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2020

A novel model of diabetic complications: Adipocyte mitochondrial dysfunction triggers massive β-cell hyperplasia

Kusminski, C. M., Ghaben, A. L., Morley, T. S., Samms, R. J., Adams, A. C., An, Y., Johnson, J. A., Joffin, N., Onodera, T., Crewe, C., Holland, W. L., Gordillo, R. & Scherer, P. E., Mar 1 2020, In : Diabetes. 69, 3, p. 313-330 18 p.

Research output: Contribution to journalArticle

Caveolin-1 as a possible target in the treatment for acne

Kruglikov, I. L. & Scherer, P. E., Feb 1 2020, In : Experimental Dermatology. 29, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

Tran, D. H., May, H. I., Li, Q., Luo, X., Huang, J., Zhang, G., Niewold, E., Wang, X., Gillette, T. G., Deng, Y. & Wang, Z. V., Dec 1 2020, In : Nature communications. 11, 1, 1771.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Critical role of matrix metalloproteinase 14 in adipose tissue remodeling during obesity

Li, X., Zhao, Y., Chen, C., Yang, L., Lee, H. H., Wang, Z., Zhang, N., Kolonin, M. G., An, Z., Ge, X., Scherer, P. E. & Sun, K., Mar 1 2020, In : Molecular and cellular biology. 40, 8, e00564-19.

Research output: Contribution to journalArticle

4 Scopus citations

Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer

Pedersen, L., Panahandeh, P., Siraji, M. I., Knappskog, S., Lønning, P. E., Gordillo, R., Scherer, P. E., Molven, A., Teigen, K. & Halberg, N., Jun 1 2020, In : Cancer research. 80, 11, p. 2163-2174 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Induction of effective immunity against Trypanosoma cruzi

Williams, T., Guerrero-Ros, I., Ma, Y., Dos Santos, F. M., Scherer, P. E., Gordillo, R., Horta, A., Macian, F., Weiss, L. M. & Huang, H., Apr 1 2020, In : Infection and immunity. 88, 4, e00908-19.

Research output: Contribution to journalArticle

1 Scopus citations

Isolation of adipogenic and fibro-inflammatory stromal cell subpopulations from murine intra-abdominal adipose depots

Peics, J., Vishvanath, L., Zhang, Q., Shan, B., Pedersen, T. & Gupta, R. K., Aug 2020, In : Journal of Visualized Experiments. 2020, 162, p. 1-14 14 p., e61610.

Research output: Contribution to journalArticle

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress

Delitsikou, V., Jarad, G., Rajaram, R. D., Ino, F., Rutkowski, J. M., Chen, C. D., Santos, C. X. C., Scherer, P. E., Abraham, C. R., Shah, A. M., Feraille, E., Miner, J. H. & de Seigneux, S., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2087-2104 18 p.

Research output: Contribution to journalArticle

Open Access

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Dai, C., Li, Q., May, H. I., Li, C., Zhang, G., Sharma, G., Sherry, A. D., Malloy, C. R., Khemtong, C., Zhang, Y., Deng, Y., Gillette, T. G., Xu, J., Scadden, D. T. & Wang, Z., Sep 1 2020, In : Cell Reports. 32, 9, 108087.

Research output: Contribution to journalArticle

Open Access

Leptin: Less is more

Zhao, S., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., May 1 2020, In : Diabetes. 69, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Low- And high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

Song, A., Dai, W., Jang, M. J., Medrano, L., Li, Z., Zhao, H., Shao, M., Tan, J., Li, A., Ning, T., Miller, M. M., Armstrong, B., Huss, J. M., Zhu, Y., Liu, Y., Gradinaru, V., Wu, X., Jiang, L., Scherer, P. E. & Wang, Q. A., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 247-257 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Zhao, S., Li, N., Zhu, Y., Straub, L., Zhang, Z., Wang, M. Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K. & Scherer, P. E., Jul 2020, In : Molecular Metabolism. 37, 100995.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity

Paschoal, V. A., Walenta, E., Talukdar, S., Pessentheiner, A. R., Osborn, O., Hah, N., Chi, T. J., Tye, G. L., Armando, A. M., Evans, R. M., Chi, N. W., Quehenberger, O., Olefsky, J. M. & Oh, D. Y., Jun 2 2020, In : Cell Metabolism. 31, 6, p. 1173-1188.e5

Research output: Contribution to journalArticle

Suppressing adipocyte inflammation promotes insulin resistance in mice

Zhu, Q., An, Y. A., Kim, M., Zhang, Z., Zhao, S., Zhu, Y., Asterholm, I. W., Kusminski, C. M. & Scherer, P. E., Sep 2020, In : Molecular Metabolism. 39, 101010.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance

El Ouarrat, D., Isaac, R., Lee, Y. S., Oh, D. Y., Wollam, J., Lackey, D., Riopel, M., Bandyopadhyay, G., Seo, J. B., Sampath-Kumar, R. & Olefsky, J. M., Jan 7 2020, In : Cell Metabolism. 31, 1, p. 162-173.e5

Research output: Contribution to journalArticle

5 Scopus citations

The MMP14–caveolin axis and its potential relevance for lipoedema

Kruglikov, I. L., Joffin, N. & Scherer, P. E., 2020, (Accepted/In press) In : Nature Reviews Endocrinology.

Research output: Contribution to journalArticle

The Role of Adipocytes and Adipocyte-Like Cells in the Severity of COVID-19 Infections

Kruglikov, I. L. & Scherer, P. E., Jul 1 2020, In : Obesity. 28, 7, p. 1187-1190 4 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
Open Access
2019

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

Caron, A., Reynolds, R. P., Castorena, C. M., Michael, N. J., Lee, C. E., Lee, S., Berdeaux, R., Scherer, P. E. & Elmquist, J. K., Sep 2019, In : Molecular Metabolism. 27, p. 11-21 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice

Lackey, D. E., Reis, F. C. G., Isaac, R., Zapata, R. C., El Ouarrat, D., Lee, Y. S., Bandyopadhyay, G., Ofrecio, J. M., Oh, D. Y. & Osborn, O., Dec 1 2019, In : Scientific reports. 9, 1, 14779.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Adipogenesis and metabolic health

Ghaben, A. L. & Scherer, P. E., Jan 1 2019, (Accepted/In press) In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journalArticle

107 Scopus citations

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. & Lu, X. Y., Jan 1 2019, In : Molecular psychiatry. 24, 1, p. 126-144 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

Wang, W., Ishibashi, J., Trefely, S., Shao, M., Cowan, A. J., Sakers, A., Lim, H. W., O'Connor, S., Doan, M. T., Cohen, P., Baur, J. A., King, M. T., Veech, R. L., Won, K. J., Rabinowitz, J. D., Snyder, N. W., Gupta, R. K. & Seale, P., Jul 2 2019, In : Cell Metabolism. 30, 1, p. 174-189.e5

Research output: Contribution to journalArticle

19 Scopus citations

Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

Kruglikov, I. L. & Scherer, P. E., Dec 1 2019, In : npj Regenerative Medicine. 4, 1, 9.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Cellular origins of beige fat cells revisited

Shao, M., Wang, Q. A., Song, A., Vishvanath, L., Busbuso, N. C., Scherer, P. E. & Gupta, R. K., Oct 1 2019, In : Diabetes. 68, 10, p. 1874-1885 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease

Lee, C., Kim, M., Lee, J. H., Oh, J., Shin, H. H., Lee, S. M., Scherer, P. E., Kwon, H. M., Choi, J. H. & Park, J., Jan 2019, In : Journal of Pathology. 247, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

Zhang, Z., Shao, M., Hepler, C., Zi, Z., Zhao, S., An, Y. A., Zhu, Y., Ghaben, A. L., May-Yun, W., Li, N., Onodera, T., Joffin, N., Crewe, C., Zhu, Q., Vishvanath, L., Kumar, A., Xing, C., Wang, Q. A., Gautron, L., Deng, Y. & 5 others, Gordillo, R., Kruglikov, I., Kusminski, C. M., Gupta, R. K. & Scherer, P. E., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5327-5342 16 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

An, Y. A., Crewe, C., Asterholm, I. W., Sun, K., Chen, S., Zhang, F., Shao, M., Funcke, J. B., Zhang, Z., Straub, L., Yoshino, J., Klein, S., Kusminski, C. M. & Scherer, P. E., Dec 1 2019, In : Nature Metabolism. 1, 12, p. 1243-1257 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

FOXN3 controls liver glucose metabolism by regulating gluconeogenic substrate selection

Karanth, S., Chaurasia, B., Bowman, F. M., Tippetts, T. S., Holland, W. L., Summers, S. A. & Schlegel, A., Sep 1 2019, In : Physiological Reports. 7, 18, e14238.

Research output: Contribution to journalArticle

Open Access

GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)

Zhang, G., Wang, X., Bi, X., Li, C., Deng, Y., Al-Hashimi, A. A., Luo, X., Gillette, T. G., Austin, R. C., Wang, Y. & Wang, Z. V., Jan 1 2019, In : Hypertension. 73, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R., Fujikawa, T., Castorena, C. M., Richardson, J., Shelton, J. M., Ayers, C. R., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human endotrophin as a driver of malignant tumor growth

Bu, D., Crewe, C., Kusminski, C. M., Gordillo, R., Ghaben, A. L., Kim, M., Park, J., Deng, H., Xiong, W., Liu, X. Z., Lønning, P. E., Halberg, N., Rios, A., Chang, Y., Gonzalez, A., Zhang, N., An, Z. & Scherer, P. E., 2019, In : JCI Insight. 4, 9, e125094.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling

Buffolo, M., Pires, K. M., Ferhat, M., Ilkun, O., Makaju, A., Achenbach, A., Bowman, F., Atkinson, D. L., Holland, W. L., Amri, E. Z., Chaurasia, B., Franklin, S. & Boudina, S., Oct 8 2019, In : Cell Reports. 29, 2, p. 270-282.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

Suh, E. H., Hackett, E. P., Wynn, R. M., Chuang, D. T., Zhang, B., Luo, W., Sherry, A. D. & Park, J. M., Dec 1 2019, In : Scientific reports. 9, 1, 340.

Research output: Contribution to journalArticle

2 Scopus citations

Lipotoxicity and B cell maintenance in obesity and type 2 diabetes

Ye, R., Onodera, T. & Scherer, P. E., Mar 2019, In : Journal of the Endocrine Society. 3, 3, p. 617-631 15 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Metabolic Messengers: adiponectin

Straub, L. G. & Scherer, P. E., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 334-339 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Obesity dysregulates fasting-induced changes in glucagon secretion

Stern, J. H., Smith, G. I., Chen, S., Unger, R. H., Klein, S. & Scherer, P. E., Nov 1 2019, In : The Journal of endocrinology. 243, 2, p. 149-160 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., Deng, H., Sun, J., Deng, Y., Kim, M., Lee, C. E., Gordillo, R., Liu, T., Odle, A. K., Childs, G. V., Zhang, N. & 5 others, Kusminski, C. M., Elmquist, J. K., Williams, K. W., An, Z. & Scherer, P. E., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 706-719.e6

Research output: Contribution to journalArticle

23 Scopus citations
Open Access
2 Scopus citations

Spliced X-box binding protein 1 stimulates adaptive growth through activation of mTOR

Wang, X., Deng, Y., Zhang, G., Li, C., Ding, G., May, H. I., Tran, D. H., Luo, X., Jiang, D. S., Li, D. L., Wei, X., Xu, L., Ferdous, A., Gillette, T. G., Scherer, P. E., Jiang, X. & Wang, Z. V., Aug 13 2019, In : Circulation. 140, 7, p. 566-579 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Chaurasia, B., Tippetts, T. S., Monibas, R. M., Liu, J., Li, Y., Wang, L., Wilkerson, J. L., Rufus Sweeney, C., Pereira, R. F., Sumida, D. H., Alan Maschek, J., Cox, J. E., Kaddai, V., Lancaster, G. I., Siddique, M. M., Poss, A., Pearson, M., Satapati, S., Zhou, H., McLaren, D. G. & 15 others, Previs, S. F., Chen, Y., Qian, Y., Petrov, A., Wu, M., Shen, X., Yao, J., Nunes, C. N., Howard, A. D., Wang, L., Erion, M. D., Rutter, J., Holland, W. L., Kelley, D. E. & Summers, S. A., Jul 26 2019, In : Science. 365, 6451, p. 386-392 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

Beaudry, J. L., Kaur, K. D., Varin, E. M., Baggio, L. L., Cao, X., Mulvihill, E. E., Stern, J. H., Campbell, J. E., Scherer, P. E. & Drucker, D. J., Apr 2019, In : Molecular Metabolism. 22, p. 37-48 12 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure

Chen, M., Gao, C., Yu, J., Ren, S., Wang, M., Wynn, R. M., Chuang, D. T., Wang, Y. & Sun, H., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e011625.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

Chakraborty, A., Barajas, S., Lammoglia, G. M., Reyna, A. J., Morley, T. S., Johnson, J. A., Scherer, P. E. & Rutkowski, J. M., Apr 2019, In : American Journal of Pathology. 189, 4, p. 924-939 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

XBP1s regulates MUC5B in a promoter variant-dependent pathway in idiopathic pulmonary fibrosis airway epithelia

Chen, G., Ribeiro, C. M. P., Sun, L., Okuda, K., Kato, T., Gilmore, R. C., Martino, M. B., Dang, H., Abzhanova, A., Lin, J. M., Hull-Ryde, E. A., Volmer, A. S., Randell, S. H., Livraghi-Butrico, A., Deng, Y., Scherer, P. E., Stripp, B. R., O'Neal, W. K. & Boucher, R. C., 2019, In : American journal of respiratory and critical care medicine. 200, 2, p. 220-234 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis

Ye, R., Onodera, T., Blanchard, P. G., Kusminski, C. M., Esser, V., Brekken, R. A. & Scherer, P. E., Apr 2019, In : American Journal of Pathology. 189, 4, p. 813-825 13 p.

Research output: Contribution to journalArticle

2018

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Deng, Y., Wang, Z., Gordillo, R., Zhu, Y., Ali, A., Zhang, C., Wang, X., Shao, M., Zhang, Z., Iyengar, P., Gupta, R. K., Horton, J. D., Hill, J. A. & Scherer, P. E., May 2018, In : Molecular Metabolism. 11, p. 1-17 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose

Karanth, S., Adams, J. D., Serrano, M. D. L. A., Quittner-Strom, E. B., Simcox, J., Villanueva, C. J., Ozcan, L., Holland, W. L., Yost, H. J., Vella, A. & Schlegel, A., Jul 10 2018, In : Cell Reports. 24, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

4 Scopus citations