Research Output

2019

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

2 Scopus citations

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

Hu, Z., Qu, G., Yu, X., Jiang, H., Teng, X. L., Ding, L., Hu, Q., Guo, X., Zhou, Y., Wang, F., Li, H. B., Chen, L., Jiang, J., Su, B., Liu, J. & Zou, Q., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 290-302.e5

Research output: Contribution to journalArticle

3 Scopus citations

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A. & Mangelsdorf, D. J., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 246-253 8 p.

Research output: Contribution to journalReview article

15 Scopus citations

Astrocyte-Specific Deletion of Sox2 Promotes Functional Recovery After Traumatic Brain Injury

Chen, C., Zhong, X., Smith, D. K., Tai, W., Yang, J., Zou, Y., Wang, L. L., Sun, J., Qin, S. & Zhang, C-L., Jan 1 2019, In : Cerebral cortex (New York, N.Y. : 1991). 29, 1, p. 54-69 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Author Correction: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 (Nature, (2014), 512, 7515, (431-435), 10.1038/nature13375)

Krzeszinski, J. Y., Wei, W., Huynh, H. D., Jin, Z., Wang, X., Chang, T-C., Xie, X-J., He, L., Mangala, L. S., Lopez-Berestein, G., Sood, A. K., Mendell, J. T. & Wan, Y., Jan 1 2019, In : Nature.

Research output: Contribution to journalComment/debate

Open Access

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

Gui, X., Yang, H., Li, T., Tan, X., Shi, P., Li, M., Du, F. & Chen, Z., Mar 14 2019, In : Nature. 567, 7747, p. 262-266 5 p.

Research output: Contribution to journalLetter

36 Scopus citations

Autophagy Keeps the Balance in Tissue Homeostasis

Buszczak, M. & Kramer, H., May 20 2019, In : Developmental Cell. 49, 4, p. 499-500 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Black, M. H., Osinski, A., Gradowski, M., Servage, K. A., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 24 2019, In : Science (New York, N.Y.). 364, 6442, p. 787-792 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

Hashimoto, H., Wang, Z., Garry, G. A., Malladi, V. S., Botten, G. A., Ye, W., Zhou, H., Osterwalder, M., Dickel, D. E., Visel, A., Liu, N., Bassel-Duby, R. & Olson, E. N., Jul 3 2019, In : Cell Stem Cell. 25, 1, p. 69-86.e5

Research output: Contribution to journalArticle

2 Scopus citations

Cardio-omentopexy Reduces Cardiac Fibrosis and Heart Failure After Experimental Pressure Overload

Wang, J., Zhang, Q. J., Pirolli, T. J., Liu, Z-P., Powell, L. S., Thorp, E. B., Jessen, M. E. & Forbess, J. M., Jan 1 2019, In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

1 Scopus citations

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E. N., Verma, U. & Brekken, R. A., Jul 23 2019, In : JCI Insight. 4, 16, e129212.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

Xiao, N., Wei, J., Xu, S., Du, H., Huang, M., Zhang, S., Ye, W., Sun, L. & Chen, Q., Jun 1 2019, In : Journal of Autoimmunity. 100, p. 84-94 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

cGAS in action: Expanding roles in immunity and inflammation

Ablasser, A. & Chen, Z., Mar 8 2019, In : Science (New York, N.Y.). 363, 6431

Research output: Contribution to journalReview article

40 Scopus citations

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Jan 1 2019, In : Autophagy.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Clearing debris

Meng, D. & Jewell, J. L., Aug 1 2019, In : Nature chemical biology. 15, 8, p. 760-761 2 p.

Research output: Contribution to journalComment/debate

Correction to: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress (Cell Death & Differentiation, (2018), 10.1038/s41418-018-0197-1)

Bravo-Sagua, R., Parra, V., Ortiz-Sandoval, C., Navarro-Marquez, M., Rodríguez, A. E., Diaz-Valdivia, N., Sanhueza, C., Lopez-Crisosto, C., Tahbaz, N., Rothermel, B. A., Hill, J. A., Cifuentes, M., Simmen, T., Quest, A. F. G. & Lavandero, S., Jan 1 2019, In : Cell Death and Differentiation.

Research output: Contribution to journalComment/debate

CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells

Min, Y. L., Li, H., Rodriguez-Caycedo, C., Mireault, A. A., Huang, J., Shelton, J. M., McAnally, J. R., Amoasii, L., Mammen, P. P., Bassel-Duby, R. S. & Olson, E. N., Jan 1 2019, In : Science Advances. 5, 3, eaav4324.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Shang, G., Zhang, C., Chen, Z., Bai, X. & Zhang, X., Mar 21 2019, In : Nature. 567, 7748, p. 389-393 5 p.

Research output: Contribution to journalLetter

25 Scopus citations

Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism

Van Esch, H., Colnaghi, R., Freson, K., Starokadomskyy, P., Zankl, A., Backx, L., Abramowicz, I., Outwin, E., Rohena, L., Faulkner, C., Leong, G. M., Newbury-Ecob, R. A., Challis, R. C., Õunap, K., Jaeken, J., Seuntjens, E., Devriendt, K., Burstein, E., Low, K. J. & O'Driscoll, M., May 2 2019, In : American Journal of Human Genetics. 104, 5, p. 957-967 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group

Fonseca, A., Xia, C., Lorenzo, A. J., Krailo, M., Olson, T. A., Pashankar, F., Malogolowkin, M. H., Amatruda, J. F., Billmire, D. F., Rodriguez-Galindo, C., Frazier, A. L. & Shaikh, F., Feb 10 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 5, p. 396-402 7 p.

Research output: Contribution to journalArticle

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection

De Nisco, N. J., Neugent, M., Mull, J. A., Chen, L., Kuprasertkul, A., de Souza Santos, M., Palmer, K. L., Zimmern, P. E. & Orth, K. A., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

3 Scopus citations

Dissecting primate early post-implantation development using long-term in vitro embryo culture

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, J., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G. & 4 others, Peng, G., Belmonte, J. C. I., Ji, W. & Tan, T., Nov 15 2019, In : Science. 366, 6467, eaaw5754.

Research output: Contribution to journalArticle

3 Scopus citations

DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy

Nakada, Y., Nhi Nguyen, N. U., Xiao, F., Savla, J. J., Lam, N. T., Abdisalaam, S., Bhattacharya, S., Mukherjee, S., Asaithamby, A., Gillette, T. G., Hill, J. A. & Sadek, H. A., Feb 26 2019, In : Circulation. 139, 9, p. 1237-1239 3 p.

Research output: Contribution to journalLetter

2 Scopus citations

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

Abdullah, C. S., Alam, S., Aishwarya, R., Miriyala, S., Bhuiyan, M. A. N., Panchatcharam, M., Pattillo, C. B., Orr, A. W., Sadoshima, J., Hill, J. A. & Bhuiyan, M. S., Dec 1 2019, In : Scientific Reports. 9, 1, 2002.

Research output: Contribution to journalArticle

9 Scopus citations

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Zhu, W., Miyata, N., Winter, M. G., Arenales, A., Hughes, E. R., Spiga, L., Kim, J., Sifuentes-Dominguez, L., Starokadomskyy, P., Gopal, P., Byndloss, M. X., Santos, R. L., Burstein, E. & Winter, S. E., Oct 7 2019, In : The Journal of experimental medicine. 216, 10, p. 2378-2393 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Embryonic chimeras with human pluripotent stem cells

De Los Angeles, A., Sakurai, M. & Wu, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 125-151 27 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E. & Billadeau, D. D., Sep 19 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery

O'Donnell-Mendell, K. A., Guo, Y., Suresh, S., Updegraff, B. L. & Zhou, X., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 145-157 13 p. (Methods in Molecular Biology; vol. 1907).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fibroblast Primary Cilia Are Required for Cardiac Fibrosis

Villalobos, E., Criollo, A., Schiattarella, G. G., Altamirano, F., French, K. M., May, H. I., Jiang, N., Nguyen, N. U. N., Romero, D., Roa, J. C., García, L., Diaz-Araya, G., Morselli, E., Ferdous, A., Conway, S. J., Sadek, H. A., Gillette, T. G., Lavandero, S. & Hill, J. A., May 14 2019, In : Circulation. 139, 20, p. 2342-2357 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H. K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J. & Izpisua Belmonte, J. C., Oct 17 2019, In : Cell. 179, 3, p. 687-702.e18

Research output: Contribution to journalArticle

4 Scopus citations

Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system

Xu, J., Yu, L., Guo, J., Xiang, J., Zheng, Z., Gao, D., Shi, B., Hao, H., Jiao, D., Zhong, L., Wang, Y., Wu, J., Wei, H. & Han, J., Jun 27 2019, In : Stem Cell Research and Therapy. 10, 1, 193.

Research output: Contribution to journalArticle

Open Access

Genetics of testicular germ cell tumors

Singla, N., Lafin, J. T., Ghandour, R. A., Kaffenberger, S., Amatruda, J. F. & Bagrodia, A., Jul 1 2019, In : Current opinion in urology. 29, 4, p. 344-349 6 p.

Research output: Contribution to journalArticle

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Jewell, J. L., Fu, V., Hong, A. W., Yu, F. X., Meng, D., Melick, C. H., Wang, H., Lam, W. L. M., Yuan, H. X., Taylor, S. S. & Guan, K. L., May 21 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming

Fernandez-Perez, A., Sathe, A. A., Bhakta, M., Leggett, K., Xing, C. & Munshi, N. V., May 21 2019, In : Cell Reports. 27, 8, p. 2354-2369.e7

Research output: Contribution to journalArticle

Open Access

HDAC inhibition as a therapeutic strategy in myocardial ischemia/reperfusion injury

Xie, M., Tang, Y. & Hill, J. A., Apr 1 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 188-192 5 p.

Research output: Contribution to journalReview article

Highly efficient derivation of pluripotent stem cells from mouse preimplantation and postimplantation embryos in serum-free conditions

De Los Angeles, A., Okamura, D. & Wu, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 29-36 8 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R., Fujikawa, T., Castorena, C. M., Richardson, J., Shelton, J. M., Ayers, C., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 1 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access

Hippo signaling is intrinsically regulated during cell cycle progression by APC/C Cdh1

Kim, W., Cho, Y. S., Wang, X., Park, O., Ma, X., Kim, H., Gan, W., Jho, E. H., Cha, B., Jeung, Y. J., Zhang, L., Gao, B., Wei, W., Jiang, J., Chung, K. S. & Yang, Y., May 7 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 19, p. 9423-9432 10 p.

Research output: Contribution to journalArticle

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H. F., Toombs, J. E., Chimalapati, S., Kim, M. S., Malladi, V. S., Brekken, R. & Orth, K., May 28 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans

Dehghan, E., Goodarzi, M., Saremi, B., Lin, R. & Mirzaei, H., Dec 1 2019, In : Nature communications. 10, 1, 4905.

Research output: Contribution to journalArticle

Open Access

Identification of testicular cancer driver genes by a cross-species comparative oncology approach

Sanchez, A., Xu, L., Pierce, J. L., Lafin, J. T., Abe, D., Bagrodia, A., Frazier, A. L. & Amatruda, J. F., Jan 1 2019, In : Andrology.

Research output: Contribution to journalArticle

Insights into pediatric rhabdomyosarcoma research: Challenges and goals

Yohe, M. E., Heske, C. M., Stewart, E., Adamson, P. C., Ahmed, N., Antonescu, C. R., Chen, E., Collins, N., Ehrlich, A., Galindo, R. L., Gryder, B. E., Hahn, H., Hammond, S., Hatley, M. E., Hawkins, D. S., Hayes, M. N., Hayes-Jordan, A., Helman, L. J., Hettmer, S., Ignatius, M. S. & 13 others, Keller, C., Khan, J., Kirsch, D. G., Linardic, C. M., Lupo, P. J., Rota, R., Shern, J. F., Shipley, J., Sindiri, S., Tapscott, S. J., Vakoc, C. R., Wexler, L. H. & Langenau, D. M., Jan 1 2019, In : Pediatric Blood and Cancer. 66, 10, e27869.

Research output: Contribution to journalReview article

2 Scopus citations

In vitro breeding: Application of embryonic stem cells to animal production

Goszczynski, D. E., Cheng, H., Demyda-Peyrás, S., Medrano, J. F., Wu, J. & Ross, P. J., Jan 1 2019, In : Biology of reproduction. 100, 4, p. 885-895 11 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation

Braitsch, C. M., Azizoglu, D. B., Htike, Y., Barlow, H. R., Schnell, U., Chaney, C. P., Carroll, T. J., Stanger, B. Z. & Cleaver, O., Jul 1 2019, In : PLoS biology. 17, 7, e3000382.

Research output: Contribution to journalArticle

Open Access

Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention

Luitel, K., Kim, S. B., Barron, S., Richardson, J. A. & Shay, J. W., Jan 1 2019, (Accepted/In press) In : Life Sciences in Space Research.

Research output: Contribution to journalArticle

Mean platelet volume predicts survival in patients with hepatocellular carcinoma and type 2 diabetes

Yin, J. B., Niu, Y., Qian, L. Y., Zhang, X., Liu, Z-P. & Wang, R. T., May 1 2019, In : Diabetes Research and Clinical Practice. 151, p. 120-127 8 p.

Research output: Contribution to journalArticle

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling

Wang, Z., Cui, M., Shah, A. M., Ye, W., Tan, W., Min, Y. L., Botten, G. A., Shelton, J. M., Liu, N., Bassel-Duby, R. S. & Olson, E. N., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18455-18465 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Medical misinformation: Vet the message!

Hill, J. A., Agewall, S., Baranchuk, A., Booz, G. W., Borer, J. S., Camici, P. G., Chen, P. S., Dominiczak, A. F., Erol, Ç., Grines, C. L., Gropler, R., Guzik, T. J., Heinemann, M. K., Iskandrian, A. E., Knight, B. P., London, B., Lüscher, T. F., Metra, M., Musunuru, K., Nallamothu, B. K. & 9 others, Natale, A., Saksena, S., Picard, M. H., Rao, S. V., Remme, W. J., Rosenson, R. S., Sweitzer, N. K., Timmis, A. & Vrints, C., Feb 1 2019, In : Circulation: Cardiovascular Imaging. 12, 2, e008809.

Research output: Contribution to journalEditorial

Open Access

Medical misinformation: Vet the message!

Hill, J. A., Agewall, S., Baranchuk, A., Booz, G. W., Borer, J. S., Camici, P. G., Chen, P. S., Dominiczak, A. F., Erol, Ç., Grines, C. L., Gropler, R., Guzik, T. J., Heinemann, M. K., Iskandrian, A. E., Knight, B. P., London, B., Lüscher, T. F., Metra, M., Musunuru, K., Nallamothu, B. K. & 9 others, Natale, A., Saksena, S., Picard, M. H., Rao, S. V., Remme, W. J., Rosenson, R. S., Sweitzer, N. K., Timmis, A. & Vrints, C., Apr 1 2019, In : European Heart Journal - Quality of Care and Clinical Outcomes. 5, 2, p. 83-84 2 p.

Research output: Contribution to journalEditorial

Open Access