Immunology - Microarray Core

Research Output 1998 2019

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2019
3 Citations (Scopus)

A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First-Degree Relatives of Systemic Lupus Erythematosus Patients

Ogunrinde, E., Zhou, Z., Luo, Z., Alekseyenko, A., Li, Q. Z., Macedo, D., Kamen, D. L., Oates, J. C., Gilkeson, G. S. & Jiang, W., Nov 1 2019, In : Arthritis and Rheumatology. 71, 11, p. 1858-1868 11 p.

Research output: Contribution to journalArticle

Microbiota
Systemic Lupus Erythematosus
Autoantibodies
Bacteria
Lipopolysaccharides
1 Citation (Scopus)

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians

Molineros, J. E., Looger, L. L., Kim, K., Okada, Y., Terao, C., Sun, C., Zhou, X. J., Raj, P., Kochi, Y., Suzuki, A., Akizuki, S., Nakabo, S., Bang, S. Y., Lee, H. S., Kang, Y. M., Suh, C. H., Chung, W. T., Park, Y. B., Choe, J. Y., Shim, S. C. & 13 others, Lee, S. S., Zuo, X., Yamamoto, K., Li, Q., Shen, N., Porter, L. L., Harley, J. B., Chua, K. H., Zhang, H., Wakeland, E. K., Tsao, B. P., Bae, S. C. & Nath, S. K., Apr 1 2019, In : PLoS genetics. 15, 4, p. e1008092

Research output: Contribution to journalArticle

Open Access
lupus erythematosus
antibody formation
HLA Antigens
antigen
Systemic Lupus Erythematosus
2 Citations (Scopus)

A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud

Xu, C., Yang, X., Zhou, H., Li, Y., Xing, C., Zhou, T., Zhong, D., Lian, C., Yan, M., Chen, T., Liao, Z., Gao, B., Su, D., Wang, T., Sharma, S., Mohan, C., Ahituv, N., Malik, S., Li, Q. Z. & Su, P., Jan 1 2019, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalArticle

Open Access
Polydactyly
Limb Buds
Hedgehogs
Caco-2 Cells
HEK293 Cells

Body Mass Index Drives Changes in DNA Methylation: A Longitudinal Study

Sun, D., Zhang, T., Su, S., Hao, G., Chen, T., Li, Q. Z., Bazzano, L., He, J., Wang, X., Li, S. & Chen, W., Oct 11 2019, In : Circulation research. 125, 9, p. 824-833 10 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Cytosine
Guanine
Longitudinal Studies
Body Mass Index

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

Chen, Y., Yu, M., Zheng, Y., Fu, G., Xin, G., Zhu, W., Luo, L., Burns, R., Li, Q. Z., Dent, A. L., Zhu, N., Cui, W., Malherbe, L., Wen, R. & Wang, D., Dec 1 2019, In : Nature communications. 10, 1, 4415.

Research output: Contribution to journalArticle

Open Access
T-cells
Helper-Inducer T-Lymphocytes
B-Lymphocytes
Cells
Autoantibodies

Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus

Mohammed, S., Vineetha, N. S., James, S., Aparna, J. S., Lankadasari, M. B., Allegood, J. C., Li, Q. Z., Spiegel, S. & Harikumar, K. B., Jun 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 7061-7071 11 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Dendritic Cells
Sphingolipids
Chemical activation
Autoimmunity

Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function

Zhao, X., Xie, H., Zhao, M., Ahsan, A., Li, X., Wang, F., Yi, J., Yang, Z., Wu, C., Raman, I., Li, Q., Kim, T. J. & Liu, W., Jul 17 2019, In : Science Advances. 5, 7, eaaw0315.

Research output: Contribution to journalArticle

Open Access
activation
synapses
phosphorylation
antigens
antibodies

High TLR7 expression drives the expansion of CD19+CD24HiCD38hi transitional B cells and autoantibody production in SLE patients

Wang, T., Marken, J., Chen, J., Tran, V. B., Li, Q., Li, M., Cerosaletti, K., Elkon, K. B., Zeng, X. & Giltiay, N. V., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1243.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 7
B-Lymphoid Precursor Cells
Systemic Lupus Erythematosus
Autoantibodies
B-Lymphocytes

Increased serum matrix metalloproteinase-9 levels are associated with Anti-JO1 but not Anti-MDA5 in myositis patients

Liu, Y., Luo, H., Wang, L., Li, C., Liu, L., Huang, L., Liu, K., Liu, M., Gao, S., Xiao, Y., Zhu, H., Zuo, X., Zhang, H. & Li, Q., Jan 1 2019, In : Aging and Disease. 10, 4, p. 746-755 10 p.

Research output: Contribution to journalArticle

Open Access
Myositis
Matrix Metalloproteinase 9
Serum
Blood Sedimentation
Creatine Kinase

Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells

Pouzolles, M., Machado, A., Guilbaud, M., Irla, M., Gailhac, S., Barennes, P., Cesana, D., Calabria, A., Benedicenti, F., Sergé, A., Raman, I., Li, Q. Z., Montini, E., Klatzmann, D., Adjali, O., Taylor, N. & Zimmermann, V. S., Jan 1 2019, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Dependovirus
ZAP-70 Protein-Tyrosine Kinase
Thymocytes
T-Lymphocytes
Genes
1 Citation (Scopus)

Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus

Luo, H., Wang, L., Bao, D., Wang, L., Zhao, H., Lian, Y., Yan, M., Mohan, C. & Li, Q., Jan 1 2019, (Accepted/In press) In : Genomics, Proteomics and Bioinformatics.

Research output: Contribution to journalArticle

Open Access
Autoantibodies
Cell death
DNA Repair
Systemic Lupus Erythematosus
Repair
3 Citations (Scopus)

Sputum antineutrophil cytoplasmic antibodies in serum antineutrophil cytoplasmic antibody–negative eosinophilic granulomatosis with polyangiitis

Mukherjee, M., Thomas, S. R., Radford, K., Dvorkin-Gheva, A., Davydchenko, S., Kjarsgaard, M., Svenningsen, S., Almas, S., Felix, L. C., Stearns, J., Li, Q., Khalidi, N., Lacy, P. & Nair, P. K., Jan 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 2, p. 158-170 13 p.

Research output: Contribution to journalArticle

Antineutrophil Cytoplasmic Antibodies
Granulomatosis with Polyangiitis
Sputum
Serum
Eosinophils

Systemic translocation of Staphylococcus drives autoantibody production in HIV disease

Luo, Z., Li, M., Wu, Y., Meng, Z., Martin, L., Zhang, L., Ogunrinde, E., Zhou, Z., Qin, S., Wan, Z., Westerink, M. A. J., Warth, S., Liu, H., Jin, P., Stroncek, D., Li, Q. Z., Wang, E., Wu, X., Heath, S. L., Li, Z. & 2 others, Alekseyenko, A. V. & Jiang, W., Feb 14 2019, In : Microbiome. 7, 1, 25.

Research output: Contribution to journalArticle

Open Access
Staphylococcus
Autoantibodies
HIV
B-Lymphocytes
Germinal Center
2018

Foxo3 promotes apoptosis of B cell receptor-stimulated immature B cells, thus limiting the window for receptor editing

Ottens, K., Hinman, R. M., Barrios, E., Skaug, B., Davis, L. S., Li, Q. Z., Castrillon, D. H. & Satterthwaite, A. B., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 940-949 10 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
B-Lymphocytes
Apoptosis
Systemic Lupus Erythematosus
Autoantibodies
16 Citations (Scopus)

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

Preite, S., Cannons, J. L., Radtke, A. J., Vujkovic-Cvijin, I., Gomez-Rodriguez, J., Volpi, S., Huang, B., Cheng, J., Collins, N., Reilley, J., Handon, R., Dobbs, K., Huq, L., Raman, I., Zhu, C., Li, Q. Z., Li, M. O., Pittaluga, S., Uzel, G., Notarangelo, L. D. & 3 others, Belkaid, Y., Germain, R. N. & Schwartzberg, P. L., Sep 1 2018, In : Nature Immunology. 19, 9, p. 986-1000 15 p.

Research output: Contribution to journalArticle

Humoral Immunity
Phosphatidylinositol 3-Kinases
Germinal Center
Microbiota
Helper-Inducer T-Lymphocytes

IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1

Palmer, V. L., Worth, A. N., Scott, R. L., Perry, G. A., Yan, M., Li, Q. Z. & Swanson, P. C., Sep 1 2018, In : Cellular Immunology. 331, p. 110-120 11 p.

Research output: Contribution to journalArticle

Interleukin-10
Transgenic Mice
B-Lymphocytes
Autoantibodies
Immunoglobulin M
3 Citations (Scopus)
Systemic Scleroderma
DNA Methylation
Methylation
Blood Cells
Genome
2 Citations (Scopus)

TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression

Arkatkar, T., Jacobs, H. M., Du, S. W., Li, Q. Z., Hudkins, K. L., Alpers, C. E., Rawlings, D. J. & Jackson, S. W., Jan 1 2018, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

B-Cell Activating Factor
Lupus Nephritis
B-Lymphocytes
Systemic Lupus Erythematosus
Autoantibodies
11 Citations (Scopus)

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis

Zhang, Y., Burberry, A., Wang, J. Y., Sandoe, J., Ghosh, S., Udeshi, N. D., Svinkina, T., Mordes, D. A., Mok, J., Charlton, M., Li, Q. Z., Carr, S. A. & Eggan, K., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 929-943 15 p.

Research output: Contribution to journalArticle

Exocytosis
Amyotrophic Lateral Sclerosis
Autoimmunity
Macrophages
Lysosome-Associated Membrane Glycoproteins
2017
37 Citations (Scopus)

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

Zhao, J., Ma, J., Deng, Y., Kelly, J. A., Kim, K., Bang, S. Y., Lee, H. S., Li, Q. Z., Wakeland, E. K., Qiu, R., Liu, M., Guo, J., Li, Z., Tan, W., Rasmussen, A., Lessard, C. J., Sivils, K. L., Hahn, B. H., Grossman, J. M., Kamen, D. L. & 5 others, Gilkeson, G. S., Bae, S. C., Gaffney, P. M., Shen, N. & Tsao, B. P., Mar 1 2017, In : Nature Genetics. 49, 3, p. 433-437 5 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Odds Ratio
Systemic Lupus Erythematosus
Reactive Oxygen Species
Interferon Type I
5 Citations (Scopus)

Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy

Silva, S. L., Albuquerque, A., Amaral, A. J., Li, Q. Z., Mota, C., Cheynier, R., Victorino, R. M. M., Pereira-Santos, M. C. & Sousa, A. E., Jul 1 2017, In : PLoS One. 12, 7, e0180385.

Research output: Contribution to journalArticle

Allergies
Thymectomy
autoimmunity
T-cells
infancy
11 Citations (Scopus)

Circadian clock cryptochrome proteins regulate autoimmunity

Cao, Q., Zhao, X., Bai, J., Gery, S., Sun, H., Lin, D. C., Chen, Q., Chen, Z., Mack, L., Yang, H., Deng, R., Shi, X., Chong, L. W., Cho, H., Xie, J., Li, Q. Z., Müschen, M., Atkins, A. R., Liddle, C., Yu, R. T. & 6 others, Alkan, S., Said, J. W., Zheng, Y., Downes, M., Evans, R. M. & Koeffler, H. P., Nov 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12548-12553 6 p.

Research output: Contribution to journalArticle

Cryptochromes
Circadian Clocks
Autoimmunity
B-Lymphocytes
Knockout Mice
1 Citation (Scopus)

Protein array autoantibody profiles to determine diagnostic markers for neuropsychiatric systemic lupus erythematosus

van der Meulen, P. M., Barendregt, A. M., Cuadrado, E., Magro-Checa, C., Steup-Beekman, G. M., Meinema, D. S., Merlijn Van den Berg, J., Li, Q. Z., Baars, P. A., Wouters, D., Voskuyl, A. E., Ineke, I. R., Tom, T. W. & Kuijpers, T. W., Aug 1 2017, In : Rheumatology (United Kingdom). 56, 8, p. 1407-1416 10 p.

Research output: Contribution to journalArticle

Central Nervous System Lupus Vasculitis
Protein Array Analysis
Autoantibodies
Heparitin Sulfate
Vimentin
5 Citations (Scopus)

Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis

Gao, W., Chen, C., Zhou, T., Yang, S., Gao, B., Zhou, H., Lian, C., Wu, Z., Qiu, X., Yang, X., Alattar, E., Liu, W., Su, D., Sun, S., Chen, Y., Cheung, K. M. C., Song, Y., Luk, K. K. D., Chan, D., Sham, P. C. & 10 others, Xing, C., Khor, C. C., Liu, G., Yang, J., Deng, Y., Hao, D., Huang, D., Li, Q. Z., Xu, C. & Su, P., 2017, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

Scoliosis
Mitogen-Activated Protein Kinase 7
Clustered Regularly Interspaced Short Palindromic Repeats
Spinal Curvatures
Exome
6 Citations (Scopus)

Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2b/J mouse model

Kiripolsky, J., Shen, L., Liang, Y., Li, A., Suresh, L., Lian, Y., Li, Q. Z., Gaile, D. P. & Kramer, J. M., Mar 2 2017, (Accepted/In press) In : Clinical Immunology.

Research output: Contribution to journalArticle

Autoantibodies
Exocrine Glands
Salivary Proteins and Peptides
Kidney
Inbred NOD Mouse
2 Citations (Scopus)

The role of IFI35 in lupus nephritis and related mechanisms

Zhang, L., Zhu, H., Li, Y., Dai, X., Zhou, B., Li, Q., Zuo, X. & Luo, H., Jan 11 2017, (Accepted/In press) In : Modern Rheumatology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Interferons
Mesangial Cells
Proteins
Kidney
6 Citations (Scopus)

TNFAIP3 downregulation mediated by histone modification contributes to T-cell dysfunction in systemic lupus erythematosus

Zhao, H., Wang, L., Luo, H., Li, Q. Z. & Zuo, X., May 1 2017, In : Rheumatology (United Kingdom). 56, 5, p. 835-843 9 p.

Research output: Contribution to journalArticle

Histone Code
Systemic Lupus Erythematosus
Down-Regulation
T-Lymphocytes
Interleukin-17
80 Citations (Scopus)

Transancestral mapping and genetic load in systemic lupus erythematosus

Langefeld, C. D., Ainsworth, H. C., Graham, D. S. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bijl, M., Brown, E. E. & 88 others, Brunner, H. I., Cardiel, M. H., Catoggio, L., Cervera, R., Cucho-Venegas, J. M., Dahlqvist, S. R., D'Alfonso, S., Da Silva, B. M., De La RúaFigueroa, I., Doria, A., Edberg, J. C., Endreffy, E., Esquivel-Valerio, J. A., Fortin, P. R., Freedman, B. I., Frostegård, J., Garcýá, M. A., De La Torre, I. G., Gilkeson, G. S., Gladman, D. D., Gunnarsson, I., Guthridge, J. M., Huggins, J. L., James, J. A., Kallenberg, C. G. M., Kamen, D. L., Karp, D. R., Kaufman, K. M., Kottyan, L. C., Kovács, L., Laustrup, H., Lauwerys, B. R., Li, Q. Z., Maradiaga-Ceceną, M. A., Martín, J., McCune, J. M., McWilliams, D. R., Merrill, J. T., Miranda, P., Moctezuma, J. F., Nath, S. K., Niewold, T. B., Orozco, L., Ortego-Centeno, N., Petri, M., Pineau, C. A., Pons-Estel, B. A., Pope, J., Raj, P., Ramsey-Goldman, R., Reveille, J. D., Russell, L. P., Sabio, J. M., Aguilar-Salinas, C. A., Scherbarth, H. R., Scorza, R., Seldin, M. F., Sjöwall, C., Svenungsson, E., Thompson, S. D., Toloza, S. M. A., Truedsson, L., Tusié-Luna, T., Vasconcelos, C., Vilá, L. M., Wallace, D. J., Weisman, M. H., Wither, J. E., Bhangale, T., Oksenberg, J. R., Rioux, J. D., Gregersen, P. K., Syvänen, A. C., Rönnblom, L., Criswell, L. A., Jacob, C. O., Sivils, K. L., Tsao, B. P., Schanberg, L. E., Behrens, T. W., Silverman, E. D., Alarcón-Riquelme, M. E., Kimberly, R. P., Harley, J. B., Wakeland, E. K., Graham, R. R., Gaffney, P. M. & Vyse, T. J., Jul 17 2017, In : Nature Communications. 8, 16021.

Research output: Contribution to journalArticle

Genetic Load
Systemic Lupus Erythematosus
Hispanic Americans
Autoimmune Diseases
histories
2016
2 Citations (Scopus)

Analysis of IgM antibody production and repertoire in a mouse model of Sjögren’s syndrome

Kramer, J. M., Holodick, N. E., Vizconde, T. C., Raman, I., Yan, M., Li, Q. Z., Gaile, D. P. & Rothstein, T. L., Feb 1 2016, In : Journal of Leukocyte Biology. 99, 2, p. 321-331 11 p.

Research output: Contribution to journalArticle

Antibody Formation
Immunoglobulin M
B-Lymphocytes
Submandibular Gland
Autoantigens
11 Citations (Scopus)

Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment

Olsen, N. J., McAloose, C., Carter, J., Han, B. K., Raman, I., Li, Q. Z. & Liao, D., 2016, In : Autoimmune Diseases. 2016, 8791629.

Research output: Contribution to journalArticle

Hydroxychloroquine
Health Status
Therapeutics
Cytokines
Genes
3 Citations (Scopus)

Comprehensive transcriptome analyses of the fructose-fed syrian golden hamster liver provides novel insights into lipid metabolism

Li, Z., Xiong, C., Mo, S., Tian, H., Yu, M., Mao, T., Chen, Q., Luo, H., Li, Q., Lu, J., Zhao, Y. & Li, W., Sep 1 2016, In : PLoS One. 11, 9, e0162402.

Research output: Contribution to journalArticle

Long Noncoding RNA
Mesocricetus
Gene Expression Profiling
Fructose
MicroRNAs
4 Citations (Scopus)

Fatty acid amide hydrolase regulates peripheral B cell receptor revision, polyreactivity, and B1 cells in lupus

Pathak, S., Kumar, K. R., Kanta, H., Carr-Johnson, F., Han, J., Bashmakov, A., Faure, L., Ding, H., Vanarsa, K., Khan, S., Li, Q. Z., Chapman, K., Wakeland, E. K. & Mohan, C., Feb 15 2016, In : Journal of Immunology. 196, 4, p. 1507-1516 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Autoantibodies
Central Tolerance
Tissue Array Analysis
Chromosomes, Human, Pair 4
20 Citations (Scopus)

Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE

Orme, J. J., Du, Y., Vanarsa, K., Mayeux, J., Li, L., Mutwally, A., Arriens, C., Min, S., Hutcheson, J., Davis, L. S., Chong, B. F., Satterthwaite, A. B., Wu, T. & Mohan, C., Aug 1 2016, In : Clinical Immunology. 169, p. 58-68 11 p.

Research output: Contribution to journalArticle

Metalloproteases
Systemic Lupus Erythematosus
Leukocytes
Macrophages
Inflammation
26 Citations (Scopus)

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans

Lessard, C. J., Sajuthi, S., Zhao, J., Kim, K., Ice, J. A., Li, H., Ainsworth, H., Rasmussen, A., Kelly, J. A., Marion, M., Bang, S. Y., Bin Joo, Y., Choi, J., Lee, H. S., Mo Kang, Y., Suh, C. H., Tae Chung, W., Lee, S. K., Choe, J. Y., Cheol Shim, S. & 19 others, Hee Oh, J., Jin Kim, Y., Han, B. G., Shen, N., Siew Howe, H., Wakeland, E. K., Li, Q. Z., Wook Song, Y., Gaffney, P. M., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Vyse, T. J., Harley, J. B., Sivils, K. L., Bae, S. C., Langefeld, C. D. & Tsao, B. P., May 1 2016, In : Arthritis and Rheumatology. 68, 5, p. 1197-1209 13 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Single Nucleotide Polymorphism
Population Control
Genome-Wide Association Study
Korea
2 Citations (Scopus)

Insulin-like growth factor binding protein-4 as a marker of chronic lupus nephritis

Wu, T., Xie, C., Han, J., Ye, Y., Singh, S., Zhou, J., Li, Y., Ding, H., Li, Q. Z., Zhou, X., Putterman, C., Saxena, R. & Mohan, C., Mar 1 2016, In : PLoS One. 11, 3, e0151491.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 4
nephritis
Lupus Nephritis
insulin-like growth factor binding proteins
Pathology
65 Citations (Scopus)

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease

Burberry, A., Suzuki, N., Wang, J. Y., Moccia, R., Mordes, D. A., Stewart, M. H., Suzuki-Uematsu, S., Ghosh, S., Singh, A., Merkle, F. T., Koszka, K., Li, Q. Z., Zon, L., Rossi, D. J., Trowbridge, J. J., Notarangelo, L. D. & Eggan, K., Jul 13 2016, In : Science Translational Medicine. 8, 347, 6038.

Research output: Contribution to journalArticle

Autoimmune Diseases
Autoimmunity
Mutation
Transplantation
Bone Marrow
155 Citations (Scopus)

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

Martinez, J., Cunha, L. D., Park, S., Yang, M., Lu, Q., Orchard, R., Li, Q. Z., Yan, M., Janke, L., Guy, C., Linkermann, A., Virgin, H. W. & Green, D. R., May 5 2016, In : Nature. 533, 7601, p. 115-119 5 p.

Research output: Contribution to journalArticle

Autophagy
Phagocytosis
Systemic Lupus Erythematosus
Cytokines
Phagosomes
44 Citations (Scopus)

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B. & 9 others, Nath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In : eLife. 5, FEBRUARY2016, e12089.

Research output: Contribution to journalArticle

Polymorphism
Autoimmunity
Systemic Lupus Erythematosus
Molecules
D region
24 Citations (Scopus)

TGF-β-induced regulatory t cells directly suppress b cell responses through a noncytotoxic mechanism

Xu, A., Liu, Y., Chen, W., Wang, J., Xue, Y., Huang, F., Rong, L., Lin, J., Liu, D., Yan, M., Li, Q. Z., Li, B., Song, J., Olsen, N. & Zheng, S. G., May 1 2016, In : Journal of Immunology. 196, 9, p. 3631-3641 11 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Regulatory T-Lymphocytes
B-Lymphocyte Subsets
Autoimmune Diseases
Granzymes
31 Citations (Scopus)

Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

Zhu, H., Mi, W., Luo, H., Chen, T., Liu, S., Raman, I., Zuo, X. & Li, Q. Z., Jul 13 2016, In : Arthritis Research and Therapy. 18, 1, 162.

Research output: Contribution to journalArticle

DNA Methylation
Systemic Lupus Erythematosus
Blood Cells
Lupus Nephritis
Genome
2015
37 Citations (Scopus)

A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma

Wei, J. H., Haddad, A., Wu, K. J., Zhao, H. W., Kapur, P., Zhang, Z. L., Zhao, L. Y., Chen, Z. H., Zhou, Y. Y., Zhou, J. C., Wang, B., Yu, Y. H., Cai, M. Y., Xie, D., Liao, B., Li, C. X., Li, P. X., Wang, Z. R., Zhou, F. J., Shi, L. & 8 others, Liu, Q. Z., Gao, Z. L., He, D. L., Chen, W., Hsieh, J. T., Li, Q. Z., Margulis, V. & Luo, J. H., Oct 30 2015, In : Nature Communications. 6, 8699.

Research output: Contribution to journalArticle

methylation
Methylation
classifiers
Renal Cell Carcinoma
Assays
175 Citations (Scopus)

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Gao, D., Li, T., Li, X. D., Chen, X., Li, Q. Z., Wight-Carter, M. & Chen, Z. J., Oct 20 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. E5699-E5705

Research output: Contribution to journalArticle

GMP synthase (glutamine-hydrolyzing)
Autoimmune Diseases
DNA
Phenotype
Interferons
4 Citations (Scopus)

A locked nucleic acid (LNA)-based real-time PCR assay for the rapid detection of multiple Bacterial antibiotic resistance genes directly from positive blood culture

Zhu, L., Shen, D., Zhou, Q., Li, Z., Fang, X. & Li, Q. Z., Mar 16 2015, In : PLoS One. 10, 3, e0120464.

Research output: Contribution to journalArticle

Bacterial Drug Resistance
Cell culture
antibiotic resistance
nucleic acids
Real-Time Polymerase Chain Reaction
9 Citations (Scopus)

Arraying autoantibodies in SLE - lessons learned

Wang, L., Mohan, C. & Li, Q. Z., Jul 1 2015, In : Current Molecular Medicine. 15, 5, p. 456-461 6 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Autoantibodies
Connective Tissue Diseases
Autoantigens
Microarrays
32 Citations (Scopus)

Autoantigen Microarray for High-throughput Autoantibody Profiling in Systemic Lupus Erythematosus

Zhu, H., Luo, H., Yan, M., Zuo, X. & Li, Q. Z., Aug 1 2015, In : Genomics, Proteomics and Bioinformatics. 13, 4, p. 210-218 9 p.

Research output: Contribution to journalArticle

Autoantibodies
Autoantigens
Microarrays
Profiling
Microarray

Autoimmune Diseases in the Bioinformatics Paradigm

Li, Q. Z. & Wakeland, E. K., Aug 1 2015, In : Genomics, Proteomics and Bioinformatics. 13, 4, p. 205-207 3 p.

Research output: Contribution to journalArticle

Bioinformatics
13 Citations (Scopus)

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

Huang, Q. Q., Perlman, H., Birkett, R., Doyle, R., Fang, D., Haines, G. K., Robinson, W., Datta, S., Huang, Z., Li, Q. Z., Phee, H. & Pope, R. M., May 12 2015, In : Nature Communications. 6, 7086.

Research output: Contribution to journalArticle

arthritis
deletion
Dendritic Cells
Arthritis
T-cells
50 Citations (Scopus)

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice

Baum, R., Sharma, S., Carpenter, S., Li, Q. Z., Busto, P., Fitzgerald, K. A., Marshak-Rothstein, A. & Gravallese, E. M., Feb 1 2015, In : Journal of Immunology. 194, 3, p. 873-877 5 p.

Research output: Contribution to journalArticle

Deoxyribonucleases
Knockout Mice
Autoantibodies
Nucleic Acids
Arthritis
29 Citations (Scopus)

Cutting edge: Inhibiting TBK1 by compound II ameliorates autoimmune disease in mice

Hasan, M., Dobbs, N., Khan, S., White, M. A., Wakeland, E. K., Li, Q. Z. & Yan, N., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4573-4577 5 p.

Research output: Contribution to journalArticle

Autoimmune Diseases
Phosphotransferases
Systemic Lupus Erythematosus
Poly I-C
Protein-Serine-Threonine Kinases
38 Citations (Scopus)

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Hasan, M., Fermaintt, C. S., Gao, N., Sakai, T., Miyazaki, T., Jiang, S., Li, Q. Z., Atkinson, J. P., Morse, H. C., Lehrman, M. A. & Yan, N., Sep 15 2015, In : Immunity. 43, 3, p. 463-474 12 p., 3143.

Research output: Contribution to journalArticle

Frameshift Mutation
Deoxyribonucleases
Endoplasmic Reticulum
Polysaccharides
Dolichol