Molecular Biology - Division A

Research Output 2005 2019

2019

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

Protein Kinases
Immunity
Phosphorylation
Pathogens
Plant Immunity
4 Citations (Scopus)

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Black, M. H., Osinski, A., Gradowski, M., Servage, K. A., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 24 2019, In : Science (New York, N.Y.). 364, 6442, p. 787-792 6 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Protein Kinases
Legionella
Calmodulin

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)

Ben Djoudi Ouadda, A., Gauthier, M. S., Susan-Resiga, D., Girard, E., Essalmani, R., Black, M., Marcinkiewicz, J., Forget, D., Hamelin, J., Evagelidis, A., Ly, K., Day, R., Galarneau, L., Corbin, F., Coulombe, B., Çaku, A., Tagliabracci, V. S. & Seidah, N. G., Oct 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 10, p. 1996-2013 18 p.

Research output: Contribution to journalArticle

Open Access
Proprotein Convertases
Subtilisin
LDL Receptors
Phosphotransferases
Phosphorylation

Thinking outside of the cell: Secreted protein kinases in bacteria, parasites, and mammals

Park, B. C., Reese, M. & Tagliabracci, V. S., Jan 1 2019, In : IUBMB Life.

Research output: Contribution to journalReview article

Mammals
Protein Kinases
Bacteria
Parasites
Phosphotransferases
2018
12 Citations (Scopus)

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

Sreelatha, A., Yee, S. S., Lopez, V. A., Park, B. C., Kinch, L. N., Pilch, S., Servage, K. A., Zhang, J., Jiou, J., Karasiewicz-Urbańska, M., Łobocka, M., Grishin, N. V., Orth, K. A., Kucharczyk, R., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., Oct 18 2018, In : Cell. 175, 3, p. 809-821.e19

Research output: Contribution to journalArticle

Selenoproteins
Protein Kinases
Proteins
Adenosine Triphosphate
Catalysis
10 Citations (Scopus)

Structure and evolution of the Fam20 kinases

Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M. J., Guo, X., Tagliabracci, V. S., Dixon, J. E. & Xiao, J., Dec 1 2018, In : Nature Communications. 9, 1, 1218.

Research output: Contribution to journalArticle

Proteoglycans
Phosphotransferases
Substrate Specificity
proteins
xylose
1 Citation (Scopus)

The Golgi ‘casein kinase’ Fam20C is a genuine ‘phosvitin kinase’ and phosphorylates polyserine stretches devoid of the canonical consensus

Cozza, G., Moro, E., Black, M., Marin, O., Salvi, M., Venerando, A., Tagliabracci, V. S. & Pinna, L. A., Jan 1 2018, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Phosvitin
Casein Kinases
Consensus
Phosphotransferases
Phosphorylation
2017
54 Citations (Scopus)

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

Golden, R. J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T. C., Kopp, F., Ramirez-Martinez, A., Tagliabracci, V. S., Chen, Z. J., Xie, Y. & Mendell, J. T., Feb 9 2017, In : Nature. 542, 7640, p. 197-202 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Phosphorylation
Clustered Regularly Interspaced Short Palindromic Repeats
Argonaute Proteins
Complementary RNA
4 Citations (Scopus)

Fam20C is under the control of sphingolipid signaling in human cell lines

Cozza, G., Salvi, M., Tagliabracci, V. S. & Pinna, L. A., Apr 1 2017, In : FEBS Journal. 284, 8, p. 1246-1257 12 p.

Research output: Contribution to journalArticle

Sphingolipids
Sphingosine
Cells
Cell Line
Conditioned Culture Medium
2016
2 Citations (Scopus)

Methods to purify and assay secretory pathway kinases

Tagliabracci, V. S., Wen, J. & Xiao, J., Sep 1 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1496. p. 197-215 19 p. (Methods in Molecular Biology; vol. 1496).

Research output: Chapter in Book/Report/Conference proceedingChapter

Secretory Pathway
Phosphotransferases
Proteoglycans
Biological Phenomena
Protein Kinases
13 Citations (Scopus)

Phosphorylation of spore coat proteins by a family of atypical protein kinases

Nguyen, K. B., Sreelatha, A., Durrant, E. S., Lopez-Garrido, J., Muszewska, A., Dudkiewicz, M., Grynberg, M., Yee, S., Pogliano, K., Tomchick, D. R., Pawłowski, K., Dixon, J. E. & Tagliabracci, V. S., Jun 21 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 25, p. E3482-E3491

Research output: Contribution to journalArticle

Capsid Proteins
Spores
Protein Kinases
Phosphorylation
Germination
2015
9 Citations (Scopus)

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins

Cozza, G., Salvi, M., Banerjee, S., Tibaldi, E., Tagliabracci, V. S., Dixon, J. E. & Pinna, L. A., Oct 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Casein Kinases
Sphingosine
Up-Regulation
Proteins
Bone Morphogenetic Protein 15
43 Citations (Scopus)

A secretory kinase complex regulates extracellular protein phosphorylation

Cui, J., Xiao, J., Tagliabracci, V. S., Wen, J., Rahdar, M. & Dixon, J. E., Mar 19 2015, In : eLife. 2015, 4

Research output: Contribution to journalArticle

Phosphorylation
Secretory Pathway
Phosphotransferases
Enamels
Dental Enamel
92 Citations (Scopus)

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Tagliabracci, V. S., Wiley, S. E., Guo, X., Kinch, L. N., Durrant, E., Wen, J., Xiao, J., Cui, J., Nguyen, K. B., Engel, J. L., Coon, J. J., Grishin, N., Pinna, L. A., Pagliarini, D. J. & Dixon, J. E., Jun 20 2015, In : Cell. 161, 7, p. 1619-1632 14 p.

Research output: Contribution to journalArticle

Phosphotransferases
Phosphoproteins
Substrates
Clustered Regularly Interspaced Short Palindromic Repeats
Biomineralization
244 Citations (Scopus)

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., Jan 9 2015, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

Glutamine
Leucine
GTP Phosphohydrolases
Adenosine Triphosphatases
Amino Acids
1 Citation (Scopus)

"Genuine" Casein Kinase (Fam20C): The Mother of the Phosphosecretome

Cozza, G., Tagliabracci, V. S., Dixon, J. E. & Pinna, L. A., Oct 1 2015, Kinomics: Approaches and Applications. wiley, p. 47-62 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Casein Kinases
Caseins
Casein Kinase I
Casein Kinase II
Peptides
9 Citations (Scopus)

Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice

Irimia, J. M., Tagliabracci, V. S., Meyer, C. M., Segvich, D. M., Depaoli-Roach, A. A. & Roach, P. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22686-22698 13 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Knockout Mice
Muscle
Phosphates
18 Citations (Scopus)

The secretory pathway kinases

Sreelatha, A., Kinch, L. N. & Tagliabracci, V. S., Oct 1 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1687-1693 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Secretory Pathway
Phosphotransferases
Proteins
Extracellular Space
2014
117 Citations (Scopus)

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

Tagliabracci, V. S., Engel, J. L., Wiley, S. E., Xiao, J., Gonzalez, D. J., Appaiah, H. N., Koller, A., Nizet, V., White, K. E. & Dixon, J. E., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5520-5525 6 p.

Research output: Contribution to journalArticle

Furin
Glycosylation
Proteolysis
Phosphorylation
Proprotein Convertases
40 Citations (Scopus)

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., DePaoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Glycogen
Gene expression
Liver
Gene Expression
2013
40 Citations (Scopus)

Crystal structure of the Golgi casein kinase

Xiao, J., Tagliabracci, V. S., Wen, J., Kim, S. A. & Dixon, J. E., Jun 25 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 26, p. 10574-10579 6 p.

Research output: Contribution to journalArticle

Casein Kinases
Protein Kinases
Developmental Bone Disease
Secretory Pathway
Caenorhabditis elegans
14 Citations (Scopus)

Phosphorylation of substrates destined for secretion by the Fam20 kinases

Tagliabracci, V. S., Xiao, J. & Dixon, J. E., Aug 1 2013, In : Biochemical Society Transactions. 41, 4, p. 1061-1065 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Substrates
Protein Kinases
Proteins
2 Citations (Scopus)

Response to Wang et al. Secreted protein kinases?

Tagliabracci, V. S., Pinna, L. A. & Dixon, J. E., Sep 1 2013, In : Trends in Biochemical Sciences. 38, 9, 1 p.

Research output: Contribution to journalLetter

Protein Kinases
Animals
68 Citations (Scopus)

Secreted protein kinases

Tagliabracci, V. S., Pinna, L. A. & Dixon, J. E., Mar 1 2013, In : Trends in Biochemical Sciences. 38, 3, p. 121-130 10 p.

Research output: Contribution to journalReview article

Protein Kinases
Caseins
Biomineralization
Proteins
Phosphoproteins
11 Citations (Scopus)

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., DePaoli-Roach, A., Roach, P. J. & Hurley, T. D., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Phosphates
Uridine Diphosphate
Glucose
2012
257 Citations (Scopus)

Glycogen and its metabolism: Some new developments and old themes

Roach, P. J., Depaoli-Roach, A. A., Hurley, T. D. & Tagliabracci, V. S., Feb 1 2012, In : Biochemical Journal. 441, 3, p. 763-787 25 p.

Research output: Contribution to journalReview article

Glycogen
Metabolism
Glycogen Synthase
Epinephrine
Lafora Disease
217 Citations (Scopus)

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization

Tagliabracci, V. S., Engel, J. L., Wen, J., Wiley, S. E., Worby, C. A., Kinch, L. N., Xiao, J., Grishin, N. V. & Dixon, J. E., Jun 1 2012, In : Science. 336, 6085, p. 1150-1153 4 p.

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Casein Kinases
Developmental Bone Disease
Phosphorylation
2011
44 Citations (Scopus)

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

Jewell, J. L., Oh, E., Ramalingam, L., Kalwat, M. A., Tagliabracci, V. S., Tackett, L., Elmendorf, J. S. & Thurmond, D. C., Apr 4 2011, In : Journal of Cell Biology. 193, 1, p. 185-199 15 p.

Research output: Contribution to journalArticle

SNARE Proteins
Insulin Receptor
Exocytosis
Qa-SNARE Proteins
Phosphorylation
68 Citations (Scopus)

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T. D., Depaoli-Roach, A. A. & Roach, P. J., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Phosphates
Progressive Myoclonic Epilepsy
Uridine Diphosphate Glucose

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism (Journal of Biological Chemistry (2010) 285, (34960-34971))

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., DePaoli-Roach, A. A., Wells, C. D., Skurat, A. V. & Roach, P. J., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, 1 p.

Research output: Contribution to journalComment/debate

Glycogen
Starch
Protein Domains
36 Citations (Scopus)

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity

Guo, X., Engel, J. L., Xiao, J., Tagliabracci, V. S., Wang, X., Huang, L. & Dixon, J. E., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. 18649-18654 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Phosphoric Monoester Hydrolases
ATP dependent 26S protease
Proteolysis
2010
72 Citations (Scopus)

Genetic depletion of the malin e3 ubiquitin ligase in mice leads to Lafora bodies and the accumulation of insoluble laforin

DePaoli-Roach, A. A., Tagliabracci, V. S., Segvich, D. M., Meyer, C. M., Irimia, J. M. & Roach, P. J., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25372-25381 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Glycogen
Brain
Lafora Disease
Muscle
4 Citations (Scopus)
Non-Receptor Protein Tyrosine Phosphatases
Molecular Sequence Data
Carbohydrate Sequence
Dual-Specificity Phosphatases
Arabidopsis Proteins
68 Citations (Scopus)

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., DePaoli-Roach, A. A., Wells, C. D., Skurat, A. V. & Roach, P. J., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34960-34971 12 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Starch
Proteins
Lysosomal-Associated Membrane Protein 1
2009
13 Citations (Scopus)

Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene

Heyen, C. A., Tagliabracci, V. S., Zhai, L. & Roach, P. J., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1414-1418 5 p.

Research output: Contribution to journalArticle

Pyrophosphatases
Uridine Diphosphate Glucose
Genes
Adenosine Diphosphate Ribose
Uridine Monophosphate
2008
111 Citations (Scopus)

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

Tagliabracci, V. S., Girard, J. M., Segvich, D., Meyer, C., Turnbull, J., Zhao, X., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 33816-33825 10 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Metabolism
Phosphates
Phosphorylation
41 Citations (Scopus)

Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNs) against glutamate-induced neurotoxicity

Wei, X., Ma, Z., Fontanilla, C. V., Zhao, L., Xu, Z. C., Taggliabraci, V., Johnstone, B. H., Dodel, R. C., Farlow, M. R. & Du, Y., Sep 9 2008, In : Neuroscience. 155, 4, p. 1098-1105 8 p.

Research output: Contribution to journalArticle

Glutamic Acid
Neurons
Neuroprotective Agents
Caspase 3
Phosphorylation
2007
131 Citations (Scopus)

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

Tagliabracci, V. S., Turnbull, J., Wang, W., Girard, J. M., Zhao, X., Skurat, A. V., Delgado-Escueta, A. V., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19262-19266 5 p.

Research output: Contribution to journalArticle

Glycogen
Phosphoric Monoester Hydrolases
Phosphorylation
Lafora Disease
Phosphates
2005
4 Citations (Scopus)

Albumin protects cultured cerebellar granule neurons against zinc neurotoxicity

Lin, S., Tagliabracci, V. S., Chen, X. & Du, Y., Sep 8 2005, In : NeuroReport. 16, 13, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

Zinc
Albumins
Neurons
Serum Albumin
Buffers