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Smagris, E., Basuray, S., Gromada, J., Cohen, J. C. & Hobbs, H. H., Feb 1 2016, In : Hepatology. 63, 2, p. 677 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y. A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., De Brabander, J. K. & Shay, J. W., Oct 19 2016, In : Science translational medicine. 8, 361, 361ra140.

Research output: Contribution to journalArticle

20 Scopus citations

Simple purification of adeno-associated virus-DJ for liver-specific gene expression

Liu, J. & Moon, Y. A., May 2016, In : Yonsei medical journal. 57, 3, p. 790-794 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development

Shi, X., Wang, Q., Gu, J., Xuan, Z. & Wu, J. I., Nov 3 2016, In : Oncogene. 35, 44, p. 5746-5758 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Splicing therapeutics for Alzheimer's disease

Wasser, C. R. & Herz, J., 2016, (Accepted/In press) In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

3 Scopus citations

Steroid 5α-reductase 2 deficiency

Mendonca, B. B., Batista, R. L., Domenice, S., Costa, E. M. F., Arnhold, I. J. P., Russell, D. W. & Wilson, J. D., Mar 16 2016, (Accepted/In press) In : Journal of Steroid Biochemistry and Molecular Biology.

Research output: Contribution to journalArticle

32 Scopus citations

Structure of human Niemann-Pick C1 protein

Li, X., Wang, J., Coutavas, E., Shi, H., Hao, Q. & Blobel, G., Jul 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 29, p. 8212-8217 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism

Vastermark, A., Driker, A., Weng, J., Li, X., Wang, J. & Saier, M. H., Dec 1 2016, In : Journal of Structural Biology. 196, 3, p. 496-502 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice

Tsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Nov 1 2016, In : Endocrinology. 157, 11, p. 4146-4157 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Toll-like receptor 4 signaling has a critical role in Porphyromonas gingivalis-accelerated neointimal formation after arterial injury in mice

Kobayashi, N., Suzuki, J. I., Aoyama, N., Sato, H., Akimoto, S., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., Izumi, Y. & Isobe, M., Oct 1 2016, In : Hypertension Research. 39, 10, p. 717-722 6 p.

Research output: Contribution to journalArticle

Transcription factor hepatocyte nuclear factor-1β regulates renal cholesterol metabolism

Aboudehen, K., Kim, M. S., Mitsche, M., Garland, K., Anderson, N., Noureddine, L., Pontoglio, M., Patel, V., Xie, Y., Debose-Boyd, R. & Igarashi, P., Aug 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2408-2421 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Acute myocardial infarction that resulted from poor adherence to medical treatment for giant coronary aneurysm the importance of patient education in the chronic phase of Kawasaki disease

Motozawa, Y., Uozumi, H., Maemura, S., Nakata, R., Yamamoto, K., Takizawa, M., Kumagai, H., Ikeda, Y., Komuro, I. & Ikenouchi, H., Sep 29 2015, In : International Heart Journal. 56, 5, p. 551-554 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency

Stender, S., Chakrabarti, R. S., Xing, C., Gotway, G., Cohen, J. C. & Hobbs, H. H., Sep 8 2015, (Accepted/In press) In : Molecular Genetics and Metabolism.

Research output: Contribution to journalArticle

17 Scopus citations

A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling

Nakayama, A., Morita, H., Nakao, T., Yamaguchi, T., Sumida, T., Ikeda, Y., Kumagai, H., Motozawa, Y., Takahashi, T., Imaizumi, A., Hashimoto, T., Nagai, R. & Komuro, I., Sep 1 2015, In : PloS one. 10, 9, e0137106.

Research output: Contribution to journalArticle

10 Scopus citations

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

Gusarova, V., Alexa, C. A., Wang, Y., Rafique, A., Kim, J. H., Buckler, D., Mintah, I. J., Shihanian, L. M., Cohen, J. C., Hobbs, H. H., Xin, Y., Valenzuela, D. M., Murphy, A. J., Yancopoulos, G. D. & Gromada, J., Jul 1 2015, In : Journal of Lipid Research. 56, 7, p. 1308-1317 10 p.

Research output: Contribution to journalArticle

75 Scopus citations
4 Scopus citations

A Well-Hung Horse: Sired by Knowledge and Imagination

Goldstein, J. L., Sep 10 2015, In : Cell. 162, 6, p. 1179-1182 4 p.

Research output: Contribution to journalArticle

Biased agonism of the angiotensin II type I receptor a potential strategy for the treatment of acute heart failure

Ikeda, Y., Kumagai, H., Motozawa, Y., Suzuki, J. I. & Komuro, I., Sep 29 2015, In : International Heart Journal. 56, 5, p. 485-488 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Biomarkers of NAFLD progression: A lipidomics approach to an epidemic 1

Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., Min, J., Spann, N. J., McDonald, J. G., Kelly, S. L., Duan, J., Sullards, M. C., Leiker, T. J., Barkley, R. M., Quehenberger, O., Armando, A. M., Milne, S. B., Mathews, T. P., Armstrong, M. D., Li, C. & 13 others, Melvin, W. V., Clements, R. H., Washington, M. K., Mendonsa, A. M., Witztum, J. L., Guan, Z., Glass, C. K., Murphy, R. C., Dennis, E. A., Merrill, A. H., Russell, D. W., Subramaniam, S. & Brown, H. A., Mar 1 2015, In : Journal of lipid research. 56, 3, p. 722-736 15 p.

Research output: Contribution to journalArticle

111 Scopus citations

Corrigendum to "Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis" [Neuroscience, 301 (2015) 323-337]

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Sep 1 2015, In : Neuroscience. 303, p. 630 1 p.

Research output: Contribution to journalArticle

Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

Ren, R., Zhou, X., He, Y., Ke, M., Wu, J., Liu, X., Yan, C., Wu, Y., Gong, X., Lei, X., Yan, S. F., Radhakrishnan, A. & Yan, N., Jul 10 2015, In : Science. 349, 6244, p. 187-191 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Crystal structure of a phosphorylation-coupled vitamin C transporter

Luo, P., Yu, X., Wang, W., Fan, S., Li, X. & Wang, J., Mar 6 2015, In : Nature Structural and Molecular Biology. 22, 3, p. 238-241 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of lipid research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

37 Scopus citations

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

Nagahara, T., Saitoh, T., Kutsumura, N., Irukayama-Tomobe, Y., Ogawa, Y., Kuroda, D., Gouda, H., Kumagai, H., Fujii, H., Yanagisawa, M. & Nagase, H., Aug 12 2015, In : Journal of Medicinal Chemistry. 58, 20, p. 7931-7937 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Endothelin-1 as a master regulator of whole-body Na+ homeostasis

Speed, J. S., Heimlich, J. B., Hyndman, K. A., Fox, B. M., Patel, V., Yanagisawa, M., Pollock, J. S., Titze, J. M. & Pollock, D. M., Dec 1 2015, In : FASEB Journal. 29, 12, p. 4937-4944 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Experimental therapies in the neuronal ceroid lipofuscinoses

Neverman, N. J., Best, H. L., Hofmann, S. L. & Hughes, S. M., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 10, p. 2292-2300 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness

Suh, J., Moncaster, J. A., Wang, L., Hafeez, I., Herz, J., Tanzi, R. E., Goldstein, L. E. & Guénette, S. Y., Jun 1 2015, In : FASEB Journal. 29, 6, p. 2628-2639 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, M. A., McDonald, J. G., Hobbs, H. H. & Cohen, J. C., Jun 26 2015, In : eLife. 4, JUNE 2015, p. 1-21 21 p., e07999.

Research output: Contribution to journalArticle

48 Scopus citations

GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice

Matsuki, T., Takasu, M., Hirose, Y., Murakoshi, N., Sinton, C. M., Motoike, T. & Yanagisawa, M., Dec 1 2015, In : Neuroscience. 284, p. 217-224 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertension

Martínez-Martínez, E., Calvier, L., Fernández-Celis, A., Rousseau, E., Jurado-López, R., Rossoni, L. V., Jaisser, F., Zannad, F., Rossignol, P., Cachofeiro, V. & López-Andrés, N., Oct 11 2015, In : Hypertension. 66, 4, p. 767-775 9 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

Wang, Y., McNutt, M. C., Banfi, S., Levin, M. G., Holland, W. L., Gusarova, V., Gromada, J., Cohen, J. C. & Hobbs, H. H., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11630-11635 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice

Tsuneki, H., Tokai, E., Nakamura, Y., Takahashi, K., Fujita, M., Asaoka, T., Kon, K., Anzawa, Y., Wada, T., Takasaki, I., Kimura, K., Inoue, H., Yanagisawa, M., Sakurai, T. & Sasaoka, T., Feb 1 2015, In : Diabetes. 64, 2, p. 459-470 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Identification of CREB3L1 as a biomarker predicting doxorubicin treatment outcome

Denard, B., Pavia-Jimenez, A., Chen, W., Williams, N. S., Naina, H., Collins, R., Brugarolas, J. & Ye, J., Jun 25 2015, In : PLoS One. 10, 6, e0129233.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Lu, F., Liang, Q., Abi-Mosleh, L., Das, A., de Brabander, J. K., Goldstein, J. L. & Brown, M. S., Dec 8 2015, In : eLife. 4, December2015, e12177.

Research output: Contribution to journalArticle

103 Scopus citations

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

Wang, Y., Gusarova, V., Banfi, S., Gromada, J., Cohen, J. C. & Hobbs, H. H., Jul 1 2015, In : Journal of lipid research. 56, 7, p. 1296-1307 12 p.

Research output: Contribution to journalArticle

74 Scopus citations

Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis

Lu, J. Y., Nelvagal, H. R., Wang, L., Birnbaum, S. G., Cooper, J. D. & Hofmann, S. L., Sep 1 2015, In : Molecular Genetics and Metabolism. 116, 1-2, p. 98-105 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
7 Scopus citations

Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis

Ding, Y., Xian, X., Holland, W. L., Tsai, S. & Herz, J., Nov 13 2015, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

24 Scopus citations

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity

Pohlkamp, T., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Johnson, E. B., Hammer, R. E. & Herz, J., Feb 17 2015, In : PloS one. 10, 2, e0116701.

Research output: Contribution to journalArticle

10 Scopus citations

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

Goedeke, L., Rotllan, N., Canfrán-Duque, A., Aranda, J. F., Ramírez, C. M., Araldi, E., Lin, C. S., Anderson, N. N., Wagschal, A., De Cabo, R., Horton, J. D., Lasunción, M. A., Näär, A. M., Suárez, Y. & Fernández-Hernando, C., Nov 1 2015, In : Nature Medicine. 21, 11, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

103 Scopus citations

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: Purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

Ikeda, Y., Kumagai, H., Okazaki, H., Fujishiro, M., Motozawa, Y., Nomura, S., Takeda, N., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Komuro, I. & Yanagisawa, M., Jun 1 2015, In : PloS one. 10, 6, e0127445.

Research output: Contribution to journalArticle

5 Scopus citations

Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms

Lee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., Takahashi, J. S. & Yanagisawa, M., Mar 4 2015, In : Neuron. 85, 5, p. 1086-1102 17 p.

Research output: Contribution to journalArticle

75 Scopus citations

Next generation ARBs: Going beyond modulation of the renin-angiotensin system

Ikeda, Y., Kumagai, H., Motozawa, Y., Suzuki, J. I. & Komuro, I., Dec 2 2015, In : International Heart Journal. 56, 6, p. 585-586 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

Smagris, E., Basuray, S., Li, J., Huang, Y., Lai, K. M. V., Gromada, J., Cohen, J. C. & Hobbs, H. H., Jan 1 2015, In : Hepatology. 61, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

171 Scopus citations

Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling

Kumagai, H., Ikeda, Y., Motozawa, Y., Fujishiro, M., Okamura, T., Fujio, K., Okazaki, H., Nomura, S., Takeda, N., Harada, M., Toko, H., Takimoto, E., Akazawa, H., Morita, H., Suzuki, J. I., Yamazaki, T., Yamamoto, K., Komuro, I. & Yanagisawa, M., May 28 2015, In : PloS one. 10, 5, e0129394.

Research output: Contribution to journalArticle

6 Scopus citations
41 Scopus citations

Reelin protects against amyloid β toxicity in vivo

Lane-Donovan, C., Philips, G. T., Wasser, C. R., Durakoglugil, M. S., Masiulis, I., Upadhaya, A., Pohlkamp, T., Coskun, C., Kotti, T., Steller, L., Hammer, R. E., Frotscher, M., Bock, H. H. & Herz, J., Jul 7 2015, In : Science signaling. 8, 384, ra67.

Research output: Contribution to journalArticle

50 Scopus citations

Relative roles of ABCG5/ABCG8 in liver and intestine

Wang, J., Mitsche, M. A., Lütjohann, D., Cohen, J. C., Xie, X. S. & Hobbs, H. H., Feb 1 2015, In : Journal of lipid research. 56, 2, p. 319-330 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Scap is required for sterol synthesis and crypt growth in intestinal mucosa

McFarlane, M. R., Cantoria, M. J., Linden, A. G., January, B. A., Liang, G. & Engelking, L. J., Aug 1 2015, In : Journal of Lipid Research. 56, 8, p. 1560-1571 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPAR

Li, G., Zhou, L., Zhu, Y., Wang, C., Sha, S., Xian, X., Ji, Y., Liu, G. & Chen, L., Dec 1 2015, In : DMM Disease Models and Mechanisms. 8, 12, p. 1615-1624 10 p.

Research output: Contribution to journalArticle

10 Scopus citations