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2020

ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models

Vue, T. Y., Kollipara, R. K., Borromeo, M. D., Smith, T., Mashimo, T., Burns, D. K., Bachoo, R. & Johnson, J. E., 2020, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

Open Access

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S. & Diamond, M. I., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 2974-2983 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

Ortega, S. B., Torres, V. O., Latchney, S. E., Whoolery, C. W., Noorbhai, I. Z., Poinsatte, K., Selvaraj, U. M., Benson, M. A., Meeuwissen, A. J. M., Plautz, E. J., Kong, X., Ramirez, D. M., Ajay, A. D., Meeks, J. P., Goldberg, M. P., Monson, N. L., Eisch, A. J. & Stowe, A. M., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4983-4993 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Biolistic transfection and expression analysis of acute cortical slices

Hamad, M. I. K., Daoud, S., Petrova, P., Rabaya, O., Jbara, A., Melliti, N., Stichmann, S., Reiss, G., Herz, J. & Förster, E., May 1 2020, In : Journal of Neuroscience Methods. 337, 108666.

Research output: Contribution to journalArticle

Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals

Ju, D., Zhang, W., Yan, J., Zhao, H., Li, W., Wang, J., Liao, M., Xu, Z., Wang, Z., Zhou, G., Mei, L., Hou, N., Ying, S., Cai, T., Chen, S., Xie, X., Lai, L., Tang, C., Park, N., Takahashi, J. S. & 3 others, Huang, N., Qi, X. & Zhang, E. E., May 6 2020, In : Science translational medicine. 12, 542, eaba0769.

Research output: Contribution to journalArticle

Circadian control of interferon-sensitive gene expression in murine skin

Greenberg, E. N., Marshall, M. E., Jin, S., Venkatesh, S., Dragan, M., Tsoi, L. C., Gudjonsson, J. E., Nie, Q., Takahashi, J. S. & Andersen, B., Mar 17 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 11, p. 5761-5771 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Comparative transcriptomic analyses of developing melanocortin neurons reveal new regulators for the anorexigenic neuron identity

Chen, X., Wyler, S. C., Li, L., Arnold, A. G., Wan, R., Jia, L., Landy, M. A., Lai, H. C., Xu, P. & Liu, C., Apr 15 2020, In : Journal of Neuroscience. 40, 16, p. 3165-3177 13 p.

Research output: Contribution to journalArticle

Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression

Co, M., Hickey, S. L., Kulkarni, A., Harper, M. & Konopka, G., Mar 14 2020, In : Cerebral Cortex. 30, 3, p. 1855-1870 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression

Bai, B., Wang, X., Li, Y., Chen, P. C., Yu, K., Dey, K. K., Yarbro, J. M., Han, X., Lutz, B. M., Rao, S., Jiao, Y., Sifford, J. M., Han, J., Wang, M., Tan, H., Shaw, T. I., Cho, J. H., Zhou, S., Wang, H., Niu, M. & 14 others, Mancieri, A., Messler, K. A., Sun, X., Wu, Z., Pagala, V., High, A. A., Bi, W., Zhang, H., Chi, H., Haroutunian, V., Zhang, B., Beach, T. G., Yu, G. & Peng, J., Mar 18 2020, In : Neuron. 105, 6, p. 975-991.e7

Research output: Contribution to journalArticle

4 Scopus citations

Enhanced cortical responsiveness during natural sleep in freely behaving mice

Matsumoto, S., Ohyama, K., Díaz, J., Yanagisawa, M., Greene, R. W. & Vogt, K. E., Dec 1 2020, In : Scientific reports. 10, 1, 2278.

Research output: Contribution to journalArticle

Open Access

Epigenetic inheritance of circadian period in clonal cells

Li, Y., Shan, Y., Kilaru, G., Berto, S., Wang, G. Z., Cox, K. H., Yoo, S. H., Yang, S., Konopka, G. & Takahashi, J. S., May 2020, In : eLife. 9, p. 1-36 36 p., e54186.

Research output: Contribution to journalArticle

Open Access

Essential requirement for nicastrin in marginal zone and B-1 B cell development

Choi, J. H., Han, J., Theodoropoulos, P. C., Zhong, X., Wang, J., Medler, D., Ludwig, S., Zhan, X., Li, X., Tang, M., Gallagher, T., Yu, G. & Beutler, B., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4894-4901 8 p.

Research output: Contribution to journalArticle

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

Shah, S., Molinaro, G., Liu, B., Wang, R., Huber, K. M. & Richter, J. D., Mar 31 2020, In : Cell Reports. 30, 13, p. 4459-4472.e6

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

Gao, X., Zhang, Z., Mashimo, T., Shen, B., Nyagilo, J., Wang, H., Wang, Y., Liu, Z., Mulgaonkar, A., Hu, X. L., Piccirillo, S. G. M., Eskiocak, U., Davé, D. P., Qin, S., Yang, Y., Sun, X., Fu, Y. X., Zong, H., Sun, W., Bachoo, R. M. & 1 others, Ge, W. P., Feb 25 2020, In : Cell Reports. 30, 8, p. 2489-2500.e5

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hippocampal subfield transcriptome analysis in schizophrenia psychosis

Perez, J. M., Berto, S., Gleason, K., Ghose, S., Tan, C., Kim, T. K., Konopka, G. & Tamminga, C. A., Jan 1 2020, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome–like Behaviors in Mice

Harrington, A. J., Bridges, C. M., Berto, S., Blankenship, K., Cho, J. Y., Assali, A., Siemsen, B. M., Moore, H. W., Tsvetkov, E., Thielking, A., Konopka, G., Everman, D. B., Scofield, M. D., Skinner, S. A. & Cowan, C. W., 2020, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Modulation of the erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site

Brams, M., Govaerts, C., Kambara, K., Price, K., Spurny, R., Gharpure, A., Pardon, E., Evans, G. L., Bertrand, D., Lummis, S. C. R., Hibbs, R. E., Steyaert, J. & Ulens, C., Jan 2020, In : eLife. 9, e51511.

Research output: Contribution to journalArticle

Open Access

Multiple channels of DEET repellency in Drosophila

Guo, H., Kunwar, K. & Smith, D., Mar 1 2020, In : Pest Management Science. 76, 3, p. 880-887 8 p.

Research output: Contribution to journalArticle

Noise-driven cellular heterogeneity in circadian periodicity

Li, Y., Shan, Y., Desai, R. V., Cox, K. H., Weinberger, L. S. & Takahashi, J. S., May 12 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 19, p. 10350-10356 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive 64Cu-labelled polymers

Huang, G., Zhao, T., Wang, C., Nham, K., Xiong, Y., Gao, X., Wang, Y., Hao, G., Ge, W. P., Sun, X., Sumer, B. D. & Gao, J., Mar 1 2020, In : Nature Biomedical Engineering. 4, 3, p. 314-324 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons

Mona, B., Villarreal, J., Savage, T. K., Kollipara, R. K., Boisvert, B. E. & Johnson, J. E., May 1 2020, In : Genes and Development. 34, 9-10, p. 621-636 16 p.

Research output: Contribution to journalArticle

Open Access

Reelin signaling modulates GABAB receptor function in the neocortex

Hamad, M. I. K., Jbara, A., Rabaya, O., Petrova, P., Daoud, S., Melliti, N., Meseke, M., Lutz, D., Petrasch-Parwez, E., Schwitalla, J. C., Mark, M. D., Herlitze, S., Reiss, G., Herz, J. & Förster, E., Jan 1 2020, (Accepted/In press) In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Open Access

Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus but Leaves Cortical Layering and Behavior Unaffected

Pahle, J., Muhia, M., Wagener, R. J., Tippmann, A., Bock, H. H., Graw, J., Herz, J., Staiger, J. F., Drakew, A., Kneussel, M., Rune, G. M., Frotscher, M. & Brunne, B., Mar 14 2020, In : Cerebral Cortex. 30, 3, p. 1688-1707 20 p.

Research output: Contribution to journalArticle

Open Access

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

McCamphill, P. K., Stoppel, L. J., Senter, R. K., Lewis, M. C., Heynen, A. J., Stoppel, D. C., Sridhar, V., Collins, K. A., Shi, X., Pan, J. Q., Madison, J., Cottrell, J. R., Huber, K. M., Scolnick, E. M., Holson, E. B., Wagner, F. F. & Bear, M. F., May 20 2020, In : Science translational medicine. 12, 544, eaam8572.

Research output: Contribution to journalArticle

SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions

Jung, S., Hyun, J., Nah, J., Han, J., Kim, S. H., Park, J., Oh, Y., Gwon, Y., Moon, S., Jo, D. G. & Jung, Y. K., Mar 17 2020, In : Science signaling. 13, 623, eaax8949.

Research output: Contribution to journalArticle

Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development

Anderson, A. G., Kulkarni, A., Harper, M. & Konopka, G., Mar 3 2020, In : Cell Reports. 30, 9, p. 3051-3066.e7

Research output: Contribution to journalArticle

Open Access

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Haj-Yahya, M., Gopinath, P., Rajasekhar, K., Mirbaha, H., Diamond, M. I. & Lashuel, H. A., Mar 2 2020, In : Angewandte Chemie - International Edition. 59, 10, p. 4059-4067 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway

Kucharava, K., Brand, Y., Albano, G., Sekulic-Jablanovic, M., Glutz, A., Xian, X., Herz, J., Bodmer, D., Fuster, D. G. & Petkovic, V., Dec 1 2020, In : Scientific reports. 10, 1, 3609.

Research output: Contribution to journalArticle

Open Access

Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response

Laothamatas, I., Gao, P., Wickramaratne, A., Quintanilla, C. G., Dino, A., Khan, C. A., Liou, J. & Green, C. B., Jan 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 2, p. 993-999 7 p.

Research output: Contribution to journalArticle

Structure of cortical network activity across natural wake and sleep states in mice

Ohyama, K., Kanda, T., Miyazaki, T., Tsujino, N., Ishii, R., Ishikawa, Y., Muramoto, H., Grenier, F., Makino, Y., McHugh, T. J., Yanagisawa, M., Greene, R. W. & Vogt, K. E., May 2020, In : PloS one. 15, 5, e0233561.

Research output: Contribution to journalArticle

Open Access

The malaria parasite has an intrinsic clock

Rijo-Ferreira, F., Acosta-Rodriguez, V. A., Abel, J. H., Kornblum, I., Bento, I., Kilaru, G., Klerman, E. B., Mota, M. M. & Takahashi, J. S., May 15 2020, In : Science. 368, 6492, p. 746-753 8 p.

Research output: Contribution to journalArticle

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

Shi, Y., Sun, L., Wang, M., Liu, J., Zhong, S., Li, R., Li, P., Guo, L., Fang, A., Chen, R., Ge, W. P., Wu, Q. & Wang, X., May 2020, In : PLoS biology. 18, 5, e3000705.

Research output: Contribution to journalArticle

Open Access

Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation

Tyra, L. K., Nandi, N., Tracy, C. & Krämer, H., Mar 9 2020, In : Developmental cell. 52, 5, p. 605-616.e7

Research output: Contribution to journalArticle

1 Scopus citations
2019

3-dimensional visualization of implant-tissue interface with the polyethylene glycol associated solvent system tissue clearing method

Yi, Y., Men, Y., Jing, D., Luo, W., Zhang, S., Feng, J. Q., Liu, J., Ge, W. P., Wang, J. & Zhao, H., May 2019, In : Cell Proliferation. 52, 3, e12578.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2 Scopus citations

Accelerated evolution of oligodendrocytes in the human brain

Berto, S., Mendizabal, I., Usui, N., Toriumi, K., Chatterjee, P., Douglas, C., Tamminga, C. A., Preuss, T. M., Yi, S. V. & Konopka, G., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24334-24342 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

Gharpure, A., Teng, J., Zhuang, Y., Noviello, C. M., Walsh, R. M., Cabuco, R., Howard, R. J., Zaveri, N. T., Lindahl, E. & Hibbs, R. E., Nov 6 2019, In : Neuron. 104, 3, p. 501-511.e6

Research output: Contribution to journalArticle

11 Scopus citations

A novel mouse model overexpressing Nocturnin results in decreased fat mass in male mice

Le, P. T., Bornstein, S. A., Motyl, K. J., Tian, L., Stubblefield, J. J., Hong, H. K., Takahashi, J. S., Green, C. B., Rosen, C. J. & Guntur, A. R., Nov 2019, In : Journal of cellular physiology. 234, 11, p. 20228-20239 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

A novel mutation in Slc2a4 as a mouse model of fatigue

de Groot, M. H. M., Castorena, C. M., Cox, K. H., Kumar, V., Mohawk, J. A., Ahmed, N. I. & Takahashi, J. S., Nov 1 2019, In : Genes, Brain and Behavior. 18, 8, e12578.

Research output: Contribution to journalArticle

Antibodies raised against aldehyde-fixed antigens improve sensitivity for postembedding electron microscopy

Hussain, S., Fredriksen, I., Ringsevjen, H., Kavalali, E. T. & Davanger, S., Apr 1 2019, In : Journal of Neuroscience Methods. 317, p. 1-10 10 p.

Research output: Contribution to journalArticle

Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus

Gonzalez, D., Tomasek, M., Hays, S., Sridhar, V., Ammanuel, S., Chang, C. W., Pawlowski, K., Huber, K. M. & Gibson, J. R., Dec 4 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 49, p. 9852-9863 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Blocking skeletal muscle DHPRS/RYR1 prevents neuromuscular synapse loss in mutant mice deficient in type III neuregulin 1 (CRD-NRG1)

Liu, Y., Sugiura, Y., Chen, F., Lee, K. F., Ye, Q. & Lin, W., Mar 2019, In : PLoS genetics. 15, 3, e1007857.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations

Mann, N., Kause, F., Henze, E. K., Gharpure, A., Shril, S., Connaughton, D. M., Nakayama, M., Klämbt, V., Majmundar, A. J., Wu, C. H. W., Kolvenbach, C. M., Dai, R., Chen, J., van der Ven, A. T., Ityel, H., Tooley, M. J., Kari, J. A., Bownass, L., El Desoky, S., De Franco, E. & 13 others, Shalaby, M., Tasic, V., Bauer, S. B., Lee, R. S., Beckel, J. M., Yu, W., Mane, S. M., Lifton, R. P., Reutter, H., Ellard, S., Hibbs, R. E., Kawate, T. & Hildebrandt, F., Dec 5 2019, In : American Journal of Human Genetics. 105, 6, p. 1286-1293 8 p.

Research output: Contribution to journalArticle

Cell-specific loss of SNAP25 from cortical projection neurons allows normal development but causes subsequent neurodegeneration

Hoerder-Suabedissen, A., Korrell, K. V., Hayashi, S., Jeans, A., Ramirez, D. M. O., Grant, E., Christian, H. C., Kavalali, E. T., Wilson, M. C. & Molnár, Z., May 2019, In : Cerebral Cortex. 29, 5, p. 2148-2159 12 p., bhy127.

Research output: Contribution to journalArticle

5 Scopus citations

Cell type-specific epigenetic links to schizophrenia risk in the brain

Mendizabal, I., Berto, S., Usui, N., Toriumi, K., Chatterjee, P., Douglas, C., Huh, I., Jeong, H., Layman, T., Tamminga, C. A., Preuss, T. M., Konopka, G. & Yi, S. V., Jul 9 2019, In : Genome biology. 20, 1, 135.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon

Zoltowski, B. D., Chelliah, Y., Wickramaratne, A., Jarocha, L., Karki, N., Xu, W., Mouritsen, H., Hore, P. J., Hibbs, R. E., Green, C. B. & Takahashi, J. S., Sep 24 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19449-19457 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes

Hickey, S. L., Berto, S. & Konopka, G., May 7 2019, In : Cell Reports. 27, 6, p. 1699-1711.e9

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Circadian clock genes and the transcriptional architecture of the clock mechanism

Cox, K. H. & Takahashi, J. S., Nov 2019, In : Journal of molecular endocrinology. 63, 4, p. R93-R102

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities

Shimada, I. S., Somatilaka, B. N., Hwang, S. H., Anderson, A. G., Shelton, J. M., Rajaram, V., Konopka, G. & Mukhopadhyay, S., Jun 1 2019, In : Developmental Biology. 450, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

2 Scopus citations