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2019

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Jo, Y., Hamilton, J. S., Hwang, S., Garland, K., Smith, G. A., Su, S., Fuentes, I., Neelam, S., Thompson, B. M., McDonald, J. G. & Debose-Boyd, R. A., Feb 2019, In : eLife. 8, e44396.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

SDH5 depletion enhances radiosensitivity by regulating p53: A new method for noninvasive prediction of radiotherapy response

Zong, Y., Li, Q., Zhang, F., Xian, X., Wang, S., Xia, J., Li, J., Tuo, Z., Xiao, G., Liu, L., Li, G., Zhang, S., Wu, G. & Liu, J., Jan 1 2019, In : Theranostics. 9, 22, p. 6380-6395 16 p.

Research output: Contribution to journalArticle

Open Access

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

Crewe, C., Zhu, Y., Paschoal, V. A., Joffin, N., Ghaben, A. L., Gordillo, R., Oh, D. Y., Liang, G., Horton, J. D. & Scherer, P. E., Aug 8 2019, In : JCI Insight. 4, 15, e129397.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

Long, T., Hassan, A., Thompson, B. M., McDonald, J. G., Wang, J. & Li, X., Dec 1 2019, In : Nature communications. 10, 1, 2452.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2 Scopus citations
2018

Ablation of central serotonergic neurons decreased REM sleep and attenuated arousal response

Iwasaki, K., Komiya, H., Kakizaki, M., Miyoshi, C., Abe, M., Sakimura, K., Funato, H. & Yanagisawa, M., Aug 7 2018, In : Frontiers in Neuroscience. 12, AUG, 535.

Research output: Contribution to journalArticle

8 Scopus citations

Acute pressor response to psychosocial stress is dependent on endothelium-derived endothelin-1

Fox, B. M., Becker, B. K., Loria, A. S., Hyndman, K. A., Jin, C., Clark, H., Johns, R., Yanagisawa, M., Pollock, D. M. & Pollock, J. S., Feb 1 2018, In : Journal of the American Heart Association. 7, 4, e007863.

Research output: Contribution to journalArticle

5 Scopus citations

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Deng, Y., Wang, Z., Gordillo, R., Zhu, Y., Ali, A., Zhang, C., Wang, X., Shao, M., Zhang, Z., Iyengar, P., Gupta, R. K., Horton, J. D., Hill, J. A. & Scherer, P. E., May 2018, In : Molecular Metabolism. 11, p. 1-17 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

Sacharidou, A., Chambliss, K. L., Ulrich, V., Salmon, J. E., Shen, Y. M., Herz, J., Hui, D. Y., Terada, L. S., Shaul, P. W. & Mineo, C., May 10 2018, In : Blood. 131, 19, p. 2097-2110 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

A protein-truncating HSD17B13 variant and protection from chronic liver disease

Abul-Husn, N. S., Cheng, X., Li, A. H., Xin, Y., Schurmann, C., Stevis, P., Liu, Y., Kozlitina, J., Stender, S., Wood, G. C., Stepanchick, A. N., Still, M. D., McCarthy, S., O'Dushlaine, C., Packer, J. S., Balasubramanian, S., Gosalia, N., Esopi, D., Kim, S. Y., Mukherjee, S. & 28 others, Lopez, A. E., Fuller, E. D., Penn, J., Chu, X., Luo, J. Z., Mirshahi, U. L., Carey, D. J., Still, C. D., Feldman, M. D., Small, A., Damrauer, S. M., Rader, D. J., Zambrowicz, B., Olson, W., Murphy, A. J., Borecki, I. B., Shuldiner, A. R., Reid, J. G., Overton, J. D., Yancopoulos, G. D., Hobbs, H. H., Cohen, J. C., Gottesman, O., Teslovich, T. M., Baras, A., Mirshahi, T., Gromada, J. & Dewey, F. E., Mar 22 2018, In : New England Journal of Medicine. 378, 12, p. 1096-1106 11 p.

Research output: Contribution to journalArticle

138 Scopus citations

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

Honda, T., Fujiyama, T., Miyoshi, C., Ikkyu, A., Hotta-Hirashima, N., Kanno, S., Mizuno, S., Sugiyama, F., Takahashi, S., Funato, H. & Yanagisawa, M., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10458-10463 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

Tian, J., Wu, J., Chen, X., Guo, T., Chen, Z. J., Goldstein, J. L. & Brown, M. S., Jun 27 2018, In : eLife. 7, e36826.

Research output: Contribution to journalArticle

4 Scopus citations

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein e isoform-specific mechanism

Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M. & Zlokovic, B. V., Oct 19 2018, In : Molecular neurodegeneration. 13, 1, 57.

Research output: Contribution to journalArticle

35 Scopus citations

Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy

Kaushik, M. K., Aritake, K., Imanishi, A., Kanbayashi, T., Ichikawa, T., Shimizu, T., Urade, Y. & Yanagisawa, M., Jun 5 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 23, p. 6046-6051 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy

Denard, B., Jiang, S., Peng, Y. & Ye, J., Aug 13 2018, In : BMC Cancer. 18, 1, 813.

Research output: Contribution to journalArticle

4 Scopus citations

Cross Linked Enzyme Aggregates as Versatile Tool for Enzyme Delivery: Application to Polymeric Nanoparticles

Galliani, M., Santi, M., Del Grosso, A., Cecchettini, A., Santorelli, F. M., Hofmann, S. L., Lu, J. Y., Angella, L., Cecchini, M. & Signore, G., Mar 21 2018, (Accepted/In press) In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

10 Scopus citations

Development of a Therapeutic Drug for Narcolepsy

Irukayama-Tomobe, Y. & Yanagisawa, M., Nov 1 2018, In : Brain and nerve = Shinkei kenkyu no shinpo. 70, 11, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin

Meseke, M., Neumüller, F., Brunne, B., Li, X., Anstötz, M., Pohlkamp, T., Rogalla, M. M., Herz, J., Rune, G. M. & Bender, R. A., Sep 1 2018, In : eNeuro. 5, 5

Research output: Contribution to journalArticle

1 Scopus citations

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

Saitoh, A., Tominaga, H., Ogawa, Y., Irukayama-Tomobe, Y., Yamada, M., Yanagisawa, M. & Nagase, H., Apr 1 2018, In : Pharmacological Reports. 70, 2, p. 350-354 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Ohrui, S., Yamamoto, N., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

7 Scopus citations

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

Fujiyama, T., Miyashita, S., Tsuneoka, Y., Kanemaru, K., Kakizaki, M., Kanno, S., Ishikawa, Y., Yamashita, M., Owa, T., Nagaoka, M., Kawaguchi, Y., Yanagawa, Y., Magnuson, M. A., Muratani, M., Shibuya, A., Nabeshima, Y. I., Yanagisawa, M., Funato, H. & Hoshino, M., Jul 3 2018, In : Cell Reports. 24, 1, p. 79-94 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

Jia, L., Chang, X., Qian, S., Liu, C., Lord, C. C., Ahmed, N., Lee, C. E., Lee, S., Gautron, L., Mitchell, M. C., Horton, J. D., Scherer, P. E. & Elmquist, J. K., Aug 1 2018, In : Molecular Metabolism. 14, p. 121-129 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Hypocretin/orexin deficiency decreases cocaine abuse liability

Steiner, N., Rossetti, C., Sakurai, T., Yanagisawa, M., de Lecea, L., Magistretti, P. J., Halfon, O. & Boutrel, B., May 1 2018, In : Neuropharmacology. 133, p. 395-403 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice

Banfi, S., Gusarova, V., Gromada, J., Cohen, J. C. & Hobbs, H. H., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. E1249-E1258

Research output: Contribution to journalArticle

12 Scopus citations

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

Linden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. & Liang, G., 2018, In : Journal of lipid research. 59, 3, p. 475-487 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity

Ye, R., Gordillo, R., Shao, M., Onodera, T., Chen, Z., Chen, S., Lin, X., SoRelle, J. A., Li, X., Tang, M., Keller, M. P., Kuliawat, R., Attie, A. D., Gupta, R. K., Holland, W. L., Beutler, B. A., Herz, J. & Scherer, P. E., Mar 1 2018, In : Journal of Clinical Investigation. 128, 3, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Wang, Y., Cao, L., Lee, C. Y., Matsuo, T., Wu, K., Asher, G., Tang, L., Saitoh, T., Russell, J. L., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Chérasse, Y., Zhou, J., Li, Y., Wang, T., Zhan, X., Miyoshi, C., Irukayama, Y. & 13 others, Cao, J., Meeks, J., Gautron, L., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B. A. & Liu, Q., Dec 1 2018, In : Nature communications. 9, 1, 2041.

Research output: Contribution to journalArticle

8 Scopus citations

Localization of orexin B and orexin-2 receptor in the rat epididymis

Liguori, G., Tafuri, S., Miyoshi, C., Yanagisawa, M., Squillacioti, C., De Pasquale, V., Mirabella, N., Vittoria, A. & Costagliola, A., Jan 1 2018, (Accepted/In press) In : Acta Histochemica.

Research output: Contribution to journalArticle

3 Scopus citations

Loss of LCAT activity in the golden Syrian hamster elicits pro-atherogenic dyslipidemia and enhanced atherosclerosis

Dong, Z., Shi, H., Zhao, M., Zhang, X., Huang, W., Wang, Y., Zheng, L., Xian, X. & Liu, G., Jun 1 2018, In : Metabolism: Clinical and Experimental. 83, p. 245-255 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

Jaoude, A. A., Badiqué, L., Mlih, M., Awan, S., Guo, S., Lemle, A., Abboud, C., Foppolo, S., Host, L., Terrand, J., Justiniano, H., Herz, J., Matz, R. L. & Boucher, P., Dec 1 2018, In : Scientific Reports. 8, 1, 4501.

Research output: Contribution to journalArticle

4 Scopus citations

Low-density lipoprotein receptor–related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression

Hamlin, A. N., Chinnarasu, S., Ding, Y., Xian, X., Herz, J., Jaeschke, A. & Hui, D. Y., Jun 22 2018, In : Journal of Biological Chemistry. 293, 25, p. 9674-9684 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling

Bartelt, A., Behler-Janbeck, F., Beil, F. T., Koehne, T., Müller, B., Schmidt, T., Heine, M., Ochs, L., Yilmaz, T., Dietrich, M., Tuckermann, J. P., Amling, M., Herz, J., Schinke, T., Heeren, J. & Niemeier, A., Dec 1 2018, In : Bone Research. 6, 1, 4.

Research output: Contribution to journalArticle

12 Scopus citations

Lrp4/Wise regulates palatal rugae development through turing-type reaction-diffusion mechanisms

Kawasaki, M., Kawasaki, K., Meguro, F., Yamada, A., Ishikawa, R., Porntaveetus, T., Blackburn, J., Otsuka-Tanaka, Y., Saito, N., Ota, M. S., Sharpe, P. T., Kessler, J. A., Herz, J., Cobourne, M. T., Maeda, T. & Ohazama, A., Sep 2018, In : PloS one. 13, 9, e0204126.

Research output: Contribution to journalArticle

5 Scopus citations

Lucky, times ten: A career in Texas science

Russell, D. W., Dec 7 2018, In : Journal of Biological Chemistry. 293, 49, p. 18804-18827 24 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Trinh, M. N., Brown, M. S., Seemann, J., Goldstein, J. L. & Lu, F., Jul 26 2018, In : eLife. 7, e38564.

Research output: Contribution to journalArticle

7 Scopus citations

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

Toyama, S., Shimoyama, N., Tagaito, Y., Nagase, H., Saitoh, T., Yanagisawa, M. & Shimoyama, M., Jan 1 2018, In : Anesthesiology. 128, 5, p. 992-1003 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
30 Scopus citations

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

Wang, Z., Ma, J., Miyoshi, C., Li, Y., Sato, M., Ogawa, Y., Lou, T., Ma, C., Gao, X., Lee, C., Fujiyama, T., Yang, X., Zhou, S., Hotta-Hirashima, N., Klewe-Nebenius, D., Ikkyu, A., Kakizaki, M., Kanno, S., Cao, L., Takahashi, S. & 5 others, Peng, J., Yu, Y., Funato, H., Yanagisawa, M. & Liu, Q., Jun 21 2018, In : Nature. 558, 7710, p. 435-439 5 p.

Research output: Contribution to journalArticle

44 Scopus citations

Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride

Stender, S., Smagris, E., Lauridsen, B. K., Kofoed, K. F., Nordestgaard, B. G., Tybjærg-Hansen, A., Pennacchio, L. A., Dickel, D. E., Cohen, J. C. & Hobbs, H. H., Jun 1 2018, In : Hepatology. 67, 6, p. 2182-2195 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

Xian, X., Pohlkamp, T., Durakoglugil, M. S., Wong, C. H., Beck, J. K., Lane-Donovan, C., Plattner, F. & Herz, J., Oct 1 2018, In : eLife. 7, e40048.

Research output: Contribution to journalArticle

14 Scopus citations

Sleep/Wake Behaviors in Mice during Pregnancy and Pregnancy-Associated Hypertensive Mice

Komiya, H., Miyoshi, C., Iwasaki, K., Hotta-Hirashima, N., Ikkyu, A., Kanno, S., Honda, T., Gosho, M., Hamada, H., Satoh, T., Fukamizu, A., Funato, H. & Yanagisawa, M., Mar 1 2018, In : Sleep. 41, 3

Research output: Contribution to journalArticle

2 Scopus citations

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

DeBose-Boyd, R. A. & Ye, J., Jan 1 2018, (Accepted/In press) In : Trends in Biochemical Sciences.

Research output: Contribution to journalArticle

29 Scopus citations

Structural basis for PtdInsP2-mediated human TRPML1 regulation

Fine, M., Schmiege, P. & Li, X., Dec 1 2018, In : Nature communications. 9, 1, 4192.

Research output: Contribution to journalArticle

15 Scopus citations

The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM

Schmiege, P., Fine, M. & Li, X., Jul 2018, In : FEBS Journal. 285, 14, p. 2579-2585 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Two patched molecules engage distinct sites on hedgehog yielding a signaling-competent complex

Qi, X., Schmiege, P., Coutavas, E. & Li, X., Oct 5 2018, In : Science. 362, 6410, eaas8843.

Research output: Contribution to journalArticle

33 Scopus citations
12 Scopus citations
2017
34 Scopus citations

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Kim, C. W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Chakravarthy, M., Previs, S., Milstein, S., Fitzgerald, K., Kelley, D. E. & Horton, J. D., Aug 1 2017, In : Cell Metabolism. 26, 2, p. 394-406.e6

Research output: Contribution to journalArticle

69 Scopus citations

A consensus definitive classification of scavenger receptors and their roles in health and disease

PrabhuDas, M. R., Baldwin, C. L., Bollyky, P. L., Bowdish, D. M. E., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., McVicker, B., Means, T. K., Moestrup, S. K., Post, S. R., Sawamura, T., Silverstein, S., Speth, R. C., Telfer, J. C., Thiele, G. M., Wang, X. Y. & 2 others, Wright, S. D. & El Khoury, J., May 15 2017, In : Journal of Immunology. 198, 10, p. 3775-3789 15 p.

Research output: Contribution to journalArticle

80 Scopus citations

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI

Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E. Y., Pavía-Jiménez, A., Fulkerson, M., de Leon, A. D., Yuan, Q., Dimitrov, I. E., Yokoo, T., Ye, J., Mitsche, M. A., Kim, H., McDonald, J. G., Xi, Y., Madhuranthakam, A. J., Dwivedi, D. K., Lenkinski, R. E. & 5 others, Cadeddu, J. A., Margulis, V., Brugarolas, J., DeBerardinis, R. J. & Pedrosa, I., Aug 3 2017, In : JCI Insight. 2, 15

Research output: Contribution to journalArticle

Open Access
16 Scopus citations