Medical Dermatology

Research Output 2002 2019

2019

Overcoming BET inhibitor resistance in malignant peripheral nerve sheath tumors

Cooper, J. M., Patel, A. J., Chen, Z., Liao Ph.D., C. P., Chen, K., Mo, J., Wang, Y. & Le, L. Q., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3404-3416 13 p.

Research output: Contribution to journalArticle

Open Access
Neurilemmoma
Proteins
Neoplasms
Neurofibromatosis 1
Molecular Evolution
1 Citation (Scopus)

Spatiotemporal loss of NF1 in schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the hippo pathway

Chen, Z., Mo, J., Brosseau, J. P., Shipman, T., Wang, Y., Liao Ph.D., C. P., Cooper, J. M., Allaway, R. J., Gosline, S. J. C., Guinney, J., Carroll, T. J. & Le, L. Q., Jan 1 2019, In : Cancer Discovery. 9, 1, p. 114-129 16 p.

Research output: Contribution to journalArticle

Neurofibroma
Neurofibromatosis 1
Schwann Cells
Cell Lineage
Skin
2018
6 Citations (Scopus)

Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis

Liao, C. P., Booker, R. C., Brosseau, J. P., Chen, Z., Mo, J., Tchegnon, E., Wang, Y., Clapp, D. W. & Le, L. Q., Jul 2 2018, In : Journal of Clinical Investigation. 128, 7, p. 2848-2861 14 p.

Research output: Contribution to journalArticle

Neurofibroma
Tumor Microenvironment
Carcinogenesis
Inflammation
Mast Cells

Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Liao Ph.D., C. P., Tchegnon, E. & Le, L. Q., Jan 1 2018, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

Double-Stranded RNA
Skin
Epithelial Cells
Keratinocytes
Keratin-9
2 Citations (Scopus)

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Brosseau, J. P., Liao Ph.D., C. P., Wang, Y., Ramani, V., Vandergriff, T. W., Lee, M., Patel, A., Ariizumi, K. & Le, L. Q., Dec 1 2018, In : Nature Communications. 9, 1, 5014.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Tumors
Carcinogenesis
tumors
genes
2017
12 Citations (Scopus)

Identification of hair shaft progenitors that create a niche for hair pigmentation

Liao, C. P., Booker, R. C., Morrison, S. J. & Le, L. Q., Apr 15 2017, In : Genes and Development. 31, 8, p. 744-756 13 p.

Research output: Contribution to journalArticle

Melanocytes
Pigmentation
Stem Cell Factor
Stem Cells
Hair Follicle
2016
11 Citations (Scopus)

The role of nerve microenvironment for neurofibroma development

Liao, C. P., Pradhan, S., Chen, Z., Patel, A. J., Booker, R. C. & Le, L. Q., 2016, In : Oncotarget. 7, 38, p. 61500-61508 9 p.

Research output: Contribution to journalArticle

Neurofibroma
Neurofibromatosis 1
Peripheral Nerves
Schwann Cells
Carcinogenesis
2015
107 Citations (Scopus)

An interconnected hierarchical model of cell death regulation by the BCL-2 family

Chen, H. C., Kanai, M., Inoue-Yamauchi, A., Tu, H. C., Huang, Y., Ren, D., Kim, H., Takeda, S., Reyna, D. E., Chan, P. M., Ganesan, Y. T., Liao, C. P., Gavathiotis, E., Hsieh, J. J. & Cheng, E. H., Oct 3 2015, In : Nature Cell Biology. 17, 10, p. 1270-1281 12 p.

Research output: Contribution to journalArticle

Cell Death
Apoptosis
Puma
Noxae
Molecular Biology
2014
42 Citations (Scopus)

BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through bim induction

Patel, A., Liao, C. P., Chen, Z., Liu, C., Wang, Y. & Le, L., 2014, In : Cell Reports. 6, 1, p. 81-92 12 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Neurilemmoma
Tumors
Apoptosis
Transcriptome
33 Citations (Scopus)

Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma

Chen, Z., Liu, C., Patel, A. J., Liao, C. P., Wang, Y. & Le, L. Q., Nov 10 2014, In : Cancer Cell. 26, 5, p. 695-706 12 p.

Research output: Contribution to journalArticle

Plexiform Neurofibroma
Neurofibroma
Neoplasms
Preclinical Drug Evaluations
Inborn Genetic Diseases
2011
4 Citations (Scopus)

Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Liao, C. P., Hage, C. A., Durant, P. J., Tschang, D., Wang, S. H., Zhang, C. & Lee, C. H., Apr 1 2011, In : American Journal of Respiratory Cell and Molecular Biology. 44, 4, p. 540-547 8 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Nitric Oxide
Nitric Oxide Synthase Type II
Pneumocystis
2010
16 Citations (Scopus)

Downregulation of PU.1 leads to decreased expression of dectin-1 in alveolar macrophages during Pneumocystis pneumonia

Zhang, C., Wang, S. H., Liao, C. P., Shao, S., Lasbury, M. E., Durant, P. J. & Lee, C. H., Mar 1 2010, In : Infection and Immunity. 78, 3, p. 1058-1065 8 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Down-Regulation
Pneumocystis
Luciferases
9 Citations (Scopus)

Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages

Cheng, B. H., Liu, Y., Xuei, X., Liao, C. P., Lu, D., Lasbury, M. E., Durant, P. J. & Lee, C. H., Apr 15 2010, In : BMC Microbiology. 10, 103.

Research output: Contribution to journalArticle

Pneumocystis Infections
Alveolar Macrophages
Pneumocystis
Gene Expression
Pneumocystis Pneumonia
2009
6 Citations (Scopus)

Effects of decreased calmodulin protein on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Liao, C. P. & Lee, C. H., Aug 1 2009, In : Infection and Immunity. 77, 8, p. 3344-3354 11 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Alveolar Macrophages
Calmodulin
1-Phosphatidylinositol 4-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
19 Citations (Scopus)

Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages

Liao, C. P., Lasbury, M. E., Wang, S. H., Zhang, C., Durant, P. J., Murakami, Y., Matsufuji, S. & Lee, C. H., Mar 20 2009, In : Journal of Biological Chemistry. 284, 12, p. 8174-8184 11 p.

Research output: Contribution to journalArticle

Pneumocystis
Alveolar Macrophages
Polyamines
Pneumocystis Pneumonia
Apoptosis
6 Citations (Scopus)

Polyamine transport as a target for treatment of Pneumocystis pneumonia

Liao, C. P., Phanstiel IV, O., Lasbury, M. E., Zhang, C., Shao, S., Durant, P. J., Cheng, B. H. & Lee, C. H., Dec 1 2009, In : Antimicrobial Agents and Chemotherapy. 53, 12, p. 5259-5264 6 p.

Research output: Contribution to journalArticle

Pneumocystis Pneumonia
Polyamines
Ants
Alveolar Macrophages
Diamines
2008
17 Citations (Scopus)

Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia

Wang, S. H., Zhang, C., Lasbury, M. E., Liao, C. P., Durant, P. J., Tschang, D. & Lee, C. H., Apr 1 2008, In : Microbes and Infection. 10, 4, p. 334-341 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Pneumocystis Pneumonia
Knockout Mice
Pneumocystis
Lung
2006
1 Citation (Scopus)

Alterations in surfactant protein A form and clearance during Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein A
Animal Disease Models
Pneumocystis Pneumonia
pneumonia
respiratory disease
1 Citation (Scopus)

Caspase-9 as a target for Pneumocystis pneumonia therapy

Lasbury, M. E., Wang, S. H., Zhang, C., Liao, C. P., Durant, P. J., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Caspase 10
Pneumocystis
Pneumocystis Pneumonia
pneumonia
respiratory disease
1 Citation (Scopus)

Expression and activation of complement protein and alveolar damage during pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Tschang, D., Wang, S. H., Zhang, C., Liao, C. P. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pulmonary Alveoli
Complement C5a
Pneumocystis
Animal Disease Models
Complement C3
2 Citations (Scopus)

GM-CSF expression in the lung during Pneumocystis pneumonia

Lasbury, M. E., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Animal Disease Models
Pneumocystis Pneumonia
pneumonia
respiratory disease
Bronchoalveolar Lavage Fluid
2 Citations (Scopus)

Inflammatory cells are sources of polyamines that induce alveolar macrophage to undergo apoptosis during Pneumocystis pneumonia

Liao, C. P., Lasbury, M. E., Wang, S. H., Zhang, C., Durant, P. J., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Pneumocystis Pneumonia
Ornithine Decarboxylase
pneumonia
1 Citation (Scopus)

Survival pathway signal transduction is reduced in alveolar macrophages during Pneumocystis pneumonia

Lasbury, M. E., Ray, C. A., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Animal Disease Models
Proto-Oncogene Proteins c-akt
Pneumocystis Pneumonia
pneumonia
2 Citations (Scopus)

Syndecan-1 expression in the lung during Pneumocystis infection

Wang, S. H., Zhang, C., Liao, C. P., Lasbury, M. E., Durant, P. J., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Matrix Metalloproteinase 12
Syndecan-1
Pneumocystis Infections
Matrix Metalloproteinase 14
Animal Disease Models
5 Citations (Scopus)

Toll-like receptor 2 knockout reduces lung inflammation during Pneumocystis pneumonia but has no effect on phagocytosis of Pneumocystis organisms by alveolar macrophages

Zhang, C., Wang, S. H., Liao, C. P., Lasbury, M. E., Durant, P. J., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Pneumocystis
Animal Disease Models
Toll-Like Receptor 2
Histocytochemistry
Pneumocystis Pneumonia
51 Citations (Scopus)

Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina

Zhang, C., Wang, S. H., Lasbury, M. E., Tschang, D., Liao, C. P., Durant, P. J. & Lee, C. H., Mar 1 2006, In : Infection and Immunity. 74, 3, p. 1857-1864 8 p.

Research output: Contribution to journalArticle

Pneumocystis
Murinae
Toll-Like Receptor 2
Alveolar Macrophages
Chemokine CXCL2
3 Citations (Scopus)

Transforming growth factor-β activation and signaling in the alveolar environment during Pneumocystis pneumonia

Ray, C. A., Lasbury, M. E., Durant, P. J., Wang, S. H., Zhang, C., Liao, C. P., Tschang, D. & Lee, C. H., Nov 1 2006, In : Journal of Eukaryotic Microbiology. 53, SUPPL. 1

Research output: Contribution to journalArticle

Smad Proteins
Animal Disease Models
Pneumocystis Pneumonia
pneumonia
respiratory disease
2002
3 Citations (Scopus)

Analysis of the baseplate region of phage AR1 that specifically infects Escherichia coli O157: H7

Liao, C. P. & Syu, W. J., Dec 1 2002, In : Journal of Microbiology, Immunology and Infection. 35, 4, p. 269-271 3 p.

Research output: Contribution to journalArticle

Escherichia coli O157
Bacteriophages
Genes
Bacteria