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2015

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

Li, X., Roberti, R. & Blobel, G., Jan 1 2015, In : Nature. 517, 7532, p. 104-107 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes

Gay, A., Rye, D. & Radhakrishnan, A., Mar 24 2015, In : Biophysical journal. 108, 6, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Systematic siRNA screen unmasks NSCLC growth dependence by palmitoyltransferase DHHC5

Tian, H., Lu, J. Y., Shao, C., Huffman, K. E., Carstens, R. M., Larsen, J. E., Girard, L., Liu, H., Rodriguez-Canales, J., Frenkel, E. P., Wistuba, I. I., Minna, J. D. & Hofmann, S. L., Apr 1 2015, In : Molecular Cancer Research. 13, 4, p. 784-794 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Schumacher, M. M., Elsabrouty, R., Seemann, J., Jo, Y. & DeBose-Boyd, R. A., Mar 5 2015, In : eLife. 2015, 4, e05560.

Research output: Contribution to journalArticle

40 Scopus citations

Transient expression of neuropeptide W in postnatal mouse hypothalamus - A putative regulator of energy homeostasis

Motoike, T., Skach, A. G., Godwin, J. K., Sinton, C. M., Yamazaki, M., Abe, M., Natsume, R., Sakimura, K. & Yanagisawa, M., Aug 1 2015, In : Neuroscience. 301, p. 323-337 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Kim, H., Rodriguez-Navas, C., Kollipara, R. K., Kapur, P., Pedrosa, I., Brugarolas, J., Kittler, R. & Ye, J., Oct 20 2015, In : Cell Reports. 13, 3, p. 495-503 9 p., 2062.

Research output: Contribution to journalArticle

22 Scopus citations
2014

25-hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

Reboldi, A., Dang, E. V., McDonald, J. G., Liang, G., Russell, D. W. & Cyster, J. G., Aug 8 2014, In : Science. 345, 6197, p. 679-684 6 p.

Research output: Contribution to journalArticle

199 Scopus citations

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

257 Scopus citations

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

Duarte, J. A. G., Carvalho, F., Pearson, M., Horton, J. D., Browning, J. D., Jones, J. G. & Burgess, S. C., Jan 1 2014, In : Journal of lipid research. 55, 12, p. 2541-2553 13 p., A11.

Research output: Contribution to journalArticle

61 Scopus citations

An acetate switch regulates stress erythropoiesis

Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., Moon, Y. A., Gerard, R. D., Huang, C-L., Comerford, S. A., Hammer, R. E., Horton, J. D., Chen, R. & Garcia, J. A., Sep 1 2014, In : Nature medicine. 20, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo

Subramanian, M., Hayes, C. D., Thome, J. J., Thorp, E., Matsushima, G. K., Herz, J., Farber, D. L., Liu, K., Lakshmana, M. & Tabas, I., Mar 3 2014, In : Journal of Clinical Investigation. 124, 3, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Li, Q., Wang, R., Wang, C., Ge, K. & Wu, J., 2014, In : Nature communications. 5, 5425.

Research output: Contribution to journalArticle

47 Scopus citations

ANGPTL8/betatrophin does not control pancreatic beta cell expansion

Gusarova, V., Alexa, C. A., Na, E., Stevis, P. E., Xin, Y., Bonner-Weir, S., Cohen, J. C., Hobbs, H. H., Murphy, A. J., Yancopoulos, G. D. & Gromada, J., Oct 2014, In : Cell. 159, 3, p. 691-696 6 p.

Research output: Contribution to journalArticle

139 Scopus citations

Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice

Ulrich, V., Konaniah, E. S., Lee, W. R., Khadka, S., Shen, Y. M., Herz, J., Salmon, J. E., Hui, D. Y., Shaul, P. W. & Mineo, C., 2014, In : Journal of the American Heart Association. 3, 5, e001369.

Research output: Contribution to journalArticle

11 Scopus citations

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies

Condon, S. M., Mitsuuchi, Y., Deng, Y., Laporte, M. G., Rippin, S. R., Haimowitz, T., Alexander, M. D., Kumar, P. T., Hendi, M. S., Lee, Y. H., Benetatos, C. A., Yu, G., Kapoor, G. S., Neiman, E., Seipel, M. E., Burns, J. M., Graham, M. A., McKinlay, M. A., Li, X., Wang, J. & 9 others, Shi, Y., Feltham, R., Bettjeman, B., Cumming, M. H., Vince, J. E., Khan, N., Silke, J., Day, C. L. & Chunduru, S. K., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3666-3677 12 p.

Research output: Contribution to journalArticle

88 Scopus citations
10 Scopus citations

Characterization and distribution of reelin-positive interneuron subtypes in the rat barrel cortex

Pohlkamp, T., Dávid, C., Cauli, B., Gallopin, T., Bouché, E., Karagiannis, A., May, P., Herz, J., Frotscher, M., Staiger, J. F. & Bock, H. H., Nov 1 2014, In : Cerebral Cortex. 24, 11, p. 3046-3058 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks

Chakraborty, S., Li, L., Puliyappadamba, V. T., Guo, G., Hatanpaa, K. J., Mickey, B., Souza, R. F., Vo, P., Herz, J., Chen, M. R., Boothman, D. A., Pandita, T. K., Wang, D. H., Sen, G. C. & Habib, A. A., 2014, In : Nature communications. 5, 5811.

Research output: Contribution to journalArticle

37 Scopus citations

Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2

Gorrie, G. H., Fecto, F., Radzicki, D., Weiss, C., Shi, Y., Dong, H., Zhai, H., Fu, R., Liu, E., Li, S., Arrat, H., Bigio, E. H., Disterhoft, J. F., Martina, M., Mugnaini, E., Siddique, T., Deng, H. X. & Russell, D. W., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14524-14529 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

Wasser, C. R., Masiulis, I., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Beffert, U., Agarwala, A., Hammer, R. E. & Herz, J., Nov 25 2014, In : Science signaling. 7, 353, ra113.

Research output: Contribution to journalArticle

21 Scopus citations

Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis

Lenoir, O., Milon, M., Virsolvy, A., Hénique, C., Schmitt, A., Massé, J. M., Kotelevtsev, Y., Yanagisawa, M., Webb, D. J., Richard, S. & Tharaux, P. L., May 1 2014, In : Journal of the American Society of Nephrology. 25, 5, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Ward, M. E., Taubes, A., Chen, R., Miller, B. L., Sephton, C. F., Gelfand, J. M., Minami, S., Boscardin, J., Martens, L. H., Seeley, W. W., Yu, G., Herz, J., Filiano, A. J., Arrant, A. E., Roberson, E. D., Kraft, T. W., Farese, R. V., Green, A. & Gan, L., 2014, In : Journal of Experimental Medicine. 211, 10, p. 1937-1945 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial

Fitzgerald, K., Frank-Kamenetsky, M., Shulga-Morskaya, S., Liebow, A., Bettencourt, B. R., Sutherland, J. E., Hutabarat, R. M., Clausen, V. A., Karsten, V., Cehelsky, J., Nochur, S. V., Kotelianski, V., Horton, J., Mant, T., Chiesa, J., Ritter, J., Munisamy, M., Vaishnaw, A. K., Gollob, J. A. & Simon, A., 2014, In : The Lancet. 383, 9911, p. 60-68 9 p.

Research output: Contribution to journalArticle

339 Scopus citations

ELOVL5 mutations cause spinocerebellar ataxia 38

Di Gregorio, E., Borroni, B., Giorgio, E., Lacerenza, D., Ferrero, M., Lo Buono, N., Ragusa, N., Mancini, C., Gaussen, M., Calcia, A., Mitro, N., Hoxha, E., Mura, I., Coviello, D. A., Moon, Y. A., Tesson, C., Vaula, G., Couarch, P., Orsi, L., Duregon, E. & 15 others, Papotti, M. G., Deleuze, J. F., Imbert, J., Costanzi, C., Padovani, A., Giunti, P., Maillet-Vioud, M., Durr, A., Brice, A., Tempia, F., Funaro, A., Boccone, L., Caruso, D., Stevanin, G. & Brusco, A., Aug 7 2014, In : American Journal of Human Genetics. 95, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling

Lehmann, L. H., Rostosky, J. S., Buss, S. J., Kreusser, M. M., Krebs, J., Mier, W., Enseleit, F., Spiger, K., Hardt, S. E., Wieland, T., Haass, M., Lüscher, T. F., Schneider, M. D., Parlato, R., Gröne, H. J., Haberkorn, U., Yanagisawa, M., Katus, H. A. & Backs, J., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13499-13504 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Kozlitina, J., Smagris, E., Stender, S., Nordestgaard, B. G., Zhou, H. H., Tybjærg-Hansen, A., Vogt, T. F., Hobbs, H. H. & Cohen, J. C., Apr 2014, In : Nature genetics. 46, 4, p. 352-356 5 p.

Research output: Contribution to journalArticle

447 Scopus citations

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells

Pohlkamp, T., Steller, L., May, P., Günther, T., Schüle, R., Frotscher, M., Herz, J. & Bock, H. H., Jun 20 2014, In : PloS one. 9, 6, e100384.

Research output: Contribution to journalArticle

4 Scopus citations

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

Stiles, A. R., Kozlitina, J., Thompson, B. M., McDonald, J. G., King, K. S. & Russell, D. W., Sep 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. E4006-E4014

Research output: Contribution to journalArticle

38 Scopus citations

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from niemann-pick type C patient-specific iPS cells

Maetzel, D., Sarkar, S., Wang, H., Abi-Mosleh, L., Xu, P., Cheng, A. W., Gao, Q., Mitalipova, M. & Jaenisch, R., Jun 3 2014, In : Stem Cell Reports. 2, 6, p. 866-880 15 p.

Research output: Contribution to journalArticle

105 Scopus citations

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function

Ulrich, V., Konaniah, E. S., Herz, J., Gerard, R. D., Jung, E., Yuhanna, I. S., Ahmed, M., Hui, D. Y., Mineo, C. & Shaul, P. W., Sep 16 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 37, p. 13493-13498 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
8 Scopus citations

Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet

McFarlane, M. R., Brown, M. S., Goldstein, J. L. & Zhao, T. J., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine

McFarlane, M. R., Liang, G. & Engelking, L. J., Jan 24 2014, In : Journal of Biological Chemistry. 289, 4, p. 2148-2156 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo

Gilat-Frenkel, M., Boehm-Cagan, A., Liraz, O., Xian, X., Herz, J. & Michaelson, D. M., Jan 1 2014, In : Current Alzheimer Research. 11, 6, p. 549-557 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerates cutaneous wound healing

Makino, K., Jinnin, M., Aoi, J., Kajihara, I., Makino, T., Fukushima, S., Sakai, K., Nakayama, K., Emoto, N., Yanagisawa, M. & Ihn, H., May 22 2014, In : PloS one. 9, 5, e97972.

Research output: Contribution to journalArticle

17 Scopus citations
24 Scopus citations

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

Nguyen, L. H., Robinton, D. A., Seligson, M. T., Wu, L., Li, L., Rakheja, D., Comerford, S. A., Ramezani, S., Sun, X., Parikh, M. S., Yang, E. H., Powers, J. T., Shinoda, G., Shah, S. P., Hammer, R. E., Daley, G. Q. & Zhu, H., Aug 11 2014, In : Cancer Cell. 26, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

103 Scopus citations

Loss of function of endothelin-2 leads to reduced ovulation and CL formation

Cacioppo, J. A., Oh, S. W., Kim, H. Y., Cho, J., Lin, P. C. P., Yanagisawa, M. & Ko, C., Apr 24 2014, In : PloS one. 9, 4, e96115.

Research output: Contribution to journalArticle

16 Scopus citations

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins

Schorch, B., Song, S., Van Diemen, F. R., Bock, H. H., May, P., Herz, J., Brummelkamp, T. R., Papatheodorou, P. & Aktories, K., Apr 29 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 17, p. 6431-6436 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway

Wang, Z., Liu, S., Kakizaki, M., Hirose, Y., Ishikawa, Y., Funato, H., Yanagisawa, M., Yu, Y. & Liu, Q., Nov 14 2014, In : Journal of Biological Chemistry. 289, 46, p. 31950-31959 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways

Hasegawa, E., Yanagisawa, M., Sakurai, T. & Mieda, M., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 604-616 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action

Wei, W., Motoike, T., Krzeszinski, J. Y., Jin, Z., Xie, X-J., Dechow, P. C., Yanagisawa, M. & Wan, Y., Jun 3 2014, In : Cell Metabolism. 19, 6, p. 927-940 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
21 Scopus citations

Standardizing scavenger receptor nomenclature

PrabhuDas, M., Bowdish, D., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., Means, T. K., Moestrup, S. K., Post, S., Sawamura, T., Silverstein, S., Wang, X. Y. & Khoury, J. E., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 1997-2006 10 p.

Research output: Contribution to journalArticle

99 Scopus citations

Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1

Chen, Q., Lee, C. E., Denard, B. & Ye, J., Oct 13 2014, In : PloS one. 9, 10, e108528.

Research output: Contribution to journalArticle

14 Scopus citations

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development

Nakajima, C., Haffner, P., Goerke, S. M., Zurhove, K., Adelmann, G., Frotscher, M., Herz, J., Bock, H. H. & May, P., Dec 1 2014, In : Development (Cambridge). 141, 23, p. 4513-4525 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

The second tomoh masaki award (2013)

Emoto, N., Kasuya, Y. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 87-90 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The thirteenth international conference on endothelin (ET-13), Tokyo, 2013

Emoto, N. & Yanagisawa, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 70-76 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

Das, A., Brown, M. S., Anderson, D. D., Goldstein, J. L. & Radhakrishnan, A., Jun 11 2014, In : eLife. 2014, 3, e02882.

Research output: Contribution to journalArticle

110 Scopus citations