, A. L., Gilpin, C. J., Hooper, L. V. & Yarovinsky, F., Feb 1 2013, In : Nature immunology. 14, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

112 Scopus citations

Proteobacteria-specific IgA regulates maturation of the intestinal microbiota

Mirpuri, J., Raetz, M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V. & Yarovinsky, F., Sep 25 2013, In : Gut Microbes. 5, 1

Research output: Contribution to journalArticle

99 Scopus citations

TH17 cell differentiation is regulated by the circadian clock

Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S. & Hooper, L. V., 2013, In : Science. 342, 6159, p. 727-730 4 p.

Research output: Contribution to journalArticle

193 Scopus citations

Understanding the microbiota in the midst of Renaissance architecture and olive groves

Guarner, F., Hooper, L. V. & Núñez, G., Feb 1 2013, In : Nature immunology. 14, 2, p. 101-105 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

A composite bacteriophage alters colonization by an intestinal commensal bacterium

Duerkop, B. A., Clements, C. V., Rollins, D., Rodrigues, J. L. M. & Hooper, L. V., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17621-17626 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 2012, In : Genes and Development. 26, 12, p. 1306-1311 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling

Li, Y., Maines, J. Z., Tastan, Ö. Y., McKearin, D. M. & Buszczak, M., May 1 2012, In : Development. 139, 9, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Molecular dynamics studies of the antimicrobial peptides piscidin 1 and its mutants with a DOPC lipid bilayer

Yuan, T., Zhang, X., Hu, Z., Wang, F. & Lei, M., Dec 2012, In : Biopolymers. 97, 12, p. 998-1009 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Intestinal microbiota promote enteric virus replication and systemic pathogenesis

Kuss, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J., Frierson, J. M., Hooper, L. V., Dermody, T. S. & Pfeiffer, J. K., Oct 14 2011, In : Science. 334, 6053, p. 249-252 4 p.

Research output: Contribution to journalArticle

311 Scopus citations

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

Li, X. D., Chiu, Y. H., Ismail, A. S., Behrendt, C. L., Wight-Carter, M., Hooper, L. V. & Chen, Z. J., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17390-17395 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Recombinant lectin microarrays for glycomic analysis.

Propheter, D. C., Hsu, K. L. & Mahal, L. K., Jun 15 2011, In : Methods in molecular biology (Clifton, N.J.). 723, p. 67-77 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K. & Hooper, L. V., Oct 14 2011, In : Science. 334, 6053, p. 255-258 4 p.

Research output: Contribution to journalArticle

747 Scopus citations