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2017

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

Kaushik, M. K., Kaul, S. C., Wadhwa, R., Yanagisawa, M. & Urade, Y., Feb 2017, In : PloS one. 12, 2, e0172508.

Research output: Contribution to journalArticle

8 Scopus citations
19 Scopus citations

Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

Chakrabarti, R. S., Ingham, S. A., Kozlitina, J., Gay, A., Cohen, J. C., Radhakrishnan, A. & Hobbs, H. H., Feb 8 2017, In : eLife. 6, e23355.

Research output: Contribution to journalArticle

14 Scopus citations
2016
Open Access
3 Scopus citations

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

Cautivo, K. M., Lizama, C. O., Tapia, P. J., Agarwal, A. K., Garg, A., Horton, J. D. & Cortés, V. A., Feb 13 2016, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

11 Scopus citations

Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo

Eldridge, S., Nalesso, G., Ismail, H., Vicente-Greco, K., Kabouridis, P., Ramachandran, M., Niemeier, A., Herz, J., Pitzalis, C., Perretti, M. & Dell'Accio, F., Jun 2016, In : Annals of the Rheumatic Diseases. 75, 6, p. 1228-1235 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

An adenosine-mediated glial-neuronal circuit for homeostatic sleep

Bjorness, T., Dale, N., Mettlach, G., Sonneborn, A., Sahin, B., Fienberg, A. A., Yanagisawa, M., Bibb, J. A. & Greene, R., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3709-3721 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure

Watanabe, R., Suzuki, J. I., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I. & Isobe, M., Apr 1 2016, In : Hypertension Research. 39, 4, p. 237-244 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

Lane-Donovan, C. & Herz, J., 2016, (Accepted/In press) In : Trends in Endocrinology and Metabolism.

Research output: Contribution to journalArticle

34 Scopus citations

ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

Ulrich, V., Gelber, S. E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R. T., De Groot, P. G., Natale, D. R., Harihara, A., Redecha, P., Abrahams, V. M., Shaul, P. W., Salmon, J. E. & Mineo, C., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 730-739 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Attenuated cold defense responses in orexin neuron-ablated rats

Mohammed, M., Yanagisawa, M., Blessing, W. & Ootsuka, Y., Jul 2 2016, In : Temperature. 3, 3, p. 465-475 11 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
10 Scopus citations

Cacao polyphenols ameliorate autoimmune myocarditis in mice

Zempo, H., Suzuki, J. I., Watanabe, R., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I. & Isobe, M., Apr 1 2016, In : Hypertension Research. 39, 4, p. 203-209 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Bartuzi, P., Billadeau, D. D., Favier, R., Rong, S., Dekker, D., Fedoseienko, A., Fieten, H., Wijers, M., Levels, J. H., Huijkman, N., Kloosterhuis, N., Van Der Molen, H., Brufau, G., Groen, A. K., Elliott, A. M., Kuivenhoven, J. A., Plecko, B., Grangl, G., McGaughran, J., Horton, J. D. & 3 others, Burstein, E., Hofker, M. H. & Van De Sluis, B., Mar 11 2016, In : Nature communications. 7, 10961.

Research output: Contribution to journalArticle

53 Scopus citations

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

Li, X., Saha, P., Lib, J., Blobel, G. & Pfeffer, S. R., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. 10079-10084 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol metabolism in the liver

Hwang, S., Hartman, I. Z., Calhoun, L. N., Garland, K., Young, G. A., Mitsche, M. A., McDonald, J., Xu, F., Engelking, L. & DeBose-Boyd, R. A., Jun 24 2016, In : Journal of Biological Chemistry. 291, 26, p. 13479-13494 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Convergent signaling pathways controlled by LRP1 (Receptor-related Protein 1) cytoplasmic and extracellular domains limit cellular cholesterol accumulation

El Asmar, Z., Terrand, J., Jenty, M., Host, L., Mlih, M., Zerr, A., Justiniano, H., Matz, R. L., Boudier, C., Scholler, E., Garnier, J. M., Bertaccini, D., Thiersé, D., Schaeffer, C., Van Dorsselaer, A., Herz, J., Bruban, V. & Boucher, P., Mar 4 2016, In : Journal of Biological Chemistry. 291, 10, p. 5116-5127 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Crystal structure of the human sterol transporter ABCG5/ABCG8

Lee, J. Y., Kinch, L. N., Borek, D. M., Wang, J., Wang, J., Urbatsch, I. L., Xie, X. S., Grishin, N. V., Cohen, J. C., Otwinowski, Z., Hobbs, H. H. & Rosenbaum, D. M., May 4 2016, In : Nature. 533, 7604, p. 561-564 4 p.

Research output: Contribution to journalArticle

114 Scopus citations

Current therapies and investigational drugs for peripheral arterial disease

Suzuki, J. I., Shimamura, M., Suda, H., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Isobe, M., Komuro, I. & Morishita, R., Apr 1 2016, In : Hypertension Research. 39, 4, p. 183-191 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Direct demonstration that Loop1 of Scap binds to Loop7: A crucial event in cholesterol homeostasis

Zhang, Y., Min Lee, K., Kinch, L. N., Clark, L., Grishin, N. V., Rosenbaum, D. M., Brown, M. S., Goldstein, J. L. & Radhakrishnan, A., Jun 10 2016, In : Journal of Biological Chemistry. 291, 24, p. 12888-12896 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ephrin Bs and canonical Reelin signalling

Pohlkamp, T., Xiao, L., Sultana, R., Bepari, A., Bock, H. H., Henkemeyer, M. & Herz, J., Nov 23 2016, In : Nature. 539, 7630, p. E4-E6

Research output: Contribution to journalArticle

7 Scopus citations

Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member

Beer, A. G., Zenzmaier, C., Schreinlechner, M., Haas, J., Dietrich, M. F., Herz, J. & Marschang, P., Jan 1 2016, In : Oncotarget. 7, 42, p. 68721-68733 13 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation

Strecker, P., Ludewig, S., Rust, M., Mundinger, T. A., Görlich, A., Krächan, E. G., Mehrfeld, C., Herz, J., Korte, M., Guénette, S. Y. & Kins, S., May 11 2016, In : Scientific Reports. 6, 25652.

Research output: Contribution to journalArticle

8 Scopus citations

Forward-genetics analysis of sleep in randomly mutagenized mice

Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., Kakizaki, M., Hotta-Hirashima, N., Kanno, S., Komiya, H., Asano, F., Honda, T., Kim, S. J., Harano, K., Muramoto, H., Yonezawa, T. & 17 others, Mizuno, S., Miyazaki, S., Connor, L., Kumar, V., Miura, I., Suzuki, T., Watanabe, A., Abe, M., Sugiyama, F., Takahashi, S., Sakimura, K., Hayashi, Y., Liu, Q., Kume, K., Wakana, S., Takahashi, J. S. & Yanagisawa, M., 2016, In : Nature. 539, 7629, p. 378-383 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Functional ETA-ETB receptor cross-Talk in basilar artery in Situ from ETB receptor deficient rats

Yoon, S., Gariepy, C. E., Yanagisawa, M., Zuccarello, M. & Rapoport, R. M., Mar 1 2016, In : Journal of Cardiovascular Pharmacology. 67, 3, p. 212-217 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Galectin-3 blockade reduces renal fibrosis in two normotensive experimental models of renal damage

Martinez-Martinez, E., Ibarrola, J., Calvier, L., Fernandez-Celis, A., Leroy, C., Cachofeiro, V., Rossignol, P. & Lopez-Andres, N., Nov 1 2016, In : PloS one. 11, 11, e0166272.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Genetic restoration of plasma apoe improves cognition and partially restores synaptic defects in ApoE-deficient mice

Lane-Donovan, C., Wong, W. M., Durakoglugil, M. S., Wasser, C. R., Jiang, S., Xian, X. & Herz, J., Sep 28 2016, In : Journal of Neuroscience. 36, 39, p. 10141-10150 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

Kraehling, J. R., Chidlow, J. H., Rajagopal, C., Sugiyama, M. G., Fowler, J. W., Lee, M. Y., Zhang, X., Ramírez, C. M., Park, E. J., Tao, B., Chen, K., Kuruvilla, L., Larriveé, B., Folta-Stogniew, E., Ola, R., Rotllan, N., Zhou, W., Nagle, M. W., Herz, J., Williams, K. J. & 4 others, Eichmann, A., Lee, W. L., Fernández-Hernando, C. & Sessa, W. C., Nov 21 2016, In : Nature Communications. 7, 13516.

Research output: Contribution to journalArticle

33 Scopus citations

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi

Schumacher, M. M., Jun, D. J., Jo, Y., Seemann, J. & DeBose-Boyd, R. A., Jul 1 2016, In : Journal of Lipid Research. 57, 7, p. 1286-1299 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Sato, Y., Mii, A., Hamazaki, Y., Fujita, H., Nakata, H., Masuda, K., Nishiyama, S., Shibuya, S., Haga, H., Ogawa, O., Shimizu, A., Narumiya, S., Kaisho, T., Arita, M., Yanagisawa, M., Miyasaka, M., Sharma, K., Minato, N., Kawamoto, H. & Yanagita, M., Jan 1 2016, In : JCI Insight. 1, 11, e87680.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

High-Fat Diet Changes Hippocampal Apolipoprotein e (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice

Lane-Donovan, C. & Herz, J., Feb 1 2016, In : PloS one. 11, 2, e0148099.

Research output: Contribution to journalArticle

12 Scopus citations

High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression

Hyndman, K. A., Dugas, C., Arguello, A. M., Goodchild, T. T., Buckley, K. M., Burch, M., Yanagisawa, M. & Pollock, J. S., Aug 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 2, p. R263-R271

Research output: Contribution to journalArticle

8 Scopus citations

Histochemical localization of palmitoyl protein thioesterase-activity

Dearborn, J. T., Ramachandran, S., Shyng, C., Lu, J. Y., Thornton, J., Hofmann, S. L. & Sands, M. S., Feb 1 2016, In : Molecular genetics and metabolism. 117, 2, p. 210-216 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Identification of mutations through dominant screening for obesity using C57BL/6 substrains

Hossain, M. S., Asano, F., Fujiyama, T., Miyoshi, C., Sato, M., Ikkyu, A., Kanno, S., Hotta, N., Kakizaki, M., Honda, T., Kim, S. J., Komiya, H., Miura, I., Suzuki, T., Kobayashi, K., Kaneda, H., Kumar, V., Takahashi, J. S., Wakana, S., Funato, H. & 1 others, Yanagisawa, M., Sep 2 2016, In : Scientific reports. 6, 32453.

Research output: Contribution to journalArticle

5 Scopus citations

Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins

Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C. & Hobbs, H. H., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10659-10676 18 p.

Research output: Contribution to journalArticle

65 Scopus citations
24 Scopus citations

Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix

Chen, Q., Denard, B., Lee, C. E., Han, S., Ye, J. S. & Ye, J., Aug 18 2016, In : Molecular Cell. 63, 4, p. 567-578 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ischemic stroke in a patient with moderate to severe inherited factor VII deficiency

Reddy, M., Tawfik, B., Gavva, C., Yates, S., De Simone, N., Hofmann, S. L., Rambally, S. & Sarode, R., Dec 1 2016, In : Transfusion and Apheresis Science. 55, 3, p. 364-367 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

Akashi, K., Saegusa, J., Sendo, S., Nishimura, K., Okano, T., Yagi, K., Yanagisawa, M., Emoto, N. & Morinobu, A., May 21 2016, In : Arthritis Research and Therapy. 18, 1, 113.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation

Ding, Y., Huang, L., Xian, X., Yuhanna, I. S., Wasser, C. R., Frotscher, M., Mineo, C., Shaul, P. W. & Herz, J., Mar 15 2016, In : Science Signaling. 9, 419, RA29.

Research output: Contribution to journalArticle

17 Scopus citations

Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-mediated Process: Pilot Study in Urethral Stricture Tissue

Hofer, M. D., Kapur, P., Cordon, B. H., Hamoun, F., Russell, D. W., Scott, J. M., Roehrborn, C. & Morey, A., Dec 6 2016, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

4 Scopus citations

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

MOGAT1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

Agarwal, A. K., Tunison, K., Dalal, J. S., Yen, C. L. E., Farese, R. V., Horton, J. D. & Garg, A., Apr 1 2016, In : Journal of Lipid Research. 57, 4, p. 616-630 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice

Tsuneki, H., Nagata, T., Fujita, M., Kon, K., Wu, N., Takatsuki, M., Yamaguchi, K., Wada, T., Nishijo, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Jan 2016, In : Endocrinology. 157, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

p53 genes function to restrain mobile elements

Wylie, A., Jones, A. E., D’Brot, A., Lu, W. J., Kurtz, P., Moran, J. V., Rakheja, D., Chen, K., Hammer, R. E., Comerford, S. A., Amatruda, J. F. & Abrams, J. M., Jan 1 2016, In : Genes and Development. 30, 1, p. 64-77 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Periodontitis may deteriorate sinus of valsalva dilatation in marfan syndrome patients

Suzuki, J. I., Imai, Y., Aoki, M., Fujita, D., Takeda, N., Aoyama, N., Wakayama, K., Ikeda, Y., Kumagai, H., Akazawa, H., Izumi, Y., Isobe, M., Komuro, I. & Hirata, Y., 2016, In : International Heart Journal. 57, 4, p. 456-460 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Peripherally administered orexin improves survival of mice with endotoxin shock

Ogawa, Y., Irukayama-Tomobe, Y., Murakoshi, N., Kiyama, M., Ishikawa, Y., Hosokawa, N., Tominaga, H., Uchida, S., Kimura, S., Kanuka, M., Morita, M., Hamada, M., Takahashi, S., Hayashi, Y. & Yanagisawa, M., Dec 30 2016, In : eLife. 5, DECEMBER2016, e21055.

Research output: Contribution to journalArticle

12 Scopus citations

Physiologic Reelin does not play a strong role in protection against acute stroke

Lane-Donovan, C., Desai, C., Pohlkamp, T., Plautz, E. J., Herz, J. & Stowe, A. M., Jul 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 7, p. 1295-1303 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Prosaposin is a regulator of progranulin levels and oligomerization

Nicholson, A. M., Finch, N. C. A., Almeida, M., Perkerson, R. B., Van Blitterswijk, M., Wojtas, A., Cenik, B., Rotondo, S., Inskeep, V., Almasy, L., Dyer, T., Peralta, J., Jun, G., Wood, A. R., Frayling, T. M., Fuchsberger, C., Fowler, S., Teslovich, T. M., Manning, A. K., Kumar, S. & 20 others, Curran, J., Lehman, D., Abecasis, G., Duggirala, R., Pottier, C., Zahir, H. A., Crook, J. E., Karydas, A., Mitic, L., Sun, Y., Dickson, D. W., Bu, G., Herz, J., Yu, G., Miller, B. L., Ferguson, S., Petersen, R. C., Graff-Radford, N., Blangero, J. & Rademakers, R., Jun 30 2016, In : Nature communications. 7, 11992.

Research output: Contribution to journalArticle

26 Scopus citations

QRFP-Deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-Like behavior

Okamoto, K., Yamasaki, M., Takao, K., Soya, S., Iwasaki, M., Sasaki, K., Magoori, K., Sakakibara, I., Miyakawa, T., Mieda, M., Watanabe, M., Sakai, J., Yanagisawa, M. & Sakurai, T., Nov 2016, In : PloS one. 11, 11, e0164716.

Research output: Contribution to journalArticle

8 Scopus citations