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2011

Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease

Huang, Y., Cohen, J. C. & Hobbs, H. H., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37085-37093 9 p.

Research output: Contribution to journalArticle

155 Scopus citations

Human 1-Acylglycerol-3-phosphate O-Acyltransferase isoforms 1 and 2: Biochemical characterization and inability to rescue hepatic steatosis in Agpat2 -/- gene lipodystrophic mice

Agarwal, A. K., Sukumaran, S., Cortés, V. A., Tunison, K., Mizrachi, D., Sankella, S., Gerard, R. D., Horton, J. D. & Garg, A., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37676-37691 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII

Ding, Y., Wang, Y., Zhu, H., Fan, J., Yu, L., Liu, G. & Liu, E., Aug 1 2011, In : Transgenic Research. 20, 4, p. 867-875 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Hypothalamic orexin system: From orphan GPCR to therapeutic target

Yanagisawa, M., Jul 1 2011, In : Experimental Animals. 60, SUPPL. 3, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of alternatively spliced Dab1 and Fyn isoforms in pig

Long, H., Bock, H. H., Lei, T., Chai, X., Yuan, J., Herz, J., Frotscher, M. & Yang, Z., Feb 5 2011, In : BMC Neuroscience. 12, 17.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of luminal loop 1 of scap protein as the sterol sensor that maintains cholesterol homeostasis

Motamed, M., Zhang, Y., Wang, M. L., Seemann, J., Kwon, H. J., Goldstein, J. L. & Brown, M. S., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 18002-18012 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

Sephton, C. F., Cenik, C., Kucukural, A., Dammer, E. B., Cenik, B., Han, Y., Dewey, C. M., Roth, F. P., Herz, J., Peng, J., Moore, M. J. & Yu, G., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1204-1215 12 p.

Research output: Contribution to journalArticle

271 Scopus citations

Integrated expression profiling and Genome-Wide analysis of ChREBP targets reveals the dual role for ChREBP in Glucose-Regulated gene expression

Jeong, Y. S., Kim, D., Lee, Y. S., Kim, H. J., Han, J. Y., Im, S. S., Chong, H. K., Kwon, J. K., Cho, Y. H., Kim, W. K., Osborne, T. F., Horton, J. D., Jun, H. S., Ahn, Y. H., Ahn, S. M. & Cha, J. Y., 2011, In : PloS one. 6, 7, e22544.

Research output: Contribution to journalArticle

86 Scopus citations

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people

Sullivan, S., Fabbrini, E., Horton, J. D., Korenblat, K., Patterson, B. W. & Klein, S., Nov 2011, In : Translational Research. 158, 5, p. 302-306 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells

Liu, S., Shi, X., Bauer, I., Günther, J. & Seyfert, H. M., Mar 1 2011, In : Molecular Immunology. 48, 6-7, p. 895-908 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

Liu, Q., Zhang, J., Zerbinatti, C., Zhan, Y., Kolber, B. J., Herz, J., Muglia, L. J. & Bu, G., 2011, In : PLoS biology. 9, 1, e1000575.

Research output: Contribution to journalArticle

50 Scopus citations

LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE - carrying lipoproteins

Haas, J., Beer, A. G., Widschwendter, P., Oberdanner, J., Salzmann, K., Sarg, B., Lindner, H., Herz, J., Patsch, J. R. & Marschang, P., Jun 1 2011, In : Atherosclerosis. 216, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
47 Scopus citations

Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice

Liu, M., Blanco-Centurion, C., Konadhode, R., Begum, S., Pelluru, D., Gerashchenko, D., Sakurai, T., Yanagisawa, M., van den Pol, A. N. & Shiromani, P. J., Apr 20 2011, In : Journal of Neuroscience. 31, 16, p. 6028-6040 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing

Ida-Eto, M., Ohgami, N., Iida, M., Yajima, I., Kumasaka, M. Y., Takaiwa, K., Kimitsuki, T., Sone, M., Nakashima, T., Tsuzuki, T., Komune, S., Yanagisawa, M. & Kato, M., Aug 26 2011, In : Journal of Biological Chemistry. 286, 34, p. 29621-29626 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor

Clines, G. A., Mohammad, K. S., Grunda, J. M., Clines, K. L., Niewolna, M., McKenna, C. R., McKibbin, C. R., Yanagisawa, M., Suva, L. J., Chirgwin, J. M. & Guise, T. A., Oct 1 2011, In : Journal of Bone and Mineral Research. 26, 10, p. 2523-2536 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport

Wang, J., Grishin, N., Kinch, L., Cohen, J. C., Hobbs, H. H. & Xie, X. S., Mar 4 2011, In : Journal of Biological Chemistry. 286, 9, p. 7308-7314 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin

Chen, Z., Zhao, T. J., Li, J., Gao, Y. S., Meng, F. G., Yan, Y. B. & Zhou, H. M., Jun 1 2011, In : Biochemical Journal. 436, 2, p. 437-445 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
80 Scopus citations

Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE

Li, X., Wang, J. & Shi, Y., Aug 11 2011, In : Nature communications. 2, 1, 408.

Research output: Contribution to journalArticle

19 Scopus citations

Structure and mechanism of the uracil transporter UraA

Lu, F., Li, S., Jiang, Y., Jiang, J., Fan, H., Lu, G., Deng, D., Dang, S., Zhang, X., Wang, J. & Yan, N., Apr 14 2011, In : Nature. 472, 7342, p. 243-247 5 p.

Research output: Contribution to journalArticle

110 Scopus citations

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: Rational therapeutic approach to frontotemporal dementia

Cenik, B., Sephton, C. F., Dewey, C. M., Xian, X., Wei, S., Yu, K., Niu, W., Coppola, G., Coughlin, S. E., Lee, S. E., Dries, D. R., Almeida, S., Geschwind, D. H., Gao, F. B., Miller, B. L., Farese, R. V., Posner, B. A., Yu, G. & Herz, J., May 6 2011, In : Journal of Biological Chemistry. 286, 18, p. 16101-16108 8 p.

Research output: Contribution to journalArticle

104 Scopus citations

Surviving starvation: Essential role of the ghrelin-growth hormone axis

Goldstein, J. L., Zhao, T. J., Li, R. L., Sherbet, D. P., Liang, G. & Brown, M. S., 2011, In : Cold Spring Harbor symposia on quantitative biology. 76, p. 121-127 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

Dewey, C. M., Cenik, B., Sephton, C. F., Dries, D. R., Mayer, P., Good, S. K., Johnson, B. A., Herz, J. & Yu, G., Mar 1 2011, In : Molecular and cellular biology. 31, 5, p. 1098-1108 11 p.

Research output: Contribution to journalArticle

184 Scopus citations

The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Denard, B., Seemann, J., Chen, Q., Gay, A., Huang, H., Chen, Y. & Ye, J., Jul 21 2011, In : Cell Host and Microbe. 10, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

Kucejova, B., Sunny, N. E., Nguyen, A. D., Hallac, R., Fu, X., Pẽa-Llopis, S., Mason, R. P., Deberardinis, R. J., Xie, X. J., Debose-Boyd, R., Kodibagkar, V. D., Burgess, S. C. & Brugarolas, J., May 5 2011, In : Oncogene. 30, 18, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

34 Scopus citations
2010
58 Scopus citations

Acid regulation of NaDC-1 requires a functional endothelin B receptor

Liu, L., Zacchia, M., Tian, X., Wan, L., Sakamoto, A., Yanagisawa, M., Alpern, R. J. & Preisig, P. A., Nov 2010, In : Kidney international. 78, 9, p. 895-904 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

A feed-forward loop amplifies nutritional regulation of PNPLA3

Huang, Y., He, S., Li, J. Z., Seo, Y. K., Osborne, T. F., Cohen, J. C. & Hobbs, H. H., Apr 27 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7892-7897 6 p.

Research output: Contribution to journalArticle

219 Scopus citations

A mouse macrophage lipidome

Dennis, E. A., Deems, R. A., Harkewicz, R., Quehenberger, O., Brown, H. A., Milne, S. B., Myers, D. S., Glass, C. K., Hardiman, G., Reichart, D., Merrill, A. H., Sullards, M. C., Wang, E., Murphy, R. C., Raetz, C. R. H., Garrett, T. A., Guan, Z., Ryan, A. C., Russell, D. W., McDonald, J. G. & 8 others, Thompson, B. M., Shaw, W. A., Sud, M., Zhao, Y., Gupta, S., Maurya, M. R., Fahy, E. & Subramaniama, S., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 39976-39985 10 p.

Research output: Contribution to journalArticle

169 Scopus citations

A mutation in canine PPT1 causes early onset neuronal ceroid lipofuscinosis in a Dachshund

Sanders, D. N., Farias, F. H., Johnson, G. S., Chiang, V., Cook, J. R., O'Brien, D. P., Hofmann, S. L., Lu, J. Y. & Katz, M. L., Aug 1 2010, In : Molecular Genetics and Metabolism. 100, 4, p. 349-356 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

A novel mouse model for de novo melanoma

Kumasaka, M. Y., Yajima, I., Hossain, K., Iida, M., Tsuzuki, T., Ohno, T., Takahashi, M., Yanagisawa, M. & Kato, M., Jan 1 2010, In : Cancer research. 70, 1, p. 24-29 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
177 Scopus citations

A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition

Ohazama, A., Blackburn, J., Porntaveetus, T., Ota, M. S., Choi, H. Y., Johnson, E. B., Myers, P., Oommen, S., Eto, K., Kessler, J. A., Kondo, T., Fraser, G. J., Streelman, J. T., Pardiñas, U. F. J., Tucker, A. S., Ortiz, P. E., Charles, C., Viriot, L., Herz, J. & Sharpe, P. T., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 92-97 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

He, S., McPhaul, C., Li, J. Z., Garuti, R., Kinch, L., Grishin, N. V., Cohen, J. C. & Hobbs, H. H., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6706-6715 10 p.

Research output: Contribution to journalArticle

387 Scopus citations
425 Scopus citations

C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle

Shi, X., Liu, S., Metges, C. C. & Seyfert, H. M., Aug 1 2010, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1799, 8, p. 561-567 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structure of Spot 14, a modulator of fatty acid synthesis

Colbert, C. L., Kim, C. W., Moon, Y. A., Henry, L., Palnitkar, M., McKean, W. B., Fitzgerald, K., Deisenhofer, J., Horton, J. D. & Kwon, H. J., Nov 2 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 44, p. 18820-18825 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory

Li, Y., Hu, J., Höfer, K., Wong, A. M. S., Cooper, J. D., Birnbaum, S. G., Hammer, R. E. & Hofmann, S. L., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13022-13031 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer

Cho, S. Y., Choi, K., Jeon, J. H., Kim, C. W., Shin, D. M., Lee, J. B., Lee, S. E., Kim, C. S., Park, J. S., Jeong, E. M., Jang, G. Y., Song, K. Y. & Kim, I. G., Apr 30 2010, In : Experimental and Molecular Medicine. 42, 4, p. 310-318 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion

Stösser, S., Agarwal, N., Tappe-Theodor, A., Yanagisawa, M. & Kuner, R., Feb 1 2010, In : Pain. 148, 2, p. 206-214 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions In Vivo

Dietrich, M. F., van der Weyden, L., Prosser, H. M., Bradley, A., Herz, J. & Adams, D. J., 2010, In : PloS one. 5, 4, p. 1-7 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition

Widyantoro, B., Emoto, N., Nakayama, K., Anggrahini, D. W., Adiarto, S., Iwasa, N., Yagi, K., Miyagawa, K., Rikitake, Y., Suzuki, T., Kisanuki, Y. Y., Yanagisawa, M. & Hirata, K. I., Jun 8 2010, In : Circulation. 121, 22, p. 2407-2418 12 p.

Research output: Contribution to journalArticle

240 Scopus citations

Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia

Musunuru, K., Pirruccello, J. P., Do, R., Peloso, G. M., Guiducci, C., Sougnez, C., Garimella, K. V., Fisher, S., Abreu, J., Barry, A. J., Fennell, T., Banks, E., Ambrogio, L., Cibulskis, K., Kernytsky, A., Gonzalez, E., Rudzicz, N., Engert, J. C., DePristo, M. A., Daly, M. J. & 7 others, Cohen, J. C., Hobbs, H. H., Altshuler, D., Schonfeld, G., Gabriel, S. B., Yue, P. & Kathiresan, S., Dec 2 2010, In : New England Journal of Medicine. 363, 23, p. 2220-2227 8 p.

Research output: Contribution to journalArticle

362 Scopus citations
72 Scopus citations

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

Perello, M., Sakata, I., Birnbaum, S. G., Chuang, J. C., Osborne-Lawrence, S., Rovinsky, S. A., Woloszyn, J., Yanagisawa, M., Lutter, M. & Zigman, J. M., May 1 2010, In : Biological Psychiatry. 67, 9, p. 880-886 7 p.

Research output: Contribution to journalArticle

247 Scopus citations

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

Zhao, T. J., Liang, G., Li, R. L., Xie, X., Sleeman, M. W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Goldstein, J. L. & Brown, M. S., Apr 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 16, p. 7467-7472 6 p.

Research output: Contribution to journalArticle

283 Scopus citations
112 Scopus citations

Hair growth defects in insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin

Evers, B. M., Farooqi, M. S., Shelton, J. M., Richardson, J. A., Goldstein, J. L., Brown, M. S. & Liang, G., May 1 2010, In : Journal of Investigative Dermatology. 130, 5, p. 1237-1248 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

Hondo, M., Nagai, K., Ohno, K., Kisanuki, Y., Willie, J. T., Watanabe, T., Yanagisawa, M. & Sakurai, T., Mar 2010, In : Acta Physiologica. 198, 3, p. 287-294 8 p.

Research output: Contribution to journalArticle

41 Scopus citations