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2014

The effect of everolimus on renal angiomyolipoma in patients with tuberous sclerosis complex being treated for subependymal giant cell astrocytoma: Subgroup results from the randomized, placebo-controlled, Phase 3 trial EXIST-1

Kingswood, J. C., Jozwiak, S., Belousova, E. D., Frost, M. D., Kuperman, R. A., Bebin, E. M., Korf, B. R., Flamini, J. R., Kohrman, M. H., Sparagana, S. P., Wu, J. Y., Brechenmacher, T., Stein, K., Berkowitz, N., Bissler, J. J. & Franz, D. N., Jun 2014, In : Nephrology Dialysis Transplantation. 29, 6, p. 1203-1210 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

The role of NF-κB in the pathogenesis of glioma

Puliyappadamba, V. T., Hatanpaa, K. J., Chakraborty, S. & Habib, A. A., Sep 15 2014, In : Molecular and Cellular Oncology. 1, 3, e963478.

Research output: Contribution to journalArticle

31 Scopus citations
2013

A genetic variant of the anti-apoptotic protein Akt predicts natalizumab-induced lymphocytosis and post-natalizumab multiple sclerosis reactivation

Rossi, S., Motta, C., Studer, V., Monteleone, F., De Chiara, V., Buttari, F., Barbieri, F., Bernardi, G., Battistini, L., Cutter, G., Stüve, O., Salvetti, M. & Centonze, D., Jan 2013, In : Multiple Sclerosis Journal. 19, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
21 Scopus citations

Cytoplasmic TRADD confers a worse prognosis in glioblastoma

Chakraborty, S., Li, L., Tang, H., Xie, Y., Puliyappadamba, V. T., Raisanen, J., Burma, S., Boothman, D. A., Cochran, B., Wu, J. & Habib, A. A., Aug 2013, In : Neoplasia (United States). 15, 8, p. 888-897 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity

Hertzenberg, D., Lehmann-Horn, K., Kinzel, S., Husterer, V., Cravens, P. D., Kieseier, B. C., Hemmer, B., Brück, W., Zamvil, S. S., Stüve, O. & Weber, M. S., Aug 1 2013, In : European Journal of Immunology. 43, 8, p. 2078-2088 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy

Tumati, V., Mathur, S., Song, K., Hsieh, J. T., Zhao, D., Takahashi, M., Dobin, T., Gandee, L., Solberg, T. D., Habib, A. A. & Saha, D., May 1 2013, In : International journal of oncology. 42, 5, p. 1613-1619 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica

Kieseier, B. C., Stüve, O., Dehmel, T., Goebels, N., Leussink, V. I., Mausberg, A. K., Ringelstein, M., Turowski, B., Aktas, O., Antoch, G. & Hartung, H. P., Mar 2013, In : JAMA Neurology. 70, 3, p. 390-393 4 p.

Research output: Contribution to journalArticle

81 Scopus citations

Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab

Rossi, S., Motta, C., Studer, V., De Chiara, V., Barbieri, F., Monteleone, F., Fornasiero, A., Coarelli, G., Bernardi, G., Cutter, G., Stüve, O., Salvetti, M. & Centonze, D., Jan 1 2013, In : European Journal of Neurology. 20, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial

Franz, D. N., Belousova, E., Sparagana, S., Bebin, E. M., Frost, M., Kuperman, R., Witt, O., Kohrman, M. H., Flamini, J. R., Wu, J. Y., Curatolo, P., De Vries, P. J., Whittemore, V. H., Thiele, E. A., Ford, J. P., Shah, G., Cauwel, H., Lebwohl, D., Sahmoud, T. & Jozwiak, S., Jan 2013, In : The Lancet. 381, 9861, p. 125-132 8 p.

Research output: Contribution to journalArticle

463 Scopus citations

EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma

Li, L., Puliyappadamba, V. T., Chakraborty, S., Rehman, A., Vemireddy, V., Saha, D., Souza, R. F., Hatanpaa, K. J., Koduru, P., Burma, S., Boothman, D. A. & Habib, A. A., Dec 23 2013, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

26 Scopus citations

Functional Assessment of TSC2 Variants Identified in Individuals with Tuberous Sclerosis Complex

Hoogeveen-Westerveld, M., Ekong, R., Povey, S., Mayer, K., Lannoy, N., Elmslie, F., Bebin, M., Dies, K., Thompson, C., Sparagana, S. P., Davies, P., van den Ouweland, A., Halley, D. & Nellist, M., Jan 2013, In : Human mutation. 34, 1, p. 167-175 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Interferon beta use and disability prevention in relapsing-remitting multiple sclerosis

Greenberg, B., Balcer, L., Calabresi, P. A., Cree, B., Cross, A., Frohman, T., Gold, R., Havrdova, E., Hemmer, B., Kieseier, B. C., Lisak, R., Miller, A., Racke, M. K., Steinman, L., Stuve, O., Wiendl, H. & Frohman, E., Feb 2013, In : JAMA Neurology. 70, 2, p. 248-251 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Management of secondary progressive multiple sclerosis: Prophylactic treatment - Past, present, and future aspects

Rommer, P. S. & Stüve, O., Jun 1 2013, In : Current Treatment Options in Neurology. 15, 3, p. 241-258 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch

Puliyappadamba, V. T., Chakraborty, S., Chauncey, S., Li, L., Hatanpaa, K. J., Mickey, B., Noorani, S., Shu, H. K. G., Burma, S., Boothman, D. A. & Habib, A. A., Aug 29 2013, In : Cell Reports. 4, 4, p. 764-775 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): An adaptive, dose-ranging, randomised, phase 2 study

Selmaj, K., Li, D. K. B., Hartung, H. P., Hemmer, B., Kappos, L., Freedman, M. S., Stüve, O., Rieckmann, P., Montalban, X., Ziemssen, T., Auberson, L. Z., Pohlmann, H., Mercier, F., Dahlke, F. & Wallström, E., Aug 1 2013, In : The Lancet Neurology. 12, 8, p. 756-767 12 p.

Research output: Contribution to journalArticle

130 Scopus citations

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Saddoughi, S. A., Gencer, S., Peterson, Y. K., Ward, K. E., Mukhopadhyay, A., Oaks, J., Bielawski, J., Szulc, Z. M., Thomas, R. J., Selvam, S. P., Senkal, C. E., Garrett-Mayer, E., De Palma, R. M., Fedarovich, D., Liu, A., Habib, A. A., Stahelin, R. V., Perrotti, D. & Ogretmen, B., Jan 1 2013, In : EMBO Molecular Medicine. 5, 1, p. 105-121 17 p.

Research output: Contribution to journalArticle

150 Scopus citations

Spinal cord monitoring with transcranial motor evoked potentials in patients with neural axis abnormalities undergoing spinal deformity surgery

Muchow, R. D., McClung, A., Rampy, P., Van Allen, E., Sparagana, S. & Sucato, D. J., May 2013, In : Spine Deformity. 1, 3, p. 205-210 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Teriflunomide for the treatment of multiple sclerosis

Warnke, C., Stüve, O. & Kieseier, B. C., Dec 1 2013, In : Clinical Neurology and Neurosurgery. 115, SUPPL.1, p. S90-S94

Research output: Contribution to journalArticle

17 Scopus citations

Teriflunomid zur Behandlung der Multiplen Sklerose

Translated title of the contribution: Teriflunomide for treatment of multiple sclerosisWarnke, C., Meyer Zu Hörste, G., Menge, T., Stüve, O., Hartung, H. P., Wiendl, H. & Kieseier, B. C., Jun 1 2013, In : Nervenarzt. 84, 6, p. 724-731 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis

Cravens, P. D., Kieseier, B. C., Hussain, R., Herndon, E., Arellano, B., Ben, L. H., Timmons, B. C., Castro-Rojas, C., Hartung, H. P., Hemmer, B., Weber, M. S., Zamvil, S. S. & Stüve, O., May 24 2013, In : Journal of Neuroinflammation. 10, 67.

Research output: Contribution to journalArticle

10 Scopus citations

Tuberous sclerosis complex diagnostic criteria update: Recommendations of the 2012 international tuberous sclerosis complex consensus conference

International Tuberous Sclerosis Complex Consensus Group, Oct 1 2013, In : Pediatric Neurology. 49, 4, p. 243-254 12 p.

Research output: Contribution to journalArticle

654 Scopus citations

Tuberous sclerosis complex surveillance and management: Recommendations of the 2012 international tuberous sclerosis complex consensus conference

International Tuberous Sclerosis Complex Consensus Group, Oct 1 2013, In : Pediatric Neurology. 49, 4, p. 255-265 11 p.

Research output: Contribution to journalArticle

413 Scopus citations
2012

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

Stowe, A. M., Wacker, B. K., Cravens, P. D., Perfater, J. L., Li, M. K., Hu, R., Freie, A. B., Stüve, O. & Gidday, J. M., Feb 16 2012, In : Journal of Neuroinflammation. 9, 33.

Research output: Contribution to journalArticle

49 Scopus citations

Cytokine levels in CSF and neuropsychological performance in HIV patients

Nolting, T., Lindecke, A., Hartung, H. P., Koutsilieri, E., Maschke, M., Husstedt, I. W., Sopper, S., Stüve, O. & Arendt, G., Jun 1 2012, In : Journal of NeuroVirology. 18, 3, p. 157-161 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex

Hoogeveen-Westerveld, M., Ekong, R., Povey, S., Karbassi, I., Batish, S. D., den Dunnen, J. T., van Eeghen, A., Thiele, E., Mayer, K., Dies, K., Wen, L., Thompson, C., Sparagana, S. P., Davies, P., Aalfs, C., van den Ouweland, A., Halley, D. & Nellist, M., Mar 1 2012, In : Human mutation. 33, 3, p. 476-479 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog

Solomon, B. D., Bear, K. A., Wyllie, A., Keaton, A. A., Dubourg, C., David, V., Mercier, S., Odent, S., Hehr, U., Paulussen, A., Clegg, N. J., Delgado, M. R., Bale, S. J., Lacbawan, F., Ardinger, H. H., Aylsworth, A. S., Bhengu, N. L., Braddock, S., Brookhyser, K., Burton, B. & 25 others, Gaspar, H., Grix, A., Horovitz, D., Kanetzke, E., Kayserili, H., Lev, D., Nikkel, S. M., Norton, M., Roberts, R., Saal, H., Schaefer, G. B., Schneider, A., Smith, E. K., Sowry, E., Spence, M. A., Shalev, S. A., Steiner, C. E., Thompson, E. M., Winder, T. L., Balog, J. Z., Hadley, D. W., Zhou, N., Pineda-Alvarez, D. E., Roessler, E. & Muenke, M., Jul 2012, In : Journal of medical genetics. 49, 7, p. 473-479 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Human aquaporin 4 281-300 is the immunodominant linear determinant in the context of HLA-DRB1*03:01: Relevance for diagnosing and monitoring patients with neuromyelitis optica

Arellano, B., Hussain, R., Zacharias, T., Yoon, J., David, C., Zein, S., Steinman, L., Forsthuber, T., Greenberg, B. M., Lambracht-Washington, D., Ritchie, A. M., Bennett, J. L. & Stüve, O., Sep 1 2012, In : Archives of neurology. 69, 9, p. 1125-1131 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Improving optical contact for functional near-infrared brain spectroscopy and imaging with brush optodes

Khan, B., Wildey, C., Francis, R., Tian, F., Delgado, M. R., Liu, H., Macfarlane, D. & Alexandrakis, G., May 1 2012, In : Biomedical Optics Express. 3, 5, p. 878-898 21 p.

Research output: Contribution to journalArticle

24 Scopus citations

Objective characterization of the relative afferent pupillary defect in MS

Blazek, P., Davis, S. L., Greenberg, B., Conger, A., Conger, D., Vernino, S., Beh, S. C., Stuve, O., Saidha, S., Ratchford, J. N., Green, A., Calabresi, P. A., Balcer, L. J., Frohman, T. C. & Frohman, E., Dec 15 2012, In : Journal of the Neurological Sciences. 323, 1-2, p. 193-200 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Randomized controlled trial of atorvastatin in clinically isolated syndrome: The STAyCIS study

Waubant, E., Pelletier, D., Mass, M., Cohen, J. A., Kita, M., Cross, A., Bar-Or, A., Vollmer, T., Racke, M., Stüve, O., Schwid, S., Goodman, A., Kachuck, N., Preiningerova, J., Weinstock-Guttman, B., Calabresi, P. A., Miller, A., Mokhtarani, M., Iklé, D., Murphy, S. & 5 others, Kopetskie, H., Ding, L., Rosenberg, E., Spencer, C. & Zamvil, S. S., Apr 10 2012, In : Neurology. 78, 15, p. 1171-1178 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Rituximab dosing and monitoring strategies in neuromyelitis optica patients: Creating strategies for therapeutic success

Greenberg, B., Graves, D., Remington, G., Hardeman, P., Mann, M., Karandikar, N., Stuve, O., Monson, N. L. & Frohman, E., Jul 2012, In : Multiple Sclerosis Journal. 18, 7, p. 1022-1026 5 p.

Research output: Contribution to journalArticle

67 Scopus citations
7 Scopus citations
2011

A wireless system for monitoring transcranial motor evoked potentials

Farajidavar, A., Seifert, J. L., Bell, J. E. S., Seo, Y. S., Delgado, M. R., Sparagana, S., Romero, M. I. & Chiao, J. C., Jan 1 2011, In : Annals of Biomedical Engineering. 39, 1, p. 517-523 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements

Liu, P., Erez, A., Nagamani, S. C. S., Dhar, S. U., Kołodziejska, K. E., Dharmadhikari, A. V., Cooper, M. L., Wiszniewska, J., Zhang, F., Withers, M. A., Bacino, C. A., Campos-Acevedo, L. D., Delgado, M. R., Freedenberg, D., Garnica, A., Grebe, T. A., Hernández-Almaguer, D., Immken, L., Lalani, S. R., McLean, S. D. & 11 others, Northrup, H., Scaglia, F., Strathearn, L., Trapane, P., Kang, S. H. L., Patel, A., Cheung, S. W., Hastings, P. J., Stankiewicz, P., Lupski, J. R. & Bi, W., Sep 16 2011, In : Cell. 146, 6, p. 889-903 15 p.

Research output: Contribution to journalArticle

266 Scopus citations

Copy number gain at Xp22.31 includes complex duplication rearrangements and recurrent triplications

Liu, P., Erez, A., Nagamani, S. C. S., Bi, W., Carvalho, C. M. B., Simmons, A. D., Wiszniewska, J., Fang, P., Eng, P. A., Cooper, M. L., Sutton, V. R., Roeder, E. R., Bodensteiner, J. B., Delgado, M. R., Prakash, S. K., Belmont, J. W., Stankiewicz, P., Berg, J. S., Shinawi, M., Patel, A. & 2 others, Cheung, S. W. & Lupski, J. R., May 2011, In : Human molecular genetics. 20, 10, p. 1975-1988 14 p., ddr078.

Research output: Contribution to journalArticle

51 Scopus citations
33 Scopus citations

Holoprosencephaly in a family segregating novel variants in ZIC2 and GLI2

Wannasilp, N., Solomon, B. D., Warren-Mora, N., Clegg, N. J., Delgado, M. R., Lacbawan, F., Hu, P., Winder, T. L., Roessler, E. & Muenke, M., Apr 1 2011, In : American Journal of Medical Genetics, Part A. 155, 4, p. 860-864 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Idiopathic transverse myelitis and neuromyelitis optica: Clinical profiles, pathophysiology and therapeutic choices

Awad, A. & Stüve, O., Sep 1 2011, In : Current Neuropharmacology. 9, 3, p. 417-428 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions

Wang, X., Dong, Y., Jiwani, A. J., Zou, Y., Pastor, J., Kuro-O, M., Habib, A. A., Ruan, M., Boothman, D. A. & Yang, C. R., Sep 15 2011, In : Proteome Science. 9, 53.

Research output: Contribution to journalArticle

4 Scopus citations

Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet

Cravens, P. D., Hussain, R. Z., Zacharias, T. E., Ben, L. H., Herndon, E., Vinnakota, R., Lambracht-Washington, D., Nessler, S., Zamvil, S. S., Eagar, T. N. & Stüve, O., Jun 24 2011, In : Journal of Neuroinflammation. 8, 73.

Research output: Contribution to journalArticle

29 Scopus citations

Multiple sclerosis: Combination therapy in MS-still a valid strategy

Kieseier, B. C. & Stüve, O., Dec 1 2011, In : Nature Reviews Neurology. 7, 12, p. 659-660 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

No cerebral or cervical venous insufficiency in US veterans with multiple sclerosis

Marder, E. J., Gupta, P., Greenberg, B., Frohman, E., Awad, A. M., Bagert, B. & Stuve, O., Dec 1 2011, In : Archives of neurology. 68, 12, p. 1521-1525 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Pediatric patients with cerebral palsy or other developmental disabilities

Tilton, A. & Delgado, M. R., Jun 1 2011, In : Seminars in Pediatric Neurology. 18, 2, p. 72-73 2 p.

Research output: Contribution to journalArticle

Peripheral nerve repair through multi-luminal biosynthetic implants

Tansey, K. E., Seifert, J. L., Botterman, B., Delgado, M. R. & Romero, M. I., Jun 1 2011, In : Annals of Biomedical Engineering. 39, 6, p. 1815-1828 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules

Meyer zu Hörste, G., Mausberg, A. K., Müller, J. I., Lehmann, H. C., Löber, S., Gmeiner, P., Hartung, H. P., Stüve, O., Korth, C. & Kieseier, B. C., Jun 22 2011, In : PloS one. 6, 6, e21223.

Research output: Contribution to journalArticle

11 Scopus citations

Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis

Monson, N. L., Cravens, P., Hussain, R., Harp, C. T., Cummings, M., Martin, M. D. P., Ben, L. H., Do, J., Lyons, J. A., Lovette-Racke, A., Cross, A. H., Racke, M. K., Stüve, O., Shlomchik, M. & Eagar, T. N., 2011, In : PloS one. 6, 2, e17103.

Research output: Contribution to journalArticle

55 Scopus citations

TGIF mutations in human holoprosencephaly: Correlation between genotype and phenotype

Keaton, A. A., Solomon, B. D., Kauvar, E. F., El-Jaick, K. B., Gropman, A. L., Zafer, Y., Meck, J. M., Bale, S. J., Grange, D. K., Haddad, B. R., Gowans, G. C., Clegg, N. J., Delgado, M. R., Hahn, J. S., Pineda-Alvarez, D. E., Lacbawan, F., Vélez, J. I., Roessler, E. & Muenke, M., May 1 2011, In : Molecular Syndromology. 1, 5, p. 211-222 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Use of trihexyphenidyl in children with cerebral palsy

Carranza-Del Rio, J., Clegg, N. J., Moore, A. & Delgado, M. R., Mar 1 2011, In : Pediatric Neurology. 44, 3, p. 202-206 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2010

22q13.3 Deletion syndrome: Clinical and molecular analysis using array CGH

Dhar, S. U., Del Gaudio, D., German, J. R., Peters, S. U., Ou, Z., Bader, P. I., Berg, J. S., Blazo, M., Brown, C. W., Graham, B. H., Grebe, T. A., Lalani, S., Irons, M., Sparagana, S., Williams, M., Phillips, J. A., Beaudet, A. L., Stankiewicz, P., Patel, A., Cheung, S. W. & 1 others, Sahoo, T., Mar 1 2010, In : American Journal of Medical Genetics, Part A. 152, 3, p. 573-581 9 p.

Research output: Contribution to journalArticle

89 Scopus citations