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2012

Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease

Holtzman, D. M., Herz, J. & Bu, G., Mar 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 3

Research output: Contribution to journalArticle

367 Scopus citations

Atypical angiopoietin-like protein that regulates ANGPTL3

Quagliarini, F., Wang, Y., Kozlitina, J., Grishin, N. V., Hyde, R., Boerwinkle, E., Valenzuela, D. M., Murphy, A. J., Cohen, J. C. & Hobbs, H. H., Nov 27 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19751-19756 6 p.

Research output: Contribution to journalArticle

239 Scopus citations

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes

Engelking, L. J., McFarlane, M. R., Li, C. K. & Liang, G., Jul 2012, In : Journal of lipid research. 53, 7, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Cardiac-specific knockout of ET A receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction

Zhang, Y., Li, L., Hua, Y., Nunn, J. M., Dong, F., Yanagisawa, M. & Ren, J., Apr 1 2012, In : Journal of molecular cell biology. 4, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction

López-Andrés, N., Rousseau, A., Akhtar, R., Calvier, L., Iñigo, C., Labat, C., Zhao, X., Cruickshank, K., Díez, J., Zannad, F., Lacolley, P. & Rossignol, P., Aug 2012, In : Hypertension. 60, 2, p. 563-573 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Cellular responses to unsaturated fatty acids mediated by their sensor Ubxd8

Ye, J., Oct 18 2012, In : Frontiers in Biology. 7, 5, p. 397-403 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chronic overexpression of PNPLA3 I148M in mouse liver causes hepatic steatosis

Li, J. Z., Huang, Y., Karaman, R., Ivanova, P. T., Brown, H. A., Roddy, T., Castro-Perez, J., Cohen, J. C. & Hobbs, H. H., Nov 1 2012, In : Journal of Clinical Investigation. 122, 11, p. 4130-4144 15 p.

Research output: Contribution to journalArticle

153 Scopus citations
6 Scopus citations

Deletion of GPIHBP1 causing severe chylomicronemia

Rios, J. J., Shastry, S., Jasso, J., Hauser, N., Garg, A., Bensadoun, A., Cohen, J. C. & Hobbs, H. H., May 1 2012, In : Journal of Inherited Metabolic Disease. 35, 3, p. 531-540 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
11 Scopus citations

DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells

Li, Y., Martin, B. R., Cravatt, B. F. & Hofmann, S. L., Jan 2 2012, In : Journal of Biological Chemistry. 287, 1, p. 523-530 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Differential diagnosis in patients with suspected bile acid synthesis defects

Haas, D., Gan-Schreier, H., Langhans, C. D., Rohrer, T., Engelmann, G., Heverin, M., Russell, D. W., Clayton, P. T., Hoffmann, G. F. & Okun, J. G., Mar 14 2012, In : World Journal of Gastroenterology. 18, 10, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Denard, B., Lee, C. & Ye, J., Dec 18 2012, In : eLife. 2012, 1, e00090.

Research output: Contribution to journalArticle

67 Scopus citations

Doxorubicin induces the persistent activation of intracellular transglutaminase 2 that protects from cell death

Cho, S. Y., Jeong, E. M., Lee, J. H., Kim, H. J., Lim, J., Kim, C. W., Shin, D. M., Jeon, J. H., Choi, K. & Kim, I. G., Mar 1 2012, In : Molecules and Cells. 33, 3, p. 235-241 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin B receptor is not required but necessary for finite regulation of ovulation

Cho, J., Kim, H., Kang, D. W., Yanagisawa, M. & Ko, C., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 613-617 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endothelin XII

Barton, M., Yanagisawa, M., Vanhoutte, P. M. & Masaki, T., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 449-451 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Enhanced fatty acid flux triggered by adiponectin overexpression

Shetty, S., Ramos-Roman, M. A., Cho, Y. R., Brown, J., Plutzky, J., Muise, E. S., Horton, J. D., Scherer, P. E. & Parks, E. J., Jan 2012, In : Endocrinology. 153, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

Adiarto, S., Heiden, S., Vignon-Zellweger, N., Nakayama, K., Yagi, K., Yanagisawa, M. & Emoto, N., Oct 15 2012, In : Life Sciences. 91, 13-14, p. 651-657 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Getting to grips with hepatitis

Chen, Z. J. & Ye, J., Nov 13 2012, In : eLife. 2012, 1, e00301.

Research output: Contribution to journalArticle

6 Scopus citations
11 Scopus citations

Homozygosity mapping identifies a bile acid biosynthetic defect in an adult with cirrhosis of unknown etiology

Molho-Pessach, V., Rios, J. J., Xing, C., Setchell, K. D. R., Cohen, J. C. & Hobbs, H. H., Apr 1 2012, In : Hepatology. 55, 4, p. 1139-1145 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Owen, J. L., Zhang, Y., Bae, S. H., Farooqi, M. S., Liang, G., Hammer, R. E., Goldstein, J. L. & Brown, M. S., Oct 2 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. 16184-16189 6 p.

Research output: Contribution to journalArticle

140 Scopus citations
7 Scopus citations

Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis

Hu, J., Lu, J. Y., Wong, A. M. S., Hynan, L. S., Birnbaum, S. G., Yilmaz, D. S., Streit, B. M., Lenartowicz, E. M., Thompson, T. C. M., Cooper, J. D. & Hofmann, S. L., Sep 1 2012, In : Molecular Genetics and Metabolism. 107, 1-2, p. 213-221 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates

Du, Y., Yang, M., Wei, W., Huynh, H. D., Herz, J., Saghatelian, A. & Wan, Y., 2012, In : Nature communications. 3, 1008.

Research output: Contribution to journalArticle

16 Scopus citations

Metallothioneins protect cytosolic creatine kinases against stress induced by nitrogen-based oxidants

Chen, Z., Li, J., Zhao, T. J., Li, X. H., Meng, F. G., Mu, H., Yan, Y. B. & Zhou, H. M., Jan 15 2012, In : Biochemical Journal. 441, 2, p. 623-632 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Wang, Y., Huang, Y., Hobbs, H. H. & Cohen, J. C., Sep 1 2012, In : Journal of lipid research. 53, 9, p. 1932-1943 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

Mutation of the CYP2R1 vitamin D 25-hydroxylase in a Saudi Arabian family with severe vitamin D deficiency

Al Mutair, A. N., Nasrat, G. H. & Russell, D. W., Oct 1 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 10, p. E2022-E2025

Research output: Contribution to journalArticle

50 Scopus citations

Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses

Yi, T., Wang, X., Kelly, L. M., An, J., Xu, Y., Sailer, A. W., Gustafsson, J. A., Russell, D. W. & Cyster, J. G., Sep 21 2012, In : Immunity. 37, 3, p. 535-548 14 p.

Research output: Contribution to journalArticle

113 Scopus citations

Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids

Li, R. L., Sherbet, D. P., Elsbernd, B. L., Goldstein, J. L., Brown, M. S. & Zhao, T. J., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 17942-17950 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

Sekine, K., Kawauchi, T., Kubo, K. I., Honda, T., Herz, J., Hattori, M., Kinashi, T. & Nakajima, K., Oct 18 2012, In : Neuron. 76, 2, p. 353-369 17 p.

Research output: Contribution to journalArticle

96 Scopus citations

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

Spann, N. J., Garmire, L. X., McDonald, J. G., Myers, D. S., Milne, S. B., Shibata, N., Reichart, D., Fox, J. N., Shaked, I., Heudobler, D., Raetz, C. R. H., Wang, E. W., Kelly, S. L., Sullards, M. C., Murphy, R. C., Merrill, A. H., Brown, H. A., Dennis, E. A., Li, A. C., Ley, K. & 6 others, Tsimikas, S., Fahy, E., Subramaniam, S., Quehenberger, O., Russell, D. W. & Glass, C. K., Sep 28 2012, In : Cell. 151, 1, p. 138-152 15 p.

Research output: Contribution to journalArticle

285 Scopus citations

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

Ai, D., Chen, C., Han, S., Ganda, A., Murphy, A. J., Haeusler, R., Thorp, E., Accili, D., Horton, J. D. & Tall, A. R., Apr 2 2012, In : Journal of Clinical Investigation. 122, 4, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells

Woldt, E., Terrand, J., Mlih, M., Matz, R. L., Bruban, V., Coudane, F., Foppolo, S., El Asmar, Z., Chollet, M. E., Ninio, E., Bednarczyk, A., Thiersé, D., Schaeffer, C., Van Dorsselaer, A., Boudier, C., Wahli, W., Chambon, P., Metzger, D., Herz, J. & Boucher, P., Oct 8 2012, In : Nature communications. 3, 1077.

Research output: Contribution to journalArticle

48 Scopus citations

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

Moon, Y. A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L. & Horton, J. D., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

176 Scopus citations

Wnt signaling in the murine diastema

Porntaveetus, T., Ohazama, A., Choi, H. Y., Herz, J. & Sharpe, P. T., Aug 2012, In : European Journal of Orthodontics. 34, 4, p. 518-524 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL

Ding, Y., Zhang, L., Wang, Y., Huang, W., Tang, Y., Bai, L., Ross, C. J. D., Hayden, M. R. & Liu, G., Sep 29 2011, In : PloS one. 6, 9, e25620.

Research output: Contribution to journalArticle

3 Scopus citations
32 Scopus citations

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., De Groot, P. G., Thorpe, P. E., Salmon, J. E., Shaul, P. W. & Mineo, C., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

104 Scopus citations

ApoER2 function in the establishment and maintenance of retinal synaptic connectivity

Trotter, J. H., Klein, M., Jinwal, U. K., Abisambra, J. F., Dickey, C. A., Tharkur, J., Masiulis, I., Ding, J., Locke, K. G., Rickman, C. B., Birch, D. G., Weeber, E. J. & Herz, J., Oct 5 2011, In : Journal of Neuroscience. 31, 40, p. 14413-14423 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Apolipoprotein e induces antiinflammatory phenotype in macrophages

Baitsch, D., Bock, H. H., Engel, T., Telgmann, R., Müller-Tidow, C., Varga, G., Bot, M., Herz, J., Robenek, H., Von Eckardstein, A. & Nofer, J. R., May 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 5, p. 1160-1168 9 p.

Research output: Contribution to journalArticle

157 Scopus citations

A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice

Chandra, M., Zhou, H., Li, Q., Muallem, S., Hofmann, S. L. & Soyombo, A. A., Mar 2011, In : Gastroenterology. 140, 3, p. 857-867.e1

Research output: Contribution to journalArticle

37 Scopus citations

Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice

Kalogiannis, M., Hsu, E., Willie, J. T., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., 2011, In : PloS one. 6, 4, e18697.

Research output: Contribution to journalArticle

34 Scopus citations

Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory

Nagata-Kuroiwa, R., Furutani, N., Hara, J., Hondo, M., Ishii, M., Abe, T., Mieda, M., Tsujino, N., Motoike, T., Yanagawa, Y., Kuwaki, T., Yamamoto, M., Yanagisawa, M. & Sakurai, T., 2011, In : PloS one. 6, 2, e16972.

Research output: Contribution to journalArticle

19 Scopus citations

Decreased intake of sucrose solutions in orexin knockout mice

Matsuo, E., Mochizuki, A., Nakayama, K., Nakamura, S., Yamamoto, T., Shioda, S., Sakurai, T., Yanagisawa, M., Shiuchi, T., Minokoshi, Y. & Inoue, T., Feb 1 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Differential roles of orexin receptor-1 and -2 in the regulation of Non-REM and REM sleep

Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M. & Sakurai, T., Apr 27 2011, In : Journal of Neuroscience. 31, 17, p. 6518-6526 9 p.

Research output: Contribution to journalArticle

150 Scopus citations

Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor

Woldt, E., Matz, R. L., Terrand, J., Mlih, M., Gracia, C., Foppolo, S., Martin, S., Bruban, V., Ji, J., Velot, E., Herz, J. & Boucher, P., May 13 2011, In : Journal of Biological Chemistry. 286, 19, p. 16775-16782 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

Kozlitina, J., Boerwinkle, E., Cohen, J. C. & Hobbs, H. H., Feb 1 2011, In : Hepatology. 53, 2, p. 467-474 8 p.

Research output: Contribution to journalArticle

86 Scopus citations
46 Scopus citations

Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice

Willie, J. T., Takahira, H., Shibahara, M., Hara, J., Nomiyama, M., Yanagisawa, M. & Sakurai, T., Feb 2011, In : Journal of Molecular Neuroscience. 43, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

27 Scopus citations