Research Output

2020

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Adam, R. C., Mintah, I. J., Alexa-Braun, C. A., Shihanian, L. M., Lee, J. S., Banerjee, P., Hamon, S. C., Kim, H. I., Cohen, J. C., Hobbs, H. H., Van Hout, C., Gromada, J., Murphy, A. J., Yancopoulos, G. D., Sleeman, M. W. & Gusarova, V., Sep 1 2020, In : Journal of lipid research. 61, 9, p. 1271-1286 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ANGPTL8 has both endocrine and autocrine effects on substrate utilization

Oldoni, F., Cheng, H., Banfi, S., Gusarova, V., Cohen, J. C. & Hobbs, H. H., Sep 3 2020, In : JCI Insight. 5, 17

Research output: Contribution to journalArticle

Open Access

Apolipoprotein E: Cholesterol metabolism and Alzheimer's pathology

Pohlkamp, T., Feb 1 2020, In : Neuroforum. 26, 1, p. 25-30 6 p.

Research output: Contribution to journalReview article

Biolistic transfection and expression analysis of acute cortical slices

Hamad, M. I. K., Daoud, S., Petrova, P., Rabaya, O., Jbara, A., Melliti, N., Stichmann, S., Reiss, G., Herz, J. & Förster, E., May 1 2020, In : Journal of Neuroscience Methods. 337, 108666.

Research output: Contribution to journalArticle

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., Infante, R. E., Radhakrishnan, A., Covey, D. F., Guan, K. L., Buck, J., Levin, L. R., Tontonoz, P., Schwabe, R. F. & Tabas, I., May 5 2020, In : Cell Metabolism. 31, 5, p. 969-986.e7

Research output: Contribution to journalArticle

2 Scopus citations

Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice

Liu, C. Y., Tsai, C. J., Yasugaki, S., Nagata, N., Morita, M., Isotani, A., Yanagisawa, M. & Hayashi, Y., Jan 1 2020, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Cryo-EM structures of intact V-ATPase from bovine brain

Wang, R., Long, T., Hassan, A., Wang, J., Sun, Y., Xie, X. S. & Li, X., Dec 1 2020, In : Nature communications. 11, 1, 3921.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Delisting STAP1: The rise and fall of a putative hypercholesterolemia gene

Hegele, R. A., Knowles, J. W. & Horton, J. D., 2020, (Accepted/In press) In : Arteriosclerosis, thrombosis, and vascular biology. p. 847-849 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine

Nagumo, Y., Katoh, K., Iio, K., Saitoh, T., Kutsumura, N., Yamamoto, N., Ishikawa, Y., Irukayama-Tomobe, Y., Ogawa, Y., Baba, T., Tanimura, R., Yanagisawa, M. & Nagase, H., Sep 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 17, 127360.

Research output: Contribution to journalArticle

Dynamics of Cortical Local Connectivity during Sleep-Wake States and the Homeostatic Process

Miyazaki, T., Kanda, T., Tsujino, N., Ishii, R., Nakatsuka, D., Kizuka, M., Kasagi, Y., Hino, H. & Yanagisawa, M., Jun 1 2020, In : Cerebral cortex (New York, N.Y. : 1991). 30, 7, p. 3977-3990 14 p.

Research output: Contribution to journalArticle

Enhanced ER-associated degradation of hmg coa reductase causes embryonic lethality associated with ubiad1 deficiency

Jo, Y., Kim, S. S., Garland, K., Fuentes, I., Dicarlo, L. M., Ellis, J. L., Fu, X., Booth, S. L., Evers, B. M. & Debose-Boyd, R. A., Mar 2020, In : eLife. 9, e54841.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Yanagisawa, M. & Nagase, H., Feb 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 3, 126893.

Research output: Contribution to journalArticle

1 Scopus citations

Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway

Hirose, Y., Kitazono, T., Sezaki, M., Abe, M., Sakimura, K., Funato, H., Handa, H., Vogt, K. E. & Yanagisawa, M., Sep 15 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 37, p. 23106-23112 7 p.

Research output: Contribution to journalArticle

Isolated Erythrocytosis Associated With 3 Novel Missense Mutations in the EGLN1 Gene

Moore, J. A., Hubbi, M. E., Wang, C., Wang, Y., Luo, W., Hofmann, S. & Rambally, S., 2020, In : Journal of Investigative Medicine High Impact Case Reports. 8

Research output: Contribution to journalArticle

Open Access
Open Access

Lipid polarity gradient formed by ω- hydroxy lipids in tear film prevents dry eye disease

Miyamoto, M., Sassa, T., Sawai, M., Kihara, A. & Radhakrishnan, A., Apr 2020, In : eLife. 9, e53582.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

Park, M., Miyoshi, C., Fujiyama, T., Kakizaki, M., Ikkyu, A., Honda, T., Choi, J., Asano, F., Mizuno, S., Takahashi, S., Yanagisawa, M. & Funato, H., Dec 1 2020, In : Scientific reports. 10, 1, 8676.

Research output: Contribution to journalArticle

Open Access

Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: A consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, J., John Chapman, M., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., Nordestgaard, B. G., Watts, G. F., Bruckert, E., Fazio, S., Ference, B. A., Graham, I., Horton, J. D., Landmesser, U., Laufs, U., Masana, L. & 10 others, Pasterkamp, G., Raal, F. J., Ray, K. K., Schunkert, H., Taskinen, M. R., van de Sluis, B., Wiklund, O., Tokgozoglu, L., Catapano, A. L. & Ginsberg, H. N., Jun 21 2020, In : European heart journal. 41, 24, p. 2313-2330 18 p.

Research output: Contribution to journalReview article

Open Access
33 Scopus citations

Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments

Wang, R., Qi, X., Schmiege, P., Coutavas, E. & Li, X., Jan 1 2020, In : Science Advances. 6, 7, eaaz1466.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling

Qi, X. & Li, X., May 2020, In : Trends in biochemical sciences. 45, 5, p. 397-410 14 p.

Research output: Contribution to journalReview article

3 Scopus citations

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

Abrams, M. E., Johnson, K. A., Perelman, S. S., Zhang, L. S., Endapally, S., Mar, K. B., Thompson, B. M., McDonald, J. G., Schoggins, J. W., Radhakrishnan, A. & Alto, N. M., Jul 1 2020, In : Nature microbiology. 5, 7, p. 929-942 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis: Beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis

Kökény, G., Calvier, L., Legchenko, E., Chouvarine, P., Mózes, M. M. & Hansmann, G., Mar 1 2020, In : Current opinion in nephrology and hypertension. 29, 2, p. 171-179 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

Calvier, L., Demuth, G., Manouchehri, N., Wong, C., Sacharidou, A., Mineo, C., Shaul, P. W., Monson, N. L., Kounnas, M. Z., Stüve, O. & Herz, J., Aug 12 2020, In : Science translational medicine. 12, 556, eAAY7675.

Research output: Contribution to journalArticle

Reelin signaling modulates GABAB receptor function in the neocortex

Hamad, M. I. K., Jbara, A., Rabaya, O., Petrova, P., Daoud, S., Melliti, N., Meseke, M., Lutz, D., Petrasch-Parwez, E., Schwitalla, J. C., Mark, M. D., Herlitze, S., Reiss, G., Herz, J. & Förster, E., Jan 1 2020, (Accepted/In press) In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Open Access

Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation

Jun, D. J., Schumacher, M. M., Hwang, S., Kinch, L. N., Grishin, N. V. & DeBose-Boyd, R. A., May 1 2020, In : Journal of lipid research. 61, 5, p. 746-757 12 p.

Research output: Contribution to journalArticle

Open Access

Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus but Leaves Cortical Layering and Behavior Unaffected

Pahle, J., Muhia, M., Wagener, R. J., Tippmann, A., Bock, H. H., Graw, J., Herz, J., Staiger, J. F., Drakew, A., Kneussel, M., Rune, G. M., Frotscher, M. & Brunne, B., Mar 14 2020, In : Cerebral Cortex. 30, 3, p. 1688-1707 20 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway

Kucharava, K., Brand, Y., Albano, G., Sekulic-Jablanovic, M., Glutz, A., Xian, X., Herz, J., Bodmer, D., Fuster, D. G. & Petkovic, V., Dec 1 2020, In : Scientific reports. 10, 1, 3609.

Research output: Contribution to journalArticle

Open Access

Structural basis for itraconazole-mediated NPC1 inhibition

Long, T., Qi, X., Hassan, A., Liang, Q., De Brabander, J. K. & Li, X., Dec 1 2020, In : Nature communications. 11, 1, 152.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Structural insights into group II TRP channels

Fine, M., Li, X. & Dang, S., Mar 2020, In : Cell Calcium. 86, 102107.

Research output: Contribution to journalReview article

Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis

Chen, H., Liu, Y. & Li, X., 2020, In : Life Science Alliance. 3, 8, e202000776.

Research output: Contribution to journalArticle

Open Access

Structure of nevanimibe-bound tetrameric human ACAT1

Long, T., Sun, Y., Hassan, A., Qi, X. & Li, X., May 21 2020, In : Nature. 581, 7808, p. 339-343 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access

TRP Channel: The structural era

Li, X. & Fine, M., May 2020, In : Cell Calcium. 87, 102191.

Research output: Contribution to journalEditorial

Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice

Kashiwagi, M., Kanuka, M., Tatsuzawa, C., Suzuki, H., Morita, M., Tanaka, K., Kawano, T., Shin, J. W., Suzuki, H., Itohara, S., Yanagisawa, M. & Hayashi, Y., Mar 23 2020, In : Current Biology. 30, 6, p. 1002-1010.e4

Research output: Contribution to journalArticle

5 Scopus citations
2019

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

BasuRay, S., Wang, Y., Smagris, E., Cohen, J. C. & Hobbs, H. H., May 7 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 19, p. 9521-9526 6 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

Furuse, T., Mizuma, H., Hirose, Y., Kushida, T., Yamada, I., Miura, I., Masuya, H., Funato, H., Yanagisawa, M., Onoe, H. & Wakana, S., 2019, In : DMM Disease Models and Mechanisms. 12, 9, dmm038828.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

An interspecies study of lipid profiles and atherosclerosis in familial hypercholesterolemia animal models with low-density lipoprotein receptor deficiency

He, K., Wang, J., Shi, H., Yu, Q., Zhang, X., Guo, M., Sun, H., Lin, X., Wu, Y., Wang, L., Wang, Y., Xian, X. & Liu, G., Jan 1 2019, In : American Journal of Translational Research. 11, 5, p. 3116-3127 12 p., AJTR0086659.

Research output: Contribution to journalArticle

4 Scopus citations

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Nagati, J. S., Xu, M., Garcia, T., Comerford, S. A., Hammer, R. E. & Garcia, J. A., Nov 1 2019, In : PloS one. 14, 11, e0225105.

Research output: Contribution to journalArticle

Open Access

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In : eLife. 8, e50051.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Critical Role of SREBP-1c Large-VLDL pathway in environment-induced hypertriglyceridemia of apo AV deficiency

Takanashi, M., Kimura, T., Li, C., Tanaka, M., Matsuhashi, A., Yoshida, H., Noda, A., Xu, P., Takase, S., Okazaki, S., Iizuka, Y., Kumagai, H., Ikeda, Y., Gotoda, T., Takahashi, M., Yagyu, H., Ishibashi, S., Yamauchi, T., Kadowaki, T., Liang, G. & 1 others, Okazaki, H., Mar 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 3, p. 373-386 14 p.

Research output: Contribution to journalArticle

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Qi, X., Liu, H., Thompson, B., McDonald, J., Zhang, C. & Li, X., Jul 11 2019, In : Nature. 571, 7764, p. 279-283 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

Wang, J., Hao, J. W., Wang, X., Guo, H., Sun, H. H., Lai, X. Y., Liu, L. Y., Zhu, M., Wang, H. Y., Li, Y. F., Yu, L. Y., Xie, C., Wang, H. R., Mo, W., Zhou, H. M., Chen, S., Liang, G. & Zhao, T., Jan 2 2019, In : Cell Reports. 26, 1, p. 209-221.e5

Research output: Contribution to journalArticle

13 Scopus citations

Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters

Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G. & Xian, X., Jul 2 2019, In : International journal of molecular sciences. 20, 14, 3515.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Differential Roles of Each Orexin Receptor Signaling in Obesity

Kakizaki, M., Tsuneoka, Y., Takase, K., Kim, S. J., Choi, J., Ikkyu, A., Abe, M., Sakimura, K., Yanagisawa, M. & Funato, H., Oct 25 2019, In : iScience. 20, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening

Seol, J., Fujii, Y., Park, I., Suzuki, Y., Kawana, F., Yajima, K., Fukusumi, S., Okura, T., Satoh, M., Tokuyama, K., Kokubo, T. & Yanagisawa, M., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24353-24358 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice

Yasugaki, S., Liu, C. Y., Kashiwagi, M., Kanuka, M., Honda, T., Miyata, S., Yanagisawa, M. & Hayashi, Y., Oct 14 2019, In : Frontiers in Neuroscience. 13, 1072.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Endothelin: 30 years from discovery to therapy

Barton, M. & Yanagisawa, M., Dec 1 2019, In : Hypertension. 74, 6, p. 1232-1265 34 p.

Research output: Contribution to journalReview article

10 Scopus citations

Erratum: Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System (PLoS biology (2011) 9 1 (e1000575))

Liu, Q., Zhang, J., Zerbinatti, C., Zhan, Y., Kolber, B. J., Herz, J., Muglia, L. J. & Bu, G., Jun 1 2019, In : PLoS biology. 17, 6, p. e3000310

Research output: Contribution to journalComment/debate

Open Access