Research Output 1967 2019

2019

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Fermaintt, C. S., Sano, K., Liu, Z., Ishii, N., Seino, J., Dobbs, N., Suzuki, T., Fu, Y-X., Lehrman, M. A., Matsuo, I. & Yan, N., Dec 1 2019, In : Nature communications. 10, 1, 2377.

Research output: Contribution to journalArticle

Open Access
Disaccharides
activity (biology)
Autoimmunity
Autoimmune Diseases
Polysaccharides
1 Citation (Scopus)

A chaperone for the stator units of a bacterial flagellum

Ribardo, D. A., Kelley, B. R., Johnson, J. G. & Hendrixson, D. R., Jan 1 2019, In : mBio. 10, 4, e01732-19.

Research output: Contribution to journalArticle

Open Access
Campylobacter jejuni
Flagella
Torque
Bacteria
Electric Power Supplies

AcrAB-TolC Inhibition by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in Vitro and in Vivo

Sturge, C. R., Felder-Scott, C. F., Pifer, R., Pybus, C., Jain, R., Geller, B. L. & Greenberg, D. E., Jan 1 2019, In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Morpholinos
Anti-Bacterial Agents
Peptides
Azithromycin
Lactams

A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB

Liu, Z., Mar, K. B., Hanners, N. W., Perelman, S. S., Kanchwala, M., Xing, C., Schoggins, J. W. & Alto, N. M., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

Transcription Factors
Inflammation
Organogenesis
Homeobox Genes
Immune System Diseases
3 Citations (Scopus)

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., Scaturro, P., Mann, A., Brunotte, L., Hoffmann, H. H., Schoggins, J. W., Schwemmle, M., Mann, M., Rice, C. M. & Pichlmair, A., Jan 1 2019, In : Nature Immunology.

Research output: Contribution to journalArticle

Protein Interaction Maps
Interferons
Immune System
Gene Regulatory Networks
Genes
4 Citations (Scopus)

Bacterial stabilization of a panel of picornaviruses

Aguilera, E. R., Nguyen, Y., Sasaki, J. & Pfeiffer, J. K., Mar 1 2019, In : mSphere. 4, 2, e00183-19.

Research output: Contribution to journalArticle

Open Access
Picornaviridae
Poliovirus
Enterovirus
Kobuvirus
Bacteria
67 Citations (Scopus)

Biological Functions of Autophagy Genes: A Disease Perspective

Levine, B. & Kroemer, G., Jan 10 2019, In : Cell. 176, 1-2, p. 11-42 32 p.

Research output: Contribution to journalReview article

Autophagy
Genes
Neurodegenerative diseases
Protein Deficiency
Aging of materials
1 Citation (Scopus)

Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Frankel, A. E., Deshmukh, S., Reddy, A., Lightcap, J., Hayes, M., McClellan, S., Singh, S., Rabideau, B., Glover, T. G., Roberts, B. & Koh, A., Apr 1 2019, In : Integrative Cancer Therapies. 18

Research output: Contribution to journalReview article

Open Access
Tumor Microenvironment
Immunosuppressive Agents
Immunotherapy
Immune System
Bacteria
7 Citations (Scopus)

CDK9: a signaling hub for transcriptional control

Bacon, C. W. & D'orso, I., Mar 15 2019, In : Transcription. 10, 2, p. 57-75 19 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinase 9
Transcription
Elongation
Small Nucleolar RNA
Dichlororibofuranosylbenzimidazole

Comparative analysis of viral entry for Asian and African lineages of Zika virus

Rinkenberger, N. & Schoggins, J. W., Jul 1 2019, In : Virology. 533, p. 59-67 9 p.

Research output: Contribution to journalArticle

Virus Internalization
Zika Virus
Clathrin
Endosomes
Endocytosis

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Zhu, W., Miyata, N., Winter, M. G., Arenales, A., Hughes, E. R., Spiga, L., Kim, J., Sifuentes-Dominguez, L., Starokadomskyy, P., Gopal, P., Byndloss, M. X., Santos, R. L., Burstein, E. & Winter, S. E., Oct 7 2019, In : The Journal of experimental medicine. 216, 10, p. 2378-2393 16 p.

Research output: Contribution to journalArticle

Open Access
Azoxymethane
Colitis
Colorectal Neoplasms
Carcinogenesis
Enterobacteriaceae
2 Citations (Scopus)

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
Serum Amyloid A Protein
Retinoic Acid Receptors
Vitamin A
Immunity
Th17 Cells

Gypsy moth genome provides insights into flight capability and virus–host interactions

Zhang, J., Cong, Q., Rex, E. A., Hallwachs, W., Janzen, D. H., Grishin, N. V. & Gammon, D. B., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1669-1678 10 p.

Research output: Contribution to journalArticle

Moths
Genome
Gene Ontology
Population
Virus Diseases
1 Citation (Scopus)

Host-derived metabolites modulate transcription of salmonella genes involved in L-Lactate utilization during gut colonization

Gillis, C. C., Winter, M. G., Chanin, R. B., Zhu, W., Spiga, L. & Winter, S. E., Apr 1 2019, In : Infection and immunity. 87, 4, e00773.

Research output: Contribution to journalArticle

Salmonella
Lactic Acid
Genes
Oxygen
Electrons
1 Citation (Scopus)

Identification and characterization of a poliovirus capsid mutant with enhanced thermal stability

Nguyen, Y., Jesudhasan, P. R., Aguilera, E. R. & Pfeiffer, J. K., Mar 1 2019, In : Journal of Virology. 93, 6, e01510-18.

Research output: Contribution to journalArticle

Enterovirus C
capsid
Poliovirus
Capsid
thermal stability
1 Citation (Scopus)

IIV-6 Inhibits NF-κB Responses in Drosophila

West, C., Rus, F., Chen, Y., Kleino, A., Gangloff, M., Gammon, D. B. & Silverman, N., May 1 2019, In : Viruses. 11, 5

Research output: Contribution to journalArticle

Open Access
Immune Evasion
Diptera
Drosophila
Pectobacterium carotovorum
Candy

Immune control of the microbiota prevents obesity

Wang, Y. & Hooper, L. V., Jul 26 2019, In : Science (New York, N.Y.). 365, 6451, p. 316-317 2 p.

Research output: Contribution to journalComment/debate

Microbiota
Obesity
T-Lymphocytes
5 Citations (Scopus)

Indole signaling at the host-microbiota-pathogen interface

Kumar, A. & Sperandio, V., May 1 2019, In : mBio. 10, 3, e01031-19.

Research output: Contribution to journalArticle

Open Access
Microbiota
Citrobacter rodentium
Virulence
Enterohemorrhagic Escherichia coli
Gastrointestinal Tract
1 Citation (Scopus)

Infection-induced intestinal dysbiosis is mediated by macrophage activation and nitrate production

Wang, S., El-Fahmawi, A., Christian, D. A., Fang, Q., Radaelli, E., Chen, L., Sullivan, M. C., Misic, A. M., Ellringer, J. A., Zhu, X. Q., Winter, S. E., Hunter, C. A. & Beiting, D. P., May 1 2019, In : mBio. 10, 3, e00935-19.

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Macrophage Activation
Nitrates
Toxoplasma
Infection

Interferon-Stimulated Genes: What Do They All Do?

Schoggins, J. W., Sep 29 2019, In : Annual Review of Virology. 6, p. 567-584 18 p.

Research output: Contribution to journalArticle

Innate Immunity
Interferons
Antiviral Agents
Viruses
Genes
Open Access
Nuclear RNA
Human Herpesvirus 8
RNA Stability
Viral Proteins
Radioactivity
1 Citation (Scopus)

MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis

Kuhbandner, K., Hammer, A., Haase, S., Terbrack, E., Hoffmann, A., Schippers, A., Wagner, N., Hussain, R. Z., Miller-Little, W. A., Koh, A., Stoolman, J. S., Segal, B. M., Linker, R. A. & Stuve, O., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Autoimmune Experimental Encephalomyelitis
Cell Adhesion Molecules
Intestines
Lymphocytes
Multiple Sclerosis
Long Noncoding RNA
Prolactin
Growth Hormone
MicroRNAs
Genes

Molecular basis for retinol binding by serum amyloid A during infection

Hu, Z., Bang, Y. J., Ruhn, K. A. & Hooper, L. V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19077-19082 6 p.

Research output: Contribution to journalArticle

Open Access
Serum Amyloid A Protein
Vitamin A
Infection
HDL Lipoproteins
Mutagenesis

Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo

Peng, H., Chau, V. Q., Phetsang, W., Sebastian, R. M., Stone, M. R. L., Datta, S., Renwick, M., Tamer, Y. T., Toprak, E., Koh, A., Blaskovich, M. A. T. & Hulleman, J. D., Dec 13 2019, In : Molecular Therapy - Methods and Clinical Development. 15, p. 27-39 13 p.

Research output: Contribution to journalArticle

Open Access
Tetrahydrofolate Dehydrogenase
Trimethoprim
Blood-Retinal Barrier
Proteins
Microbial Drug Resistance

Nox2 regulates platelet activation and net formation in the lung

Hook, J. S., Cao, M., Potera, R. M., Alsmadi, N. Z., Schmidtke, D. W. & Moreland, J. G., Jan 1 2019, In : Frontiers in immunology. 10, JULY, 1472.

Research output: Contribution to journalArticle

Open Access
NADPH Oxidase
Platelet Activation
Systemic Inflammatory Response Syndrome
Lung
Blood Platelets

Rapid ultrasensitive detection platform for antimicrobial susceptibility testing

Cansizoglu, M. F., Tamer, Y. T., Farid, M., Koh, A. & Toprak, E., May 1 2019, In : PLoS biology. 17, 5, p. e3000291

Research output: Contribution to journalArticle

Open Access
detectors
anti-infective agents
Anti-Bacterial Agents
Detectors
antibiotics

Reply to wood and lee, “precedence for the role of indole with pathogens”

Sperandio, V. & Kumar, A., Jan 1 2019, In : mBio. 10, 4, e01787-19.

Research output: Contribution to journalLetter

Open Access
Enterohemorrhagic Escherichia coli
indole
2 Citations (Scopus)

Rescue of rhesus macaques from the lethality of aerosolized ricin toxin

Roy, C. J., Ehrbar, D. J., Bohorova, N., Bohorov, O., Kim, D., Pauly, M., Whaley, K., Rong, Y., Torres-Velez, F. J., Vitetta, E. S., Didier, P. J., Doyle-Meyers, L., Zeitlin, L. & Mantis, N. J., Jan 10 2019, In : JCI Insight. 4, 1, e124771.

Research output: Contribution to journalArticle

Open Access
Ricin
Macaca mulatta
Primates
Immunodominant Epitopes
Bronchiolitis
2 Citations (Scopus)

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Harris-Tryon, T., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 777-788.e8

Research output: Contribution to journalArticle

Resistin
Vitamin A
Skin
Cell Shape
Infection
1 Citation (Scopus)

Screening Mycobacterium tuberculosis secreted proteins identifies Mpt64 as a eukaryotic membrane-binding bacterial effector

Stamm, C. E., Pasko, B. L., Chaisavaneeyakorn, S., Franco, L. H., Nair, V. R., Weigele, B. A., Alto, N. M. & Shiloh, M. U., May 1 2019, In : mSphere. 4, 3, e00354-19.

Research output: Contribution to journalArticle

Open Access
Mycobacterium tuberculosis
Membranes
Proteins
Macrophages
Unfolded Protein Response
12 Citations (Scopus)

Shared and Distinct Functions of Type I and Type III Interferons

Lazear, H. M., Schoggins, J. W. & Diamond, M. S., Apr 16 2019, In : Immunity. 50, 4, p. 907-923 17 p.

Research output: Contribution to journalReview article

Interferon Type I
Interferons
Virus Activation
Virus Diseases
Infection Control

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium

Wilson, R. P., Tursi, S. A., Rapsinski, G. J., Medeiros, N. J., Le, L. S., Kotredes, K. P., Patel, S., Liverani, E., Sun, S., Zhu, W., Kilpatrick, L., Winter, S. E., Gamero, A. M. & Tükel, Ç., Apr 1 2019, In : PLoS pathogens. 15, 4, p. e1007745

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Interferon Type I
Salmonella typhimurium
Neutrophils
Bacteroidetes
1 Citation (Scopus)

STIM1 moonlights as an anchor for STING

Wu, J. & Yan, N., Feb 1 2019, In : Nature Immunology. 20, 2, p. 112-114 3 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Calcium
3 Citations (Scopus)

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

Wu, J., Chen, Y. J., Dobbs, N., Sakai, T., Liou, J., Miner, J. J. & Yan, N., Apr 1 2019, In : The Journal of experimental medicine. 216, 4, p. 867-883 17 p.

Research output: Contribution to journalArticle

Homeostasis
Cell Death
Calcium
T-Lymphocytes
Unfolded Protein Response
1 Citation (Scopus)

Strength in numbers: Mechanisms of viral co-infection

Aguilera, E. R. & Pfeiffer, J. K., May 1 2019, In : Virus Research. 265, p. 43-46 4 p.

Research output: Contribution to journalReview article

RNA Viruses
Virus Diseases
Coinfection
Viruses
Defective Viruses

Taming the beast: Interplay between gut small molecules and enteric pathogens

Kumar, A., Ellermann, M. & Sperandio, V., Sep 1 2019, In : Infection and immunity. 87, 9, e00131-19.

Research output: Contribution to journalShort survey

Anti-Bacterial Agents
Virulence
Bacteria
Centers for Disease Control and Prevention (U.S.)
Microbial Drug Resistance

The antibiotic neomycin enhances coxsackievirus plaque formation

Acevedo, M. A. W., Erickson, A. K. & Pfeiffer, J. K., Jan 1 2019, In : mSphere. 4, 1, e00632-18.

Research output: Contribution to journalArticle

Open Access
Neomycin
Enterovirus
Anti-Bacterial Agents
Microbiota
Bacteria

The gut microbiota in transplant patients

Chong, P. P. E. & Koh, A., Jan 1 2019, (Accepted/In press) In : Blood Reviews. 100614.

Research output: Contribution to journalReview article

Transplants
Hematopoietic Stem Cells
Dysbiosis
Gastrointestinal Microbiome
Probiotics

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

Kuang, Z., Wang, Y., Li, Y., Ye, C., Ruhn, K. A., Behrendt, C. L., Olson, E. N. & Hooper, L. V., Sep 27 2019, In : Science. 365, 6460, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

Circadian Rhythm
Microbiota
Lipids
Photoperiod
Periodicity
1 Citation (Scopus)

Transcriptional Circuit Fragility Influences HIV Proviral Fate

Morton, E. L., Forst, C. V., Zheng, Y., DePaula-Silva, A. B., Ramirez, N. G. P., Planelles, V. & D'orso, I., Apr 2 2019, In : Cell Reports. 27, 1, p. 154-171.e9

Research output: Contribution to journalArticle

Open Access
HIV
Networks (circuits)
Transcriptional Activation
Viruses
Chemical activation

Transition metals and host-microbe interactions in the inflamed intestine

Zhu, W., Spiga, L. & Winter, S. E., Jan 1 2019, In : BioMetals.

Research output: Contribution to journalArticle

transition elements
Intestines
Transition metals
intestines
Metals
2018
11 Citations (Scopus)

A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

Richardson, R. B., Ohlson, M. B., Eitson, J. L., Kumar, A., McDougal, M. B., Boys, I. N., Mar, K. B., De La Cruz-Rivera, P. C., Douglas, C., Konopka, G., Xing, C. & Schoggins, J. W., Nov 1 2018, In : Nature Microbiology. 3, 11, p. 1214-1223 10 p.

Research output: Contribution to journalLetter

Clustered Regularly Interspaced Short Palindromic Repeats
Flavivirus
Endoplasmic Reticulum
Interferons
Proteins

Adaptation of Candida albicans During Gastrointestinal Tract Colonization

Mishra, A. A. & Koh, A., Sep 1 2018, In : Current Clinical Microbiology Reports. 5, 3, p. 165-172 8 p.

Research output: Contribution to journalReview article

Candida albicans
Gastrointestinal Tract
Immune System
Microbiota
Virulence Factors
2 Citations (Scopus)

Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice

Potera, R. M., Cao, M., Jordan, L. F., Hogg, R. T., Hook, J. S. & Moreland, J. G., Jan 1 2018, (Accepted/In press) In : Inflammation.

Research output: Contribution to journalArticle

Alveolar Macrophages
Lung Injury
Chemokines
NADPH Oxidase
Systemic Inflammatory Response Syndrome
7 Citations (Scopus)

An increase in LRRK2 suppresses autophagy and enhances dectin-1–induced immunity in a mouse model of colitis

Takagawa, T., Kitani, A., Fuss, I., Levine, B., Brant, S. R., Peter, I., Tajima, M., Nakamura, S. & Strober, W., Jun 6 2018, In : Science Translational Medicine. 10, 444, eaan8162.

Research output: Contribution to journalArticle

Autophagy
Colitis
Dendritic Cells
Immunity
Crohn Disease
4 Citations (Scopus)

Antimicrobial activity of ibuprofen against cystic fibrosis-associated gram-negative pathogens

Shah, P. N., Marshall-Batty, K. R., Smolen, J. A., Tagaev, J. A., Chen, Q., Rodesney, C. A., Le, H. H., Gordon, V. D., Greenberg, D. E. & Cannon, C. L., Mar 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, e01574-17.

Research output: Contribution to journalArticle

Ibuprofen
Cystic Fibrosis
Bronchoalveolar Lavage Fluid
Growth
Pseudomonas
3 Citations (Scopus)

Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection

Daly, S. M., Sturge, C. R., Marshall-Batty, K. R., Felder-Scott, C. F., Jain, R., Geller, B. L. & Greenberg, D. E., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 806-814 9 p.

Research output: Contribution to journalArticle

Burkholderia Infections
Burkholderia
Cystic Fibrosis
Chronic Granulomatous Disease
Lung
1 Citation (Scopus)

Arbovirus infections as screening tools for the identification of viral immunomodulators and host antiviral factors

Rex, E. A., Seo, D. & Gammon, D. B., Sep 13 2018, In : Journal of Visualized Experiments. 2018, 139, e58244.

Research output: Contribution to journalArticle

Arbovirus Infections
Vesicular Stomatitis
Immunologic Factors
Viruses
Antiviral Agents
23 Citations (Scopus)

Autophagy and the cell biology of age-related disease

Leidal, A. M., Levine, B. & Debnath, J., Dec 1 2018, In : Nature Cell Biology. 20, 12, p. 1338-1348 11 p.

Research output: Contribution to journalReview article

Autophagy
Cell Biology
Homeostasis
Health