Neurology & Neurotherapeutics - NE Multiple Sclerosis Section

Research Output 1986 2019

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2019

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis

Aaen, G., Waltz, M., Vargas, W., Makhani, N., Ness, J., Harris, Y., Casper, T. C., Benson, L., Candee, M., Chitnis, T., Gorman, M., Graves, J., Greenberg, B., Lotze, T., Mar, S., Tillema, J. M., Rensel, M., Rodriguez, M., Rose, J., Rubin, J. & 6 others, Schreiner, T., Waldman, A., Weinstock-Guttman, B., Belman, A., Waubant, E. & Krupp, L., Mar 1 2019, In : Journal of child neurology. 34, 3, p. 148-152 5 p.

Research output: Contribution to journalArticle

Special Education
Multiple Sclerosis
Pediatrics
Walking
Motor Skills
Acute Disseminated Encephalomyelitis
Myelin-Oligodendrocyte Glycoprotein
Oligodendroglia
Intracranial Pressure
Glycoproteins
1 Citation (Scopus)

Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry

Chi, C., Shao, X., Rhead, B., Gonzales, E., Smith, J. B., Xiang, A. H., Graves, J., Waldman, A., Lotze, T., Schreiner, T., Weinstock-Guttman, B., Aaen, G., Tillema, J. M., Ness, J., Candee, M., Krupp, L., Gorman, M., Benson, L., Chitnis, T., Mar, S. & 13 others, Belman, A., Casper, T. C., Rose, J., Moodley, M., Rensel, M., Rodriguez, M., Greenberg, B., Kahn, L., Rubin, J., Schaefer, C., Waubant, E., Langer-Gould, A. & Barcellos, L. F., Jan 1 2019, In : PLoS genetics. 15, 1, e1007808.

Research output: Contribution to journalArticle

Open Access
sclerosis
antigen
ancestry
Multiple Sclerosis
allele

Core temperature is not elevated at rest in people with relapsing-remitting multiple sclerosis

Chaseling, G. K., Allen, D. R., Vucic, S., Barnett, M., Frohman, E., Davis, S. L. & Jay, O., Apr 1 2019, In : Multiple Sclerosis and Related Disorders. 29, p. 62-67 6 p.

Research output: Contribution to journalArticle

Relapsing-Remitting Multiple Sclerosis
Multiple Sclerosis
Temperature
Fatigue
Thermometry

Impaired Thermoregulatory Function during Dynamic Exercise in Multiple Sclerosis

Allen, D. R., Huang, M., Morris, N. B., Chaseling, G. K., Frohman, E., Jay, O. & Davis, S. L., Mar 1 2019, In : Medicine and science in sports and exercise. 51, 3, p. 395-404 10 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Exercise
Sweating
Thermogenesis
Skin

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS

On behalf of the US Network of Pediatric MS Centers, Jan 1 2019, In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access
Genome-Wide Association Study
MicroRNAs
Multiple Sclerosis
Pediatrics
Genes

New onset transverse myelitis diagnostic accuracy and patient experiences

Greenberg, B., Krishnan, C. & Harder, L. L., May 1 2019, In : Multiple Sclerosis and Related Disorders. 30, p. 42-44 3 p.

Research output: Contribution to journalArticle

Transverse Myelitis
Acute Disseminated Encephalomyelitis
Neuromyelitis Optica
Social Media
Patient Advocacy

Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis

Sivakolundu, D. K., West, K. L., Maruthy, G. B., Zuppichini, M., Turner, M. P., Abdelkarim, D., Zhao, Y., Nguyen, D., Spence, J. S., Lu, H., Okuda, D. & Rypma, B., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Compliance
Multiple Sclerosis
Blood Vessels
Cognition
Cerebrovascular Circulation
Relapsing-Remitting Multiple Sclerosis
Incidental Findings
Optical Coherence Tomography
Gait
Multiple Sclerosis
B-Lymphocyte Subsets
T-Lymphocyte Subsets
Amyloid
Exercise
Cognition
2 Citations (Scopus)

The Spectrum of Vestibular Migraine: Clinical Features, Triggers, and Examination Findings

Beh, S. C., Masrour, S., Smith, S. V. & Friedman, D. I., Jan 1 2019, In : Headache.

Research output: Contribution to journalArticle

Migraine Disorders
Hyperacusis
Psychiatry
Photophobia
Stroke
1 Citation (Scopus)

Three-Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

Sivakolundu, D. K., Hansen, M. R., West, K. L., Wang, Y., Stanley, T., Wilson, A., McCreary, M., Turner, M. P., Da Cunha Pinho, M., Newton, B. D., Guo, X., Rypma, B. & Okuda, D., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

Multiple Sclerosis
Oxygen
Cerebrovascular Circulation
Phenotype
Magnetic Resonance Imaging
2 Citations (Scopus)
Myelin-Oligodendrocyte Glycoprotein
Optic Neuritis
Optical Coherence Tomography
Visual Acuity
Pediatrics
1 Citation (Scopus)
Migraine Disorders
Vertigo
Meniere Disease
Dizziness
Vertebrobasilar Insufficiency
1 Citation (Scopus)

Vitamin D genes influence MS relapses in children

Graves, J. S., Barcellos, L. F., Krupp, L., Belman, A., Shao, X., Quach, H., Hart, J., Chitnis, T., Weinstock-Guttman, B., Aaen, G., Benson, L., Gorman, M., Greenberg, B., Lotze, T., Soe, M., Ness, J., Rodriguez, M., Rose, J., Schreiner, T., Tillema, J. M. & 3 others, Waldman, A., Casper, T. C. & Waubant, E., Jan 1 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Vitamin D
Multiple Sclerosis
Recurrence
Genes
Single Nucleotide Polymorphism

α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model

Hussain, R. Z., Cravens, P. D., Miller-Little, W. A., Doelger, R., Granados, V., Herndon, E., Okuda, D. T., Eagar, T. N. & Stüve, O., Jul 1 2019, In : Neurology: Neuroimmunology and NeuroInflammation. 6, 4, e563.

Research output: Contribution to journalArticle

Open Access
Integrins
Autoimmune Diseases
B-Lymphocytes
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
2018

A Case of Vestibular Migraine Resolving on Warfarin and Topiramate

Beh, S. C., Apr 1 2018, In : Headache. 58, 4, p. 599-600 2 p.

Research output: Contribution to journalArticle

Warfarin
Migraine Disorders
topiramate
3 Citations (Scopus)
Myelin-Oligodendrocyte Glycoprotein
Transverse Myelitis
Myelitis
Antibodies
Neuromyelitis Optica
13 Citations (Scopus)

Area postrema syndrome: Frequency, criteria, and severity in AQP4-IgG-positive NMOSD

Shosha, E., Dubey, D., Palace, J., Nakashima, I., Jacob, A., Fujihara, K., Takahashi, T., Whittam, D., Leite, M. I., Misu, T., Yoshiki, T., Messina, S., Elsone, L., Majed, M., Flanagan, E., Gadoth, A., Huebert, C., Sagen, J., Greenberg, B., Levy, M. & 3 others, Banerjee, A., Weinshenker, B. & Pittock, S. J., Oct 23 2018, In : Neurology. 91, 17, p. e1642-e1651

Research output: Contribution to journalArticle

Aquaporin 4
Neuromyelitis Optica
Area Postrema
Immunoglobulin G
Nausea
1 Citation (Scopus)

Assessment of Renal Deterioration and Associated Risk Factors in Patients With Multiple Sclerosis

Shakir, N. A., Satyanarayan, A., Eastman, J., Greenberg, B. & Lemack, G. E., Jan 1 2018, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Multiple Sclerosis
Kidney
Urodynamics
Creatinine
Serum
6 Citations (Scopus)

A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica

Estrada, K., Whelan, C. W., Zhao, F., Bronson, P., Handsaker, R. E., Sun, C., Carulli, J. P., Harris, T., Ransohoff, R. M., McCarroll, S. A., Day-Williams, A. G., Greenberg, B. M. & MacArthur, D. G., Dec 1 2018, In : Nature Communications. 9, 1, 1929.

Research output: Contribution to journalArticle

Neuromyelitis Optica
genome
Immunoglobulin G
Genes
Genome
13 Citations (Scopus)

Body mass index, but not vitamin D status, is associated with brain volume change in MS

Mowry, E. M., Azevedo, C. J., McCulloch, C. E., Okuda, D., Lincoln, R. R., Waubant, E., Hauser, S. L. & Pelletier, D., Dec 11 2018, In : Neurology. 91, 24, p. e2256-e2264

Research output: Contribution to journalArticle

Vitamin D
Multiple Sclerosis
Body Mass Index
Brain
Relapsing-Remitting Multiple Sclerosis
5 Citations (Scopus)

BRAF mutation leading to central nervous system rosai-dorfman disease

Richardson, T. E., Wachsmann, M., Oliver, D., Abedin, Z., Ye, D., Burns, D. K., Raisanen, J. M., Greenberg, B. M. & Hatanpaa, K. J., Jul 1 2018, In : Annals of Neurology. 84, 1, p. 147-152 6 p.

Research output: Contribution to journalArticle

Sinus Histiocytosis
Central Nervous System
Mutation
Langerhans Cell Histiocytosis
Mitogen-Activated Protein Kinases
3 Citations (Scopus)

Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome

Thouvenot, E., Hinsinger, G., Demattei, C., Uygunoglu, U., Castelnovo, G., Pittion-Vouyovitch, S., Okuda, D., Kantarci, O., Pelletier, D., Lehmann, S., Marin, P., Siva, A. & Lebrun, C., Mar 1 2018, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Relapsing-Remitting Multiple Sclerosis
Cerebrospinal Fluid
Spinal Cord
Chitinase-3-Like Protein 1
Oligoclonal Bands
16 Citations (Scopus)

Cervical spinal cord atrophy: An earlymarker of progressiveMSonset

Zeydan, B., Gu, X., Atkinson, E. J., Keegan, B. M., Weinshenker, B. G., Tillema, J. M., Pelletier, D., Azevedo, C. J., Lebrun-Frenay, C., Siva, A., Okuda, D. T., Kantarci, K. & Kantarci, O. H., Mar 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 2, e435.

Research output: Contribution to journalArticle

Atrophy
Spine
Cervical Cord
Outcome Assessment (Health Care)
6 Citations (Scopus)

Dietary factors and pediatric multiple sclerosis: A case-control study

for the US Network of Pediatric Multiple Sclerosis Centers, Jul 1 2018, In : Multiple Sclerosis Journal. 24, 8, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Case-Control Studies
Pediatrics
Iron
Guidelines

Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis

on behalf of the Network of Pediatric Multiple Sclerosis Centers., May 1 2018, In : Multiple Sclerosis and Related Disorders. 22, p. 103-107 5 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Pediatrics
Poaceae
Pacifiers
Pediculus
3 Citations (Scopus)

Heterogeneity in association of remote herpesvirus infections and pediatric MS

On behalf of the US Network of Pediatric MS Centers, Oct 1 2018, In : Annals of Clinical and Translational Neurology. 5, 10, p. 1222-1228 7 p.

Research output: Contribution to journalArticle

Herpesviridae Infections
Multiple Sclerosis
Pediatrics
HLA-DRB1 Chains
Virus Diseases
2 Citations (Scopus)
Physiologic Nystagmus
Vertigo
Migraine Disorders
Pathologic Nystagmus
Head
1 Citation (Scopus)

Identification and treatment of the visual processing asymmetry in MS patients with optic neuritis: The Pulfrich phenomenon

Sobhanian, M. J., Agarwal, R., Meltzer, E., Kildebeck, E., Frohman, B. S., Frohman, A. N., Galetta, S. L., Saidha, S., White, O., Villoslada, P., Paul, F., Petzold, A., Rennaker, R. L., Martinez-Lapiscina, E. H., Balcer, L. J., Kardon, R., Frohman, E. & Frohman, T. C., Apr 15 2018, In : Journal of the Neurological Sciences. 387, p. 60-69 10 p.

Research output: Contribution to journalArticle

Optic Neuritis
Optic Nerve Diseases
Visual Cortex
Therapeutics
Healthy Volunteers

Leveraging technology to identify subclinical deficits in radiologically isolated syndrome

Okuda, D., Jan 1 2018, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticle

Technology

Multiple Sclerosis

Okuda, D. T., Feb 1 2018, In : Neurologic Clinics. 36, 1, p. i

Research output: Contribution to journalArticle

Multiple Sclerosis
2 Citations (Scopus)

New ways of "Seeing" the mechanistic heterogeneity of multiple sclerosis plaque pathogenesis

Meltzer, E. I., Costello, F. E., Frohman, E. & Frohman, T. C., Mar 1 2018, In : Journal of Neuro-Ophthalmology. 38, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Central Nervous System
Energy Metabolism
Nerve Tissue
Oximetry
12 Citations (Scopus)

Optimal Intereye Difference Thresholds in Retinal Nerve Fiber Layer Thickness for Predicting a Unilateral Optic Nerve Lesion in Multiple Sclerosis

Nolan, R. C., Galetta, S. L., Frohman, T. C., Frohman, E., Calabresi, P. A., Castrillo-Viguera, C., Cadavid, D. & Balcer, L. J., Dec 1 2018, In : Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 38, 4, p. 451-458 8 p.

Research output: Contribution to journalArticle

Optic Nerve
Nerve Fibers
Multiple Sclerosis
Optic Neuritis
Healthy Volunteers
3 Citations (Scopus)

Post-gadolinium 3-dimensional spatial, surface, and structural characteristics of glioblastomas differentiate pseudoprogression from true tumor progression

Hansen, M. R., Pan, E., Wilson, A., McCreary, M., Wang, Y., Stanley, T., Pinho, M. C., Guo, X. & Okuda, D. T., Jun 7 2018, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Gadolinium
Glioblastoma
Neoplasms
Principal Component Analysis
Health Personnel

Precision medicine for multiple sclerosis promotes preventative medicine

Hansen, M. R. & Okuda, D. T., May 1 2018, In : Annals of the New York Academy of Sciences. 1420, 1, p. 62-71 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Preventive Medicine
Multiple Sclerosis
Medicine
Biomarkers
5 Citations (Scopus)

Preserved canonicality of the BOLD hemodynamic response reflects healthy cognition: Insights into the healthy brain through the window of Multiple Sclerosis

Turner, M. P., Hubbard, N. A., Sivakolundu, D. K., Himes, L. M., Hutchison, J. L., Hart, J., Spence, J. S., Frohman, E., Frohman, T. C., Okuda, D. & Rypma, B., Jan 1 2018, (Accepted/In press) In : NeuroImage.

Research output: Contribution to journalArticle

Neuroglia
Cognition
Multiple Sclerosis
Blood Vessels
Hemodynamics
26 Citations (Scopus)

Progressive multifocal leukoencephalopathy after fingolimod treatment

Berger, J. R., Cree, B. A., Greenberg, B., Hemmer, B., Ward, B. J., Dong, V. M. & Merschhemke, M., Jan 1 2018, In : Neurology. 90, 20, p. E1815-E1821

Research output: Contribution to journalArticle

Open Access
Progressive Multifocal Leukoencephalopathy
Therapeutics
Fingolimod Hydrochloride
Confidence Intervals
Safety
2 Citations (Scopus)

Safety and efficacy of plasma exchange in pediatric transverse myelitis

Noland, D. K. & Greenberg, B., Aug 1 2018, In : Neurology: Clinical Practice. 8, 4, p. 327-330 4 p.

Research output: Contribution to journalArticle

Transverse Myelitis
Plasma Exchange
Pediatrics
Safety
Therapeutics

Several household chemical exposures are associated with pediatric-onset multiple sclerosis

the U.S. Network of Pediatric Multiple Sclerosis Centers, Dec 1 2018, In : Annals of Clinical and Translational Neurology. 5, 12, p. 1513-1521 9 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Pediatrics
Odds Ratio
Confidence Intervals
Rodenticides

Should Spinal MRI Be Routinely Performed in Patients With Clinically Isolated Optic Neuritis?

Meltzer, E., Frohman, E., Costello, F. E., Burton, J. M. & Frohman, T. C., Dec 1 2018, In : Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 38, 4, p. 502-510 9 p.

Research output: Contribution to journalArticle

Optic Neuritis
1 Citation (Scopus)
Nervous System Diseases
Pediatrics
Differential Diagnosis
Referral and Consultation
Hashimoto's encephalitis

TLR3 agonism re-establishes CNS immune competence during α4-integrin deficiency

Hussain, R. Z., Cravens, P. C., Doelger, R., Dentel, B., Herndon, E., Loof, N., Tsai, P., Okuda, D., Racke, M. K. & Stuve, O., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Poly I-C
Integrins
Mental Competency
Central Nervous System
Autoimmune Experimental Encephalomyelitis
33 Citations (Scopus)

Trial of fingolimod versus interferon beta-1a in pediatric multiple sclerosis

PARADIGMS Study Group, Sep 13 2018, In : New England Journal of Medicine. 379, 11, p. 1017-1027 11 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Pediatrics
Recurrence
Fingolimod Hydrochloride
Interferon beta-1a
2 Citations (Scopus)

Urban air quality and associations with pediatric multiple sclerosis

Lavery, A. M., Waubant, E., Casper, T. C., Roalstad, S., Candee, M., Rose, J., Belman, A., Weinstock-Guttman, B., Aaen, G., Tillema, J. M., Rodriguez, M., Ness, J., Harris, Y., Graves, J., Krupp, L., Charvet, L., Benson, L., Gorman, M., Moodley, M., Rensel, M. & 9 others, Goyal, M., Mar, S., Chitnis, T., Schreiner, T., Lotze, T., Greenberg, B., Kahn, I., Rubin, J. & Waldman, A. T., Oct 1 2018, In : Annals of Clinical and Translational Neurology. 5, 10, p. 1146-1153 8 p.

Research output: Contribution to journalArticle

Poisons
Multiple Sclerosis
Air
Pediatrics
Equipment and Supplies

Variations of the lung microbiome and immune response in mechanically ventilated surgical patients

Huebinger, R. M., Smith, A. D., Zhang, Y., Monson, N. L., Ireland, S. J., Barber, R. C., Kubasiak, J. C., Minshall, C. T., Minei, J. P., Wolf, S. E. & Allen, M. S., Oct 1 2018, In : PLoS One. 13, 10, e0205788.

Research output: Contribution to journalArticle

Microbiota
Respiratory System
lungs
immune response
Cytokines
9 Citations (Scopus)

VDJServer: A cloud-based analysis portal and data commons for immune repertoire sequences and rearrangements

Christley, S., Scarborough, W., Salinas, E., Rounds, W. H., Toby, I. T., Fonner, J. M., Levin, M. K., Kim, M., Mock, S. A., Jordan, C., Ostmeyer, J., Buntzman, A., Rubelt, F., Davila, M. L., Monson, N. L., Scheuermann, R. H. & Cowell, L. G., May 8 2018, In : Frontiers in Immunology. 9, MAY, 976.

Research output: Contribution to journalArticle

Workflow
Information Dissemination
Software
Computing Methodologies
Web Browser
5 Citations (Scopus)

Visual fixation instability in multiple sclerosis measured using SLO-OCT

Mallery, R. M., Poolman, P., Thurtell, M. J., Full, J. M., Ledolter, J., Kimbrough, D., Frohman, E., Frohman, T. C. & Kardon, R. H., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

Ophthalmoscopes
Optical Coherence Tomography
Multiple Sclerosis
Lasers
Optic Neuritis
3 Citations (Scopus)

Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis

Nguyen, J., Rothman, A., Fitzgerald, K., Whetstone, A., Syc-Mazurek, S., Aquino, J., Balcer, L. J., Frohman, E., Frohman, T. C., Crainiceanu, C., Beier, M., Newsome, S. D., Calabresi, P. A. & Saidha, S., May 2 2018, (Accepted/In press) In : Current Eye Research. p. 1-8 8 p.

Research output: Contribution to journalArticle

Visual Pathways
Multiple Sclerosis
Optical Coherence Tomography
Ganglia
Cognition
2017
1 Citation (Scopus)

A Callosal Catastrophe: Toxic Leukoencephalopathy Associated with Thermogenic Weight Loss Supplement Use

Mahdavi, Z. K., Narayan, R., Mainali, S., Greenberg, B. M., Aiyagari, V. & McDonagh, D. L., Oct 18 2017, (Accepted/In press) In : Neurocritical Care. p. 1-4 4 p.

Research output: Contribution to journalArticle

Leukoencephalopathies
Corpus Callosum
Poisons
Dietary Supplements
Hyponatremia