Int Med - Touchstone Diab Ctr

Research Output

2020

A novel model of diabetic complications: Adipocyte mitochondrial dysfunction triggers massive β-cell hyperplasia

Kusminski, C. M., Ghaben, A. L., Morley, T. S., Samms, R. J., Adams, A. C., An, Y., Johnson, J. A., Joffin, N., Onodera, T., Crewe, C., Holland, W. L., Gordillo, R. & Scherer, P. E., Mar 1 2020, In : Diabetes. 69, 3, p. 313-330 18 p.

Research output: Contribution to journalArticle

Caveolin-1 as a possible target in the treatment for acne

Kruglikov, I. L. & Scherer, P. E., Feb 1 2020, In : Experimental Dermatology. 29, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Caveolin as a universal target in dermatology

Kruglikov, I. L. & Scherer, P. E., Jan 1 2020, In : International journal of molecular sciences. 21, 1, 80.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

Tran, D. H., May, H. I., Li, Q., Luo, X., Huang, J., Zhang, G., Niewold, E., Wang, X., Gillette, T. G., Deng, Y. & Wang, Z. V., Dec 1 2020, In : Nature communications. 11, 1, 1771.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Correction to: The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection (Parasitology Research, (2020), 119, 6, (1829-1843), 10.1007/s00436-020-06645-z)

Zaki, P., Domingues, E. L. B. C., Amjad, F. M., Narde, M. B., Gonçalves, K. R., Viana, M. L., de Paula, H., de Lima, W. G., Huang, H., Bahia, M. T., Scherer, P. E., dos Santos, F. M., Weiss, L. M. & Tanowitz, H. B., Jun 1 2020, In : Parasitology Research. 119, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Critical role of matrix metalloproteinase 14 in adipose tissue remodeling during obesity

Li, X., Zhao, Y., Chen, C., Yang, L., Lee, H. H., Wang, Z., Zhang, N., Kolonin, M. G., An, Z., Ge, X., Scherer, P. E. & Sun, K., Mar 1 2020, In : Molecular and cellular biology. 40, 8, e00564-19.

Research output: Contribution to journalArticle

4 Scopus citations

Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer

Pedersen, L., Panahandeh, P., Siraji, M. I., Knappskog, S., Lønning, P. E., Gordillo, R., Scherer, P. E., Molven, A., Teigen, K. & Halberg, N., Jun 1 2020, In : Cancer research. 80, 11, p. 2163-2174 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Induction of effective immunity against Trypanosoma cruzi

Williams, T., Guerrero-Ros, I., Ma, Y., Dos Santos, F. M., Scherer, P. E., Gordillo, R., Horta, A., Macian, F., Weiss, L. M. & Huang, H., Apr 1 2020, In : Infection and immunity. 88, 4, e00908-19.

Research output: Contribution to journalArticle

1 Scopus citations

Isolation of adipogenic and fibro-inflammatory stromal cell subpopulations from murine intra-abdominal adipose depots

Peics, J., Vishvanath, L., Zhang, Q., Shan, B., Pedersen, T. & Gupta, R. K., Aug 2020, In : Journal of Visualized Experiments. 2020, 162, p. 1-14 14 p., e61610.

Research output: Contribution to journalArticle

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress

Delitsikou, V., Jarad, G., Rajaram, R. D., Ino, F., Rutkowski, J. M., Chen, C. D., Santos, C. X. C., Scherer, P. E., Abraham, C. R., Shah, A. M., Feraille, E., Miner, J. H. & de Seigneux, S., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2087-2104 18 p.

Research output: Contribution to journalArticle

Open Access

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Dai, C., Li, Q., May, H. I., Li, C., Zhang, G., Sharma, G., Sherry, A. D., Malloy, C. R., Khemtong, C., Zhang, Y., Deng, Y., Gillette, T. G., Xu, J., Scadden, D. T. & Wang, Z., Sep 1 2020, In : Cell Reports. 32, 9, 108087.

Research output: Contribution to journalArticle

Open Access

Leptin: Less is more

Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In : Diabetes. 69, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Low- And high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

Song, A., Dai, W., Jang, M. J., Medrano, L., Li, Z., Zhao, H., Shao, M., Tan, J., Li, A., Ning, T., Miller, M. M., Armstrong, B., Huss, J. M., Zhu, Y., Liu, Y., Gradinaru, V., Wu, X., Jiang, L., Scherer, P. E. & Wang, Q. A., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M. Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., Jul 2020, In : Molecular Metabolism. 37, 100995.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

PHOSPHO1 puts the breaks on thermogenesis in brown adipocytes

Gliniak, C. M. & Scherer, P. E., Jul 21 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 29, p. 16726-16728 3 p.

Research output: Contribution to journalComment/debate

Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity

Paschoal, V. A., Walenta, E., Talukdar, S., Pessentheiner, A. R., Osborn, O., Hah, N., Chi, T. J., Tye, G. L., Armando, A. M., Evans, R. M., Chi, N. W., Quehenberger, O., Olefsky, J. M. & Oh, D. Y., Jun 2 2020, In : Cell Metabolism. 31, 6, p. 1173-1188.e5

Research output: Contribution to journalArticle

Suppressing adipocyte inflammation promotes insulin resistance in mice

Zhu, Q., An, Y. A., Kim, M., Zhang, Z., Zhao, S., Zhu, Y., Asterholm, I. W., Kusminski, C. M. & Scherer, P. E., Sep 2020, In : Molecular Metabolism. 39, 101010.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance

El Ouarrat, D., Isaac, R., Lee, Y. S., Oh, D. Y., Wollam, J., Lackey, D., Riopel, M., Bandyopadhyay, G., Seo, J. B., Sampath-Kumar, R. & Olefsky, J. M., Jan 7 2020, In : Cell Metabolism. 31, 1, p. 162-173.e5

Research output: Contribution to journalArticle

5 Scopus citations

The MMP14–caveolin axis and its potential relevance for lipoedema

Kruglikov, I. L., Joffin, N. & Scherer, P. E., 2020, (Accepted/In press) In : Nature Reviews Endocrinology.

Research output: Contribution to journalArticle

The Role of Adipocytes and Adipocyte-Like Cells in the Severity of COVID-19 Infections

Kruglikov, I. L. & Scherer, P. E., Jul 1 2020, In : Obesity. 28, 7, p. 1187-1190 4 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
Open Access
2019

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

Caron, A., Reynolds, R. P., Castorena, C. M., Michael, N. J., Lee, C. E., Lee, S., Berdeaux, R., Scherer, P. E. & Elmquist, J. K., Sep 2019, In : Molecular Metabolism. 27, p. 11-21 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice

Lackey, D. E., Reis, F. C. G., Isaac, R., Zapata, R. C., El Ouarrat, D., Lee, Y. S., Bandyopadhyay, G., Ofrecio, J. M., Oh, D. Y. & Osborn, O., Dec 1 2019, In : Scientific reports. 9, 1, 14779.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Adipogenesis and metabolic health

Ghaben, A. L. & Scherer, P. E., Jan 1 2019, (Accepted/In press) In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journalArticle

107 Scopus citations

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. & Lu, X. Y., Jan 1 2019, In : Molecular psychiatry. 24, 1, p. 126-144 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

Wang, W., Ishibashi, J., Trefely, S., Shao, M., Cowan, A. J., Sakers, A., Lim, H. W., O'Connor, S., Doan, M. T., Cohen, P., Baur, J. A., King, M. T., Veech, R. L., Won, K. J., Rabinowitz, J. D., Snyder, N. W., Gupta, R. K. & Seale, P., Jul 2 2019, In : Cell Metabolism. 30, 1, p. 174-189.e5

Research output: Contribution to journalArticle

19 Scopus citations

Beyond adiponectin and leptin: Adipose tissue-derived mediators of inter-organ communication

Funcke, J. B. & Scherer, P. E., 2019, In : Journal of lipid research. 60, 10, p. 1648-1697 50 p.

Research output: Contribution to journalReview article

19 Scopus citations

Caveolin-1 as a pathophysiological factor and target in psoriasis

Kruglikov, I. L. & Scherer, P. E., Dec 1 2019, In : npj Aging and Mechanisms of Disease. 5, 1, 4.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

Kruglikov, I. L. & Scherer, P. E., Dec 1 2019, In : npj Regenerative Medicine. 4, 1, 9.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Caveolin-1 in skin aging – From innocent bystander to major contributor

Kruglikov, I. L., Zhang, Z. & Scherer, P. E., Nov 2019, In : Ageing Research Reviews. 55, 100959.

Research output: Contribution to journalReview article

5 Scopus citations

Cellular origins of beige fat cells revisited

Shao, M., Wang, Q. A., Song, A., Vishvanath, L., Busbuso, N. C., Scherer, P. E. & Gupta, R. K., Oct 1 2019, In : Diabetes. 68, 10, p. 1874-1885 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease

Lee, C., Kim, M., Lee, J. H., Oh, J., Shin, H. H., Lee, S. M., Scherer, P. E., Kwon, H. M., Choi, J. H. & Park, J., Jan 2019, In : Journal of Pathology. 247, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

Vishvanath, L. & Gupta, R. K., Oct 1 2019, In : Journal of Clinical Investigation. 129, 10, p. 4022-4031 10 p.

Research output: Contribution to journalReview article

15 Scopus citations

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Gliniak, C. M. & Scherer, P. E., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2198-2200 3 p.

Research output: Contribution to journalReview article

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhang, Z., Shao, M., Hepler, C., Zi, Z., Zhao, S., An, Y. A., Zhu, Y., Ghaben, A. L., May-Yun, W., Li, N., Onodera, T., Joffin, N., Crewe, C., Zhu, Q., Vishvanath, L., Kumar, A., Xing, C., Wang, Q. A., Gautron, L., Deng, Y. & 5 others, Gordillo, R., Kruglikov, I., Kusminski, C. M., Gupta, R. K. & Scherer, P. E., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5327-5342 16 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

An, Y. A., Crewe, C., Asterholm, I. W., Sun, K., Chen, S., Zhang, F., Shao, M., Funcke, J. B., Zhang, Z., Straub, L., Yoshino, J., Klein, S., Kusminski, C. M. & Scherer, P. E., Dec 1 2019, In : Nature Metabolism. 1, 12, p. 1243-1257 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

FOXN3 controls liver glucose metabolism by regulating gluconeogenic substrate selection

Karanth, S., Chaurasia, B., Bowman, F. M., Tippetts, T. S., Holland, W. L., Summers, S. A. & Schlegel, A., Sep 1 2019, In : Physiological Reports. 7, 18, e14238.

Research output: Contribution to journalArticle

Open Access

GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)

Zhang, G., Wang, X., Bi, X., Li, C., Deng, Y., Al-Hashimi, A. A., Luo, X., Gillette, T. G., Austin, R. C., Wang, Y. & Wang, Z. V., Jan 1 2019, In : Hypertension. 73, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R., Fujikawa, T., Castorena, C. M., Richardson, J., Shelton, J. M., Ayers, C. R., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human endotrophin as a driver of malignant tumor growth

Bu, D., Crewe, C., Kusminski, C. M., Gordillo, R., Ghaben, A. L., Kim, M., Park, J., Deng, H., Xiong, W., Liu, X. Z., Lønning, P. E., Halberg, N., Rios, A., Chang, Y., Gonzalez, A., Zhang, N., An, Z. & Scherer, P. E., 2019, In : JCI Insight. 4, 9, e125094.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling

Buffolo, M., Pires, K. M., Ferhat, M., Ilkun, O., Makaju, A., Achenbach, A., Bowman, F., Atkinson, D. L., Holland, W. L., Amri, E. Z., Chaurasia, B., Franklin, S. & Boudina, S., Oct 8 2019, In : Cell Reports. 29, 2, p. 270-282.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Imaging metabolically active fat: A literature review and mechanistic insights

Frankl, J., Sherwood, A., Clegg, D. J., Scherer, P. E. & Öz, O. K., Nov 2019, In : International journal of molecular sciences. 20, 21, 5509.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Introduction to the thematic review series: Adipose biology

Gupta, R. K. & Attie, A. D., 2019, In : Journal of lipid research. 60, 10, p. 1646-1647 2 p.

Research output: Contribution to journalEditorial

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

Suh, E. H., Hackett, E. P., Wynn, R. M., Chuang, D. T., Zhang, B., Luo, W., Sherry, A. D. & Park, J. M., Dec 1 2019, In : Scientific reports. 9, 1, 340.

Research output: Contribution to journalArticle

2 Scopus citations

Lipotoxicity and B cell maintenance in obesity and type 2 diabetes

Ye, R., Onodera, T. & Scherer, P. E., Mar 2019, In : Journal of the Endocrine Society. 3, 3, p. 617-631 15 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Listen to your heart when ceramide's calling for higher glucose

Wilkerson, J. L., Summers, S. A. & Holland, W. L., Mar 2019, In : EBioMedicine. 41, p. 3-4 2 p.

Research output: Contribution to journalComment/debate

Open Access

Lowering ceramides to overcome diabetes

Kusminski, C. & Scherer, P. E., Jul 26 2019, In : Science (New York, N.Y.). 365, 6451, p. 319-320 2 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Metabolic Messengers: adiponectin

Straub, L. G. & Scherer, P. E., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 334-339 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Obesity dysregulates fasting-induced changes in glucagon secretion

Stern, J. H., Smith, G. I., Chen, S., Unger, R. H., Klein, S. & Scherer, P. E., Nov 1 2019, In : The Journal of endocrinology. 243, 2, p. 149-160 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., Deng, H., Sun, J., Deng, Y., Kim, M., Lee, C. E., Gordillo, R., Liu, T., Odle, A. K., Childs, G. V., Zhang, N. & 5 others, Kusminski, C. M., Elmquist, J. K., Williams, K. W., An, Z. & Scherer, P. E., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 706-719.e6

Research output: Contribution to journalArticle

23 Scopus citations