Research Output 1967 2019

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2019

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Fermaintt, C. S., Sano, K., Liu, Z., Ishii, N., Seino, J., Dobbs, N., Suzuki, T., Fu, Y-X., Lehrman, M. A., Matsuo, I. & Yan, N., Dec 1 2019, In : Nature communications. 10, 1, 2377.

Research output: Contribution to journalArticle

Open Access
Disaccharides
activity (biology)
Autoimmunity
Autoimmune Diseases
Polysaccharides
1 Citation (Scopus)

A chaperone for the stator units of a bacterial flagellum

Ribardo, D. A., Kelley, B. R., Johnson, J. G. & Hendrixson, D. R., Jan 1 2019, In : mBio. 10, 4, e01732-19.

Research output: Contribution to journalArticle

Open Access
Campylobacter jejuni
Flagella
Torque
Bacteria
Electric Power Supplies

AcrAB-TolC Inhibition by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in Vitro and in Vivo

Sturge, C. R., Felder-Scott, C. F., Pifer, R., Pybus, C., Jain, R., Geller, B. L. & Greenberg, D. E., Jan 1 2019, In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Morpholinos
Anti-Bacterial Agents
Peptides
Azithromycin
Lactams
3 Citations (Scopus)

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., Scaturro, P., Mann, A., Brunotte, L., Hoffmann, H. H., Schoggins, J. W., Schwemmle, M., Mann, M., Rice, C. M. & Pichlmair, A., Jan 1 2019, In : Nature Immunology.

Research output: Contribution to journalArticle

Protein Interaction Maps
Interferons
Immune System
Gene Regulatory Networks
Genes
4 Citations (Scopus)

Bacterial stabilization of a panel of picornaviruses

Aguilera, E. R., Nguyen, Y., Sasaki, J. & Pfeiffer, J. K., Mar 1 2019, In : mSphere. 4, 2, e00183-19.

Research output: Contribution to journalArticle

Open Access
Picornaviridae
Poliovirus
Enterovirus
Kobuvirus
Bacteria

Comparative analysis of viral entry for Asian and African lineages of Zika virus

Rinkenberger, N. & Schoggins, J. W., Jul 1 2019, In : Virology. 533, p. 59-67 9 p.

Research output: Contribution to journalArticle

Virus Internalization
Zika Virus
Clathrin
Endosomes
Endocytosis

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Zhu, W., Miyata, N., Winter, M. G., Arenales, A., Hughes, E. R., Spiga, L., Kim, J., Sifuentes-Dominguez, L., Starokadomskyy, P., Gopal, P., Byndloss, M. X., Santos, R. L., Burstein, E. & Winter, S. E., Oct 7 2019, In : The Journal of experimental medicine. 216, 10, p. 2378-2393 16 p.

Research output: Contribution to journalArticle

Open Access
Azoxymethane
Colitis
Colorectal Neoplasms
Carcinogenesis
Enterobacteriaceae
2 Citations (Scopus)

Epithelial retinoic acid receptor β regulates serum amyloid A expression and Vitamin A-dependent intestinal immunity

Gattu, S., Bang, Y. J., Pendse, M., Dende, C., Chara, A. L., Harris-Tryon, T., Wang, Y., Ruhn, K. A., Kuang, Z., Sockanathan, S. & Hooper, L. V., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10911-10916 6 p.

Research output: Contribution to journalArticle

Open Access
Serum Amyloid A Protein
Retinoic Acid Receptors
Vitamin A
Immunity
Th17 Cells

Gypsy moth genome provides insights into flight capability and virus–host interactions

Zhang, J., Cong, Q., Rex, E. A., Hallwachs, W., Janzen, D. H., Grishin, N. V. & Gammon, D. B., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1669-1678 10 p.

Research output: Contribution to journalArticle

Moths
Genome
Gene Ontology
Population
Virus Diseases
1 Citation (Scopus)

Host-derived metabolites modulate transcription of salmonella genes involved in L-Lactate utilization during gut colonization

Gillis, C. C., Winter, M. G., Chanin, R. B., Zhu, W., Spiga, L. & Winter, S. E., Apr 1 2019, In : Infection and immunity. 87, 4, e00773.

Research output: Contribution to journalArticle

Salmonella
Lactic Acid
Genes
Oxygen
Electrons
1 Citation (Scopus)

Identification and characterization of a poliovirus capsid mutant with enhanced thermal stability

Nguyen, Y., Jesudhasan, P. R., Aguilera, E. R. & Pfeiffer, J. K., Mar 1 2019, In : Journal of Virology. 93, 6, e01510-18.

Research output: Contribution to journalArticle

Enterovirus C
capsid
Poliovirus
Capsid
thermal stability
1 Citation (Scopus)

IIV-6 Inhibits NF-κB Responses in Drosophila

West, C., Rus, F., Chen, Y., Kleino, A., Gangloff, M., Gammon, D. B. & Silverman, N., May 1 2019, In : Viruses. 11, 5

Research output: Contribution to journalArticle

Open Access
Immune Evasion
Diptera
Drosophila
Pectobacterium carotovorum
Candy
5 Citations (Scopus)

Indole signaling at the host-microbiota-pathogen interface

Kumar, A. & Sperandio, V., May 1 2019, In : mBio. 10, 3, e01031-19.

Research output: Contribution to journalArticle

Open Access
Microbiota
Citrobacter rodentium
Virulence
Enterohemorrhagic Escherichia coli
Gastrointestinal Tract
1 Citation (Scopus)

Infection-induced intestinal dysbiosis is mediated by macrophage activation and nitrate production

Wang, S., El-Fahmawi, A., Christian, D. A., Fang, Q., Radaelli, E., Chen, L., Sullivan, M. C., Misic, A. M., Ellringer, J. A., Zhu, X. Q., Winter, S. E., Hunter, C. A. & Beiting, D. P., May 1 2019, In : mBio. 10, 3, e00935-19.

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Macrophage Activation
Nitrates
Toxoplasma
Infection

Interferon-Stimulated Genes: What Do They All Do?

Schoggins, J. W., Sep 29 2019, In : Annual Review of Virology. 6, p. 567-584 18 p.

Research output: Contribution to journalArticle

Innate Immunity
Interferons
Antiviral Agents
Viruses
Genes
Open Access
Nuclear RNA
Human Herpesvirus 8
RNA Stability
Viral Proteins
Radioactivity
1 Citation (Scopus)

MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis

Kuhbandner, K., Hammer, A., Haase, S., Terbrack, E., Hoffmann, A., Schippers, A., Wagner, N., Hussain, R. Z., Miller-Little, W. A., Koh, A., Stoolman, J. S., Segal, B. M., Linker, R. A. & Stuve, O., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Autoimmune Experimental Encephalomyelitis
Cell Adhesion Molecules
Intestines
Lymphocytes
Multiple Sclerosis
Long Noncoding RNA
Prolactin
Growth Hormone
MicroRNAs
Genes

Molecular basis for retinol binding by serum amyloid A during infection

Hu, Z., Bang, Y. J., Ruhn, K. A. & Hooper, L. V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19077-19082 6 p.

Research output: Contribution to journalArticle

Open Access
Serum Amyloid A Protein
Vitamin A
Infection
HDL Lipoproteins
Mutagenesis

Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo

Peng, H., Chau, V. Q., Phetsang, W., Sebastian, R. M., Stone, M. R. L., Datta, S., Renwick, M., Tamer, Y. T., Toprak, E., Koh, A., Blaskovich, M. A. T. & Hulleman, J. D., Dec 13 2019, In : Molecular Therapy - Methods and Clinical Development. 15, p. 27-39 13 p.

Research output: Contribution to journalArticle

Open Access
Tetrahydrofolate Dehydrogenase
Trimethoprim
Blood-Retinal Barrier
Proteins
Microbial Drug Resistance

Nox2 regulates platelet activation and net formation in the lung

Hook, J. S., Cao, M., Potera, R. M., Alsmadi, N. Z., Schmidtke, D. W. & Moreland, J. G., Jan 1 2019, In : Frontiers in immunology. 10, JULY, 1472.

Research output: Contribution to journalArticle

Open Access
NADPH Oxidase
Platelet Activation
Systemic Inflammatory Response Syndrome
Lung
Blood Platelets

Rapid ultrasensitive detection platform for antimicrobial susceptibility testing

Cansizoglu, M. F., Tamer, Y. T., Farid, M., Koh, A. & Toprak, E., May 1 2019, In : PLoS biology. 17, 5, p. e3000291

Research output: Contribution to journalArticle

Open Access
detectors
anti-infective agents
Anti-Bacterial Agents
Detectors
antibiotics
2 Citations (Scopus)

Rescue of rhesus macaques from the lethality of aerosolized ricin toxin

Roy, C. J., Ehrbar, D. J., Bohorova, N., Bohorov, O., Kim, D., Pauly, M., Whaley, K., Rong, Y., Torres-Velez, F. J., Vitetta, E. S., Didier, P. J., Doyle-Meyers, L., Zeitlin, L. & Mantis, N. J., Jan 10 2019, In : JCI Insight. 4, 1, e124771.

Research output: Contribution to journalArticle

Open Access
Ricin
Macaca mulatta
Primates
Immunodominant Epitopes
Bronchiolitis
2 Citations (Scopus)

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Harris-Tryon, T., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A. & Hooper, L. V., Jun 12 2019, In : Cell Host and Microbe. 25, 6, p. 777-788.e8

Research output: Contribution to journalArticle

Resistin
Vitamin A
Skin
Cell Shape
Infection
1 Citation (Scopus)

Screening Mycobacterium tuberculosis secreted proteins identifies Mpt64 as a eukaryotic membrane-binding bacterial effector

Stamm, C. E., Pasko, B. L., Chaisavaneeyakorn, S., Franco, L. H., Nair, V. R., Weigele, B. A., Alto, N. M. & Shiloh, M. U., May 1 2019, In : mSphere. 4, 3, e00354-19.

Research output: Contribution to journalArticle

Open Access
Mycobacterium tuberculosis
Membranes
Proteins
Macrophages
Unfolded Protein Response

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium

Wilson, R. P., Tursi, S. A., Rapsinski, G. J., Medeiros, N. J., Le, L. S., Kotredes, K. P., Patel, S., Liverani, E., Sun, S., Zhu, W., Kilpatrick, L., Winter, S. E., Gamero, A. M. & Tükel, Ç., Apr 1 2019, In : PLoS pathogens. 15, 4, p. e1007745

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Interferon Type I
Salmonella typhimurium
Neutrophils
Bacteroidetes
1 Citation (Scopus)

STIM1 moonlights as an anchor for STING

Wu, J. & Yan, N., Feb 1 2019, In : Nature Immunology. 20, 2, p. 112-114 3 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Calcium
3 Citations (Scopus)

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

Wu, J., Chen, Y. J., Dobbs, N., Sakai, T., Liou, J., Miner, J. J. & Yan, N., Apr 1 2019, In : The Journal of experimental medicine. 216, 4, p. 867-883 17 p.

Research output: Contribution to journalArticle

Homeostasis
Cell Death
Calcium
T-Lymphocytes
Unfolded Protein Response

The antibiotic neomycin enhances coxsackievirus plaque formation

Acevedo, M. A. W., Erickson, A. K. & Pfeiffer, J. K., Jan 1 2019, In : mSphere. 4, 1, e00632-18.

Research output: Contribution to journalArticle

Open Access
Neomycin
Enterovirus
Anti-Bacterial Agents
Microbiota
Bacteria

The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3

Kuang, Z., Wang, Y., Li, Y., Ye, C., Ruhn, K. A., Behrendt, C. L., Olson, E. N. & Hooper, L. V., Sep 27 2019, In : Science. 365, 6460, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

Circadian Rhythm
Microbiota
Lipids
Photoperiod
Periodicity
1 Citation (Scopus)

Transcriptional Circuit Fragility Influences HIV Proviral Fate

Morton, E. L., Forst, C. V., Zheng, Y., DePaula-Silva, A. B., Ramirez, N. G. P., Planelles, V. & D'orso, I., Apr 2 2019, In : Cell Reports. 27, 1, p. 154-171.e9

Research output: Contribution to journalArticle

Open Access
HIV
Networks (circuits)
Transcriptional Activation
Viruses
Chemical activation

Transition metals and host-microbe interactions in the inflamed intestine

Zhu, W., Spiga, L. & Winter, S. E., Jan 1 2019, In : BioMetals.

Research output: Contribution to journalArticle

transition elements
Intestines
Transition metals
intestines
Metals
2018
2 Citations (Scopus)

Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice

Potera, R. M., Cao, M., Jordan, L. F., Hogg, R. T., Hook, J. S. & Moreland, J. G., Jan 1 2018, (Accepted/In press) In : Inflammation.

Research output: Contribution to journalArticle

Alveolar Macrophages
Lung Injury
Chemokines
NADPH Oxidase
Systemic Inflammatory Response Syndrome
7 Citations (Scopus)

An increase in LRRK2 suppresses autophagy and enhances dectin-1–induced immunity in a mouse model of colitis

Takagawa, T., Kitani, A., Fuss, I., Levine, B., Brant, S. R., Peter, I., Tajima, M., Nakamura, S. & Strober, W., Jun 6 2018, In : Science Translational Medicine. 10, 444, eaan8162.

Research output: Contribution to journalArticle

Autophagy
Colitis
Dendritic Cells
Immunity
Crohn Disease
4 Citations (Scopus)

Antimicrobial activity of ibuprofen against cystic fibrosis-associated gram-negative pathogens

Shah, P. N., Marshall-Batty, K. R., Smolen, J. A., Tagaev, J. A., Chen, Q., Rodesney, C. A., Le, H. H., Gordon, V. D., Greenberg, D. E. & Cannon, C. L., Mar 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, e01574-17.

Research output: Contribution to journalArticle

Ibuprofen
Cystic Fibrosis
Bronchoalveolar Lavage Fluid
Growth
Pseudomonas
3 Citations (Scopus)

Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection

Daly, S. M., Sturge, C. R., Marshall-Batty, K. R., Felder-Scott, C. F., Jain, R., Geller, B. L. & Greenberg, D. E., May 11 2018, In : ACS Infectious Diseases. 4, 5, p. 806-814 9 p.

Research output: Contribution to journalArticle

Burkholderia Infections
Burkholderia
Cystic Fibrosis
Chronic Granulomatous Disease
Lung
1 Citation (Scopus)

Arbovirus infections as screening tools for the identification of viral immunomodulators and host antiviral factors

Rex, E. A., Seo, D. & Gammon, D. B., Sep 13 2018, In : Journal of Visualized Experiments. 2018, 139, e58244.

Research output: Contribution to journalArticle

Arbovirus Infections
Vesicular Stomatitis
Immunologic Factors
Viruses
Antiviral Agents
33 Citations (Scopus)

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

Erickson, A. K., Jesudhasan, P. R., Mayer, M. J., Narbad, A., Winter, S. E. & Pfeiffer, J. K., Jan 10 2018, In : Cell Host and Microbe. 23, 1, p. 77-88.e5

Research output: Contribution to journalArticle

Enterovirus Infections
Coinfection
Genetic Recombination
Bacteria
Virus Diseases
11 Citations (Scopus)

Bacteriophage Transcription Factor Cro Regulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli

Hernandez-Doria, J. D. & Sperandio, V., May 9 2018, (Accepted/In press) In : Cell Host and Microbe. p. 607-617.e6

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Bacteriophages
Virulence
Transcription Factors
Gene Expression
5 Citations (Scopus)

Balance between MAT2A intron detention and splicing is determined cotranscriptionally

Pendleton, K. E., Park, S. K., Hunter, O. V., Bresson, S. M. & Conrad, N. K., Jun 1 2018, In : RNA. 24, 6, p. 778-786 9 p.

Research output: Contribution to journalArticle

Introns
S-Adenosylmethionine
Messenger RNA
RNA Precursors
Methionine Adenosyltransferase
18 Citations (Scopus)

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

Sun, Y., Yao, X., Zhang, Q. J., Zhu, M., Liu, Z-P., Ci, B., Xie, Y., Carlson, D. L., Rothermel, B. A., Sun, Y., Levine, B., Hill, J. A., Wolf, S. E., Minei, J. P. & Zang, Q., Nov 13 2018, In : Circulation. 138, 20, p. 2247-2262 16 p.

Research output: Contribution to journalArticle

Autophagy
Sepsis
Lipopolysaccharides
Sirolimus
Mitochondrial Degradation

Biophysical insights into a highly selective l-arginine-binding lipoprotein of a pathogenic treponeme

Deka, R. K., Liu, W. Z., Tso, S. C., Norgard, M. V. & Brautigam, C. A., Jan 1 2018, (Accepted/In press) In : Protein Science.

Research output: Contribution to journalArticle

Lipoproteins
Arginine
Treponema pallidum
Proteins
Carrier Proteins
6 Citations (Scopus)

Campylobacter jejuni: collective components promoting a successful enteric lifestyle

Burnham, P. M. & Hendrixson, D. R., Jun 11 2018, (Accepted/In press) In : Nature Reviews Microbiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
Life Style
Nutritional Requirements
Symbiosis
Flagella
8 Citations (Scopus)

Campylobact er jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin

He, Z., Gharaibeh, R. Z., Newsome, R. C., Pope, J. L., Dougherty, M. W., Tomkovich, S., Pons, B., Mirey, G., Vignard, J., Hendrixson, D. R. & Jobin, C., Jan 1 2018, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Campylobacter jejuni
Carcinogenesis
Campylobacter Infections
Sirolimus
Ribosomal DNA
12 Citations (Scopus)

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

Peraro, L., Deprey, K. L., Moser, M. K., Zou, Z., Ball, H. L., Levine, B. & Kritzer, J. A., Sep 12 2018, In : Journal of the American Chemical Society. 140, 36, p. 11360-11369 10 p.

Research output: Contribution to journalArticle

Assays
Peptides
Drug Discovery
Throughput
Cell Line

Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012–2015

Aroh, C., Liang, C., Raj, P., Wakeland, B., Yan, N. & Wakeland, E., Dec 1 2018, In : Infection, Genetics and Evolution. 66, p. 13-17 5 p.

Research output: Contribution to journalArticle

West Nile virus
Satellite Viruses
Disease Outbreaks
persistence
West Nile Fever
2 Citations (Scopus)

Complete genome sequence of Escherichia albertii strain 1551-2, a potential extracellular and intracellular pathogen

Romão, F. T., Hernandes, R. T., Ooka, T., Hayashi, T., Sperandio, V. & Gomes, T. A. T., Mar 1 2018, In : Genome Announcements. 6, 9, e00075-18.

Research output: Contribution to journalArticle

Escherichia
Genome
Birds
Chromosomes
1 Citation (Scopus)
Treponema pallidum
Carrier Proteins
Ligands
Glucose
Crystals
58 Citations (Scopus)

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Jun 7 2018, In : Nature. 558, 7708, p. 136-140 5 p.

Research output: Contribution to journalArticle

Autophagy
Premature Aging
Phenotype
Mutation
Infertility
1 Citation (Scopus)

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., Tang, Y. W., Hooper, L. V., Bordenstein, S. R., Das, S. R. & Weitkamp, J. H., Oct 1 2018, In : PLoS One. 13, 10, e0206366.

Research output: Contribution to journalArticle

enterocolitis
Necrotizing Enterocolitis
microbial communities
Microbiota
antibiotics