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Review article

Understanding Vascular Diseases: Lessons From Premature Aging Syndromes

Ikeda, Y., Kumagai, H., Motozawa, Y., Suzuki, J. I., Akazawa, H. & Komuro, I., May 1 2016, In : Canadian Journal of Cardiology. 32, 5, p. 650-658 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Two 7α-hydroxylase enzymes in bile acid biosynthesis

Schwarz, M., Lund, E. G. & Russell, D. W., 1998, In : Current opinion in lipidology. 9, 2, p. 113-118 6 p.

Research output: Contribution to journalReview article

83 Scopus citations
Open Access

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M. & Yanagisawa, M., Aug 11 2001, In : Annual Review of Neuroscience. 24, p. 429-458 30 p.

Research output: Contribution to journalReview article

613 Scopus citations

The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Brown, M. S. & Goldstein, J. L., May 2 1997, In : Cell. 89, 3, p. 331-340 10 p.

Research output: Contribution to journalReview article

2666 Scopus citations

The SCAP/SREBP pathway: A mediator of hepatic steatosis

Moon, Y. A., Mar 1 2017, In : Endocrinology and Metabolism. 32, 1, p. 6-10 5 p.

Research output: Contribution to journalReview article

24 Scopus citations

The low density lipoprotein pathway in human fibroblasts

Brown, M. S. & Goldstein, J. L., Jul 1976, In : Trends in Biochemical Sciences. 1, 3, p. 193-195 3 p.

Research output: Contribution to journalReview article

12 Scopus citations

The low density lipoprotein pathway in human fibroblasts

Brown, M. S. & Goldstein, J. L., Sep 1976, In : Trends in Biochemical Sciences. 1, 9, p. 193-195 3 p.

Research output: Contribution to journalReview article

1 Scopus citations

The low-density lipoprotein pathway and its relation to atherosclerosis.

Goldstein, J. L. & Brown, M. S., 1977, In : Annual review of biochemistry. 46, p. 897-930 34 p.

Research output: Contribution to journalReview article

1549 Scopus citations

The LDL-receptor-related protein - portrait of a multifunctional receptor

Herz, J., Jan 1 1993, In : Current Opinion in Lipidology. 4, 2, p. 107-113 7 p.

Research output: Contribution to journalReview article

75 Scopus citations

The LDL receptor locus and the genetics of familial hypercholesterolemia.

Goldstein, J. L. & Brown, M. S., 1979, In : Annual review of genetics. 13, p. 259-289 31 p.

Research output: Contribution to journalReview article

134 Scopus citations

The LDL receptor gene family: Signaling functions during development

Howell, B. W. & Herz, J., 2001, In : Current Opinion in Neurobiology. 11, 1, p. 74-81 8 p.

Research output: Contribution to journalReview article

66 Scopus citations

The LDL receptor

Goldstein, J. L. & Brown, M. S., Apr 1 2009, In : Arteriosclerosis, thrombosis, and vascular biology. 29, 4, p. 431-438 8 p.

Research output: Contribution to journalReview article

655 Scopus citations

The enzymes, regulation, and genetics of bile acid synthesis

Russell, D. W., 2003, In : Annual review of biochemistry. 72, p. 137-174 38 p.

Research output: Contribution to journalReview article

1069 Scopus citations

The card players of Caravaggio, Cézanne and Mark Twain: Tips for getting lucky in high-stakes research

Goldstein, J. L., Oct 1 2011, In : Nature medicine. 17, 10, p. 1201-1205 5 p.

Research output: Contribution to journalReview article

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

Lane-Donovan, C. & Herz, J., Jun 2017, In : Journal of lipid research. 58, 6, p. 1036-1043 8 p.

Research output: Contribution to journalReview article

21 Scopus citations

TDP-43 in central nervous system development and function: Clues to TDP-43-associated neurodegeneration

Sephton, C. F., Cenik, B., Cenik, B. K., Herz, J. & Yu, G., Jul 1 2012, In : Biological Chemistry. 393, 7, p. 589-594 6 p.

Research output: Contribution to journalReview article

33 Scopus citations

TDP-43 aggregation in neurodegeneration: Are stress granules the key?

Dewey, C. M., Cenik, B., Sephton, C. F., Johnson, B. A., Herz, J. & Yu, G., Jun 26 2012, In : Brain Research. 1462, p. 16-25 10 p.

Research output: Contribution to journalReview article

121 Scopus citations
1023 Scopus citations

Structural insights into group II TRP channels

Fine, M., Li, X. & Dang, S., Mar 2020, In : Cell Calcium. 86, 102107.

Research output: Contribution to journalReview article

Structural biology of intramembrane proteases: Mechanistic insights from rhomboid and S2P to γ-secretase

Sun, L., Li, X. & Shi, Y., Apr 1 2016, In : Current Opinion in Structural Biology. 37, p. 97-107 11 p.

Research output: Contribution to journalReview article

22 Scopus citations

Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis

Horton, J. D. & Shimomura, L., Apr 1999, In : Current opinion in lipidology. 10, 2, p. 143-150 8 p.

Research output: Contribution to journalReview article

257 Scopus citations

Steroid 5α-reductase: Two genes/two enzymes

Russell, D. W. & Wilson, J. D., 1994, In : Annual review of biochemistry. 63, p. 25-61 37 p.

Research output: Contribution to journalReview article

936 Scopus citations
Open Access
3171 Scopus citations

Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Mieda, M. & Yanagisawa, M., Jun 1 2002, In : Current Opinion in Neurobiology. 12, 3, p. 339-345 7 p.

Research output: Contribution to journalReview article

86 Scopus citations

Scientific side trips: Six excursions from the beaten path

Brown, M. S. & Goldstein, J. L., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22418-22435 18 p.

Research output: Contribution to journalReview article

5 Scopus citations

Science Signaling podcast: 25 November 2014

Wasser, C. R., Herz, J. & VanHook, A. M., Nov 25 2014, In : Science Signaling. 7, 353, pc30.

Research output: Contribution to journalReview article

Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity

Ye, J., 2013, In : Biochimica et Biophysica Acta - Biomembranes. 1828, 12, p. 2926-2932 7 p.

Research output: Contribution to journalReview article

10 Scopus citations

Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics

Kitamura, T., Koshino, Y., Shibata, F., Oki, T., Nakajima, H., Nosaka, T. & Kumagai, H., Nov 2003, In : Experimental Hematology. 31, 11, p. 1007-1014 8 p.

Research output: Contribution to journalReview article

550 Scopus citations

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Brown, M. S., Radhakrishnan, A. & Goldstein, J. L., Jun 20 2018, In : Annual review of biochemistry. 87, p. 783-807 25 p.

Research output: Contribution to journalReview article

73 Scopus citations

Reprint of “Steroid 5α-reductase 2 deficiency”

Mendonca, B. B., Batista, R. L., Domenice, S., Costa, E. M. F., Arnhold, I. J. P., Russell, D. W. & Wilson, J. D., Jan 1 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 165, p. 95-100 6 p.

Research output: Contribution to journalReview article

6 Scopus citations

Renal tubular effects of endothelin-B receptor signaling: Its role in cardiovascular homeostasis and extracellular volume regulation

Ohuchi, T., Yanagisawa, M. & Gariepy, C. E., Jul 24 2000, In : Current opinion in nephrology and hypertension. 9, 4, p. 435-439 5 p.

Research output: Contribution to journalReview article

27 Scopus citations

Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus

Ye, J., Aug 2007, In : PLoS pathogens. 3, 8, p. 1017-1022 6 p.

Research output: Contribution to journalReview article

112 Scopus citations

Regulation of the mevalonate pathway

Goldstein, J. L. & Brown, M. S., Jan 1 1990, In : Nature. 343, 6257, p. 425-430 6 p.

Research output: Contribution to journalReview article

4207 Scopus citations

Regulation of plasma cholesterol by lipoprotein receptors

Brown, M. S., Kovanen, P. T. & Goldstein, J. L., 1981, In : Science. 212, 4495, p. 628-635 8 p.

Research output: Contribution to journalReview article

580 Scopus citations

Regulation of cholesterol and fatty acid synthesis

Ye, J. & DeBose-Boyd, R. A., Jul 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 7, p. 1-13 13 p.

Research output: Contribution to journalReview article

136 Scopus citations

Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans

Brown, M. S., Ye, J., Rawson, R. B. & Goldstein, J. L., Feb 18 2000, In : Cell. 100, 4, p. 391-398 8 p.

Research output: Contribution to journalReview article

Open Access
1073 Scopus citations

Reelin, lipoprotein receptors and synaptic plasticity

Herz, J. & Chen, Y., Nov 1 2006, In : Nature Reviews Neuroscience. 7, 11, p. 850-859 10 p.

Research output: Contribution to journalReview article

372 Scopus citations

Reelin: Neurodevelopmental architect and homeostatic regulator of excitatory synapses

Wasser, C. R. & Herz, J., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1330-1338 9 p.

Research output: Contribution to journalReview article

35 Scopus citations
Open Access
466 Scopus citations

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

Goldstein, J. L., Brown, M. S., Anderson, R. G., Russell, D. W. & Schneider, W. J., 1985, In : Annual review of cell biology. 1, p. 1-39 39 p.

Research output: Contribution to journalReview article

1057 Scopus citations

Protein sensors for membrane sterols

Goldstein, J. L., DeBose-Boyd, R. A. & Brown, M. S., Jan 13 2006, In : Cell. 124, 1, p. 35-46 12 p.

Research output: Contribution to journalReview article

1060 Scopus citations

PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis: Beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis

Kökény, G., Calvier, L., Legchenko, E., Chouvarine, P., Mózes, M. M. & Hansmann, G., Mar 1 2020, In : Current opinion in nephrology and hypertension. 29, 2, p. 171-179 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

Periodontitis and myocardial hypertrophy

Suzuki, J. I., Sato, H., Kaneko, M., Yoshida, A., Aoyama, N., Akimoto, S., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Izumi, Y., Isobe, M. & Komuro, I., Apr 1 2017, In : Hypertension Research. 40, 4, p. 324-328 5 p.

Research output: Contribution to journalReview article

5 Scopus citations

PCSK9: A convertase that coordinates LDL catabolism

Horton, J. D., Cohen, J. C. & Hobbs, H. H., Apr 2009, In : Journal of lipid research. 50, SUPPL., p. S172-S177

Research output: Contribution to journalReview article

380 Scopus citations

Oxysterol biosynthetic enzymes

Russell, D. W., Dec 15 2000, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1529, 1-3, p. 126-135 10 p.

Research output: Contribution to journalReview article

275 Scopus citations

Orexins: From neuropeptides to energy homeostasis and sleep/wake regulation

Beuckmann, C. T. & Yanagisawa, M., Jul 25 2002, In : Journal of Molecular Medicine. 80, 6, p. 329-342 14 p.

Research output: Contribution to journalReview article

122 Scopus citations

Nuclear orphan receptors control cholesterol catabolism

Russell, D. W., May 28 1999, In : Cell. 97, 5, p. 539-542 4 p.

Research output: Contribution to journalReview article

182 Scopus citations