Immunology - Stroynowski Lab

Research Output 1976 2011

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Article
2011
3 Citations (Scopus)

Isoforms of the nonclassical class i MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide

Renthal, N. E., Guidry, P. A., Shanmuganad, S., Renthal, W. & Stroynowski, I., Jan 2011, In : Immunogenetics. 63, 1, p. 57-64 8 p.

Research output: Contribution to journalArticle

H-2 Antigens
Major Histocompatibility Complex
Protein Isoforms
HLA-G Antigens
Peptides
2008
25 Citations (Scopus)

An MHC class Ib-restricted CD8 T cell response confers antiviral immunity

Swanson, P. A., Pack, C. D., Hadley, A., Wang, C. R., Stroynowski, I., Jensen, P. E. & Lukacher, A. E., Jul 7 2008, In : Journal of Experimental Medicine. 205, 7, p. 1647-1657 11 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Antiviral Agents
Immunity
Polyomavirus
T-Lymphocytes
2006
7 Citations (Scopus)

The role of structurally conserved class I MHC in tumor rejection: Contribution of the Q8 locus

Chiang, E. Y. & Stroynowski, I., Aug 15 2006, In : Journal of Immunology. 177, 4, p. 2123-2130 8 p.

Research output: Contribution to journalArticle

MHC Class I Genes
Neoplasms
Peptides
Haplotypes
Genetic Recombination
2005
33 Citations (Scopus)
Antigen Presentation
Proteasome Endopeptidase Complex
Hepatocytes
Molecular Weight
Peptides
14 Citations (Scopus)

Protective immunity against disparate tumors is mediated by a nonpolymorphic MHC class I molecule

Chiang, E. Y. & Stroynowski, I., May 1 2005, In : Journal of Immunology. 174, 9, p. 5367-5374 8 p.

Research output: Contribution to journalArticle

Immunity
Neoplasms
Melanoma
T-Cell Lymphoma
Immunologic Memory
12 Citations (Scopus)
HLA-G Antigens
Blastocyst
Protein Isoforms
Alleles
NK Cell Lectin-Like Receptor Subfamily C
2004
20 Citations (Scopus)

A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor

Chiang, E. Y. & Stroynowski, I., Oct 1 2004, In : Journal of Immunology. 173, 7, p. 4394-4401 8 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasms
Knockout Mice
Immunity
Immunologic Memory
2003
22 Citations (Scopus)

Correction of defects responsible for impaired Qa-2 class Ib MHC expression on melanoma cells protects mice from tumor growth

Chiang, E. Y., Henson, M. & Stroynowski, I., May 1 2003, In : Journal of Immunology. 170, 9, p. 4515-4523 9 p.

Research output: Contribution to journalArticle

Melanoma
Growth
Neoplasms
Tumor Escape
MHC Class I Genes
15 Citations (Scopus)

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

Gao, J. X., Liu, X., Wen, J., Caligiuri, M. A., Stroynowski, I., Zheng, P. & Liu, Y., Dec 15 2003, In : Blood. 102, 13, p. 4456-4463 8 p.

Research output: Contribution to journalArticle

T-cells
Natural Killer Cells
Tumors
Chemical activation
Cells
2002
37 Citations (Scopus)
Lymphokine-Activated Killer Cells
Major Histocompatibility Complex
Natural Killer Cells
Neoplasms
Melanoma
2001

Erratum: The journal of experimental medicine (November 20, 2000) 192:10 (1521-1527)

Das, G., Gould, D. S., Augustine, M. M., Fragoso, G., Sciutto, E., Stroynowski, I., Van Kaer, L., Schust, D. J., Ploegh, H. & Janeway, C. A., Feb 5 2001, In : Journal of Experimental Medicine. 193, 3, p. 413 1 p.

Research output: Contribution to journalArticle

Biomedical Research
45 Citations (Scopus)

Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation

He, X. L., Tabaczewski, P., Ho, J., Stroynowski, I. & Garcia, K. C., 2001, In : Structure. 9, 12, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

Antigen Presentation
Peptides
MHC Ib Qa-2 antigen
Ribosomal Proteins
Adaptive Immunity
19 Citations (Scopus)

Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells

Ungchusri, T., Chiang, E. Y., Brown, G., Chen, M., Tabaczewski, P., Timares, L. & Stroynowski, I., 2001, In : Immunogenetics. 53, 6, p. 455-467 13 p.

Research output: Contribution to journalArticle

Epithelial Cells
Mucosal Immunity
Glycosylphosphatidylinositols
Histocompatibility Antigens Class II
Antigen-Presenting Cells
2000
43 Citations (Scopus)

Qa-2-dependent selection of CD8α/α T cell receptor α/β+ cells in murine intestinal intraepithelial lymphocytes

Das, G., Gould, D. S., Augustine, M. M., Fragoso, G., Sciutto, E., Stroynowski, I., Van Kaer, L., Schust, D. J., Ploegh, H. & Janeway, C. A., Nov 20 2000, In : Journal of Experimental Medicine. 192, 10, p. 1521-1527 7 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Lymphocytes
T-Lymphocytes
CD1d Antigen
Knockout Mice
17 Citations (Scopus)

The murine liver-specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire

Zappacosta, F., Tabaczewski, P., Parker, K. C., Coligan, J. E. & Stroynowski, I., Feb 15 2000, In : Journal of Immunology. 164, 4, p. 1906-1915 10 p.

Research output: Contribution to journalArticle

Peptides
Liver
Ligands
Mass Spectrometry
Proteins
1999
41 Citations (Scopus)

Expression of a nonclassical MHC class Ib molecule in the eye

Niederkorn, J. Y., Chiang, E. Y., Ungchusri, T. & Stroynowski, I., Dec 15 1999, In : Transplantation. 68, 11, p. 1790-1799 10 p.

Research output: Contribution to journalArticle

Anterior Chamber
Corneal Endothelium
Interferons
Corneal Epithelium
Ciliary Body
1997
29 Citations (Scopus)

Alternative peptide binding motifs of Qa-2 class Ib molecules define rules for binding of self and nonself peptides

Tabaczewski, P., Chiang, E., Henson, M. & Stroynowski, I., 1997, In : Journal of Immunology. 159, 6, p. 2771-2781 11 p.

Research output: Contribution to journalArticle

Peptides
Ligands
Peptide Receptors
Membranes
Protein Isoforms
1996
28 Citations (Scopus)

Multiple products of class Ib Qa-2 genes which ones are functional?

Stroynowski, I. & Tabaczewski, P., 1996, In : Research in Immunology. 147, 5, p. 290-301 12 p.

Research output: Contribution to journalArticle

Genes
1995
46 Citations (Scopus)

Aglycosylated and phosphatidylinositol-anchored MHC class 1 molecules are associated with calnexin: Evidence implicating the class i-connecting peptide segment in calnexin association

Carreno, B. M., Schreiber, K. L., McKean, D. J., Stroynowski, I. & Hansen, T. H., 1995, In : Journal of Immunology. 154, 10, p. 5173-5180 8 p.

Research output: Contribution to journalArticle

Calnexin
C-Peptide
Phosphatidylinositols
Protein Isoforms
Carbohydrates
17 Citations (Scopus)

Novel molecules related to MHC antigens

Stroynowski, I. & Forman, J., 1995, In : Current Opinion in Immunology. 7, 1, p. 97-102 6 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Antigens
5 Citations (Scopus)

Nucleotide sequences of H2g7K and D loci of nonobese diabetic mice

Girgis, K. R., Capra, J. D. & Stroynowski, I., Apr 1995, In : Immunogenetics. 41, 6, p. 386 1 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Sequence Data
H-2 Antigens
MHC Class I Genes
Amino Acid Sequence Homology
102 Citations (Scopus)

TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man

Carreno, B. M., Solheim, J. C., Harris, M., Stroynowski, I., Connolly, J. M. & Hansen, T. H., 1995, In : Journal of Immunology. 155, 10, p. 4726-4733 8 p.

Research output: Contribution to journalArticle

Calnexin
L Forms
Cell Line
Peptides
12 Citations (Scopus)

Tissue-specific, peptide-binding transplantation antigens: Lessons from the Qa-2 system

Stroynowski, I., 1995, In : Immunological Reviews. 147, p. 90-108 19 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Histocompatibility Antigens Class I
Organ Specificity
Histocompatibility Antigens
Antigen Presentation
1994
31 Citations (Scopus)
Alternative Splicing
Major Histocompatibility Complex
Exons
Antigens
Peptides
86 Citations (Scopus)

A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides

Joyce, S., Tabaczewski, P., Angeletti, R. H., Nathenson, S. G. & Stroynowski, I., Feb 1 1994, In : Journal of Experimental Medicine. 179, 2, p. 579-588 10 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Peptides
Leucine
Actin Depolymerizing Factors
Peptide T
63 Citations (Scopus)

Antigen presentation by non-classical class I molecules

Stroynowski, I. & Lindahl, K. F., 1994, In : Current Opinion in Immunology. 6, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

MHC Class I Genes
Antigen Presentation
Tissue Distribution
Anura
Mammals
35 Citations (Scopus)

Expression of secreted and glycosylphosphatidylinositol-bound Qa-2 molecules is dependent on functional TAP-2 peptide transporter

Tabaczewski, P. & Stroynowski, I., Jun 1 1994, In : Journal of Immunology. 152, 11, p. 5268-5274 7 p.

Research output: Contribution to journalArticle

trypsinogen activation peptide
Glycosylphosphatidylinositols
Peptides
Endoplasmic Reticulum
Calnexin
1993
21 Citations (Scopus)

The α3 domain of the Qa-2 molecule is defective for CD8 binding and cytotoxic T lymphocyte activation

Teitell, M., Holcombe, H., Cheroutre, H., Aldrich, C. J., Stroynowski, I., Forman, J. & Kronenberg, M., Dec 1 1993, In : Journal of Experimental Medicine. 178, 6, p. 2139-2145 7 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Lymphocyte Activation
Histocompatibility Antigens Class I
Major Histocompatibility Complex
Cell Adhesion
1991
98 Citations (Scopus)
Phosphatidylinositols
Membrane Proteins
Membranes
Glycosylphosphatidylinositols
Fluorescence Recovery After Photobleaching
75 Citations (Scopus)

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

Aldrich, C. J., Hammer, R. E., Jones-Youngblood, S., Koszinowski, U., Hood, L., Stroynowski, I. T. & Forman D.M.D/Ph.D., J. M., Aug 22 1991, In : Nature. 352, 6337, p. 718-721 4 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Major Histocompatibility Complex
T-Lymphocytes
Antigens
Peptide T
19 Citations (Scopus)

The Q7 α3 domain alters T cell recognition of class I antigens

Aldrich, C. J., Lowen, L. C., Mann, D., Nishimura, M., Hood, L., Stroynowski, I. & Forman, J., May 1 1991, In : Journal of Immunology. 146, 9, p. 3082-3090 9 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class I
Phosphatidylinositols
T-Lymphocytes
Peptides
Muromegalovirus
1990
37 Citations (Scopus)

Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen

Ulker, N., Lewis, K. D., Hood, L. E. & Stroynowski, I., 1990, In : EMBO Journal. 9, 12, p. 3839-3847 9 p.

Research output: Contribution to journalArticle

T-cells
H-2 Antigens
T-Lymphocytes
Exons
Messenger RNA
6 Citations (Scopus)

Molecular signals for phosphatidylinositol modification of the Qa-2 antigen

Ulker, N., Hood, L. E. & Stroynowski, I., Oct 1 1990, In : Journal of Immunology. 145, 7, p. 2214-2219 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Protein Precursors
Membrane Proteins
Peptides
Histocompatibility Antigens
143 Citations (Scopus)

Molecules related to class-I major histocompatibility complex antigens

Stroynowski, I., 1990, In : Annual Review of Immunology. 8, 1, p. 501-530 30 p.

Research output: Contribution to journalArticle

1989
14 Citations (Scopus)
Cytotoxic T-Lymphocytes
Phosphatidylinositols
Epitopes
Vesicular Stomatitis
Lectins
15 Citations (Scopus)

Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex

Ostrand-Rosenberg, S., Nickerson, D. A., Clements, V. K., Garcia, E. P., Lamouse-Smith, E., Hood, L. & Stroynowski, I., 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 13, p. 5084-5088 5 p.

Research output: Contribution to journalArticle

MHC Class I Genes
Embryonal Carcinoma Stem Cells
Major Histocompatibility Complex
Histocompatibility Antigens
Embryonal Carcinoma
35 Citations (Scopus)

Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies

Sharrow, S. O., Arn, J. S., Stroynowski, I., Hood, L. & Sachs, D. H., 1989, In : Journal of Immunology. 142, 10, p. 3495-3502 8 p.

Research output: Contribution to journalArticle

vif Genes
Epitopes
Monoclonal Antibodies
Antibodies
Cell Line
1988
51 Citations (Scopus)

H-2Kb antigen expression has no effect on natural killer susceptibility and tumorigenicity of a murine hepatoma

Nishimura, M. I., Stroynowski, I., Hood, L. & Ostrand-Rosenberg, S., 1988, In : Journal of Immunology. 141, 12, p. 4403-4409 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Natural Killer Cells
Neoplasms
Clone Cells
H antigen
33 Citations (Scopus)
MHC Class I Genes
Gene Expression
Histocompatibility Antigens Class I
Peptides
Gene Dosage
91 Citations (Scopus)

Regulation of gene expression by interferons: Control of H-2 promoter responses

Korber, B., Mermod, N., Hood, L. & Stroynowski, I., 1988, In : Science. 239, 4846, p. 1302-1306 5 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Interferons
Transcription Factor AP-1
Genes
1987
85 Citations (Scopus)

A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: Anchoring of the product by a phospholipid tail

Stroynowski, I., Soloski, M., Low, M. G. & Hood, L., Aug 28 1987, In : Cell. 50, 5, p. 759-768 10 p.

Research output: Contribution to journalArticle

Histocompatibility
Phospholipids
Genes
Membranes
Liver
24 Citations (Scopus)

Cytotoxic T lymphocytes from mice with soluble class I Q10 molecules in their serum are not tolerant to membrane-bound Q10

Mann, D. W., Stroynowski, I., Hood, L. & Forman, J., 1987, In : Journal of Immunology. 138, 1, p. 240-245 6 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Membranes
Serum
Genes
Protein Splicing
61 Citations (Scopus)

On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes

Braciale, T. J., Braciale, V. L., Winkler, M., Stroynowski, I., Hood, L., Sambrook, J. & Gething, M. J., 1987, In : Journal of Experimental Medicine. 166, 3, p. 678-692 15 p.

Research output: Contribution to journalArticle

Hemagglutinins
Human Influenza
T-Lymphocytes
Clone Cells
Epitopes
59 Citations (Scopus)
MHC Class I Genes
Transcription Initiation Site
Interferons
Gene Expression
Histocompatibility Antigens
1985
26 Citations (Scopus)

Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens

Stroynowski, I., Forman, J., Goodenow, R. S., Schiffer, S. G., McMillan, M., Sharrow, S. O., Sachs, D. H. & Hood, L., 1985, In : Journal of Experimental Medicine. 161, 5, p. 935-952 18 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
Major Histocompatibility Complex
T-Lymphocytes
Antigens
Genes
23 Citations (Scopus)

Expression of hybrid class I genes of the major histocompatibility complex in mouse L cells

Straus, D. S., Stroynowski, I., Schiffer, S. G. & Hood, L., 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 18, p. 6245-6249 5 p.

Research output: Contribution to journalArticle

MHC Class I Genes
Major Histocompatibility Complex
Genes
Histocompatibility Antigens
Developmental Gene Expression Regulation
26 Citations (Scopus)

Interaction of α1 with α2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells

Stroynowski, I., Clark, S., Henderson, L. A., Hood, L., McMillan, M. & Forman, J., 1985, In : Journal of Immunology. 135, 3, p. 2160-2166 7 p.

Research output: Contribution to journalArticle

MHC Class I Genes
T-Lymphocytes
Histocompatibility Antigens
Antibodies
Genes
1984
25 Citations (Scopus)

Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by α1 and α2 but not α3 external domains

Stroynowski, I., Orn, A., Goodenow, R. S., McMillan, M., Forman, J., Brayton, P. R., Frelingers, J. & Hood, L., Aug 1984, In : Immunogenetics. 20, 2, p. 141-154 14 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Lymphocytic choriomeningitis virus
Antigens
Viruses
Hybrid Cells

Structure function relationship of MHC class I molecules

Clark, S. S., Stroynowski, I., Hood, L. & Forman, J., 1984, In : Federation Proceedings. 43, 6

Research output: Contribution to journalArticle

1983
40 Citations (Scopus)

Expression of complete transplantation antigens by mammalian cells transformed with truncated class i genes

Goodenow, R. S., Stroynowski, I., McMillan, M., Nicolson, M., Eakle, K., Taylor Sher, B., Davidson, N. & Hood, L., 1983, In : Nature. 301, 5899, p. 388-394 7 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
Haplotypes
Genes
MHC Class I Genes
Homologous Recombination