Research Output

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Review article
2020

Apolipoprotein E: Cholesterol metabolism and Alzheimer's pathology

Pohlkamp, T., Feb 1 2020, In : Neuroforum. 26, 1, p. 25-30 6 p.

Research output: Contribution to journalReview article

Delisting STAP1: The rise and fall of a putative hypercholesterolemia gene

Hegele, R. A., Knowles, J. W. & Horton, J. D., 2020, (Accepted/In press) In : Arteriosclerosis, thrombosis, and vascular biology. p. 847-849 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: A consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, J., John Chapman, M., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., Nordestgaard, B. G., Watts, G. F., Bruckert, E., Fazio, S., Ference, B. A., Graham, I., Horton, J. D., Landmesser, U., Laufs, U., Masana, L. & 10 others, Pasterkamp, G., Raal, F. J., Ray, K. K., Schunkert, H., Taskinen, M. R., van de Sluis, B., Wiklund, O., Tokgozoglu, L., Catapano, A. L. & Ginsberg, H. N., Jun 21 2020, In : European heart journal. 41, 24, p. 2313-2330 18 p.

Research output: Contribution to journalReview article

Open Access
33 Scopus citations

Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling

Qi, X. & Li, X., May 2020, In : Trends in biochemical sciences. 45, 5, p. 397-410 14 p.

Research output: Contribution to journalReview article

3 Scopus citations

PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis: Beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis

Kökény, G., Calvier, L., Legchenko, E., Chouvarine, P., Mózes, M. M. & Hansmann, G., Mar 1 2020, In : Current opinion in nephrology and hypertension. 29, 2, p. 171-179 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Structural insights into group II TRP channels

Fine, M., Li, X. & Dang, S., Mar 2020, In : Cell Calcium. 86, 102107.

Research output: Contribution to journalReview article

Open Access
2019

Endothelin: 30 years from discovery to therapy

Barton, M. & Yanagisawa, M., Dec 1 2019, In : Hypertension. 74, 6, p. 1232-1265 34 p.

Research output: Contribution to journalReview article

10 Scopus citations

IL-33 in murine abdominal aortic aneurysm: A novel inflammatory mediator awaiting clinical translation

Tsai, S. & Xian, X., Jun 1 2019, In : Journal of Thoracic Disease. 11, 6, p. 2181-2184 4 p.

Research output: Contribution to journalReview article

2018

2018 association of American physicians George M. Kober lecture science, serendipity, and the single degree

Hobbs, H. H., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4218-4223 6 p.

Research output: Contribution to journalReview article

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Brown, M. S., Radhakrishnan, A. & Goldstein, J. L., Jun 20 2018, In : Annual review of biochemistry. 87, p. 783-807 25 p.

Research output: Contribution to journalReview article

73 Scopus citations
2017

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

Lane-Donovan, C. & Herz, J., Apr 1 2017, In : Trends in Endocrinology and Metabolism. 28, 4, p. 273-284 12 p.

Research output: Contribution to journalReview article

37 Scopus citations

Functional roles of the interaction of APP and lipoprotein receptors

Pohlkamp, T., Wasser, C. R. & Herz, J., Mar 1 2017, In : Frontiers in Molecular Neuroscience. 10, 54.

Research output: Contribution to journalReview article

22 Scopus citations

News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1

Van De Sluis, B., Wijers, M. & Herz, J., Jun 1 2017, In : Current opinion in lipidology. 28, 3, p. 241-247 7 p.

Research output: Contribution to journalReview article

27 Scopus citations

Periodontitis and myocardial hypertrophy

Suzuki, J. I., Sato, H., Kaneko, M., Yoshida, A., Aoyama, N., Akimoto, S., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Izumi, Y., Isobe, M. & Komuro, I., Apr 1 2017, In : Hypertension Research. 40, 4, p. 324-328 5 p.

Research output: Contribution to journalReview article

5 Scopus citations

Reelin: Neurodevelopmental architect and homeostatic regulator of excitatory synapses

Wasser, C. R. & Herz, J., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1330-1338 9 p.

Research output: Contribution to journalReview article

35 Scopus citations

Reprint of “Steroid 5α-reductase 2 deficiency”

Mendonca, B. B., Batista, R. L., Domenice, S., Costa, E. M. F., Arnhold, I. J. P., Russell, D. W. & Wilson, J. D., Jan 1 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 165, p. 95-100 6 p.

Research output: Contribution to journalReview article

6 Scopus citations

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

Lane-Donovan, C. & Herz, J., Jun 2017, In : Journal of lipid research. 58, 6, p. 1036-1043 8 p.

Research output: Contribution to journalReview article

21 Scopus citations

The SCAP/SREBP pathway: A mediator of hepatic steatosis

Moon, Y. A., Mar 1 2017, In : Endocrinology and Metabolism. 32, 1, p. 6-10 5 p.

Research output: Contribution to journalReview article

24 Scopus citations
2016

Current therapies and investigational drugs for peripheral arterial disease

Suzuki, J. I., Shimamura, M., Suda, H., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Isobe, M., Komuro, I. & Morishita, R., Apr 1 2016, In : Hypertension Research. 39, 4, p. 183-191 9 p.

Research output: Contribution to journalReview article

22 Scopus citations

Structural biology of intramembrane proteases: Mechanistic insights from rhomboid and S2P to γ-secretase

Sun, L., Li, X. & Shi, Y., Apr 1 2016, In : Current Opinion in Structural Biology. 37, p. 97-107 11 p.

Research output: Contribution to journalReview article

22 Scopus citations

Understanding Vascular Diseases: Lessons From Premature Aging Syndromes

Ikeda, Y., Kumagai, H., Motozawa, Y., Suzuki, J. I., Akazawa, H. & Komuro, I., May 1 2016, In : Canadian Journal of Cardiology. 32, 5, p. 650-658 9 p.

Research output: Contribution to journalReview article

5 Scopus citations
2015

A century of cholesterol and coronaries: From plaques to genes to statins

Goldstein, J. L. & Brown, M. S., Mar 26 2015, In : Cell. 161, 1, p. 161-172 12 p., 8011.

Research output: Contribution to journalReview article

366 Scopus citations
2014

25 Years of endothelin research: The next generation

Emoto, N., Vignon-Zellweger, N., Lopes, R. A. M., Cacioppo, J., Desbiens, L., Kamato, D., Leurgans, T., Moorhouse, R., Straube, J., Wurm, R., Heiden, S., Ergul, A., Yanagisawa, M. & Barton, M., Nov 24 2014, In : Life Sciences. 118, 2, p. 77-86 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Cellular responses to excess fatty acids: Focus on ubiquitin regulatory X domain-containing protein 8

Kim, H. & Ye, J., Apr 2014, In : Current opinion in lipidology. 25, 2, p. 118-124 7 p.

Research output: Contribution to journalReview article

3 Scopus citations

More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

Lane-Donovan, C., Philips, G. T. & Herz, J., Aug 20 2014, In : Neuron. 83, 4, p. 771-787 17 p.

Research output: Contribution to journalReview article

69 Scopus citations

Science Signaling podcast: 25 November 2014

Wasser, C. R., Herz, J. & VanHook, A. M., Nov 25 2014, In : Science Signaling. 7, 353, pc30.

Research output: Contribution to journalReview article

2013

Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity

Ye, J., 2013, In : Biochimica et Biophysica Acta - Biomembranes. 1828, 12, p. 2926-2932 7 p.

Research output: Contribution to journalReview article

10 Scopus citations
2012

Scientific side trips: Six excursions from the beaten path

Brown, M. S. & Goldstein, J. L., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22418-22435 18 p.

Research output: Contribution to journalReview article

5 Scopus citations

TDP-43 aggregation in neurodegeneration: Are stress granules the key?

Dewey, C. M., Cenik, B., Sephton, C. F., Johnson, B. A., Herz, J. & Yu, G., Jun 26 2012, In : Brain Research. 1462, p. 16-25 10 p.

Research output: Contribution to journalReview article

121 Scopus citations

TDP-43 in central nervous system development and function: Clues to TDP-43-associated neurodegeneration

Sephton, C. F., Cenik, B., Cenik, B. K., Herz, J. & Yu, G., Jul 1 2012, In : Biological Chemistry. 393, 7, p. 589-594 6 p.

Research output: Contribution to journalReview article

33 Scopus citations
2011

Human fatty liver disease: Old questions and new insights

Cohen, J. C., Horton, J. D. & Hobbs, H. H., Jun 24 2011, In : Science. 332, 6037, p. 1519-1523 5 p.

Research output: Contribution to journalReview article

1261 Scopus citations

Regulation of cholesterol and fatty acid synthesis

Ye, J. & DeBose-Boyd, R. A., Jul 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 7, p. 1-13 13 p.

Research output: Contribution to journalReview article

136 Scopus citations

The card players of Caravaggio, Cézanne and Mark Twain: Tips for getting lucky in high-stakes research

Goldstein, J. L., Oct 1 2011, In : Nature medicine. 17, 10, p. 1201-1205 5 p.

Research output: Contribution to journalReview article

2010
98 Scopus citations

Emerging topics in Reelin function

Förster, E., Bock, H. H., Herz, J., Chai, X., Frotscher, M. & Zhao, S., May 2010, In : European Journal of Neuroscience. 31, 9, p. 1511-1518 8 p.

Research output: Contribution to journalReview article

95 Scopus citations

Lipoprotein receptors-an evolutionarily ancient multifunctional receptor family

Dieckmann, M., Dietrich, M. F. & Herz, J., Nov 1 2010, In : Biological Chemistry. 391, 11, p. 1341-1363 23 p.

Research output: Contribution to journalReview article

65 Scopus citations

Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis

Ohazama, A., Porntaveetus, T., Ota, M. S., Herz, J. & Sharpe, P. T., Dec 2010, In : American Journal of Medical Genetics, Part A. 152 A, 12, p. 2974-2983 10 p.

Research output: Contribution to journalReview article

21 Scopus citations
2009

Apolipoprotein E receptors in the nervous system

Herz, J., Jun 2009, In : Current opinion in lipidology. 20, 3, p. 190-196 7 p.

Research output: Contribution to journalReview article

53 Scopus citations

Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain

Russell, D. W., Halford, R. W., Ramirez, D. M. O., Shah, R. & Kotti, T., 2009, In : Annual review of biochemistry. 78, p. 1017-1040 24 p.

Research output: Contribution to journalReview article

154 Scopus citations

Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL

Brown, M. S. & Goldstein, J. L., Apr 2009, In : Journal of lipid research. 50, SUPPL., p. S15-S27

Research output: Contribution to journalReview article

307 Scopus citations

Expanding functions of lipoprotein receptors

Herz, J., Chen, Y., Masiulis, I. & Zhou, L., Apr 2009, In : Journal of lipid research. 50, SUPPL., p. S287-S292

Research output: Contribution to journalReview article

53 Scopus citations

Fifty years of advances in bile acid synthesis and metabolism

Russell, D. W., Apr 2009, In : Journal of lipid research. 50, SUPPL., p. S120-S125

Research output: Contribution to journalReview article

188 Scopus citations

PCSK9: A convertase that coordinates LDL catabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Apr 2009, In : Journal of lipid research. 50, SUPPL., p. S172-S177

Research output: Contribution to journalReview article

380 Scopus citations

The LDL receptor

Goldstein, J. L. & Brown, M. S., Apr 1 2009, In : Arteriosclerosis, thrombosis, and vascular biology. 29, 4, p. 431-438 8 p.

Research output: Contribution to journalReview article

655 Scopus citations
2008

Endothelin: 20 Years from discovery to therapy

Barton, M. & Yanagisawa, M., Aug 1 2008, In : Canadian Journal of Physiology and Pharmacology. 86, 8, p. 485-498 14 p.

Research output: Contribution to journalReview article

213 Scopus citations
2007

Molecular biology of PCSK9: its role in LDL metabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Feb 1 2007, In : Trends in Biochemical Sciences. 32, 2, p. 71-77 7 p.

Research output: Contribution to journalReview article

373 Scopus citations

Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus

Ye, J., Aug 2007, In : PLoS pathogens. 3, 8, p. 1017-1022 6 p.

Research output: Contribution to journalReview article

112 Scopus citations
2006

Functional biology of the neuronal ceroid lipofuscinoses (NCL) proteins

Kyttälä, A., Lahtinen, U., Braulke, T. & Hofmann, S. L., Oct 1 2006, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1762, 10, p. 920-933 14 p.

Research output: Contribution to journalReview article

69 Scopus citations

Lowering LDL - Not only how low, but how long?

Brown, M. S. & Goldstein, J. L., Mar 24 2006, In : Science. 311, 5768, p. 1721-1723 3 p.

Research output: Contribution to journalReview article

158 Scopus citations