Immunology - Hooper Lab

Research Output 1990 2019

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2019

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
Serum Amyloid A Protein
Retinoic Acid Receptors
Vitamin A
Immunity
Th17 Cells
1 Citation (Scopus)

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Harris-Tryon, T., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 777-788.e8

Research output: Contribution to journalArticle

Resistin
Vitamin A
Skin
Cell Shape
Infection
2018
1 Citation (Scopus)

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., Tang, Y. W., Hooper, L. V., Bordenstein, S. R., Das, S. R. & Weitkamp, J. H., Oct 1 2018, In : PLoS One. 13, 10, e0206366.

Research output: Contribution to journalArticle

enterocolitis
Necrotizing Enterocolitis
microbial communities
Microbiota
antibiotics
23 Citations (Scopus)

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Paneth Cells
Autophagy
Toxoplasma
Inflammation
Microbiota

Maternal high-fat diet results in microbiota-dependent expansion of ILC3s in mice offspring

Babu, S. T., Niu, X., Raetz, M., Savani, R. C., Hooper, L. V. & Mirpuri Hathiramani, J., Oct 4 2018, In : JCI insight. 3, 19

Research output: Contribution to journalArticle

Open Access
Microbiota
High Fat Diet
Mothers
Interleukin-17
Obesity
17 Citations (Scopus)

Murine colitis reveals a disease-associated bacteriophage community

Duerkop, B. A., Kleiner, M., Paez-Espino, D., Zhu, W., Bushnell, B., Hassell, B., Winter, S. E., Kyrpides, N. C. & Hooper, L. V., Jan 1 2018, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Colitis
Bacteriophages
Inflammatory Bowel Diseases
Dysbiosis
Metagenomics
72 Citations (Scopus)

Precision editing of the gut microbiota ameliorates colitis

Zhu, W., Winter, M. G., Byndloss, M. X., Spiga, L., Duerkop, B. A., Hughes, E. R., Büttner, L., De Lima Romão, E., Behrendt, C. L., Lopez, C. A., Sifuentes-Dominguez, L., Huff-Hardy, K., Wilson, R. P., Gillis, C. C., Tükel, Ç., Koh, A. Y., Burstein, E., Hooper, L. V., Bäumler, A. J. & Winter, S. E., Jan 11 2018, In : Nature. 553, 7687, p. 208-211 4 p.

Research output: Contribution to journalArticle

Colitis
Microbiota
Dysbiosis
Enterobacteriaceae
Inflammation
5 Citations (Scopus)

Secretory autophagy of lysozyme in Paneth cells

Bel, S. & Hooper, L. V., Mar 1 2018, (Accepted/In press) In : Autophagy. p. 1-3 3 p.

Research output: Contribution to journalArticle

Paneth Cells
Autophagy
Muramidase
Crohn Disease
Mutation
4 Citations (Scopus)

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

Zhao, D., Kim, Y. H., Jeong, S., Greenson, J. K., Chaudhry, M. S., Hoepting, M., Anderson, E. R., van den Brink, M. R., Peled, J. U., Gomes, A. L., Slingerland, A. E., Donovan, M. J., Harris, A. C., Levine, J. E., Ozbek, U., Hooper, L. V., Stappenbeck, T. S., Ver Heul, A., Liu, T. C., Reddy, P. & 1 others, Ferrara, J. L., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4970-4979 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Paneth Cells
Apoptosis
Survival
Transplantation
9 Citations (Scopus)

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V. & Farrar, J. D., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Interleukin-10
Adrenergic Receptors
Norepinephrine
Inflammation
Lipopolysaccharides
2017
23 Citations (Scopus)

An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate

Spiga, L., Winter, M. G., Furtado de Carvalho, T., Zhu, W., Hughes, E. R., Gillis, C. C., Behrendt, C. L., Kim, J., Chessa, D., Andrews-Polymenis, H. L., Beiting, D. P., Santos, R. L., Hooper, L. V. & Winter, S. E., 2017, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Microbiota
Succinic Acid
Salmonella
Citric Acid Cycle
Fermentation
25 Citations (Scopus)

Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth

Gillis, C. C., Hughes, E. R., Spiga, L., Winter, M. G., Zhu, W., Furtado de Carvalho, T., Chanin, R. B., Behrendt, C. L., Hooper, L. V., Santos, R. L. & Winter, S. E., Jan 1 2017, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Dysbiosis
Salmonella
Lactic Acid
Growth
Clostridium
13 Citations (Scopus)

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice

Choi, J. H., Wang, K. W., Zhang Ph.D., D-W., Zhan, X., Wang, T., Bu, C. H., Behrendt, C. L., Zeng, M., Wang, Y., Misawa, T., Li, X., Tang, M., Zhan, X., Scott, L., Hildebrand, S., Murray, A. R., Moresco, E. M. Y., Hooper, L. V. & Beutler, B. A., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. E1196-E1204

Research output: Contribution to journalArticle

Immunoglobulin Class Switching
Immunoglobulin D
Microbiota
Lymphoid Tissue
Mucous Membrane
44 Citations (Scopus)

Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis

Hughes, E. R., Winter, M. G., Duerkop, B. A., Spiga, L., Furtado de Carvalho, T., Zhu, W., Gillis, C. C., Büttner, L., Smoot, M. P., Behrendt, C. L., Cherry, S., Santos, R. L., Hooper, L. V. & Winter, S. E., Feb 8 2017, In : Cell Host and Microbe. 21, 2, p. 208-219 12 p.

Research output: Contribution to journalArticle

formic acid
Dysbiosis
Respiration
Inflammation
Proteobacteria
17 Citations (Scopus)

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways

Udden, S. M. N., Peng, L., Gan, J. L., Shelton, J. M., Malter, J. S., Hooper, L. V. & Zaki, M. H., Jun 27 2017, In : Cell Reports. 19, 13, p. 2756-2770 15 p.

Research output: Contribution to journalArticle

Carcinogenesis
Down-Regulation
Genes
Chemical activation
Colon
59 Citations (Scopus)

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Bel, S., Pendse, M., Wang, Y., Ii, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J. & Hooper, L. V., Jul 27 2017, (Accepted/In press) In : Science. p. 1-9 9 p.

Research output: Contribution to journalArticle

Paneth Cells
Autophagy
Muramidase
Bacterial Infections
Intestines
22 Citations (Scopus)
Resistin
Microbiota
Epithelium
Mucus
Proteins
45 Citations (Scopus)

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M. & Hooper, L. V., Sep 1 2017, In : Science. 357, 6354, p. 912-916 5 p.

Research output: Contribution to journalArticle

Circadian Clocks
Microbiota
Body Composition
Epithelial Cells
Lipids
2016
67 Citations (Scopus)

Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species

Chatzidaki-Livanis, M., Geva-Zatorsky, N., Comstock, L. E. & Hooper, L. V., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3627-3632 6 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Immunity
Proteins
Prokaryotic Cells
Multiprotein Complexes
77 Citations (Scopus)

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

Wang, L., Fouts, D. E., Stärkel, P., Hartmann, P., Chen, P., Llorente, C., DePew, J., Moncera, K., Ho, S. B., Brenner, D. A., Hooper, L. V. & Schnabl, B., Feb 10 2016, In : Cell host & microbe. 19, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Bacterial Translocation
Microbiota
Fatty Liver
Lectins
16 Citations (Scopus)

Molecular basis for lytic bacteriophage resistance in enterococci

Duerkop, B. A., Huo, W., Bhardwaj, P., Palmer, K. L. & Hooper, L. V., Jul 1 2016, In : mBio. 7, 4, e01304-16.

Research output: Contribution to journalArticle

Enterococcus
Bacteriophages
Enterococcus faecalis
Intestines
Bacteria
4 Citations (Scopus)

Mum's microbes boost baby's immunity

Pendse, M. & Hooper, L. V., May 5 2016, In : Nature. 533, 7601, p. 42-43 2 p.

Research output: Contribution to journalArticle

Maternally Acquired Immunity
cells and cell components
immune system
immunity
vitamin
34 Citations (Scopus)

Pulmonary Th17 antifungal immunity is regulated by the gut microbiome

McAleer, J. P., Nguyen, N. L. H., Chen, K., Kumar, P., Ricks, D. M., Binnie, M., Armentrout, R. A., Pociask, D. A., Hein, A., Yu, A., Vikram, A., Bibby, K., Umesaki, Y., Rivera, A., Sheppard, D., Ouyang, W., Hooper, L. V. & Kolls, J. K., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 97-107 11 p.

Research output: Contribution to journalArticle

Immunity
Lung
Th17 Cells
Bacteria
Vancomycin
2015
81 Citations (Scopus)

Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization

Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V. & Koh, A., Jun 8 2015, In : Nature Medicine. 21, 7, p. 808-814 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Candida
Candida albicans
Bacteria
Chemical activation
85 Citations (Scopus)

Antimicrobial Defense of the Intestine

Mukherjee, S. & Hooper, L. V., Jan 20 2015, In : Immunity. 42, 1, p. 28-39 12 p.

Research output: Contribution to journalArticle

Intestines
Proteins
Insurance Benefits
Gastrointestinal Tract
Anti-Bacterial Agents
4 Citations (Scopus)

Bacteria Come into Focus: New Tools for Visualizing the Microbiota

Propheter, D. C. & Hooper, L. V., Oct 14 2015, In : Cell Host and Microbe. 18, 4, p. 392-394 3 p., 1348.

Research output: Contribution to journalArticle

Microbiota
Bacteria
Health
41 Citations (Scopus)

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis

Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V. & Koh, A. Y., Aug 1 2015, In : PLoS Pathogens. 11, 8, e1005129.

Research output: Contribution to journalArticle

Candida albicans
Pseudomonas aeruginosa
Virulence
Iron
pyochelin
6 Citations (Scopus)

Cutting edge: Developmental regulation of IFN-γ production by mouse neutrophil precursor cells

Sturge, C. R., Burger, E., Raetz, M., Hooper, L. V. & Yarovinsky, F., Jul 1 2015, In : Journal of Immunology. 195, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

Neutrophils
Granulocyte Precursor Cells
Neutrophil Activation
Interleukin-12
Infection
33 Citations (Scopus)

Epithelial Cell Contributions to Intestinal Immunity

Hooper, L. V., 2015, In : Advances in Immunology. 126, p. 129-172 44 p.

Research output: Contribution to journalArticle

Immunity
Epithelial Cells
Adaptive Immunity
Intestinal Mucosa
Intestines
3 Citations (Scopus)
Allergy and Immunology
Homeostasis
Gastrointestinal Microbiome
50 Citations (Scopus)

Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes

Kleiner, M., Hooper, L. V. & Duerkop, B. A., Jan 22 2015, In : BMC Genomics. 16, 1, 7.

Research output: Contribution to journalArticle

Metagenomics
Virion
Deoxyribonucleases
Density Gradient Centrifugation
Bacteriophages
4 Citations (Scopus)

Immunology: A bacterial nudge to T-cell function

Bel, S. & Hooper, L. V., Oct 15 2015, In : Nature. 526, 7573, p. 328-330 3 p.

Research output: Contribution to journalArticle

cells and cell components
digestive system
immune system
rodent
gene expression
45 Citations (Scopus)
Inflammasomes
Interleukin-18
Homeostasis
Escherichia coli
DNA
2014
116 Citations (Scopus)

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo-Rey, J., Grabe, M., Jiang, Q. X. & Hooper, L. V., 2014, In : Nature. 505, 7481, p. 103-107 5 p.

Research output: Contribution to journalArticle

C-Type Lectins
Bacteria
Membranes
Symbiosis
Peptidoglycan
2 Citations (Scopus)
Fucose
Salmonella Infections
Microbiota
Salmonella typhimurium
Intestinal Mucosa
68 Citations (Scopus)

Proteobacteria-specific IgA regulates maturation of the intestinal microbiota

Mirpuri, J., Raetz, M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V. & Yarovinsky, F., Jan 1 2014, In : Gut Microbes. 5, 1, p. 28-39 12 p.

Research output: Contribution to journalArticle

Proteobacteria
Immunoglobulin A
Microbiota
B-Lymphocytes
Gastrointestinal Microbiome
47 Citations (Scopus)

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S. & Hooper, L. V., 2014, In : eLife. 3, p. e03206

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Retinol-Binding Proteins
Protein Transport
Vitamin A
Bacterial Infections
114 Citations (Scopus)

The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor

Yu, X., Wang, Y., Deng Ph.D., M., Li, Y., Ruhn, K. A., Zhang, C. & Hooper, L. V., Oct 13 2014, In : eLife. 3

Research output: Contribution to journalArticle

Basic-Leucine Zipper Transcription Factors
Bone
Transcription Factors
Cells
Lymphocytes
2013
141 Citations (Scopus)

Intestinal epithelial autophagy is essential for host defense against invasive bacteria

Benjamin, J. L., Sumpter, R., Levine, B. & Hooper, L. V., Jun 12 2013, In : Cell Host and Microbe. 13, 6, p. 723-734 12 p.

Research output: Contribution to journalArticle

Autophagy
Epithelial Cells
Bacteria
Myeloid Differentiation Factor 88
Salmonella typhimurium
29 Citations (Scopus)

Mei-P26 Cooperates with Bam, Bgcn and Sxl to Promote Early Germline Development in the Drosophila Ovary

Li, Y., Zhang, Q., Carreira-Rosario, A., Maines, J. Z., McKearin, D. M. & Buszczak, M., Mar 20 2013, In : PLoS One. 8, 3, e58301.

Research output: Contribution to journalArticle

Protein Biosynthesis
translation (genetics)
Drosophila
Ovary
germ cells
99 Citations (Scopus)

Parasite-induced T H 1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

Raetz, M., Hwang, S. H., Wilhelm, C. L., Kirkland, D., Benson, A., Sturge, C. R., Mirpuri, J., Vaishnava, S., Hou, B., Defranco, A. L., Gilpin, C. J., Hooper, L. V. & Yarovinsky, F., Feb 2013, In : Nature Immunology. 14, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

Dysbiosis
Paneth Cells
Parasites
Toll-Like Receptors
T-Lymphocytes
109 Citations (Scopus)

Resident viruses and their interactions with the immune system

Duerkop, B. A. & Hooper, L. V., Jul 2013, In : Nature Immunology. 14, 7, p. 654-659 6 p.

Research output: Contribution to journalArticle

Immune System
Viruses
Metagenome
Human Body
Immunity
154 Citations (Scopus)

TH17 cell differentiation is regulated by the circadian clock

Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S. & Hooper, L. V., 2013, In : Science. 342, 6159, p. 727-730 4 p.

Research output: Contribution to journalArticle

Th17 Cells
Circadian Clocks
Cell Differentiation
Transcription Factors
Orphan Nuclear Receptors
2 Citations (Scopus)

Understanding the microbiota in the midst of Renaissance architecture and olive groves

Guarner, F., Hooper, L. V. & Núñez, G., Feb 2013, In : Nature Immunology. 14, 2, p. 101-105 5 p.

Research output: Contribution to journalArticle

Microbiota
Olea
Spain
Immunity
Renaissance
2012
102 Citations (Scopus)

A composite bacteriophage alters colonization by an intestinal commensal bacterium

Duerkop, B. A., Clements, C. V., Rollins, D., Rodrigues, J. L. M. & Hooper, L. V., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17621-17626 6 p.

Research output: Contribution to journalArticle

Bacteriophages
Prophages
Bacteria
Enterococcus faecalis
Intestines
389 Citations (Scopus)

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L. & Hooper, L. V., Jul 2012, In : Nature Reviews Immunology. 12, 7, p. 503-516 14 p.

Research output: Contribution to journalArticle

Intestines
Skin
Proteins
Microbiota
Mucous Membrane
1612 Citations (Scopus)

Interactions between the microbiota and the immune system

Hooper, L. V., Littman, D. R. & Macpherson, A. J., Jun 8 2012, In : Science. 336, 6086, p. 1268-1273 6 p.

Research output: Contribution to journalArticle

Microbiota
Immune System
Immunity
Homeostasis
Pathology
27 Citations (Scopus)

Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

Du, Y., Yang, M., Lee, S., Behrendt, C. L., Hooper, L. V., Saghatelian, A. & Wan, Y., Jun 2012, In : Genes and Development. 26, 12, p. 1306-1311 6 p.

Research output: Contribution to journalArticle

Milk
Mothers
Ceramides
Poisons
Toll-Like Receptors
36 Citations (Scopus)

Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling

Li, Y., Maines, J. Z., Tastan, Ö. Y., McKearin, D. M. & Buszczak, M., May 1 2012, In : Development. 139, 9, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Stem Cells
Maintenance
MicroRNAs
Calcium Carbonate
2011
2 Citations (Scopus)

Eat your carrots! T cells are RARing to Go

Vaishnava, S. & Hooper, L. V., Mar 25 2011, In : Immunity. 34, 3, p. 290-292 3 p.

Research output: Contribution to journalArticle

Daucus carota
Adaptive Immunity
Regulatory T-Lymphocytes
Vitamin A
Immunity