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2020

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia

Fernández, Á. F., Liu, Y., Ginet, V., Shi, M., Nah, J., Zou, Z., Zhou, A., Posner, B. A., Xiao, G., Tanguy, M., Paradis, V., Sadoshima, J., Rautou, P. E., Puyal, J., Hu, M. C. & Levine, B., Jan 16 2020, In : JCI Insight. 5, 1, e133282.

Research output: Contribution to journalArticle

Open Access

The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance

Shi, M., Maique, J., Shaffer, J., Davidson, T., Sebti, S., Fernández, Á. F., Zou, Z., Yan, S., Levine, B., Moe, O. W. & Hu, M. C., Feb 1 2020, In : FASEB Journal. 34, 2, p. 3129-3150 22 p.

Research output: Contribution to journalArticle

Open Access

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Liu, Y., Nguyen, P. T., Wang, X., Zhao, Y., Meacham, C. E., Zou, Z., Bordieanu, B., Johanns, M., Vertommen, D., Wijshake, T., May, H., Xiao, G., Shoji-Kawata, S., Rider, M. H., Morrison, S. J., Mishra, P. & Levine, B., Feb 27 2020, In : Nature. 578, 7796, p. 605-609 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury

Nah, J., Zhai, P., Huang, C. Y., Fernández, Á. F., Mareedu, S., Levine, B. & Sadoshima, J., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 2978-2991 14 p.

Research output: Contribution to journalArticle

Open Access
2019

Identification of de novo enhancers activated by tgfβ to drive expression of CDKN2A and B in hela cells

Liu, Y. T., Xu, L., Bennett, L., Hooks, J. C., Liu, J., Zhou, Q., Liem, P., Zheng, Y. & Skapek, S. X., 2019, In : Molecular Cancer Research. 17, 9, p. 1854-1866 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Testis-specific Arf promoter expression in a transposase-aided BAC transgenic mouse model

Sung, C. Y., Liu, Y. T., Bennett, L. B., Devitt, C. C. & Skapek, S. X., Dec 1 2019, In : Molecular Biology Reports. 46, 6, p. 6243-6252 10 p.

Research output: Contribution to journalArticle

2018

An increase in LRRK2 suppresses autophagy and enhances dectin-1–induced immunity in a mouse model of colitis

Takagawa, T., Kitani, A., Fuss, I., Levine, B., Brant, S. R., Peter, I., Tajima, M., Nakamura, S. & Strober, W., Jun 6 2018, In : Science Translational Medicine. 10, 444, eaan8162.

Research output: Contribution to journalArticle

17 Scopus citations

Beclin-1-Dependent Autophagy Protects the Heart during Sepsis

Sun, Y., Yao, X., Zhang, Q. J., Zhu, M., Liu, Z-P., Ci, B., Xie, Y., Carlson, D. L., Rothermel, B. A., Sun, Y., Levine, B., Hill, J. A., Wolf, S. E., Minei, J. P. & Zang, Q., Nov 13 2018, In : Circulation. 138, 20, p. 2247-2262 16 p.

Research output: Contribution to journalArticle

45 Scopus citations

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

Peraro, L., Deprey, K. L., Moser, M. K., Zou, Z., Ball, H. L., Levine, B. & Kritzer, J. A., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11360-11369 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Jun 7 2018, In : Nature. 558, 7708, p. 136-140 5 p.

Research output: Contribution to journalArticle

110 Scopus citations

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding

Chiang, W. C., Wei, Y., Kuo, Y. C., Wei, S., Zhou, A., Zou, Z., Yehl, J., Ranaghan, M. J., Skepner, A., Bittker, J. A., Perez, J. R., Posner, B. A. & Levine, B., May 7 2018, (Accepted/In press) In : ACS Chemical Biology.

Research output: Contribution to journalArticle

19 Scopus citations

Increased autophagy blocks HER2-mediated breast tumorigenesis

Vega-Rubín-De-Celis, S., Zou, Z., Fernández, Á. F., Ci, B., Kim, M., Xiao, G., Xie, Y. & Levine, B., Apr 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. 4176-4181 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Feb 14 2018, In : Cell Host and Microbe. 23, 2, p. 177-190.e4

Research output: Contribution to journalArticle

32 Scopus citations
2017

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 2017, In : PLoS genetics. 13, 8, e1006962.

Research output: Contribution to journalArticle

29 Scopus citations
61 Scopus citations

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy

Su, M., Li, Y., Wyborny, S., Neau, D., Chakravarthy, S., Levine, B., Colbert, C. L. & Sinha, S. C., May 1 2017, In : Protein Science. 26, 5, p. 972-984 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

Peraro, L., Zou, Z., Makwana, K. M., Cummings, A. E., Ball, H. L., Yu, H., Lin, Y. S., Levine, B. & Kritzer, J. A., Jun 14 2017, In : Journal of the American Chemical Society. 139, 23, p. 7792-7802 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice

Bian, A., Shi, M., Flores, B., Gillings, N., Li, P., Yan, S. X., Levine, B., Xing, C. & Hu, M. C., Sep 2017, In : PloS one. 12, 9, e0181848.

Research output: Contribution to journalArticle

16 Scopus citations

Emerging functions of the Fanconi anemia pathway at a glance

Sumpter, R. & Levine, B., Aug 15 2017, In : Journal of Cell Science. 130, 16, p. 2657-2662 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells

Hu, J., Nie, Y., Chen, S., Xie, C., Fan, Q., Wang, Z., Long, B., Yan, G., Zhong, Q. & Yan, X., Aug 1 2017, In : International Journal of Biochemistry and Cell Biology. 89, p. 42-56 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

MTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy

Bartolomeo, R., Cinque, L., De Leonibus, C., Forrester, A., Salzano, A. C., Monfregola, J., De Gennaro, E., Nusco, E., Azario, I., Lanzara, C., Serafini, M., Levine, B., Ballabio, A. & Settembre, C., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3717-3729 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., Kim, J., Guan, K. L., Li, D. & Zhong, Q., Mar 4 2017, In : Autophagy. 13, 3, p. 592-607 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

Peroxisomal protein PEX13 functions in selective autophagy

Lee, M. Y., Sumpter, R., Zou, Z., Sirasanagandla, S., Wei, Y., Mishra, P., Rosewich, H., Crane, D. I. & Levine, B., Jan 1 2017, In : EMBO Reports. 18, 1, p. 48-60 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Wei, Y., Chiang, W. C., Sumpter, R., Mishra, P. & Levine, B., Jan 12 2017, In : Cell. 168, 1-2, p. 224-238.e10

Research output: Contribution to journalArticle

195 Scopus citations

Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein

Li, Y., Zhao, Y., Su, M., Glover, K., Chakravarthy, S., Colbert, C. L., Levine, B. & Sinha, S. C., Sep 1 2017, In : Acta Crystallographica Section D: Structural Biology. 73, 9, p. 775-792 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains to Form a Homodimer with Submicromolar Affinity

Ranaghan, M. J., Durney, M. A., Mesleh, M. F., McCarren, P. R., Garvie, C. W., Daniels, D. S., Carey, K. L., Skepner, A. P., Levine, B. & Perez, J. R., Dec 26 2017, In : Biochemistry. 56, 51, p. 6639-6651 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense

Franco, L. H., Nair, V. R., Scharn, C. R., Xavier, R. J., Torrealba, J. R., Shiloh, M. U. & Levine, B., Jan 11 2017, In : Cell Host and Microbe. 21, 1, p. 59-72 14 p.

Research output: Contribution to journalArticle

55 Scopus citations
2016

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

Park, S., Buck, M. D., Desai, C., Zhang, X., Loginicheva, E., Martinez, J., Freeman, M. L., Saitoh, T., Akira, S., Guan, J. L., He, Y. W., Blackman, M. A., Handley, S. A., Levine, B., Green, D. R., Reese, T. A., Artyomov, M. N. & Virgin, H. W., Jan 13 2016, In : Cell Host and Microbe. 19, 1, p. 91-101 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., Senovilla, L., Marino, G., Aranda, F., Durand, S., Sica, V., Chery, A., Lachkar, S., Sigl, V., Bloy, N., Buque, A. & 10 others, Falzoni, S., Ryffel, B., Apetoh, L., Di Virgilio, F., Madeo, F., Maiuri, M. C., Zitvogel, L., Levine, B., Penninger, J. M. & Kroemer, G., Jul 11 2016, In : Cancer Cell. 30, 1, p. 147-160 14 p.

Research output: Contribution to journalArticle

152 Scopus citations

Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Mar 29 2016, In : Circulation. 133, 13, p. 1249-1263 15 p.

Research output: Contribution to journalArticle

127 Scopus citations

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis

Dong, X., Cheng, A., Zou, Z., Yang, Y. S., Sumpter, R. M., Huang, C. L., Bhagat, G., Virgin, H. W., Lira, S. A. & Levine, B., Mar 15 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 11, p. 2994-2999 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fanconi Anemia Proteins Function in Mitophagy and Immunity

Sumpter, R., Sirasanagandla, S., Fernández, Á. F., Wei, Y., Dong, X., Franco, L., Zou, Z., Marchal, C., Lee, M. Y., Clapp, D. W., Hanenberg, H. & Levine, B., May 5 2016, In : Cell. 165, 4, p. 867-881 15 p.

Research output: Contribution to journalArticle

97 Scopus citations

Genetic inhibition of autophagy promotes p53 loss-ofheterozygosity and tumorigenesis

Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B. & Amatruda, J. F., Jan 1 2016, In : Oncotarget. 7, 42, p. 67919-67933 15 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

Nair, V. R., Franco, L. H., Zacharia, V. M., Khan, H. S., Stamm, C. E., You, W., Marciano, D. K., Yagita, H., Levine, B. & Shiloh, M. U., Aug 2 2016, In : Cell Reports. 16, 5, p. 1253-1258 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

Li, X., Zhu, F., Jiang, J., Sun, C., Zhong, Q., Shen, M., Wang, X., Tian, R., Shi, C., Xu, M., Peng, F., Guo, X., Hu, J., Ye, D., Wang, M. & Qin, R., Sep 1 2016, In : Autophagy. 12, 9, p. 1521-1537 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

SNARE-mediated membrane fusion in autophagy

Wang, Y., Li, L., Hou, C., Lai, Y., Long, J., Liu, J., Zhong, Q. & Diao, J., May 4 2016, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

29 Scopus citations

αklotho mitigates progression of aki to ckd through activation of autophagy

Shi, M., Flores, B., Gillings, N., Bian, A., Cho, H. J., Yan, S. X., Liu, Y., Levine, B., Moe, O. W. & Hu, M. C., 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2331-2345 15 p.

Research output: Contribution to journalArticle

50 Scopus citations
2015

A noncanonical autophagy pathway restricts toxoplasma gondii growth in a strain-specific manner in IFN-γ-activated human cells

Selleck, E. M., Orchard, R. C., Lassen, K. G., Beatty, W. L., Xavier, R. J., Levine, B., Virgin, H. W. & David Sibley, L., 2015, In : mBio. 6, 5, e01157-15.

Research output: Contribution to journalArticle

61 Scopus citations

ATG14 controls SNARE-mediated autophagosome fusion with a lysosome

Liu, R., Zhi, X. & Zhong, Q., Jan 1 2015, In : Autophagy. 11, 5, p. 847-849 3 p.

Research output: Contribution to journalArticle

29 Scopus citations

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Diao, J., Liu, R., Rong, Y., Zhao, M., Zhang, J., Lai, Y., Zhou, Q., Wilz, L. M., Li, J., Vivona, S., Pfuetzner, R. A., Brunger, A. T. & Zhong, Q., Apr 23 2015, In : Nature. 520, 7548, p. 563-566 4 p.

Research output: Contribution to journalArticle

230 Scopus citations

Autophagy in cancer

Zhi, X. & Zhong, Q., Feb 3 2015, In : F1000Prime Reports. 7, 18.

Research output: Contribution to journalArticle

59 Scopus citations

Autophagy in malignant transformation and cancer progression

Galluzzi, L., Pietrocola, F., Bravo-San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., Kimmelman, A., Kumar, S., Levine, B., Maiuri, M. C., Martin, S. J., Penninger, J., Piacentini, M., Rubinsztein, D. C., Simon, H. U., Simonsen, A. & 4 others, Thorburn, A. M., Velasco, G., Ryan, K. M. & Kroemer, G., Apr 1 2015, In : EMBO Journal. 34, 7, p. 856-880 25 p.

Research output: Contribution to journalArticle

574 Scopus citations

BAX and BAK1 are dispensable for ABT-737- induced dissociation of the BCL2-BECN1 complex and autophagy

Pedro, J. M. B. S., Wei, Y., Sica, V., Maiuri, M. C., Zou, Z., Kroemer, G. & Levine, B., Jan 1 2015, In : Autophagy. 11, 3, p. 452-459 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

C-terminal variable AGES domain of Thymosin β4: The molecule's primary contribution in support of post-ischemic cardiac function and repair

Hinkel, R., Ball, H. L., DiMaio, J. M., Shrivastava, S., Thatcher, J. E., Singh, A. N., Sun, X., Faskerti, G., Olson, E. N., Kupatt, C. & Bock-Marquette, I., Oct 1 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 113-125 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

Tang, H., Sebti, S., Titone, R., Zhou, Y., Isidoro, C., Ross, T. S., Hibshoosh, H., Xiao, G., Packer, M., Xie, Y. & Levine, B., Mar 1 2015, In : EBioMedicine. 2, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

GABARAP-mediated targeting of PI4K2A/PI4KIIatα autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion

Albanesi, J., Wang, H., Sun, H. Q., Levine, B. & Yin, H., Jan 1 2015, In : Autophagy. 11, 11, p. 2127-2129 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

GABARAPs regulate PI4P-dependent autophagosome: Lysosome fusion

Wang, H., Sun, H. Q., Zhu, X., Zhang, L., Albanesi, J., Levine, B. & Yin, H., Jun 2 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 22, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Identification of secreted proteins that reflect autophagy dynamics within tumor cells

Kraya, A. A., Piao, S., Xu, X., Zhang, G., Herlyn, M., Gimotty, P., Levine, B., Amaravadi, R. K. & Speicher, D. W., Jan 1 2015, In : Autophagy. 11, 1, p. 60-74 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

Interaction between microbes and host intestinal health: Modulation by dietary nutrients and gut-brain-endocrine-immune axis

Chen, J., Li, Y., Tian, Y., Huang, C., Li, D., Zhong, Q. & Ma, X., Aug 1 2015, In : Current Protein and Peptide Science. 16, 7, p. 592-603 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

IScreen: Image-Based High-Content RNAi Screening Analysis Tools

Zhong, R., Dong, X., Levine, B., Xie, Y. & Xiao, G., Sep 24 2015, In : Journal of Biomolecular Screening. 20, 8, p. 998-1002 5 p.

Research output: Contribution to journalArticle

2 Scopus citations