Int Med - Autophagy Rsrch Ctr

Research Output 1990 2019

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2018
7 Citations (Scopus)

An increase in LRRK2 suppresses autophagy and enhances dectin-1–induced immunity in a mouse model of colitis

Takagawa, T., Kitani, A., Fuss, I., Levine, B., Brant, S. R., Peter, I., Tajima, M., Nakamura, S. & Strober, W., Jun 6 2018, In : Science Translational Medicine. 10, 444, eaan8162.

Research output: Contribution to journalArticle

Autophagy
Colitis
Dendritic Cells
Immunity
Crohn Disease
18 Citations (Scopus)

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

Sun, Y., Yao, X., Zhang, Q. J., Zhu, M., Liu, Z-P., Ci, B., Xie, Y., Carlson, D. L., Rothermel, B. A., Sun, Y., Levine, B., Hill, J. A., Wolf, S. E., Minei, J. P. & Zang, Q., Nov 13 2018, In : Circulation. 138, 20, p. 2247-2262 16 p.

Research output: Contribution to journalArticle

Autophagy
Sepsis
Lipopolysaccharides
Sirolimus
Mitochondrial Degradation
12 Citations (Scopus)

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

Peraro, L., Deprey, K. L., Moser, M. K., Zou, Z., Ball, H. L., Levine, B. & Kritzer, J. A., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11360-11369 10 p.

Research output: Contribution to journalArticle

Assays
Peptides
Drug Discovery
Throughput
Cell Line
58 Citations (Scopus)

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Jun 7 2018, In : Nature. 558, 7708, p. 136-140 5 p.

Research output: Contribution to journalArticle

Autophagy
Premature Aging
Phenotype
Mutation
Infertility
13 Citations (Scopus)

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding

Chiang, W. C., Wei, Y., Kuo, Y. C., Wei, S., Zhou, A., Zou, Z., Yehl, J., Ranaghan, M. J., Skepner, A., Bittker, J. A., Perez, J. R., Posner, B. A. & Levine, B., May 7 2018, (Accepted/In press) In : ACS Chemical Biology.

Research output: Contribution to journalArticle

Autophagy
Assays
Chemical compounds
Throughput
Molecules
13 Citations (Scopus)

Increased autophagy blocks HER2-mediated breast tumorigenesis

Vega-Rubín-De-Celis, S., Zou, Z., Fernández, Á. F., Ci, B., Kim, M., Xiao, G., Xie, Y. & Levine, B., Apr 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. 4176-4181 6 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Breast
Breast Neoplasms
human ERBB2 protein
25 Citations (Scopus)

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Paneth Cells
Autophagy
Toxoplasma
Inflammation
Microbiota
2017
21 Citations (Scopus)

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 1 2017, In : PLoS Genetics. 13, 8, e1006962.

Research output: Contribution to journalArticle

autophagy
cognition
Autophagy
amyloid
Alzheimer disease
44 Citations (Scopus)
Autophagy
Saccharomyces cerevisiae
Biomedical Research
Medicine
Nobel Prize
3 Citations (Scopus)

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy

Su, M., Li, Y., Wyborny, S., Neau, D., Chakravarthy, S., Levine, B., Colbert, C. L. & Sinha, S. C., May 1 2017, In : Protein Science. 26, 5, p. 972-984 13 p.

Research output: Contribution to journalArticle

Autophagy
Thermodynamic stability
Homeostasis
Hot Temperature
Association reactions
41 Citations (Scopus)

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

Peraro, L., Zou, Z., Makwana, K. M., Cummings, A. E., Ball, H. L., Yu, H., Lin, Y. S., Levine, B. & Kritzer, J. A., Jun 14 2017, In : Journal of the American Chemical Society. 139, 23, p. 7792-7802 11 p.

Research output: Contribution to journalArticle

Autophagy
Helper-Inducer T-Lymphocytes
Peptides
Neurodegenerative diseases
Neurodegenerative Diseases
8 Citations (Scopus)

Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice

Bian, A., Shi, M., Flores, B., Gillings, N., Li, P., Yan, S. X., Levine, B., Xing, C. & Hu, M. C., Sep 1 2017, In : PLoS One. 12, 9, e0181848.

Research output: Contribution to journalArticle

autophagy
C-reactive protein
Autophagy
ischemia
Acute Kidney Injury
12 Citations (Scopus)

Emerging functions of the Fanconi anemia pathway at a glance

Sumpter, R. & Levine, B., Aug 15 2017, In : Journal of Cell Science. 130, 16, p. 2657-2662 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
DNA Damage
Autophagy
Fanconi Anemia Complementation Group Proteins
Posters
6 Citations (Scopus)

Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells

Hu, J., Nie, Y., Chen, S., Xie, C., Fan, Q., Wang, Z., Long, B., Yan, G., Zhong, Q. & Yan, X., Aug 1 2017, In : International Journal of Biochemistry and Cell Biology. 89, p. 42-56 15 p.

Research output: Contribution to journalArticle

Sirolimus
Leucine
Energy Metabolism
Reactive Oxygen Species
Swine
17 Citations (Scopus)

MTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy

Bartolomeo, R., Cinque, L., De Leonibus, C., Forrester, A., Salzano, A. C., Monfregola, J., De Gennaro, E., Nusco, E., Azario, I., Lanzara, C., Serafini, M., Levine, B., Ballabio, A. & Settembre, C., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3717-3729 13 p.

Research output: Contribution to journalArticle

Bone Development
Autophagy
Chondrocytes
Phosphatidylinositols
Cartilage
23 Citations (Scopus)

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., Kim, J., Guan, K. L., Li, D. & Zhong, Q., Mar 4 2017, In : Autophagy. 13, 3, p. 592-607 16 p.

Research output: Contribution to journalArticle

Class III Phosphatidylinositol 3-Kinases
Phosphatidylinositol 3-Kinase
Autophagy
Phosphorylation
Starvation
137 Citations (Scopus)

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Wei, Y., Chiang, W. C., Sumpter, R., Mishra, P. & Levine, B., Jan 12 2017, In : Cell. 168, 1-2, p. 224-238.e10

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondrial Membranes
Mitochondria
Membranes
Membrane Proteins
2 Citations (Scopus)

Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein

Li, Y., Zhao, Y., Su, M., Glover, K., Chakravarthy, S., Colbert, C. L., Levine, B. & Sinha, S. C., Sep 1 2017, In : Acta Crystallographica Section D: Structural Biology. 73, 9, p. 775-792 18 p.

Research output: Contribution to journalArticle

Autophagy
Proteins
X-Rays
Dimerization
Beclin-1
5 Citations (Scopus)

The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains to Form a Homodimer with Submicromolar Affinity

Ranaghan, M. J., Durney, M. A., Mesleh, M. F., McCarren, P. R., Garvie, C. W., Daniels, D. S., Carey, K. L., Skepner, A. P., Levine, B. & Perez, J. R., Dec 26 2017, In : Biochemistry. 56, 51, p. 6639-6651 13 p.

Research output: Contribution to journalArticle

Dimerization
Viruses
Neurodegenerative diseases
Mutagenesis
Phosphorylation
40 Citations (Scopus)

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense

Franco, L. H., Nair, V. R., Scharn, C. R., Xavier, R. J., Torrealba, J. R., Shiloh, M. U. & Levine, B., Jan 11 2017, In : Cell Host and Microbe. 21, 1, p. 59-72 14 p.

Research output: Contribution to journalArticle

Autophagy
Ligases
Ubiquitin
Mycobacterium tuberculosis
Ubiquitination
2016
28 Citations (Scopus)

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

Park, S., Buck, M. D., Desai, C., Zhang, X., Loginicheva, E., Martinez, J., Freeman, M. L., Saitoh, T., Akira, S., Guan, J. L., He, Y. W., Blackman, M. A., Handley, S. A., Levine, B., Green, D. R., Reese, T. A., Artyomov, M. N. & Virgin, H. W., Jan 13 2016, In : Cell Host and Microbe. 19, 1, p. 91-101 11 p.

Research output: Contribution to journalArticle

Virus Latency
Autophagy
Interferons
Macrophages
Inflammation
125 Citations (Scopus)

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., Senovilla, L., Marino, G., Aranda, F., Durand, S., Sica, V., Chery, A., Lachkar, S., Sigl, V., Bloy, N., Buque, A. & 10 others, Falzoni, S., Ryffel, B., Apetoh, L., Di Virgilio, F., Madeo, F., Maiuri, M. C., Zitvogel, L., Levine, B., Penninger, J. M. & Kroemer, G., Jul 11 2016, In : Cancer Cell. 30, 1, p. 147-160 14 p.

Research output: Contribution to journalArticle

Immunologic Monitoring
Caloric Restriction
Autophagy
Neoplasms
ATP Citrate (pro-S)-Lyase
97 Citations (Scopus)

Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Mar 29 2016, In : Circulation. 133, 13, p. 1249-1263 15 p.

Research output: Contribution to journalArticle

Autophagy
Heart Failure
Pressure
Constriction
Down-Regulation
6 Citations (Scopus)

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis

Dong, X., Cheng, A., Zou, Z., Yang, Y. S., Sumpter, R. M., Huang, C. L., Bhagat, G., Virgin, H. W., Lira, S. A. & Levine, B., Mar 15 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 11, p. 2994-2999 6 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Viral Proteins
G-Protein-Coupled Receptors
Innate Immunity
Carcinogenesis
76 Citations (Scopus)

Fanconi Anemia Proteins Function in Mitophagy and Immunity

Sumpter, R., Sirasanagandla, S., Fernández, Á. F., Wei, Y., Dong, X., Franco, L., Zou, Z., Marchal, C., Lee, M. Y., Clapp, D. W., Hanenberg, H. & Levine, B., May 5 2016, In : Cell. 165, 4, p. 867-881 15 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
Mitochondrial Degradation
Fanconi Anemia
Immunity
Genes
8 Citations (Scopus)

Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis

Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B. & Amatruda, J. F., Oct 18 2016, In : Oncotarget. 7, 42, p. 67919-67933 15 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Autophagy
Carcinogenesis
Neoplasms
Zebrafish
19 Citations (Scopus)

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

Nair, V. R., Franco, L. H., Zacharia, V. M., Khan, H. S., Stamm, C. E., You, W., Marciano, D. K., Yagita, H., Levine, B. & Shiloh, M. U., Aug 2 2016, In : Cell Reports. 16, 5, p. 1253-1258 6 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Infection
Aerosols
Lymph Nodes
Epithelial Cells
13 Citations (Scopus)

Peroxisomal protein PEX13 functions in selective autophagy

Lee, M. Y., Sumpter, R., Zou, Z., Sirasanagandla, S., Wei, Y., Mishra, P., Rosewich, H., Crane, D. I. & Levine, B., 2016, (Accepted/In press) In : EMBO Reports.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Zellweger Syndrome
Autophagy
Peroxisomes
Proteins
29 Citations (Scopus)

Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

Li, X., Zhu, F., Jiang, J., Sun, C., Zhong, Q., Shen, M., Wang, X., Tian, R., Shi, C., Xu, M., Peng, F., Guo, X., Hu, J., Ye, D., Wang, M. & Qin, R., Sep 1 2016, In : Autophagy. 12, 9, p. 1521-1537 17 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Pancreatic Neoplasms
19 Citations (Scopus)

SNARE-mediated membrane fusion in autophagy

Wang, Y., Li, L., Hou, C., Lai, Y., Long, J., Liu, J., Zhong, Q. & Diao, J., May 4 2016, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

SNARE Proteins
Membrane Fusion
Autophagy
Lysosomes
Membranes
43 Citations (Scopus)

αklotho mitigates progression of aki to ckd through activation of autophagy

Shi, M., Flores, B., Gillings, N., Bian, A., Cho, H. J., Yan, S. X., Liu, Y., Levine, B., Moe, O. W. & Hu, M. C., 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2331-2345 15 p.

Research output: Contribution to journalArticle

Autophagy
Kidney
Fibrosis
Reperfusion Injury
Up-Regulation
2015
52 Citations (Scopus)

A noncanonical autophagy pathway restricts toxoplasma gondii growth in a strain-specific manner in IFN-γ-activated human cells

Selleck, E. M., Orchard, R. C., Lassen, K. G., Beatty, W. L., Xavier, R. J., Levine, B., Virgin, H. W. & David Sibley, L., 2015, In : mBio. 6, 5, e01157-15.

Research output: Contribution to journalArticle

Autophagy
Toxoplasma
Interferons
Vacuoles
Growth
22 Citations (Scopus)

ATG14 controls SNARE-mediated autophagosome fusion with a lysosome

Liu, R., Zhi, X. & Zhong, Q., Jan 1 2015, In : Autophagy. 11, 5, p. 847-849 3 p.

Research output: Contribution to journalArticle

SNARE Proteins
Lysosomes
Class III Phosphatidylinositol 3-Kinases
Phosphatidylinositol 3-Kinase
Autophagosomes
188 Citations (Scopus)

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Diao, J., Liu, R., Rong, Y., Zhao, M., Zhang, J., Lai, Y., Zhou, Q., Wilz, L. M., Li, J., Vivona, S., Pfuetzner, R. A., Brunger, A. T. & Zhong, Q., Apr 23 2015, In : Nature. 520, 7548, p. 563-566 4 p.

Research output: Contribution to journalArticle

Membrane Fusion
SNARE Proteins
Qa-SNARE Proteins
Autophagy
R-SNARE Proteins
55 Citations (Scopus)

Autophagy in cancer

Zhi, X. & Zhong, Q., Feb 3 2015, In : F1000Prime Reports. 7, 18.

Research output: Contribution to journalArticle

Autophagy
Neoplasms
Organelles
Critical Pathways
Lysosomes
487 Citations (Scopus)

Autophagy in malignant transformation and cancer progression

Galluzzi, L., Pietrocola, F., Bravo-San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., Kimmelman, A., Kumar, S., Levine, B., Maiuri, M. C., Martin, S. J., Penninger, J., Piacentini, M., Rubinsztein, D. C., Simon, H. U., Simonsen, A. & 4 others, Thorburn, A. M., Velasco, G., Ryan, K. M. & Kroemer, G., Apr 1 2015, In : EMBO Journal. 34, 7, p. 856-880 25 p.

Research output: Contribution to journalArticle

Autophagy
Tumors
Neoplasms
Oncogene Proteins
Modulators
42 Citations (Scopus)

BAX and BAK1 are dispensable for ABT-737- induced dissociation of the BCL2-BECN1 complex and autophagy

Pedro, J. M. B. S., Wei, Y., Sica, V., Maiuri, M. C., Zou, Z., Kroemer, G. & Levine, B., Jan 1 2015, In : Autophagy. 11, 3, p. 452-459 8 p.

Research output: Contribution to journalArticle

Autophagy
Peptidomimetics
HCT116 Cells
Colonic Neoplasms
Fibroblasts
61 Citations (Scopus)

Beclin orthologs: Integrative hubs of cell signaling, membrane trafficking, and physiology

Levine, B., Liu, R., Dong, X. & Zhong, Q., Sep 1 2015, In : Trends in Cell Biology. 25, 9, p. 533-544 12 p.

Research output: Contribution to journalArticle

Autophagy
Cell Membrane
Membranes
Yeasts
Genes
11 Citations (Scopus)

C-terminal variable AGES domain of Thymosin β4: The molecule's primary contribution in support of post-ischemic cardiac function and repair

Hinkel, R., Ball, H. L., DiMaio, J. M., Shrivastava, S., Thatcher, J. E., Singh, A. N., Sun, X., Faskerti, G., Olson, E. N., Kupatt, C. & Bock-Marquette, I., Oct 1 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 113-125 13 p.

Research output: Contribution to journalArticle

Thymosin
Infarction
Cardiac Myocytes
Muscle Cells
Cell Movement
43 Citations (Scopus)

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

Tang, H., Sebti, S., Titone, R., Zhou, Y., Isidoro, C., Ross, T. S., Hibshoosh, H., Xiao, G., Packer, M., Xie, Y. & Levine, B., Mar 1 2015, In : EBioMedicine. 2, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Tumors
Breast Neoplasms
Messenger RNA
Genes
146 Citations (Scopus)

Development of autophagy inducers in clinical medicine

Levine, B., Packer, M. & Codogno, P., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

Clinical Medicine
Autophagy
Caloric Restriction
Metabolic Diseases
Insurance Benefits
448 Citations (Scopus)

Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., Baehrecke, E. H., Bazan, N. G., Bertrand, M. J., Bianchi, K., Blagosklonny, M. V., Blomgren, K., Borner, C., Bredesen, D. E., Brenner, C., Campanella, M. & 88 others, Candi, E., Cecconi, F., Chan, F. K., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria, R., Debatin, K. M., Di Daniele, N., Dixit, V. M., Dynlacht, B. D., El-Deiry, W. S., Fimia, G. M., Flavell, R. A., Fulda, S., Garrido, C., Gougeon, M. L., Green, D. R., Gronemeyer, H., Hajnoczky, G., Hardwick, J. M., Hengartner, M. O., Ichijo, H., Joseph, B., Jost, P. J., Kaufmann, T., Kepp, O., Klionsky, D. J., Knight, R. A., Kumar, S., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lugli, E., Madeo, F., Malorni, W., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Meier, P., Melino, S., Mizushima, N., Moll, U., Muñoz-Pinedo, C., Nuñez, G., Oberst, A., Panaretakis, T., Penninger, J. M., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H., Puthalakath, H., Rabinovich, G. A., Ravichandran, K. S., Rizzuto, R., Rodrigues, C. M., Rubinsztein, D. C., Rudel, T., Shi, Y., Simon, H. U., Stockwell, B. R., Szabadkai, G., Tait, S. W., Tang, H. L., Tavernarakis, N., Tsujimoto, Y., Vanden Berghe, T., Vandenabeele, P., Villunger, A., Wagner, E. F., Walczak, H., White, E., Wood, W. G., Yuan, J., Zakeri, Z., Zhivotovsky, B., Melino, G. & Kroemer, G., Jan 1 2015, In : Cell Death and Differentiation. 22, 1, p. 58-73 16 p.

Research output: Contribution to journalArticle

Cell Death
Biochemical Phenomena
Genetic Engineering
Cytoprotection
Caspases
14 Citations (Scopus)

GABARAP-mediated targeting of PI4K2A/PI4KIIatα autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion

Albanesi, J., Wang, H., Sun, H. Q., Levine, B. & Yin, H., Jan 1 2015, In : Autophagy. 11, 11, p. 2127-2129 3 p.

Research output: Contribution to journalArticle

Protein Transport
GABA-A Receptors
Lysosomes
Phosphatidylinositols
Phosphatidylinositol 4,5-Diphosphate
62 Citations (Scopus)

GABARAPs regulate PI4P-dependent autophagosome: Lysosome fusion

Wang, H., Sun, H. Q., Zhu, X., Zhang, L., Albanesi, J., Levine, B. & Yin, H., Jun 2 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 22, p. 7015-7020 6 p.

Research output: Contribution to journalArticle

Lysosomes
Autophagy
Phosphotransferases
Phosphatidylinositol 4,5-Diphosphate
Aminobutyrates
48 Citations (Scopus)

Identification of secreted proteins that reflect autophagy dynamics within tumor cells

Kraya, A. A., Piao, S., Xu, X., Zhang, G., Herlyn, M., Gimotty, P., Levine, B., Amaravadi, R. K. & Speicher, D. W., Jan 1 2015, In : Autophagy. 11, 1, p. 60-74 15 p.

Research output: Contribution to journalArticle

Autophagy
Neoplasms
Proteins
Melanoma
Tumor Microenvironment
60 Citations (Scopus)

Interaction between microbes and host intestinal health: Modulation by dietary nutrients and gut-brain-endocrine-immune axis

Chen, J., Li, Y., Tian, Y., Huang, C., Li, D., Zhong, Q. & Ma, X., Aug 1 2015, In : Current Protein and Peptide Science. 16, 7, p. 592-603 12 p.

Research output: Contribution to journalArticle

Immune system
Nutrients
Immune System
Brain
Homeostasis
2 Citations (Scopus)

IScreen: Image-Based High-Content RNAi Screening Analysis Tools

Zhong, R., Dong, X., Levine, B., Xie, Y. & Xiao, G., Sep 24 2015, In : Journal of Biomolecular Screening. 20, 8, p. 998-1002 5 p.

Research output: Contribution to journalArticle

RNA Interference
Screening
RNA
Genome
Technology
65 Citations (Scopus)

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

Wei, Y., An, Z., Zou, Z., Sumpter, R., Su, M., Zang, X., Sinha, S., Gaestel, M. & Levine, B., Feb 18 2015, In : eLife. 2015, 4, e05289.

Research output: Contribution to journalArticle

Phosphorylation
Autophagy
Starvation
Phosphotransferases
Amino Acids
2014
55 Citations (Scopus)

Autophagy is essential for cardiac morphogenesis during vertebrate development

Lee, E., Koo, Y., Ng, A., Wei, Y., Luby-Phelps, K., Juraszek, A., Xavier, R. J., Cleaver, O., Levine, B. & Amatruda, J. F., 2014, In : Autophagy. 10, 4, p. 572-587 16 p.

Research output: Contribution to journalArticle

Autophagy
Morphogenesis
Vertebrates
Zebrafish
Morpholinos
29 Citations (Scopus)

Autophagy is required for G1/G0quiescence in response to nitrogen starvation in Saccharomyces cerevisiae

An, Z., Tassa, A., Thomas, C., Zhong, R., Xiao, G., Fotedar, R., Tu, B. P., Klionsky, D. J. & Levine, B., Oct 1 2014, In : Autophagy. 10, 10, p. 1702-1711 10 p.

Research output: Contribution to journalArticle

Autophagy
Starvation
Saccharomyces cerevisiae
Nitrogen
Yeasts