Research Output

2020

Apolipoprotein E: Cholesterol metabolism and Alzheimer's pathology

Pohlkamp, T., Feb 1 2020, In : Neuroforum. 26, 1, p. 25-30 6 p.

Research output: Contribution to journalReview article

Biolistic transfection and expression analysis of acute cortical slices

Hamad, M. I. K., Daoud, S., Petrova, P., Rabaya, O., Jbara, A., Melliti, N., Stichmann, S., Reiss, G., Herz, J. & Förster, E., May 1 2020, In : Journal of Neuroscience Methods. 337, 108666.

Research output: Contribution to journalArticle

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., Infante, R. E., Radhakrishnan, A., Covey, D. F., Guan, K. L., Buck, J., Levin, L. R., Tontonoz, P., Schwabe, R. F. & Tabas, I., May 5 2020, In : Cell Metabolism. 31, 5, p. 969-986.e7

Research output: Contribution to journalArticle

Copine-7 is required for REM sleep regulation following cage change or water immersion and restraint stress in mice

Liu, C. Y., Tsai, C. J., Yasugaki, S., Nagata, N., Morita, M., Isotani, A., Yanagisawa, M. & Hayashi, Y., Jan 1 2020, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Enhanced cortical responsiveness during natural sleep in freely behaving mice

Matsumoto, S., Ohyama, K., Díaz, J., Yanagisawa, M., Greene, R. W. & Vogt, K. E., Dec 1 2020, In : Scientific reports. 10, 1, 2278.

Research output: Contribution to journalArticle

Open Access

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Yanagisawa, M. & Nagase, H., Feb 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 3, 126893.

Research output: Contribution to journalArticle

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

Abrams, M. E., Johnson, K. A., Perelman, S. S., Zhang, L. S., Endapally, S., Mar, K. B., Thompson, B. M., McDonald, J. G., Schoggins, J. W., Radhakrishnan, A. & Alto, N. M., Jan 1 2020, (Accepted/In press) In : Nature microbiology.

Research output: Contribution to journalArticle

Reelin signaling modulates GABAB receptor function in the neocortex

Hamad, M. I. K., Jbara, A., Rabaya, O., Petrova, P., Daoud, S., Melliti, N., Meseke, M., Lutz, D., Petrasch-Parwez, E., Schwitalla, J. C., Mark, M. D., Herlitze, S., Reiss, G., Herz, J. & Förster, E., Jan 1 2020, (Accepted/In press) In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Open Access

Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus but Leaves Cortical Layering and Behavior Unaffected

Pahle, J., Muhia, M., Wagener, R. J., Tippmann, A., Bock, H. H., Graw, J., Herz, J., Staiger, J. F., Drakew, A., Kneussel, M., Rune, G. M., Frotscher, M. & Brunne, B., Mar 14 2020, In : Cerebral Cortex. 30, 3, p. 1688-1707 20 p.

Research output: Contribution to journalArticle

Open Access

Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway

Kucharava, K., Brand, Y., Albano, G., Sekulic-Jablanovic, M., Glutz, A., Xian, X., Herz, J., Bodmer, D., Fuster, D. G. & Petkovic, V., Dec 1 2020, In : Scientific reports. 10, 1, 3609.

Research output: Contribution to journalArticle

Open Access

Structural basis for itraconazole-mediated NPC1 inhibition

Long, T., Qi, X., Hassan, A., Liang, Q., De Brabander, J. K. & Li, X., Dec 1 2020, In : Nature communications. 11, 1, 152.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Structural insights into group II TRP channels

Fine, M., Li, X. & Dang, S., Mar 2020, In : Cell Calcium. 86, 102107.

Research output: Contribution to journalReview article

Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice

Kashiwagi, M., Kanuka, M., Tatsuzawa, C., Suzuki, H., Morita, M., Tanaka, K., Kawano, T., Shin, J. W., Suzuki, H., Itohara, S., Yanagisawa, M. & Hayashi, Y., Mar 23 2020, In : Current Biology. 30, 6, p. 1002-1010.e4

Research output: Contribution to journalArticle

2 Scopus citations
2019

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

BasuRay, S., Wang, Y., Smagris, E., Cohen, J. C. & Hobbs, H. H., May 7 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 19, p. 9521-9526 6 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

Furuse, T., Mizuma, H., Hirose, Y., Kushida, T., Yamada, I., Miura, I., Masuya, H., Funato, H., Yanagisawa, M., Onoe, H. & Wakana, S., Sep 12 2019, In : Disease models & mechanisms. 12, 9

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

An interspecies study of lipid profiles and atherosclerosis in familial hypercholesterolemia animal models with low-density lipoprotein receptor deficiency

He, K., Wang, J., Shi, H., Yu, Q., Zhang, X., Guo, M., Sun, H., Lin, X., Wu, Y., Wang, L., Wang, Y., Xian, X. & Liu, G., Jan 1 2019, In : American Journal of Translational Research. 11, 5, p. 3116-3127 12 p., AJTR0086659.

Research output: Contribution to journalArticle

2 Scopus citations

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Nagati, J. S., Xu, M., Garcia, T., Comerford, S. A., Hammer, R. E. & Garcia, J. A., Jan 1 2019, In : PloS one. 14, 11, e0225105.

Research output: Contribution to journalArticle

Open Access

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In : eLife. 8, e50051.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency

Takanashi, M., Kimura, T., Li, C., Tanaka, M., Matsuhashi, A., Yoshida, H., Noda, A., Xu, P., Takase, S., Okazaki, S., Iizuka, Y., Kumagai, H., Ikeda, Y., Gotoda, T., Takahashi, M., Yagyu, H., Ishibashi, S., Yamauchi, T., Kadowaki, T., Liang, G. & 1 others, Okazaki, H., Mar 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 3, p. 373-386 14 p.

Research output: Contribution to journalArticle

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Qi, X., Liu, H., Thompson, B., McDonald, J., Zhang, C. & Li, X., Jan 1 2019, (Accepted/In press) In : Nature.

Research output: Contribution to journalLetter

13 Scopus citations

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

Wang, J., Hao, J. W., Wang, X., Guo, H., Sun, H. H., Lai, X. Y., Liu, L. Y., Zhu, M., Wang, H. Y., Li, Y. F., Yu, L. Y., Xie, C., Wang, H. R., Mo, W., Zhou, H. M., Chen, S., Liang, G. & Zhao, T. J., Jan 2 2019, In : Cell Reports. 26, 1, p. 209-221.e5

Research output: Contribution to journalArticle

9 Scopus citations

Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters

Wang, J., He, K., Yang, C., Lin, X., Zhang, X., Wang, Y., Liu, G. & Xian, X., Jul 2 2019, In : International journal of molecular sciences. 20, 14, 3515.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Differential Roles of Each Orexin Receptor Signaling in Obesity

Kakizaki, M., Tsuneoka, Y., Takase, K., Kim, S. J., Choi, J., Ikkyu, A., Abe, M., Sakimura, K., Yanagisawa, M. & Funato, H., Oct 25 2019, In : iScience. 20, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening

Seol, J., Fujii, Y., Park, I., Suzuki, Y., Kawana, F., Yajima, K., Fukusumi, S., Okura, T., Satoh, M., Tokuyama, K., Kokubo, T. & Yanagisawa, M., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24353-24358 6 p.

Research output: Contribution to journalArticle

Effects of 3 Weeks of Water Immersion and Restraint Stress on Sleep in Mice

Yasugaki, S., Liu, C. Y., Kashiwagi, M., Kanuka, M., Honda, T., Miyata, S., Yanagisawa, M. & Hayashi, Y., Oct 14 2019, In : Frontiers in Neuroscience. 13, 1072.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Erratum: Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System (PLoS biology (2011) 9 1 (e1000575))

Liu, Q., Zhang, J., Zerbinatti, C., Zhan, Y., Kolber, B. J., Herz, J., Muglia, L. J. & Bu, G., Jun 1 2019, In : PLoS biology. 17, 6, p. e3000310

Research output: Contribution to journalComment/debate

Open Access

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity

Saitoh, T., Seki, K., Nakajima, R., Yamamoto, N., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Tanimura, R., Yanagisawa, M. & Nagase, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations

Identification of residues critical for topology inversion of the transmembrane protein TM4SF20 through regulated alternative translocation

Wang, J., Kinch, L. N., Denard, B., Lee, C. E., Gharehdaghi, E. E., Grishin, N. & Ye, J., Apr 12 2019, In : Journal of Biological Chemistry. 294, 15, p. 6054-6061 8 p.

Research output: Contribution to journalArticle

IL-33 in murine abdominal aortic aneurysm: A novel inflammatory mediator awaiting clinical translation

Tsai, S. & Xian, X., Jun 1 2019, In : Journal of Thoracic Disease. 11, 6, p. 2181-2184 4 p.

Research output: Contribution to journalReview article

Improvement of slow wave sleep continuity by mattresswith better body pressure dispersal

Kayaba, M., Ogata, H., Park, I., Ishihara, A., Kawana, F., Kokubo, T., Fukusumi, S., Hayashi, M., Tokuyama, K., Yanagisawa, M. & Satoh, M., Dec 1 2019, In : Sleep Medicine Research. 10, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

Open Access

Intravascular triglyceride lipolysis becomes crystal clear

Horton, J. D., Jan 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 5, p. 1480-1482 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Moreno-Yruela, C., Fass, D. M., Cheng, C., Herz, J., Olsen, C. A. & Haggarty, S. J., Aug 21 2019, In : ACS Chemical Neuroscience. 10, 8, p. 3769-3777 9 p.

Research output: Contribution to journalArticle

Large triglyceride-rich lipoproteins in hypertriglyceridemia are associated with the severity of acute pancreatitis in experimental mice

Zhang, Y., He, W., He, C., Wan, J., Lin, X., Zheng, X., Li, L., Li, X., Yang, X., Yu, B., Xian, X., Zhu, Y., Wang, Y., Liu, G. & Lu, N., Oct 1 2019, In : Cell Death and Disease. 10, 10, 728.

Research output: Contribution to journalArticle

Open Access

LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation

Calvier, L., Boucher, P., Herz, J. & Hansmann, G., Jun 7 2019, In : Circulation research. 124, 12, p. 1778-1785 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks

Yamabe, M., Horie, K., Shiokawa, H., Funato, H., Yanagisawa, M. & Kitagawa, H., Dec 1 2019, In : Scientific reports. 9, 1, 15793.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice

Miyoshi, C., Kim, S. J., Ezaki, T., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Kakizaki, M., Yamada, M., Wakana, S., Yanagisawa, M. & Funato, H., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16062-16067 6 p.

Research output: Contribution to journalArticle

Open Access

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Endapally, S., Frias, D., Grzemska, M., Gay, A., Tomchick, D. R. & Radhakrishnan, A., Feb 21 2019, In : Cell. 176, 5, p. 1040-1053.e17

Research output: Contribution to journalArticle

20 Scopus citations
3 Scopus citations

Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum

Johnson, K. A., Endapally, S., Vazquez, D. C., Infante, R. E. & Radhakrishnan, A., Nov 15 2019, In : Journal of Biological Chemistry. 294, 46, p. 17289-17300 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

Wang, Y., Kory, N., BasuRay, S., Cohen, J. C. & Hobbs, H. H., Jun 2019, In : Hepatology. 69, 6, p. 2427-2441 15 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Regulating G protein-coupled receptors by topological inversion

Denard, B., Han, S., Kim, J. Y., Ross, E. M. & Ye, J., Mar 2019, In : eLife. 8, e40234.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Jo, Y., Hamilton, J. S., Hwang, S., Garland, K., Smith, G. A., Su, S., Fuentes, I., Neelam, S., Thompson, B. M., McDonald, J. G. & Debose-Boyd, R. A., Feb 2019, In : eLife. 8, e44396.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

SDH5 depletion enhances radiosensitivity by regulating p53: A new method for noninvasive prediction of radiotherapy response

Zong, Y., Li, Q., Zhang, F., Xian, X., Wang, S., Xia, J., Li, J., Tuo, Z., Xiao, G., Liu, L., Li, G., Zhang, S., Wu, G. & Liu, J., Jan 1 2019, In : Theranostics. 9, 22, p. 6380-6395 16 p.

Research output: Contribution to journalArticle

Open Access

Seurat's Dots: A Shot Heard ’Round the Art World—Fired by an Artist, Inspired by a Scientist

Goldstein, J. L., Sep 19 2019, In : Cell. 179, 1, p. 46-50 5 p.

Research output: Contribution to journalComment/debate

Open Access

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J. & Li, X., Dec 1 2019, In : Nature communications. 10, 1, 2452.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Uptake of HDL-cholesterol contributes to lipid accumulation in clear cell renal cell carcinoma

Kim, J. Y., Thompson, B., Han, S., Lotan, Y., McDonald, J. G. & Ye, J., Dec 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 12, 158525.

Research output: Contribution to journalArticle

1 Scopus citations