Molecular Biology - Division A

Research Output

2020

A Legionella effector kinase is activated by host inositol hexakisphosphate

Sreelatha, A., Nolan, C., Park, B. C., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 6214-6224 11 p.

Research output: Contribution to journalArticle

Proprotein convertase 7 (PCSK7) reduces apoA-V levels

Ashraf, Y., Duval, S., Sachan, V., Essalmani, R., Susan-Resiga, D., Roubtsova, A., Hamelin, J., Gerhardy, S., Kirchhofer, D., Tagliabracci, V. S., Prat, A., Kiss, R. S. & Seidah, N. G., Jan 1 2020, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

2019

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

6 Scopus citations

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Black, M. H., Osinski, A., Gradowski, M., Servage, K. A., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 24 2019, In : Science (New York, N.Y.). 364, 6442, p. 787-792 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Ser-phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family with Sequence Similarity 20, Member C) kinase enhances its ability to degrade the LDLR (Low-Density Lipoprotein Receptor)

Ben Djoudi Ouadda, A., Gauthier, M. S., Susan-Resiga, D., Girard, E., Essalmani, R., Black, M., Marcinkiewicz, J., Forget, D., Hamelin, J., Evagelidis, A., Ly, K., Day, R., Galarneau, L., Corbin, F., Coulombe, B., Çaku, A., Tagliabracci, V. S. & Seidah, N. G., Oct 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 10, p. 1996-2013 18 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals

Park, B. C., Reese, M. & Tagliabracci, V. S., Jun 2019, In : IUBMB life. 71, 6, p. 749-759 11 p.

Research output: Contribution to journalReview article

2 Scopus citations
2018

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

26 Scopus citations

Structure and evolution of the Fam20 kinases

Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M. J., Guo, X., Tagliabracci, V. S., Dixon, J. E. & Xiao, J., Dec 1 2018, In : Nature Communications. 9, 1, 1218.

Research output: Contribution to journalArticle

16 Scopus citations

The Golgi ‘casein kinase’ Fam20C is a genuine ‘phosvitin kinase’ and phosphorylates polyserine stretches devoid of the canonical consensus

Cozza, G., Moro, E., Black, M., Marin, O., Salvi, M., Venerando, A., Tagliabracci, V. S. & Pinna, L. A., Dec 2018, In : FEBS Journal. 285, 24, p. 4674-4683 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T. C., Kopp, F., Ramirez-Martinez, A., Tagliabracci, V. S., Chen, Z. J., Xie, Y. & Mendell, J. T., Feb 9 2017, In : Nature. 542, 7640, p. 197-202 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

Fam20C is under the control of sphingolipid signaling in human cell lines

Cozza, G., Salvi, M., Tagliabracci, V. S. & Pinna, L. A., Apr 1 2017, In : FEBS Journal. 284, 8, p. 1246-1257 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Methods to purify and assay secretory pathway kinases

Tagliabracci, V. S., Wen, J. & Xiao, J., Sep 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1496. p. 197-215 19 p. (Methods in Molecular Biology; vol. 1496).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Phosphorylation of spore coat proteins by a family of atypical protein kinases

Nguyen, K. B., Sreelatha, A., Durrant, E. S., Lopez-Garrido, J., Muszewska, A., Dudkiewicz, M., Grynberg, M., Yee, S., Pogliano, K., Tomchick, D. R., Pawłowski, K., Dixon, J. E. & Tagliabracci, V. S., Jun 21 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 25, p. E3482-E3491

Research output: Contribution to journalArticle

20 Scopus citations
2015

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins

Cozza, G., Salvi, M., Banerjee, S., Tibaldi, E., Tagliabracci, V. S., Dixon, J. E. & Pinna, L. A., Oct 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

A secretory kinase complex regulates extracellular protein phosphorylation

Cui, J., Xiao, J., Tagliabracci, V. S., Wen, J., Rahdar, M. & Dixon, J. E., Mar 19 2015, In : eLife. 2015, 4, e06120.

Research output: Contribution to journalArticle

55 Scopus citations

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Tagliabracci, V. S., Wiley, S. E., Guo, X., Kinch, L. N., Durrant, E., Wen, J., Xiao, J., Cui, J., Nguyen, K. B., Engel, J. L., Coon, J. J., Grishin, N., Pinna, L. A., Pagliarini, D. J. & Dixon, J. E., Jun 20 2015, In : Cell. 161, 7, p. 1619-1632 14 p.

Research output: Contribution to journalArticle

116 Scopus citations

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., Jan 9 2015, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

293 Scopus citations

"Genuine" Casein Kinase (Fam20C): The Mother of the Phosphosecretome

Cozza, G., Tagliabracci, V. S., Dixon, J. E. & Pinna, L. A., Oct 1 2015, Kinomics: Approaches and Applications. wiley, p. 47-62 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice

Irimia, J. M., Tagliabracci, V. S., Meyer, C. M., Segvich, D. M., Depaoli-Roach, A. A. & Roach, P. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22686-22698 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

The secretory pathway kinases

Sreelatha, A., Kinch, L. N. & Tagliabracci, V. S., Oct 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1687-1693 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

Tagliabracci, V. S., Engel, J. L., Wiley, S. E., Xiao, J., Gonzalez, D. J., Appaiah, H. N., Koller, A., Nizet, V., White, K. E. & Dixon, J. E., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5520-5525 6 p.

Research output: Contribution to journalArticle

144 Scopus citations

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., DePaoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

50 Scopus citations
2013

Crystal structure of the Golgi casein kinase

Xiao, J., Tagliabracci, V. S., Wen, J., Kim, S. A. & Dixon, J. E., Jun 25 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 26, p. 10574-10579 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phosphorylation of substrates destined for secretion by the Fam20 kinases

Tagliabracci, V. S., Xiao, J. & Dixon, J. E., Aug 1 2013, In : Biochemical Society Transactions. 41, 4, p. 1061-1065 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Response to Wang et al. Secreted protein kinases?

Tagliabracci, V. S., Pinna, L. A. & Dixon, J. E., Sep 1 2013, In : Trends in Biochemical Sciences. 38, 9, 1 p.

Research output: Contribution to journalLetter

2 Scopus citations

Secreted protein kinases

Tagliabracci, V. S., Pinna, L. A. & Dixon, J. E., Mar 1 2013, In : Trends in Biochemical Sciences. 38, 3, p. 121-130 10 p.

Research output: Contribution to journalReview article

74 Scopus citations

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., DePaoli-Roach, A., Roach, P. J. & Hurley, T. D., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Glycogen and its metabolism: Some new developments and old themes

Roach, P. J., Depaoli-Roach, A. A., Hurley, T. D. & Tagliabracci, V. S., Feb 1 2012, In : Biochemical Journal. 441, 3, p. 763-787 25 p.

Research output: Contribution to journalReview article

290 Scopus citations

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization

Tagliabracci, V. S., Engel, J. L., Wen, J., Wiley, S. E., Worby, C. A., Kinch, L. N., Xiao, J., Grishin, N. V. & Dixon, J. E., Jun 1 2012, In : Science. 336, 6085, p. 1150-1153 4 p.

Research output: Contribution to journalArticle

254 Scopus citations
2011

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

Jewell, J. L., Oh, E., Ramalingam, L., Kalwat, M. A., Tagliabracci, V. S., Tackett, L., Elmendorf, J. S. & Thurmond, D. C., Apr 4 2011, In : Journal of Cell Biology. 193, 1, p. 185-199 15 p.

Research output: Contribution to journalArticle

48 Scopus citations

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T. D., Depaoli-Roach, A. A. & Roach, P. J., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism (Journal of Biological Chemistry (2010) 285, (34960-34971))

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., DePaoli-Roach, A. A., Wells, C. D., Skurat, A. V. & Roach, P. J., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity

Guo, X., Engel, J. L., Xiao, J., Tagliabracci, V. S., Wang, X., Huang, L. & Dixon, J. E., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. 18649-18654 6 p.

Research output: Contribution to journalArticle

42 Scopus citations
2010

Genetic depletion of the malin e3 ubiquitin ligase in mice leads to Lafora bodies and the accumulation of insoluble laforin

DePaoli-Roach, A. A., Tagliabracci, V. S., Segvich, D. M., Meyer, C. M., Irimia, J. M. & Roach, P. J., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25372-25381 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
4 Scopus citations

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., DePaoli-Roach, A. A., Wells, C. D., Skurat, A. V. & Roach, P. J., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34960-34971 12 p.

Research output: Contribution to journalArticle

72 Scopus citations
2009

Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene

Heyen, C. A., Tagliabracci, V. S., Zhai, L. & Roach, P. J., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1414-1418 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2008

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

Tagliabracci, V. S., Girard, J. M., Segvich, D., Meyer, C., Turnbull, J., Zhao, X., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 33816-33825 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity

Wei, X., Ma, Z., Fontanilla, C. V., Zhao, L., Xu, Z. C., Taggliabraci, V., Johnstone, B. H., Dodel, R. C., Farlow, M. R. & Du, Y., Sep 9 2008, In : Neuroscience. 155, 4, p. 1098-1105 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2007

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

Tagliabracci, V. S., Turnbull, J., Wang, W., Girard, J. M., Zhao, X., Skurat, A. V., Delgado-Escueta, A. V., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19262-19266 5 p.

Research output: Contribution to journalArticle

137 Scopus citations
2005

Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity

Lin, S., Tagliabracci, V. S., Chen, X. & Du, Y., Sep 8 2005, In : NeuroReport. 16, 13, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

4 Scopus citations