Research output per year
Research output per year
- 50 results
Search results
-
2024
Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation
Randolph, K., Hyder, U., Challa, A., Perez, E. & D’Orso, I., Jan 2024, In: Viruses. 16, 1, 116.Research output: Contribution to journal › Article › peer-review
Open Access -
HIV-1 Proviral Genome Engineering with CRISPR-Cas9 for Mechanistic Studies
Hyder, U., Shukla, A., Challa, A. & D’Orso, I., Feb 2024, In: Viruses. 16, 2, 287.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Mathematical Models of HIV-1 Dynamics, Transcription, and Latency
D’Orso, I. & Forst, C. V., Oct 2023, In: Viruses. 15, 10, 2119.Research output: Contribution to journal › Review article › peer-review
Open Access -
2022
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis
Ramirez, N. G. P., Lee, J., Zheng, Y., Li, L., Dennis, B., Chen, D., Challa, A., Planelles, V., Westover, K. D., Alto, N. M. & D’Orso, I., Dec 2022, In: Nature communications. 13, 1, 1109.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Decoding Human Genome Regulatory Features That Influence HIV-1 Proviral Expression and Fate Through an Integrated Genomics Approach
Ruess, H., Lee, J., Guzman, C., Malladi, V. & D’Orso, I., Feb 2022, In: Bioinformatics and Biology Insights. 16Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity
Cruz-Lorenzo, E., Ramirez, N. G. P., Lee, J., Pandhe, S., Wang, L., Hernandez-Doria, J., Spivak, A. M., Planelles, V., Petersen, T., Jain, M. K., Martinez, E. D. & D’Orso, I., Oct 2022, In: Viruses. 14, 10, 2288.Research output: Contribution to journal › Article › peer-review
Open Access -
KAP1/TRIM28: Transcriptional Activator and/or Repressor of Viral and Cellular Programs?
Randolph, K., Hyder, U. & D’Orso, I., Feb 23 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 834636.Research output: Contribution to journal › Review article › peer-review
Open Access24 Scopus citations -
The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication
Devlin, A. M., Shukla, A., Ruiz, J. C., Barnes, S. D., Govindan, A., Hunter, O. V., Scarborough, A. M., D’Orso, I. & Conrad, N. K., Dec 2022, In: Nature communications. 13, 1, 7447.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Cleavage and polyadenylation specificity factor 6 is required for efficient hiv-1 latency reversal
Zheng, Y., Schubert, H. L., Singh, P. K., Martins, L. J., Engelman, A. N., D’orso, I., Hill, C. P. & Planelles, V., Jun 2021, In: mBio. 12, 3, e01098-21.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Nascent RNA: Friend or foe of the chromatin bound?
Hyder, U. & D'Orso, I., Jul 15 2021, In: Molecular cell. 81, 14, p. 2871-2872 2 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
HIV-1 proviral transcription and latency in the new era
Shukla, A., Ramirez, N. G. P. & D'Orso, I., May 2020, In: Viruses. 12, 5, v12050555.Research output: Contribution to journal › Review article › peer-review
Open Access31 Scopus citations -
KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs
Bacon, C. W., Challa, A., Hyder, U., Shukla, A., Borkar, A. N., Bayo, J., Liu, J., Wu, S. Y., Chiang, C. M., Kutateladze, T. G. & D'Orso, I., Jun 18 2020, In: Molecular cell. 78, 6, p. 1133-1151.e14Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
The ARF tumor suppressor targets PPM1G/PP2Cγ to counteract NF-κB transcription tuning cell survival and the inflammatory response
Hyder, U., McCann, J. L., Wang, J., Fung, V., Bayo, J. & D'Orso, I., Dec 22 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 51, p. 32594-32605 12 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2019
CDK9: a signaling hub for transcriptional control
Bacon, C. W. & D’Orso, I., Mar 15 2019, In: Transcription. 10, 2, p. 57-75 19 p.Research output: Contribution to journal › Review article › peer-review
Open Access123 Scopus citations -
Transcriptional Circuit Fragility Influences HIV Proviral Fate
Morton, E. L., Forst, C. V., Zheng, Y., DePaula-Silva, A. B., Ramirez, N. G. P., Planelles, V. & D'Orso, I., Apr 2 2019, In: Cell Reports. 27, 1, p. 154-171.e9Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2018
Structural basis for assembly and function of the 7SK snRNP complex
Borkar, A. N. & D’Orso, I., Dec 2018, In: Non-Coding RNA Investigation. 2, 70.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Scopus citations -
The HIV-1 tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation
Faust, T. B., Li, Y., Bacon, C. W., Jang, G. M., Weiss, A., Jayaraman, B., Newton, B. W., Krogan, N. J., D’orso, I. & Frankel, A. D., May 30 2018, In: eLife. 7, e31879.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2017
CIPHER: A flexible and extensive workflow platform for integrative next-generation sequencing data analysis and genomic regulatory element prediction
Guzman, C. & D'Orso, I., Aug 8 2017, In: BMC Bioinformatics. 18, 1, 363.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Tandem affinity purification of protein complexes from eukaryotic cells
Ma, Z., Fung, V. & D'orso, I., Jan 26 2017, In: Journal of Visualized Experiments. 2017, 119, e55236.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2016
7SKiing on chromatin: Move globally, act locally
D'Orso, I., Jun 2 2016, In: RNA Biology. 13, 6, p. 545-553 9 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II
McNamara, R. P., Guzman, C., Reeder, J. E. & D'Orso, I., Mar 1 2016, In: Genomics Data. 7, p. 250-255 6 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II
McNamara, R. P., Reeder, J. E., McMillan, E. A., Bacon, C. W., McCann, J. L. & D'Orso, I., Jan 7 2016, In: Molecular cell. 61, 1, p. 39-53 15 p.Research output: Contribution to journal › Article › peer-review
Open Access96 Scopus citations -
Transcription elongation control by the 7SK snRNP complex: Releasing the pause
McNamara, R. P., Bacon, C. W. & D'Orso, I., Aug 17 2016, In: Cell Cycle. 15, 16, p. 2115-2123 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access29 Scopus citations -
2015
Association of UBP1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P32 protein
Cassola, A., Romaniuk, M. A., Primrose, D., Cervini, G., D'Orso, I. & Frasch, A. C., Sep 1 2015, In: Molecular Microbiology. 97, 6, p. 1079-1096 18 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells
Reeder, J. E., Kwak, Y. T., McNamara, R. P., Forst, C. V. & D’Orso, I., Oct 21 2015, In: eLife. 4, OCTOBER2015, e08955.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
PPM1G binds 7SK RNA and Hexim1 to block P-TEFb assembly into the 7SK snRNP and sustain transcription elongation
Gudipaty, S. A., McNamara, R. P., Morton, E. L. & D'Orso, I., 2015, In: Molecular and cellular biology. 35, 22, p. 3810-3828 19 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
2013
Mechanisms of eukaryotic transcription: a meeting report August 27–31, 2013, CSHL, Cold Spring Harbor, New York
D'Orso, I., 2013, In: Transcription. 4, 5, p. 273-285 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Transcription factors mediate the enzymatic disassembly of promoter-bound 7sk snrnp to locally recruit p-tefb for transcription elongation
McNamara, R., McCann, J., Gudipaty, S. A. & D'Orso, I., Dec 12 2013, In: Cell Reports. 5, 5, p. 1256-1268 13 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
2012
Global landscape of HIV-human protein complexes
Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J. R., McGovern, K. E., Clarke, S. C., Shales, M., Mercenne, G., Pache, L., Li, K., Hernandez, H., Jang, G. M., Roth, S. L., Akiva, E., Marlett, J., Stephens, M., D'Orso, I., Fernandes, J., Fahey, M., Mahon, C., & 17 others, Jan 19 2012, In: Nature. 481, 7381, p. 365-370 6 p.Research output: Contribution to journal › Article › peer-review
Open Access553 Scopus citations -
Transcription control by long non-coding RNAs
Faust, T., Frankel, A. D. & D'Orso, I., 2012, In: Transcription. 3, 2, p. 78-86 9 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Transition step during assembly of HIV tat: P-TEFb transcription complexes and transfer to TAR RNA
D'orso, I., Jang, G. M., Pastuszak, A. W., Faust, T. B., Quezada, E., Booth, D. S. & Frankel, A. D., Dec 2012, In: Molecular and cellular biology. 32, 23, p. 4780-4793 14 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
2011
Purification and characterization of HIV-human protein complexes
Jäger, S., Gulbahce, N., Cimermancic, P., Kane, J., He, N., Chou, S., D'Orso, I., Fernandes, J., Jang, G., Frankel, A. D., Alber, T., Zhou, Q. & Krogan, N. J., Jan 2011, In: Methods. 53, 1, p. 13-19 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access52 Scopus citations -
2010
HIV-1 Tat: Its dependence on host factors is crystal clear
D'Orso, I. & Frankel, A. D., Oct 2010, In: Viruses. 2, 10, p. 2226-2234 9 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
D'Orso, I. & Frankel, A. D., Jul 2010, In: Nature Structural and Molecular Biology. 17, 7, p. 815-821 7 p.Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
2009
Host cell factors in HIV replication: Meta-analysis of genome-wide studies
Bushman, F. D., Malani, N., Fernandes, J., D'Orso, I., Cagney, G., Diamond, T. L., Zhou, H., Hazuda, D. J., Espeseth, A. S., König, R., Bandyopadhyay, S., Ideker, T., Goff, S. P., Krogan, N. J., Frankel, A. D., Young, J. A. T. & Chanda, S. K., May 2009, In: PLoS pathogens. 5, 5, e1000437.Research output: Contribution to journal › Review article › peer-review
373 Scopus citations -
Tat acetylation modulates assembly of a viral-host RNA-protein transcription complex
D'Orso, I. & Frankel, A. D., Mar 3 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3101-3106 6 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
2008
A Solution to Limited Genomic Capacity: Using Adaptable Binding Surfaces to Assemble the Functional HIV Rev Oligomer on RNA
Daugherty, M. D., D'Orso, I. & Frankel, A. D., Sep 26 2008, In: Molecular cell. 31, 6, p. 824-834 11 p.Research output: Contribution to journal › Article › peer-review
92 Scopus citations -
Targeting Tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes
D'Orso, I., Grunwell, J. R., Nakamura, R. L., Das, C. & Frankel, A. D., Oct 2008, In: Journal of virology. 82, 19, p. 9492-9504 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2007
mRNA maturation by two-step trans-splicing/polyadenylation processing in trypanosomes
Jäger, A. V., De Gaudenzi, J. G., Cassola, A., D'Orso, I. & Frasch, A. C., Feb 13 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 7, p. 2035-2042 8 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes
Hartmann, C., Benz, C., Brems, S., Ellis, L., Luu, V. D., Stewart, M., D'Orso, I., Busold, C., Fellenberg, K., Frasch, A. C. C., Carrington, M., Hoheisel, J. & Clayton, C. E., Nov 2007, In: Eukaryotic Cell. 6, 11, p. 1964-1978 15 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
2005
Insights into a CRM1-mediated RNA-nuclear export pathway in Trypanosoma cruzi
Cuevas, I. C., Frasch, A. C. C. & D'Orso, I., Jan 2005, In: Molecular and Biochemical Parasitology. 139, 1, p. 15-24 10 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: Contribution of a β hairpin to RNA binding
Volpon, L., D'Orso, I., Young, C. R., Frasch, A. C. & Gehring, K., Mar 15 2005, In: Biochemistry. 44, 10, p. 3708-3717 10 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
2003
RNA-binding proteins and mRNA turnover in trypanosomes
D'Orso, I., De Gaudenzi, J. G. & Frasch, A. C. C., Apr 1 2003, In: Trends in Parasitology. 19, 4, p. 151-155 5 p.Research output: Contribution to journal › Review article › peer-review
50 Scopus citations -
RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivo
De Gaudenzi, J. G., D'Orso, I. & Frasch, A. C. C., May 23 2003, In: Journal of Biological Chemistry. 278, 21, p. 18884-18894 11 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Solution structure of the C-terminal domain from poly(A)-binding protein in trypanosoma cruzi: A vegetal PABC domain
Siddiqui, N., Kozlov, G., D'Orso, I., Trempe, J. F. & Gehring, K., Sep 1 2003, In: Protein Science. 12, 9, p. 1925-1933 9 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2002
TcUBP-1, an mRNA destabilizing factor from trypanosomes, homodimerizes and interacts with novel AU-rich element- and poly(A)-binding proteins forming a ribonucleoprotein complex
D'Orso, I. & Frasch, A. C. C., Dec 27 2002, In: Journal of Biological Chemistry. 277, 52, p. 50520-50528 9 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
2001
Functionally Different AU- and G-rich cis-Elements Confer Developmentally Regulated mRNA Stability in Trypanosoma cruzi by Interaction with Specific RNA-binding Proteins
D'Orso, I. & Frasch, A. C. C., May 11 2001, In: Journal of Biological Chemistry. 276, 19, p. 15783-15793 11 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes
D'Orso, I. & Frasch, A. C. C., Sep 14 2001, In: Journal of Biological Chemistry. 276, 37, p. 34801-34809 9 p.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
2000
AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency
Di Noia, J. M., D'Orso, I., Sánchez, D. O. & Frasch, A. C. C., Apr 7 2000, In: Journal of Biological Chemistry. 275, 14, p. 10218-10227 10 p.Research output: Contribution to journal › Article › peer-review
120 Scopus citations -
1998
The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions
Di Noia, J. M., D'Orso, I., Åslund, L., Sánchez, D. O. & Frasch, A. C. C., May 1 1998, In: Journal of Biological Chemistry. 273, 18, p. 10843-10850 8 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations