Microbiology - Pfeiffer Lab

Research output

Research output per year 1999 2010 2011 2014 2016 2017 2019 2020 2021 2023

• 37 Article
• 4 Review article
• 3 Editorial
• 2 Comment/debate
• 5 More
  • 2 Letter
  • 2 Short survey
  • 1 Book

Research output per year

Research output per year

Search results

• 2023

  Introduction

  Dermody, T. S. & Pfeiffer, J. K., Sep 29 2023, In: Annual Review of Virology. 10, 1, p. I

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
• 2022

  Stabilization of Murine Norovirus by Bacteria

  Budicini, M. R. & Pfeiffer, J. K., Jun 2022, In: mSphere. 7, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Norovirus 100%
  • Bacteria 52%
  • Virion 36%
  • Enterovirus 26%
  • Gram-Negative Bacteria 23%
  3 Scopus citations
• 2021

  Beth Levine M.D. Prize in Autophagy Research

  Vitetta, E. S., Cobb, M. H., Hobbs, H. H., Hooper, L., Morrison, S. J., Orth, K., Pfeiffer, J., Rosen, M. K., Takahashi, J. S. & Wang, T., 2021, In: Autophagy. 17, 9, p. 2053 1 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Microbiota-immune system interactions and enteric virus infection

  Woods Acevedo, M. A. & Pfeiffer, J. K., Feb 2021, In: Current Opinion in Virology. 46, p. 15-19 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Enterovirus Infections 100%
  • Microbiota 69%
  • Immune System 56%
  • Enterovirus 54%
  • Gastrointestinal Microbiome 46%
  9 Scopus citations

• Sorting nexin 5 mediates virus-induced autophagy and immunity

  Dong, X., Yang, Y., Zou, Z., Zhao, Y., Ci, B., Zhong, L., Bhave, M., Wang, L., Kuo, Y. C., Zang, X., Zhong, R., Aguilera, E. R., Richardson, R. B., Simonetti, B., Schoggins, J. W., Pfeiffer, J. K., Yu, L., Zhang, X., Xie, Y., Schmid, S. L., & 6 othersXiao, G., Gleeson, P. A., Ktistakis, N. T., Cullen, P. J., Xavier, R. J. & Levine, B., Jan 21 2021, In: Nature. 589, 7842, p. 456-461 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sorting Nexins 100%
  • Autophagy 58%
  • Immunity 49%
  • phosphatidylinositol 3-phosphate 48%
  • Viruses 40%
  50 Scopus citations

• Sting mediates immune responses in the closest living relatives of animals

  Woznica, A., Kumar, A., Sturge, C. R., Xing, C., King, N. & Pfeiffer, J. K., Nov 2021, In: eLife. 10, e70436.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bites and Stings 100%
  • Dinucleotide 98%
  • Cell Death 48%
  • cyclic guanosine monophosphate-adenosine monophosphate 46%
  • Animals 45%
  21 Scopus citations

• Tradeoffs for a viral mutant with enhanced replication speed

  Lanahan, M. R., Maples, R. W. & Pfeiffer, J. K., Jul 27 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 30, e2105288118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mutation 100%
  • Cultured Cells 75%
  • Viruses 59%
  • Capsid 51%
  • Enterovirus 51%
  3 Scopus citations
• 2020

  Microbiota-independent antiviral effects of antibiotics on poliovirus and coxsackievirus: Antiviral Effects of Antibiotics on Enteric Viruses

  Woods Acevedo, M. A. & Pfeiffer, J. K., Jul 2020, In: Virology. 546, p. 20-24 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poliovirus 100%
  • Enterovirus 91%
  • Microbiota 79%
  • Antiviral Agents 68%
  • Anti-Bacterial Agents 52%
  5 Scopus citations

• Rapid dissemination and monopolization of viral populations in mice revealed using a panel of barcoded viruses

  McCune, B. T., Lanahan, M. R., TenOever, B. R. & Pfeiffer, J. K., Jan 1 2020, In: Journal of virology. 94, 2, e01590-19.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus 100%
  • Viruses 52%
  • viruses 51%
  • mice 45%
  • Population 30%
  9 Scopus citations

• Use of a glycan library reveals a new model for enteric virus oligosaccharide binding and virion stabilization

  Lu, H., Lehrman, M. A. & Pfeiffer, J. K., Mar 1 2020, In: Journal of virology. 94, 6, e01894-19.

  Research output: Contribution to journal › Article › peer-review

  • Virus Attachment 100%
  • Enterovirus 96%
  • carbohydrate binding 93%
  • Poliovirus 84%
  • Oligosaccharides 84%
  3 Scopus citations
• 2019

  Bacterial stabilization of a panel of picornaviruses

  Aguilera, E. R., Nguyen, Y., Sasaki, J. & Pfeiffer, J. K., Mar 1 2019, In: mSphere. 4, 2, e00183-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Picornaviridae 100%
  • Poliovirus 60%
  • Kobuvirus 56%
  • Enterovirus 55%
  • Bacteria 48%
  33 Scopus citations

• Identification and characterization of a poliovirus capsid mutant with enhanced thermal stability

  Nguyen, Y., Jesudhasan, P. R., Aguilera, E. R. & Pfeiffer, J. K., Mar 1 2019, In: Journal of virology. 93, 6, e01510-18.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus C 100%
  • Poliovirus 97%
  • capsid 91%
  • Capsid 89%
  • virion 74%
  12 Scopus citations

• Related enteric viruses have different requirements for host microbiota in mice

  Robinson, C. M., Woods Acevedo, M. A., McCune, B. T. & Pfeiffer, J. K., Dec 1 2019, In: Journal of virology. 9, 23, e01339-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus 100%
  • Microbiota 78%
  • microbiome 76%
  • Enterovirus C 73%
  • Poliovirus 72%
  23 Scopus citations

• Strength in numbers: Mechanisms of viral co-infection

  Aguilera, E. R. & Pfeiffer, J. K., May 2019, In: Virus Research. 265, p. 43-46 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • RNA Viruses 100%
  • Coinfection 85%
  • Virus Diseases 64%
  • Defective Viruses 61%
  • RNA Replicase 59%
  19 Scopus citations

• The Antibiotic Neomycin Enhances Coxsackievirus Plaque Formation

  Woods Acevedo, M. A., Erickson, A. K. & Pfeiffer, J. K., Feb 20 2019, In: mSphere. 4, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neomycin 100%
  • Enterovirus 91%
  • Anti-Bacterial Agents 52%
  • Microbiota 39%
  • Bacteria 33%
  7 Scopus citations
• 2018

  Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

  Erickson, A. K., Jesudhasan, P. R., Mayer, M. J., Narbad, A., Winter, S. E. & Pfeiffer, J. K., Jan 10 2018, In: Cell Host and Microbe. 23, 1, p. 77-88.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus Infections 100%
  • genetic recombination 92%
  • Enterovirus 89%
  • mixed infection 75%
  • Coinfection 68%
  124 Scopus citations
• 2017

  Plaques formed by mutagenized viral populations have elevated coinfection frequencies

  Aguilera, E. R., Erickson, A. K., Jesudhasan, P. R., Robinson, C. M. & Pfeiffer, J. K., Mar 1 2017, In: mBio. 8, 2, e02020-16.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coinfection 100%
  • Viruses 68%
  • Population 40%
  • Poliovirus 16%
  • Genome 13%
  42 Scopus citations

• Reply to Drayman, “Observed high coinfection rates seem to be a result of overlapping plaques”

  Pfeiffer, J. K., Jul 1 2017, In: mBio. 8, 4, e01201-17.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Sex-dependent intestinal replication of an enteric virus

  Robinson, C. M., Wang, Y. & Pfeiffer, J. K., 2017, In: Journal of virology. 91, 7, e02101-16.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus 100%
  • Intestines 51%
  • gender 48%
  • intestines 41%
  • virus replication 33%
  19 Scopus citations

• The importance of model systems: Why we study a virus on the brink of global eradication

  Pfeiffer, J. K., Apr 2017, In: PLoS pathogens. 13, 4, e1006330.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  1 Scopus citations
• 2016

  Comparison of three neurotropic viruses reveals differences in viral dissemination to the centrl nervous system

  Luethy, L. N., Erickson, A. K., Jesudhasan, P. R., Ikizler, M., Dermody, T. S. & Pfeiffer, J. K., Jan 1 2016, In: Virology. 487, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poliovirus 100%
  • Nervous System 81%
  • Central Nervous System 73%
  • Viruses 66%
  • Sciatic Nerve 63%
  26 Scopus citations

• Emergence of a large-plaque variant in mice infected with coxsackievirus B3

  Wang, Y. & Pfeiffer, J. K., Mar 29 2016, In: mBio. 7, 2, e00119-16.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enterovirus 100%
  • Agar 16%
  • Viruses 11%
  • Polysaccharides 10%
  • Capsid Proteins 6%
  27 Scopus citations

• Host response: Microbiota prime antiviral response

  Pfeiffer, J. K., Jan 27 2016, In: Nature Microbiology. 1, 2, 15029.

  Research output: Contribution to journal › Short survey › peer-review
  24 Scopus citations

• Viral immunity: Transkingdom control of viral infection and immunity in the mammalian intestine

  Pfeiffer, J. K. & Virgin, H. W., Jan 15 2016, In: Science. 351, 6270, aad5872.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Intestines 100%
  • Immunity 89%
  • Enterovirus 84%
  • Virus Diseases 81%
  • Microbiota 72%
  184 Scopus citations
• 2015

  Is the debate and “pause” on experiments that alter pathogens with pandemic potential influencing future plans of graduate students and postdoctoral fellows?

  Pfeiffer, J. K., Jan 20 2015, In: mBio. 6, 1, e02525-14.

  Research output: Contribution to journal › Letter › peer-review
  8 Scopus citations

• Spectrum of disease outcomes in mice infected with YFV-17D

  Erickson, A. K. & Pfeiffer, J. K., 2015, In: Journal of General Virology. 96, p. 1328-1339 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Yellow fever virus 100%
  • Viral Load 9%
  • Monocyte Chemoattractant Proteins 7%
  • Flavivirus Infections 7%
  • Yellow Fever Vaccine 7%
  19 Scopus citations
• 2014

  A backup for bacteria

  Wang, Y. & Pfeiffer, J. K., Dec 4 2014, In: Nature. 516, 729, p. 42-43 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  1 Scopus citations

• Bacterial lipopolysaccharide binding enhances virion stability and promotes environmental fitness of an enteric virus

  Robinson, C. M., Jesudhasan, P. R. & Pfeiffer, J. K., Jan 15 2014, In: Cell Host and Microbe. 15, 1, p. 36-46 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus C 100%
  • Enterovirus 98%
  • Poliovirus 97%
  • virion 74%
  • lipopolysaccharides 74%
  226 Scopus citations

• Leaping the norovirus hurdle: Bacteria and B cells solve the problem of culturing human norovirus in the laboratory

  Robinson, C. M. & Pfeiffer, J. K., Nov 7 2014, In: Science. 346, 6210, p. 700-701 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Scopus citations

• Welcome from the gems associate editors

  Goodrum, F., Pfeiffer, J., Schultz-Cherry, S., Sullivan, C. & Tsai, B., 2014, In: Journal of virology. 88, 10, p. 5207 1 p.

  Research output: Contribution to journal › Editorial › peer-review
• 2013

  Dynamic viral dissemination in mice infected with yellow fever virus strain 17D

  Erickson, A. K. & Pfeiffer, J. K., 2013, In: Journal of virology. 87, 22, p. 12392-12397 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Yellow fever virus 100%
  • mice 37%
  • Arboviruses 33%
  • arboviruses 30%
  • Vertebrates 29%
  26 Scopus citations
• 2012

  Viral infection brings mitochondrial traffic to a standstill

  Luethy, L. N. & Pfeiffer, J. K., May 17 2012, In: Cell Host and Microbe. 11, 5, p. 420-421 2 p.

  Research output: Contribution to journal › Short survey › peer-review

  • virus replication 100%
  • traffic 92%
  • Organelles 85%
  • organelles 76%
  • neurons 74%
  1 Scopus citations

• Viral population dynamics and virulence thresholds

  Lancaster, K. Z. & Pfeiffer, J. K., Aug 2012, In: Current Opinion in Microbiology. 15, 4, p. 525-530 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Population Dynamics 100%
  • RNA Viruses 95%
  • Quasispecies 88%
  • Virulence 72%
  • Asymptomatic Diseases 26%
  20 Scopus citations
• 2011

  Host-based ribavirin resistance influences hepatitis C virus replication and treatment response

  Ibarra, K. D., Jain, M. K. & Pfeiffer, J. K., Jul 2011, In: Journal of virology. 85, 14, p. 7273-7283 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepatitis C virus 100%
  • Ribavirin 77%
  • virus replication 76%
  • Virus Replication 69%
  • Hepacivirus 63%
  17 Scopus citations

• Intestinal microbiota promote enteric virus replication and systemic pathogenesis

  Kuss, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J., Frierson, J. M., Hooper, L. V., Dermody, T. S. & Pfeiffer, J. K., Oct 14 2011, In: Science. 334, 6053, p. 249-252 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poliovirus 100%
  • Enterovirus 91%
  • Virus Replication 80%
  • Gastrointestinal Microbiome 78%
  • Bacteria 43%
  470 Scopus citations

• Mechanisms controlling virulence thresholds of mixed viral populations

  Lancaster, K. Z. & Pfeiffer, J. K., Oct 2011, In: Journal of virology. 85, 19, p. 9778-9788 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Virulence 100%
  • virulence 92%
  • Viruses 76%
  • viruses 74%
  • Enterovirus C 65%
  12 Scopus citations

• The intestinal microbiota and viral susceptibility

  Pfeiffer, J. K. & Sonnenburg, J. L., 2011, In: Frontiers in Microbiology. 2, APR

  Research output: Contribution to journal › Article › peer-review

  • Gastrointestinal Microbiome 100%
  • Host Microbial Interactions 63%
  • Microbiota 50%
  • Viruses 33%
  • Infections 24%
  31 Scopus citations
• 2010

  Innate host barriers to viral trafficking and population diversity. Lessons learned from poliovirus

  Pfeiffer, J. K., 2010, C ed. Unknown Publisher. 34 p. (Advances in Virus Research; vol. 77, no. C)

  Research output: Book/Report › Book

  • Poliovirus 100%
  • Central Nervous System 47%
  • Poliomyelitis 37%
  • Population 31%
  • Vaccines 23%
  33 Scopus citations

• Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon response

  Lancaster, K. Z. & Pfeiffer, J. K., Mar 2010, In: PLoS pathogens. 6, 3, e1000791.

  Research output: Contribution to journal › Article › peer-review

  • axonal transport 100%
  • Enterovirus C 91%
  • Poliovirus 88%
  • Axonal Transport 88%
  • Interferon Type I 84%
  57 Scopus citations

• Ribavirin Improves Early Responses to Peginterferon Through Improved Interferon Signaling

  Feld, J. J., Lutchman, G. A., Heller, T., Hara, K., Pfeiffer, J. K., Leff, R. D., Meek, C., Rivera, M., Ko, M., Koh, C., Rotman, Y., Ghany, M. G., Haynes-Williams, V., Neumann, A. U., Liang, T. J. & Hoofnagle, J. H., Jul 2010, In: Gastroenterology. 139, 1, p. 154-162.e4

  Research output: Contribution to journal › Article › peer-review

  • Ribavirin 100%
  • Interferons 81%
  • Hepacivirus 32%
  • Kinetics 32%
  • Mutation Rate 18%
  95 Scopus citations
• 2009

  Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance

  Ibarra, K. D. & Pfeiffer, J. K., May 2009, In: Journal of virology. 83, 9, p. 4538-4547 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleoside Transport Proteins 100%
  • drug resistance 78%
  • Ribavirin 74%
  • nucleosides 71%
  • Drug Resistance 60%
  52 Scopus citations
• 2008

  Multiple host barriers restrict poliovirus trafficking in mice

  Kuss, S. K., Etheredge, C. A. & Pfeiffer, J. K., Jun 2008, In: PLoS pathogens. 4, 6, e1000082.

  Research output: Contribution to journal › Article › peer-review

  • poliovirus receptor 100%
  • Enterovirus C 76%
  • Poliovirus 74%
  • mice 34%
  • receptors 25%
  85 Scopus citations
• 2006

  Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain

  Pfeiffer, J. K. & Kirkegaard, K., Apr 4 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 14, p. 5520-5525 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Quasispecies 100%
  • RNA Viruses 80%
  • Poliovirus 44%
  • Viruses 35%
  • Brain 34%
  99 Scopus citations
• 2005

  Increased fidelity reduces poliovirus fitness and virulence under selective pressure in mice

  Pfeiffer, J. K. & Kirkegaard, K., 2005, In: PLoS pathogens. 1, 2, p. 102-110 9 p., e11.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus C 100%
  • Poliovirus 97%
  • Virulence 67%
  • virulence 62%
  • Viruses 51%
  308 Scopus citations

• Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA

  Pfeiffer, J. K. & Kirkegaard, K., Feb 2005, In: Journal of virology. 79, 4, p. 2346-2355 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepatitis C virus 100%
  • Replicon 86%
  • replicon 85%
  • Ribavirin 77%
  • Hepacivirus 63%
  73 Scopus citations
• 2003

  A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity

  Pfeiffer, J. K. & Kirkegaard, K., Jun 10 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 12, p. 7289-7294 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Replicase 100%
  • Poliovirus 92%
  • Ribavirin 83%
  • Nucleotides 59%
  • Mutation 41%
  329 Scopus citations
• 2002

  RNase H activity is required for high-frequency repeat deletion during Moloney murine leukemia virus replication

  Brincat, J. L., Pfeiffer, J. K. & Telesnitsky, A., 2002, In: Journal of virology. 76, 1, p. 88-95 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ribonuclease H 100%
  • Moloney murine leukemia virus 97%
  • Murine leukemia virus 97%
  • RNA-directed DNA polymerase 82%
  • virus replication 77%
  27 Scopus citations
• 2001

  Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication

  Pfeiffer, J. K. & Telesnitsky, A., 2001, In: Journal of virology. 75, 23, p. 11263-11274 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Moloney murine leukemia virus 100%
  • Murine leukemia virus 99%
  • virus replication 79%
  • Virus Replication 71%
  • Genetic Recombination 68%
  41 Scopus citations
• 2000

  Replication of lengthened Moloney murine leukemia virus genomes is impaired at multiple stages

  Shin, N. H., Hartigan-O'Connor, D., Pfeiffer, J. K. & Telesnitsky, A., 2000, In: Journal of virology. 74, 6, p. 2694-2702 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Moloney murine leukemia virus 100%
  • Murine leukemia virus 99%
  • RNA packaging 53%
  • RNA 49%
  • Genome 48%
  33 Scopus citations

• Structure-based Moloney murine leukemia virus reverse transcriptase mutants with altered intracellular direct-repeat deletion frequencies

  Pfeiffer, J. K., Georgiadis, M. M. & Telesnitsky, A., 2000, In: Journal of virology. 74, 20, p. 9629-9636 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Moloney murine leukemia virus 100%
  • Murine leukemia virus 99%
  • Nucleic Acid Repetitive Sequences 86%
  • RNA-directed DNA polymerase 85%
  • RNA-Directed DNA Polymerase 83%
  23 Scopus citations