Research output per year
Research output per year
- 1 - 50 out of 57 results
Search results
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2024
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
Rex, E. A., Seo, D., Chappidi, S., Pinkham, C., Brito Oliveira, S., Embry, A., Heisler, D., Liu, Y., Munir, M., Luger, K., Alto, N. M., da Fonseca, F. G., Orchard, R., Hancks, D. C. & Gammon, D. B., 2024, (Accepted/In press) In: Nature microbiology.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Monkeypox virus infection of human astrocytes causes gasdermin B cleavage and pyroptosis
Miranzadeh Mahabadi, H., Lin, Y. C. J., Ogando, N. S., Moussa, E. W., Mohammadzadeh, N., Julien, O., Alto, N. M., Noyce, R. S., Evans, D. H. & Power, C., Feb 20 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 8, p. e2315653121Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A Concerted Mechanism Involving ACAT and SREBPs By which Oxysterols Deplete Accessible Cholesterol To Restrict Microbial Infection
Heisler, D. B., Johnson, K. A., Ma, D., Ohlson, M. B., Zhang, L., Tran, M., Corley, C. D., Abrams, M. E., McDonald, J. G., Schoggins, J. W., Alto, N. M. & Radhakrishnan, A., Jan 2023, In: eLife. 12, e83534.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8
Yin, H., Zheng, J., He, Q., Zhang, X., Li, X., Ma, Y., Liang, X., Gao, J., Kocsis, B. L., Li, Z., Liu, X., Alto, N. M., Li, L. & Zhang, H., Dec 2023, In: Nature communications. 14, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2022
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis
Ramirez, N. G. P., Lee, J., Zheng, Y., Li, L., Dennis, B., Chen, D., Challa, A., Planelles, V., Westover, K. D., Alto, N. M. & D’Orso, I., Dec 2022, In: Nature communications. 13, 1, 1109.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2021
Over-expression Screen of Interferon-Stimulated Genes Identifies RARRES3 as a Restrictor of Toxoplasma gondii Infection
Rinkenberger, N., Abrams, M. E., Matta, S. K., Schoggins, J. W., Alto, N. M. & Sibley, D., Dec 2021, In: eLife. 10, e73137.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions
Hansen, J. M., de Jong, M. F., Wu, Q., Zhang, L. S., Heisler, D. B., Alto, L. T. & Alto, N. M., Jun 10 2021, In: Cell. 184, 12, p. 3178-3191.e18Research output: Contribution to journal › Article › peer-review
Open Access92 Scopus citations -
Systematic reconstruction of an effector-gene network reveals determinants of Salmonella cellular and tissue tropism
Chen, D., Burford, W. B., Pham, G., Zhang, L., Alto, L. T., Ertelt, J. M., Winter, M. G., Winter, S. E., Way, S. S. & Alto, N. M., Oct 13 2021, In: Cell Host and Microbe. 29, 10, p. 1531-1544.e9Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Toxins, mutations and adaptations
DE JONG, M. & Alto, N. M., Feb 2021, In: eLife. 10, p. 1-4 4 p., e66676.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
2020
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein
Zhang, R., Lee, D. M., Jimah, J. R., Gerassimov, N., Yang, C., Kim, S., Luvsanjav, D., Winkelman, J., Mettlen, M., Abrams, M. E., Kalia, R., Keene, P., Pandey, P., Ravaux, B., Kim, J. H., Ditlev, J. A., Zhang, G., Rosen, M. K., Frost, A., Alto, N. M., & 5 others, Jun 1 2020, In: Nature cell biology. 22, 6, p. 674-688 15 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
Abrams, M. E., Johnson, K. A., Perelman, S. S., Zhang, L. S., Endapally, S., Mar, K. B., Thompson, B. M., McDonald, J. G., Schoggins, J. W., Radhakrishnan, A. & Alto, N. M., Jul 1 2020, In: Nature microbiology. 5, 7, p. 929-942 14 p.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
2019
A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB
Liu, Z., Mar, K. B., Hanners, N. W., Perelman, S. S., Kanchwala, M., Xing, C., Schoggins, J. W. & Alto, N. M., Apr 11 2019, In: Nature. 568, 7751, p. 249-253 5 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Screening Mycobacterium tuberculosis secreted proteins identifies Mpt64 as a eukaryotic membrane-binding bacterial effector
Stamm, C. E., Pasko, B. L., Chaisavaneeyakorn, S., Franco, L. H., Nair, V. R., Weigele, B. A., Alto, N. M. & Shiloh, M. U., May 1 2019, In: mSphere. 4, 3, e00354-19.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2018
Cooperative immune suppression by Escherichia coli and Shigella effector proteins
de Jong, M. F. & Alto, N. M., Apr 1 2018, In: Infection and immunity. 86, 4, e00560-17.Research output: Contribution to journal › Short survey › peer-review
Open Access15 Scopus citations -
2017
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
Weigele, B. A., Orchard, R. C., Jimenez, A., Cox, G. W. & Alto, N. M., Dec 1 2017, In: Nature communications. 8, 1, 532.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
2016
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection
Perelman, S. S., Abrams, M. E., Eitson, J. L., Chen, D., Jimenez, A., Mettlen, M., Schoggins, J. W. & Alto, N. M., Dec 21 2016, In: PLoS pathogens. 12, 12, e1006102.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
How Bacteria Subvert Animal Cell Structure and Function
Jimenez, A., Chen, D. & Alto, N. M., Oct 6 2016, In: Annual Review of Cell and Developmental Biology. 32, p. 373-397 25 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation
De Jong, M. F., Liu, Z., Chen, D. & Alto, N. M., May 27 2016, In: Nature microbiology. 1, 7, 16084.Research output: Contribution to journal › Article › peer-review
72 Scopus citations -
2015
Myristoylome profiling reveals a concerted mechanism of ARF GTPase deacylation by the bacterial protease IpaJ
Burnaevskiy, N., Peng, T., Reddick, L. E., Hang, H. C. & Alto, N. M., Apr 2 2015, In: Molecular cell. 58, 1, p. 110-122 13 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
STING activation by translocation from the ER is associated with infection and autoinflammatory disease
Dobbs, N., Burnaevskiy, N., Chen, D., Gonugunta, V. K., Alto, N. M. & Yan, N., Aug 12 2015, In: Cell Host and Microbe. 18, 2, p. 157-168 12 p.Research output: Contribution to journal › Article › peer-review
Open Access387 Scopus citations -
2014
Bacteria fighting back: How pathogens target and subvert the host innate immune system
Reddick, L. E. & Alto, N. M., Apr 24 2014, In: Molecular cell. 54, 2, p. 321-328 8 p.Research output: Contribution to journal › Review article › peer-review
154 Scopus citations -
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration
Glotfelty, L. G., Zahs, A., Hodges, K., Shan, K., Alto, N. M. & Hecht, G. A., Dec 1 2014, In: Cellular Microbiology. 16, 12, p. 1767-1783 17 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Selective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest
Selyunin, A. S., Reddick, L. E., Weigele, B. A. & Alto, N. M., 2014, In: Cell Reports. 6, 5, p. 878-891 14 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Thinking outside the Osp(G) - Kinase activation by E2-ubiquitin
De Jong, M. F. & Alto, N. M., Mar 3 2014, In: EMBO Journal. 33, 5, p. 403-404 2 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2013
Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ
Burnaevskiy, N., Fox, T. G., Plymire, D. A., Ertelt, J. M., Weigele, B. A., Selyunin, A. S., Way, S. S., Patrie, S. M. & Alto, N. M., Apr 4 2013, In: Nature. 496, 7443, p. 106-109 4 p.Research output: Contribution to journal › Article › peer-review
Open Access125 Scopus citations -
2012
Correlative light and electron microscopy (CLEM) as a tool to visualize microinjected molecules and their eukaryotic sub-cellular targets
Evan Reddick, L. & Alto, N. M., May 4 2012, In: Journal of Visualized Experiments. 63, p. 1 1 p., A2.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Express Your LOV: An Engineered Flavoprotein as a Reporter for Protein Expression and Purification
Gawthorne, J. A., Reddick, L. E., Akpunarlieva, S. N., Beckham, K. S. H., Christie, J. M., Alto, N. M., Gabrielsen, M. & Roe, A. J., Dec 27 2012, In: PloS one. 7, 12, e52962.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit
Orchard, R. C., Kittisopikul, M., Altschuler, S. J., Wu, L. F., Süel, G. M. & Alto, N. M., Feb 17 2012, In: Cell. 148, 4, p. 803-815 13 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Mimicking GEFs: A common theme for bacterial pathogens
Orchard, R. C. & Alto, N. M., Jan 2012, In: Cellular Microbiology. 14, 1, p. 10-18 9 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Subversion of cell signaling by pathogens
Alto, N. M. & Orth, K., Sep 2012, In: Cold Spring Harbor Perspectives in Biology. 4, 9Research output: Contribution to journal › Article › peer-review
88 Scopus citations -
2011
Activation of PAK by a bacterial type III effector EspG reveals alternative mechanisms of GTPase pathway regulation
Selyunin, A. S. & Alto, N. M., 2011, In: Small GTPases. 2, 4, p. 217-221 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold
Selyunin, A. S., Sutton, S. E., Weigele, B. A., Reddick, L. E., Orchard, R. C., Bresson, S. M., Tomchick, D. R. & Alto, N. M., Jan 6 2011, In: Nature. 469, 7328, p. 107-113 7 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
2010
E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism
Weflen, A. W., Alto, N. M., Viswanathan, V. K. & Hecht, G., Jul 2010, In: Cellular Microbiology. 12, 7, p. 919-929 11 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Rab32 modulates apoptosis onset and Mitochondria-associated Membrane (MAM) properties
Bui, M., Gilady, S. Y., Fitzsimmons, R. E. B., Benson, M. D., Lynes, E. M., Gesson, K., Alto, N. M., Strack, S., Scott, J. D. & Simmen, T., Oct 8 2010, In: Journal of Biological Chemistry. 285, 41, p. 31590-31602 13 p.Research output: Contribution to journal › Article › peer-review
131 Scopus citations -
Salmonella taking charge
Weigele, B. A. & Alto, N. M., Jun 17 2010, In: Cell Host and Microbe. 7, 6, p. 421-422 2 p.Research output: Contribution to journal › Comment/debate › peer-review
4 Scopus citations -
2009
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
Huang, Z., Sutton, S. E., Wallenfang, A. J., Orchard, R. C., Wu, X., Feng, Y., Chai, J. & Alto, N. M., Aug 2009, In: Nature Structural and Molecular Biology. 16, 8, p. 853-860 8 p.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
Tight junctions and enteropathogenic E. coli
Weflen, A. W., Alto, N. M. & Hecht, G. A., May 2009, Molecular Structure and Function of the Tight Junction From Basic Mechanisms to Clinical Manifestations. Blackwell Publishing Inc., p. 169-174 6 p. (Annals of the New York Academy of Sciences; vol. 1165).Research output: Chapter in Book/Report/Conference proceeding › Chapter
20 Scopus citations -
2008
Analysis of Rho-GTPase Mimicry by a Family of Bacterial Type III Effector Proteins
Alto, N. M. & Dixon, J. E., 2008, In: Methods in Enzymology. 439, p. 131-143 13 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Mimicking small G-proteins: An emerging theme from the bacterial virulence arsenal
Alto, N. M., Mar 2008, In: Cellular Microbiology. 10, 3, p. 566-575 10 p.Research output: Contribution to journal › Short survey › peer-review
14 Scopus citations -
Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation
Ohlson, M. B., Huang, Z., Alto, N. M., Blanc, M. P., Dixon, J. E., Chai, J. & Miller, S. I., Nov 13 2008, In: Cell Host and Microbe. 4, 5, p. 434-446 13 p.Research output: Contribution to journal › Article › peer-review
147 Scopus citations -
Subversion of Myosin Function by E. coli
Mattoo, S., Alto, N. M. & Dixon, J. E., Jan 15 2008, In: Developmental cell. 14, 1, p. 8-10 3 p.Research output: Contribution to journal › Short survey › peer-review
3 Scopus citations -
The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity
Hodges, K., Alto, N. M., Ramaswamy, K., Dudeja, P. K. & Hecht, G., Aug 2008, In: Cellular Microbiology. 10, 8, p. 1735-1745 11 p.Research output: Contribution to journal › Article › peer-review
57 Scopus citations -
2007
Shigella Puts the Brakes on the Host Cell Cycle
Alto, N. M., Sep 13 2007, In: Cell Host and Microbe. 2, 3, p. 141-142 2 p.Research output: Contribution to journal › Short survey › peer-review
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The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways
Alto, N. M., Weflen, A. W., Rardin, M. J., Yarar, D., Lazar, C. S., Tonikian, R., Koller, A., Taylor, S. S., Boone, C., Sidhu, S. S., Schmid, S. L., Hecht, G. A. & Dixon, J. E., Sep 24 2007, In: Journal of Cell Biology. 178, 7, p. 1265-1278 14 p.Research output: Contribution to journal › Article › peer-review
107 Scopus citations -
2006
Identification of a bacterial type III effector family with G protein mimicry functions
Alto, N. M., Shao, F., Lazar, C. S., Brost, R. L., Chua, G., Mattoo, S., McMahon, S. A., Ghosh, P., Hughes, T. R., Boone, C. & Dixon, J. E., Jan 13 2006, In: Cell. 124, 1, p. 133-145 13 p.Research output: Contribution to journal › Article › peer-review
222 Scopus citations -
2005
Functions of the Yersinia effector proteins in inhibiting host immune responses
Navarro, L., Alto, N. M. & Dixon, J. E., Feb 2005, In: Current Opinion in Microbiology. 8, 1, p. 21-27 7 p.Research output: Contribution to journal › Review article › peer-review
99 Scopus citations -
2004
The role of A-Kinase anchoring proteins in cAMP-mediated signal transduction pathways.
Alto, N. M. & Scott, J. D., 2004, In: Cell biochemistry and biophysics. 40, 3 Suppl, p. 201-207 7 p.Research output: Contribution to journal › Review article › peer-review
7 Scopus citations -
2003
Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring
Alto, N. M., Soderling, S. H., Hoshi, N., Langeberg, L. K., Fayos, R., Jennings, P. A. & Scott, J. D., Apr 15 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 8, p. 4445-4450 6 p.Research output: Contribution to journal › Article › peer-review
147 Scopus citations -
Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation
Kraiss, L. W., Alto, N. M., Dixon, D. A., McIntyre, T. M., Weyrich, A. S. & Zimmerman, G. A., Jan 1 2003, In: Journal of vascular surgery. 37, 1, p. 161-168 8 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
2002
Intracellular targeting of protein kinases and phosphatases
Alto, N., Carlisle Michel, J. J., Dodge, K. L., Langeberg, L. K. & Scott, J. D., Dec 1 2002, In: Diabetes. 51, SUPPL. 3, p. S385-S388Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations