Microbiology - Sperandio Lab

Research Output 1993 2019

2019
5 Citations (Scopus)

Indole signaling at the host-microbiota-pathogen interface

Kumar, A. & Sperandio, V., May 1 2019, In : mBio. 10, 3, e01031-19.

Research output: Contribution to journalArticle

Open Access
Microbiota
Citrobacter rodentium
Virulence
Enterohemorrhagic Escherichia coli
Gastrointestinal Tract

Reply to wood and lee, “precedence for the role of indole with pathogens”

Sperandio, V. & Kumar, A., Jan 1 2019, In : mBio. 10, 4, e01787-19.

Research output: Contribution to journalLetter

Open Access
Enterohemorrhagic Escherichia coli
indole

Taming the beast: Interplay between gut small molecules and enteric pathogens

Kumar, A., Ellermann, M. & Sperandio, V., Sep 1 2019, In : Infection and immunity. 87, 9, e00131-19.

Research output: Contribution to journalShort survey

Anti-Bacterial Agents
Virulence
Bacteria
Centers for Disease Control and Prevention (U.S.)
Microbial Drug Resistance
2018
11 Citations (Scopus)

Bacteriophage Transcription Factor Cro Regulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli

Hernandez-Doria, J. D. & Sperandio, V., May 9 2018, (Accepted/In press) In : Cell Host and Microbe. p. 607-617.e6

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Bacteriophages
Virulence
Transcription Factors
Gene Expression
2 Citations (Scopus)

Complete genome sequence of Escherichia albertii strain 1551-2, a potential extracellular and intracellular pathogen

Romão, F. T., Hernandes, R. T., Ooka, T., Hayashi, T., Sperandio, V. & Gomes, T. A. T., Mar 1 2018, In : Genome Announcements. 6, 9, e00075-18.

Research output: Contribution to journalArticle

Escherichia
Genome
Birds
Chromosomes
4 Citations (Scopus)

Enterohemorrhagic Escherichia coli outwits hosts through sensing small molecules

Carlson-Banning, K. M. & Sperandio, V., Feb 1 2018, In : Current Opinion in Microbiology. 41, p. 83-88 6 p.

Research output: Contribution to journalReview article

Enterohemorrhagic Escherichia coli
Metabolomics
Microbiota
Virulence
Gastrointestinal Tract
3 Citations (Scopus)

Microbiota and Pathogen Proteases Modulate Type III Secretion Activity in Enterohemorrhagic Escherichia coli

Cameron, E. A., Curtis, M. M., Kumar, A., Dunny, G. M. & Sperandio, V., Dec 4 2018, In : mBio. 9, 6

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Microbiota
Peptide Hydrolases
Bacteroides
Syringes
1 Citation (Scopus)

Pathogens’ adaptation to the human host

Sperandio, V., Sep 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9342-9343 2 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut

Pifer, R., Russell, R. M., Kumar, A., Curtis, M. M. & Sperandio, V., Nov 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. E10712-E10719

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Oxidation-Reduction
Virulence
Fatty Acids
Amino Acids
2 Citations (Scopus)

The QseG lipoprotein impacts the virulence of enterohemorrhagic Escherichia coli and Citrobacter rodentium and regulates flagellar phase variation in Salmonella enterica serovar typhimurium

Cameron, E. A., Gruber, C. C., Ritchie, J. M., Waldor, M. K. & Sperandio, V., Apr 1 2018, In : Infection and Immunity. 86, 4, e00936-17.

Research output: Contribution to journalArticle

Citrobacter rodentium
Enterohemorrhagic Escherichia coli
Salmonella enterica
Lipoproteins
Virulence
2017
17 Citations (Scopus)

Bacterial chat: Intestinal metabolites and signals in host-microbiota-pathogen interactions

Lustri, B. C., Sperandio, V. & Moreira, C. G., Jan 1 2017, In : Infection and Immunity. 85, 12, e00476-17.

Research output: Contribution to journalShort survey

Host-Pathogen Interactions
Microbiota
Enterohemorrhagic Escherichia coli
Bacteria
Virulence
9 Citations (Scopus)

Escherichia albertii, a novel human enteropathogen, colonizes rat enterocytes and translocates to extra-intestinal sites

Denise, Y., Rodrigo, T. H., Ana, M. A. L., Abe, C. M., De Rodrigo, B. S., Fabiano, T. R., Vanessa, S., Ivan, H. K. & Tânia, A. T. G., Feb 1 2017, In : PLoS One. 12, 2, e0171385.

Research output: Contribution to journalArticle

Escherichia albertii
enteropathogens
Escherichia
Enterocytes
enterocytes
6 Citations (Scopus)

Genetic and mechanistic analyses of the periplasmic domain of the enterohemorrhagic Escherichia coli QseC histidine sensor kinase

Parker, C. T., Russell, R., Njoroge, J. W., Jimenez, A. G., Taussig, R. & Sperandio, V., Apr 1 2017, In : Journal of Bacteriology. 199, 8, e00861-16.

Research output: Contribution to journalArticle

Shiga Toxin
Enterohemorrhagic Escherichia coli
Enterocytes
Amino Acids
Flagella
1 Citation (Scopus)

Take Your Pick: Vitamins and Microbiota Facilitate Pathogen Clearance

Sperandio, V., Feb 8 2017, In : Cell Host and Microbe. 21, 2, p. 130-131 2 p.

Research output: Contribution to journalShort survey

Vitamin B 6
Metabolome
Microbiota
Vitamins
Salmonella
2016
29 Citations (Scopus)

Bacterial adrenergic sensors regulate virulence of enteric pathogens in the gut

Moreira, C. G., Russell, R., Mishra, A. A., Narayanan, S., Ritchie, J. M., Waldor, M. K., Curtis, M. M., Winter, S. E., Weinshenker, D. & Sperandio, V., 2016, In : mBio. 7, 3, e00826-16.

Research output: Contribution to journalArticle

Citrobacter rodentium
Adrenergic Agents
Enterohemorrhagic Escherichia coli
Virulence
Neurotransmitter Agents
16 Citations (Scopus)

Catabolite and oxygen regulation of enterohemorrhagic Escherichia coli virulence

Carlson-Banning, K. M. & Sperandio, V., Jan 1 2016, In : mBio. 7, 6, e01852-16.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Virulence
Oxygen
Mucins
Microbiota
237 Citations (Scopus)

Interactions between the microbiota and pathogenic bacteria in the gut

Baümler, A. J. & Sperandio, V., Jul 6 2016, In : Nature. 535, 7610, p. 85-93 9 p.

Research output: Contribution to journalReview article

Microbiota
Bacteria
Communicable Diseases
Virulence
Respiration

In vivo influence of in vitro up-regulated genes in the virulence of an APEC strain associated with swollen head syndrome

de Paiva, J. B., da Silva, L. P. M., Casas, M. R. T., Conceição, R. A., Nakazato, G., de Pace, F., Sperandio, V. & da Silveira, W. D., Jan 2 2016, In : Avian Pathology. 45, 1, p. 94-105 12 p.

Research output: Contribution to journalArticle

Virulence
virulence
Head
Poultry
Mannose
11 Citations (Scopus)

The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157: H7

Moreira, C. G. & Sperandio, V., 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 874. p. 247-261 15 p. (Advances in Experimental Medicine and Biology; vol. 874).

Research output: Chapter in Book/Report/Conference proceedingChapter

Escherichia coli O157
Flagella
Escherichia coli
Epinephrine
Virulence
34 Citations (Scopus)

What a dinner party! mechanisms and functions of interkingdom signaling in host-pathogen associations

Kendall, M. M. & Sperandio, V., Mar 1 2016, In : mBio. 7, 2, e01748-15.

Research output: Contribution to journalArticle

Meals
Quorum Sensing
Immunologic Factors
Virulence
Hormones
2015
1 Citation (Scopus)

Bacterial reductionism: Host thiols enhance virulence

Sperandio, V., 2015, In : Cell Host and Microbe. 18, 1, p. 7-8 2 p.

Research output: Contribution to journalArticle

Burkholderia pseudomallei
Sulfhydryl Compounds
Glutathione
Virulence
Up-Regulation
15 Citations (Scopus)

Enteric pathogens exploit the microbiota-generated nutritional environment of the gut

Pacheco, A. R. & Sperandio, V., 2015, In : Microbiology spectrum. 3, 3, MBP-0001-2014.

Research output: Contribution to journalArticle

Microbiota
virulence
pathogen
Enterohemorrhagic Escherichia coli
Virulence
27 Citations (Scopus)

Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions

Cameron, E. A. & Sperandio, V., Sep 9 2015, In : Cell Host and Microbe. 18, 3, p. 275-284 10 p.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Microbiota
Food
Virulence
Nutritional Physiological Phenomena
29 Citations (Scopus)

Global analysis of posttranscriptional regulation by GlmY and GlmZ in enterohemorrhagic Escherichia coli O157: H7

Gruber, C. C. & Sperandio, V., 2015, In : Infection and Immunity. 83, 4, p. 1286-1295 10 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Escherichia coli O157
Enterocytes
Operon
RNA Sequence Analysis
12 Citations (Scopus)

Influence of the major nitrite transporter NirC on the virulence of a Swollen Head Syndrome Avian Pathogenic E. coli (APEC) strain

de Paiva, J. B., Leite, J. L., da Silva, L. P. M., Rojas, T. C. G., de Pace, F., Conceição, R. A., Sperandio, V. & da Silveira, W. D., Jan 30 2015, In : Veterinary Microbiology. 175, 1, p. 123-131 9 p.

Research output: Contribution to journalArticle

Nitrites
nitrites
Virulence
transporters
virulence
31 Citations (Scopus)

Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator

Nguyen, Y., Nguyen, N. X., Rogers, J. L., Liao, J., Macmillan, J. B., Jiang, Y. & Sperandio, V., Mar 31 2015, In : mBio. 6, 2, e02429-14.

Research output: Contribution to journalArticle

Acyl-Butyrolactones
Quorum Sensing
Ligands
Enterohemorrhagic Escherichia coli
Orphaned Children
4 Citations (Scopus)
Uropathogenic Escherichia coli
Biofilms
Pseudomonas aeruginosa
Anti-Bacterial Agents
Growth
2014
10 Citations (Scopus)

Cell-to-cell signaling in Escherichia coli and Salmonella

Kendall, M. M. & Sperandio, V., 2014, In : EcoSal Plus. 6, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Salmonella
Escherichia coli
Bacteria
Quorum Sensing
Population Density
28 Citations (Scopus)

Posttranscriptional control of microbe-induced rearrangement of host cell actin

Gruber, C. C. & Sperandio, V., Jan 14 2014, In : mBio. 5, 1, e01025-13.

Research output: Contribution to journalArticle

Actins
Enterocytes
RNA
Cytoskeleton
Cell Biology
50 Citations (Scopus)

QseC inhibitors as an antivirulence approach for gram-negative pathogens

Curtis, M. M., Russell, R., Moreira, C. G., Adebesin, A. M., Wang, C., Williams, N. S., Taussig, R., Stewart, D., Zimmern, P. E., Lu, B., Prasad, R. N., Zhu, C., Rasko, D. A., Huntley, J. F., Falck, J. R. & Sperandio, V., Oct 17 2014, In : mBio. 5, 6, e02165-14.

Research output: Contribution to journalArticle

Virulence
Information Science
Microbiota
Prodrugs
Structure-Activity Relationship
18 Citations (Scopus)

Recurrent urinary tract infections in healthy and nonpregnant women

Glover, M., Moreira, C. G., Sperandio, V. & Zimmern, P., 2014, In : Urological Science. 25, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Urinary Tract Infections
Genetic Predisposition to Disease
Infection
Urinary Bladder
Age Groups
84 Citations (Scopus)

The gut commensal bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape

Curtis, M. M., Hu, Z., Klimko, C., Narayanan, S., Deberardinis, R. & Sperandio, V., Dec 10 2014, In : Cell Host and Microbe. 16, 6, p. 759-769 11 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Microbiota
Infection
Virulence
Citrobacter rodentium
12 Citations (Scopus)

The interplay between the microbiota and enterohemorrhagic Escherichia coli

Pifer, R. & Sperandio, V., 2014, In : Microbiology spectrum. 2, 5, EHEC-0015-2013.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Microbiota
Dysbiosis
Gastrointestinal Tract
gene expression
2013

Interference with Bacterial Cell-to-Cell Chemical Signaling in Development of New Anti-Infectives

Njoroge, J. W. & Sperandio, V., Oct 4 2013, Antibiotics: Targets, Mechanisms and Resistance. wiley, p. 241-261 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Antibiosis
7 Citations (Scopus)

Nutrient and chemical sensing by intestinal pathogens

Hernandez-Doria, J. D. & Sperandio, V., Nov 2013, In : Microbes and Infection. 15, 12, p. 759-764 6 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Escherichia coli O157
Enterobacteriaceae
Virulence
Bacteria
3 Citations (Scopus)

Restrictive streptomycin resistance mutations decrease the formation of attaching and effacing lesions in escherichia coli O157: H7 strains

Chen, C., Blumentritt, C. A., Curtis, M. M., Sperandio, V., Torres, A. G. & Dudley, E. G., Sep 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4260-4266 7 p.

Research output: Contribution to journalArticle

Escherichia coli O157
Streptomycin
Mutation
Enterocytes
Phenotype
11 Citations (Scopus)

SdiA aids enterohemorrhagic escherichia coli carriage by cattle fed a forage or grain diet

Sheng, H., Nguyen, Y. N., Hovde, C. J. & Sperandio, V., 2013, In : Infection and Immunity. 81, 9, p. 3472-3478 7 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Rumen
Diet
Acyl-Butyrolactones
Mucous Membrane
2 Citations (Scopus)
Virulence
Bacteria
5 Citations (Scopus)

The acyl-homoserine lactone synthase YenI from Yersinia enterocolitica modulates virulence gene expression in enterohemorrhagic Escherichia coli O157: H7

Nguyen, Y. N., Sheng, H., Dakarapu, R., Falck, J. R., Hovde, C. J. & Sperandio, V., Nov 2013, In : Infection and Immunity. 81, 11, p. 4192-4199 8 p.

Research output: Contribution to journalArticle

Acyl-Butyrolactones
Enterohemorrhagic Escherichia coli
Yersinia enterocolitica
Escherichia coli O157
Virulence
23 Citations (Scopus)

The interacting Cra and KdpE regulators are involved in the expression of multiple virulence factors in enterohemorrhagic Escherichia coli

Njoroge, J. W., Gruber, C. & Sperandio, V., Jun 2013, In : Journal of Bacteriology. 195, 11, p. 2499-2508 10 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Virulence Factors
Enterocytes
Genes
Virulence
24 Citations (Scopus)

Virulence and stress-related periplasmic protein (VisP) in bacterial/host associations

Moreira, C. G., Herrera, C. M., Needham, B. D., Parker, C. T., Libby, S. J., Fang, F. C., Trent, M. S. & Sperandio, V., Jan 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1470-1475 6 p.

Research output: Contribution to journalArticle

Periplasmic Proteins
Virulence
Lipid A
Vacuoles
Oligosaccharides
2012
1 Citation (Scopus)

Cell regulation

Sperandio, V. & Freitag, N., Apr 2012, In : Current Opinion in Microbiology. 15, 2, p. 115-117 3 p.

Research output: Contribution to journalArticle

Bacterial Gene Expression Regulation
Host-Pathogen Interactions
Bacterial Proteins
Biofilms
Signal Transduction
110 Citations (Scopus)

Enterohemorrhagic E. coli (EHEC) pathogenesis.

Nguyen, Y. & Sperandio, V., 2012, In : Frontiers in cellular and infection microbiology. 2, p. 90 1 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Disease Outbreaks
Shiga Toxin
Escherichia coli Infections
Hemolytic-Uremic Syndrome
41 Citations (Scopus)

Enterohemorrhagic escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE

Njoroge, J. & Sperandio, V., Feb 2012, In : Infection and Immunity. 80, 2, p. 688-703 16 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Adrenergic Agents
Virulence
Phosphotransferases
Epinephrine
89 Citations (Scopus)

Ethanolamine controls expression of genes encoding components involved in interkingdom signaling and virulence in enterohemorrhagic escherichia coli O157: H7

Kendall, M. M., Gruber, C. C., Parker, C. T. & Sperandio, V., May 2012, In : mBio. 3, 3

Research output: Contribution to journalArticle

Gene Components
Enterohemorrhagic Escherichia coli
Ethanolamine
Escherichia coli O157
Virulence
199 Citations (Scopus)

Fucose sensing regulates bacterial intestinal colonization

Pacheco, A. R., Curtis, M. M., Ritchie, J. M., Munera, D., Waldor, M. K., Moreira, C. G. & Sperandio, V., Dec 6 2012, In : Nature. 491, 7427, p. 113-117 5 p.

Research output: Contribution to journalArticle

Fucose
Enterohemorrhagic Escherichia coli
Virulence
Microbiota
Mucins
24 Citations (Scopus)

Interplay between the qsec and qsee bacterial adrenergic sensor kinases in salmonella enterica serovar typhimurium pathogenesis

Moreira, C. G. & Sperandio, V., 2012, In : Infection and Immunity. 80, 12, p. 4344-4353 10 p.

Research output: Contribution to journalArticle

Salmonella enterica
Adrenergic Agents
Epinephrine
Phosphotransferases
Gene Expression
55 Citations (Scopus)
Shiga Toxin
Enterohemorrhagic Escherichia coli
Virulence
Hemolytic-Uremic Syndrome
Quorum Sensing
56 Citations (Scopus)

Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli

Njoroge, J. W., Nguyen, Y., Curtis, M. M., Moreira, C. G. & Sperandio, V., 2012, In : mBio. 3, 5

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Enterocytes
Virulence
Genes
Carbon

Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli.

Njoroge, J. W., Nguyen, Y., Curtis, M. M., Moreira, C. G. & Sperandio, V., 2012, In : mBio. 3, 5

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Enterocytes
Virulence
Cues
Genes