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2017

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

Stender, S., Kozlitina, J., Nordestgaard, B. G., Tybjærg-Hansen, A., Hobbs, H. H. & Cohen, J. C., Jun 1 2017, In : Nature Genetics. 49, 6, p. 842-847 6 p.

Research output: Contribution to journalArticle

94 Scopus citations

A highly durable RNAi therapeutic inhibitor of PCSK9

Fitzgerald, K., White, S., Borodovsky, A., Bettencourt, B. R., Strahs, A., Clausen, V., Wijngaard, P., Horton, J. D., Taubel, J., Brooks, A., Fernando, C., Kauffman, R. S., Kallend, D., Vaishnaw, A. & Simon, A., Jan 5 2017, In : New England Journal of Medicine. 376, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

121 Scopus citations

An adipo-biliary-uridine axis that regulates energy homeostasis

Deng, Y., Wang, Z., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., De Brabander, J. K., Elmquist, J. K., Horton, J. D., Hill, J. A., Klein, S. & Scherer, P. E., Mar 17 2017, In : Science. 355, 6330, eaaf5375.

Research output: Contribution to journalArticle

37 Scopus citations

Anatomical and electrophysiological development of the hypothalamic orexin neurons from embryos to neonates

Ogawa, Y., Kanda, T., Vogt, K. & Yanagisawa, M., Dec 15 2017, In : Journal of Comparative Neurology. 525, 18, p. 3809-3820 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

ANGPTL8 blockade with a monoclonal antibody promotes triglyceride clearance, energy expenditure, and weight loss in mice

Gusarova, V., Banfi, S., Alexa-Braun, C. A., Shihanian, L. M., Mintah, I. J., Lee, J. S., Xin, Y., Su, Q., Kamat, V., Cohen, J. C., Hobbs, H. H., Zambrowicz, B., Yancopoulos, G. D., Murphy, A. J. & Gromada, J., May 1 2017, In : Endocrinology. 158, 5, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

Haller, J. F., Mintah, I. J., Shihanian, L. M., Stevis, P., Buckler, D., Alexa-Braun, C. A., Kleiner, S., Banfi, S., Cohen, J. C., Hobbs, H. H., Yancopoulos, G. D., Murphy, A. J., Gusarova, V. & Gromada, J., Jun 2017, In : Journal of lipid research. 58, 6, p. 1166-1173 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

Watanabe, R., Suzuki, J. I., Wakayama, K., Maejima, Y., Shimamura, M., Koriyama, H., Nakagami, H., Kumagai, H., Ikeda, Y., Akazawa, H., Morishita, R., Komuro, I. & Isobe, M., Mar 7 2017, In : Scientific Reports. 7, 43920.

Research output: Contribution to journalArticle

9 Scopus citations

A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice

Sato, H., Suzuki, J. I., Aoyama, N., Watanabe, R., Kaneko, M., Shiheido, Y., Yoshida, A., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., Isobe, M. & Izumi, Y., Jan 1 2017, In : Hypertension Research. 40, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Building a better blood-brain barrier

Lane-Donovan, C. & Herz, J., Oct 10 2017, In : eLife. 6, e31808.

Research output: Contribution to journalArticle

2 Scopus citations
2 Scopus citations
12 Scopus citations
43 Scopus citations

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Nagase, H., Yamamoto, N., Yata, M., Ohrui, S., Okada, T., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ishikawa, Y., Ogawa, Y., Hirayama, S., Kuroda, D., Watanabe, Y., Gouda, H. & Yanagisawa, M., Feb 9 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1018-1040 23 p.

Research output: Contribution to journalArticle

16 Scopus citations

Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia

Aoyama, N., Suzuki, J. I., Kobayashi, N., Hanatani, T., Ashigaki, N., Yoshida, A., Shiheido, Y., Sato, H., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., Minabe, M., Izumi, Y. & Isobe, M., Oct 17 2017, In : BMC Cardiovascular Disorders. 17, 1, 267.

Research output: Contribution to journalArticle

2 Scopus citations

Developmental and extrahepatic physiological functions of SREBP pathway genes in mice

Engelking, L. J., Cantoria, M. J., Xu, Y. & Liang, G., 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

3 Scopus citations

Difference distance map data of alternative crystal forms of UlaA

Vastermark, A., Driker, A., Weng, J., Li, X., Wang, J. & Saier, M. H., Feb 1 2017, In : Data in Brief. 10, p. 198-201 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

Kamo, T., Akazawa, H., Suda, W., Saga-Kamo, A., Shimizu, Y., Yagi, H., Liu, Q., Nomura, S., Naito, A. T., Takeda, N., Harada, M., Toko, H., Kumagai, H., Ikeda, Y., Takimoto, E., Suzuki, J. I., Honda, K., Morita, H., Hattori, M. & Komuro, I., Mar 2017, In : PloS one. 12, 3, e0174099.

Research output: Contribution to journalArticle

49 Scopus citations

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Yamamoto, N., Ohrui, S., Okada, T., Yata, M., Saitoh, T., Kutsumura, N., Nagumo, Y., Irukayama-Tomobe, Y., Ogawa, Y., Ishikawa, Y., Watanabe, Y., Hayakawa, D., Gouda, H., Yanagisawa, M. & Nagase, H., Sep 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 4176-4179 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y. A., Hammer, R. E. & Horton, J. D., Feb 28 2017, In : eLife. 6, e25015.

Research output: Contribution to journalArticle

39 Scopus citations

Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/ GPR44) receptors for prostaglandin D2

Nagata, N., Iwanari, H., Kumagai, H., Kusano-Arai, O., Ikeda, Y., Aritake, K., Hamakubo, T. & Urade, Y., Apr 2017, In : PloS one. 12, 4, e0175452.

Research output: Contribution to journalArticle

3 Scopus citations

Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

Sumazin, P., Chen, Y., Treviño, L. R., Sarabia, S. F., Hampton, O. A., Patel, K., Mistretta, T. A., Zorman, B., Thompson, P., Heczey, A., Comerford, S. A., Wheeler, D. A., Chintagumpala, M., Meyers, R., Rakheja, D., Finegold, M. J., Tomlinson, G., Parsons, D. W. & López-Terrada, D., Jan 1 2017, In : Hepatology. 65, 1, p. 104-121 18 p.

Research output: Contribution to journalArticle

52 Scopus citations

Human TRPML1 channel structures in open and closed conformations

Schmiege, P., Fine, M., Blobel, G. & Li, X., Oct 19 2017, In : Nature. 550, 7676, 24036.

Research output: Contribution to journalArticle

47 Scopus citations
15 Scopus citations

Imaging subcellular dynamics with fast and lightefficient volumetrically parallelized microscopy

Dean, K. M., Roudot, P., Welf, E. S., Pohlkamp, T., Garrelts, G., Herz, J. & Fiolka, R., Feb 20 2017, In : Optica. 4, 2, p. 263-271 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice

Berger, J. M., Valdes, A. L., Gromada, J., Anderson, N. & Horton, J. D., 2017, In : Journal of lipid research. 58, 8, p. 1661-1669 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

Guo, X., Gao, M., Wang, Y., Lin, X., Yang, L., Cong, N., An, X., Wang, F., Qu, K., Yu, L., Wang, Y., Wang, J., Zhu, H., Xian, X. & Liu, G., Jan 1 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

17 Scopus citations

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Evers, B. M., Rodriguez-Navas, C., Tesla, R. J., Prange-Kiel, J., Wasser, C. R., Yoo, K. S., McDonald, J., Cenik, B., Ravenscroft, T. A., Plattner, F., Rademakers, R., Yu, G., White, C. L. & Herz, J., Sep 12 2017, In : Cell Reports. 20, 11, p. 2565-2574 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Liver receptor homolog-1 regulates mouse superoxide dismutase 2

Lee, J. S., Bae, S., Kang, H. S., Im, S. S. & Moon, Y. A., Jul 29 2017, In : Biochemical and Biophysical Research Communications. 489, 3, p. 299-304 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Ferris, H. A., Perry, R. J., Moreira, G. V., Shulman, G. I., Horton, J. D. & Kahn, C. R., Jan 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1189-1194 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement fromthe European Atherosclerosis Society Consensus Panel

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watt, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., Van De Sluis, B., Taskinen, M. R., Tokgözoǧlu, L. & 6 others, Landmesser, U., Laufs, U., Wiklund, O., Stock, J. K., Chapman, M. J. & Catapano, A. L., Aug 21 2017, In : European heart journal. 38, 32, p. 2459-2472 14 p.

Research output: Contribution to journalArticle

567 Scopus citations

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

Xian, X., Ding, Y., Dieckmann, M., Zhou, L., Plattner, F., Liu, M., Parks, J. S., Hammer, R. E., Boucher, P., Tsai, S. & Herz, J., Nov 16 2017, In : eLife. 6, e29292.

Research output: Contribution to journalArticle

19 Scopus citations
11 Scopus citations

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe, Y., Ogawa, Y., Tominaga, H., Ishikawa, Y., Hosokawa, N., Ambai, S., Kawabe, Y., Uchida, S., Nakajima, R., Saitoh, T., Kanda, T., Vogt, K., Sakurai, T., Nagase, H. & Yanagisawa, M., May 30 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5731-5736 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Octacosanol restores stress-affected sleep in mice by alleviating stress

Kaushik, M. K., Aritake, K., Takeuchi, A., Yanagisawa, M. & Urade, Y., Dec 1 2017, In : Scientific reports. 7, 1, 8892.

Research output: Contribution to journalArticle

7 Scopus citations

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Dang, E. V., McDonald, J. G., Russell, D. W. & Cyster, J. G., 2017, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

67 Scopus citations

Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation

Aoyama, N., Suzuki, J. I., Kobayashi, N., Hanatani, T., Ashigaki, N., Yoshida, A., Shiheido, Y., Sato, H., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., Izumi, Y. & Isobe, M., May 31 2017, (Accepted/In press) In : Heart and Vessels. p. 1-6 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting

Lee, J. H., Kang, H. S., Park, H. Y., Moon, Y. A., Kang, Y. N., Oh, B. C., Song, D. K., Bae, J. H. & Im, S. S., Dec 1 2017, In : Scientific Reports. 7, 1, 9958.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system

Han, Y., Xiong, Y., Shi, X., Wu, J., Zhao, Y. & Jiang, J., Aug 1 2017, In : PLoS Biology. 15, 8, e2002063.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of INSIG2 by microRNA-96

Jo, Y., Cha, J. Y. & Moon, Y. A., Jun 10 2017, (Accepted/In press) In : Animal Cells and Systems. p. 1-6 6 p.

Research output: Contribution to journalArticle

Resolution of acute hepatitis B-associated aplastic anaemia with antiviral therapy

Hendren, N., Moore, J., Hofmann, S. & Rambally, S., 2017, In : BMJ Case Reports. 2017, bcr-2017-221503.

Research output: Contribution to journalArticle

Role of hormone-sensitive lipase in leptin-promoted fat loss and glucose lowering

Takanashi, M., Taira, Y., Okazaki, S., Takase, S., Kimura, T., Li, C. C., Xu, P. F., Noda, A., Sakata, I., Kumagai, H., Ikeda, Y., Iizuka, Y., Yahagi, N., Shimano, H., Osuga, J. I., Ishibashi, S., Kadowaki, T. & Okazaki, H., 2017, In : Journal of atherosclerosis and thrombosis. 24, 11, p. 1105-1116 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

She, A., Kurtser, I., Reis, S. A., Hennig, K., Lai, J., Lang, A., Zhao, W. N., Mazitschek, R., Dickerson, B. C., Herz, J. & Haggarty, S. J., Jul 20 2017, In : Cell Chemical Biology. 24, 7, p. 892-906.e5

Research output: Contribution to journalArticle

15 Scopus citations

Significance and regulation of lipid metabolism

DeBose-Boyd, R. A., Jan 1 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

2 Scopus citations

Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients

Aoyama, N., Suzuki, J. I., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., Minabe, M., Izumi, Y. & Isobe, M., Aug 12 2017, (Accepted/In press) In : Heart and Vessels. p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer

Suresh, S., Durakoglugil, D., Zhou, X., Zhu, B., Comerford, S. A., Xing, C., Xie, X. J., York, B. & O’Donnell, K. A., Mar 2017, In : PLoS genetics. 13, 3, e1006650.

Research output: Contribution to journalArticle

4 Scopus citations

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Airola, M. V., Shanbhogue, P., Shamseddine, A. A., Guja, K. E., Senkal, C. E., Maini, R., Bartke, N., Wu, B. X., Obeid, L. M., Garcia-Diaz, M., Hannun, Y. A. & Russell, D. W., Jul 11 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 28, p. E5549-E5558

Research output: Contribution to journalArticle

26 Scopus citations

Synergistic Impact of d-δ-Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells

Yeganehjoo, H., DeBose-Boyd, R., McFarlin, B. K. & Mo, H., Mar 29 2017, (Accepted/In press) In : Nutrition and Cancer. p. 1-10 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

T cells upon activation promote endothelin 1 production in monocytes via IFN-γ and TNF-α

Shinagawa, S., Okazaki, T., Ikeda, M., Yudoh, K., Kisanuki, Y. Y., Yanagisawa, M., Kawahata, K. & Ozaki, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14500.

Research output: Contribution to journalArticle

4 Scopus citations

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

Basuray, S., Smagris, E., Cohen, J. C. & Hobbs, H. H., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

74 Scopus citations

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Trinha, M. N., Lua, F., Lib, X., Dasa, A., Liangd, Q., De Brabanderd, J. K., Browna, M. S. & Goldsteina, J. L., Jan 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

16 Scopus citations