Research Output 1964 2019

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2019

Changing Times in Liver Transplantation for Alcohol-Associated Liver Disease

Mitchell, M. C. & Maddrey, W. C., Jan 1 2019, (Accepted/In press) In : JAMA Internal Medicine.

Research output: Contribution to journalArticle

Liver Transplantation
Liver Diseases
Alcohols
2018
16 Citations (Scopus)

Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo—a Meta-analysis of Individual Data From Controlled Trials

Louvet, A., Thursz, M. R., Kim, D. J., Labreuche, J., Atkinson, S. R., Sidhu, S. S., O'Grady, J. G., Akriviadis, E., Sinakos, E., Carithers, R. L., Ramond, M. J., Maddrey, W. C., Morgan, T. R., Duhamel, A. & Mathurin, P., Aug 1 2018, In : Gastroenterology. 155, 2, p. 458-468.e8

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Pentoxifylline
Meta-Analysis
Adrenal Cortex Hormones
Therapeutics
2017
5 Citations (Scopus)

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCϵ-dependent Pathway

Wei, S. C., Yang-Yen, H. F., Tsao, P. N., Weng, M. T., Tung, C. C., Yu, L. C. H., Lai, L. C., Hsiao, J. H., Chuang, E. Y., Shun, C. T., Ni, Y. H., Xavier, R. J., Podolsky, D. K., Yen, J. J. Y. & Wong, J. M., Oct 1 2017, In : Inflammatory Bowel Diseases. 23, 10, p. 1730-1740 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Crohn Disease
Dextran Sulfate
Autistic Disorder
Electric Impedance
10 Citations (Scopus)

The Ribavirin Pregnancy Registry: An Interim Analysis of Potential Teratogenicity at the Mid-Point of Enrollment

Sinclair, S. M., Jones, J. K., Miller, R. K., Greene, M. F., Kwo, P. Y. & Maddrey, W. C., Jul 8 2017, (Accepted/In press) In : Drug Safety. p. 1-14 14 p.

Research output: Contribution to journalArticle

Ribavirin
Registries
Pregnancy
Defects
Pregnant Women
2015

Gastroenterology, Academic Medicine and a Changing Landscape

Podolsky, D. K., Sep 23 2015, In : Digestive Diseases. 33, p. 57-60 4 p.

Research output: Contribution to journalArticle

Gastroenterology
Medicine
Delivery of Health Care
Research
Foster Home Care
1 Citation (Scopus)

Reflections on mentorship on the occasion of Dr Kurt J. Isselbacher's 90th birthday

Podolsky, D. K., Aug 1 2015, In : Gastroenterology. 149, 2, p. 268-269 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Mentors
Gastroenterology
Interpersonal Relations

Texas medical center keeps its focus on process improvement

Podolsky, D. & Kutscher, B., Jul 27 2015, In : Modern Healthcare. 45, 30, p. 30-31 2 p.

Research output: Contribution to journalArticle

Value-Based Purchasing
Organizational Case Studies
Fund Raising
Hospital Design and Construction
Quality Improvement
2014
41 Citations (Scopus)

Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertension

Dingemanse, J., Sidharta, P. N., Maddrey, W. C., Rubin, L. J. & Mickail, H., Mar 2014, In : Expert Opinion on Drug Safety. 13, 3, p. 391-405 15 p.

Research output: Contribution to journalArticle

Clinical Pharmacology
Pulmonary Hypertension
Safety
Therapeutics
Morbidity
1 Citation (Scopus)

Public reporting of patient safety metrics: Ready or not?

Podolsky, D. K., Nagarkar, P. A., Reed, W. G. & Rohrich, R. J., 2014, In : Plastic and Reconstructive Surgery. 134, 6, p. 981e-985e

Research output: Contribution to journalArticle

Patient Safety
Delivery of Health Care
Safety
Medical Errors
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
8 Citations (Scopus)

SLCO3A1, a novel Crohn's disease-associated gene, regulates NF-κB activity and associates with intestinal perforation

Wei, S. C., Tan, Y. Y., Weng, M. T., Lai, L. C., Hsiao, J. H., Chuang, E. Y., Shun, C. T., Wu, D. C., Kao, A. W., Chuang, C. S., Ni, Y. H., Shieh, M. J., Tung, C. C., Chen, Y., Wang, C. Y., Xavier, R. J., Podolsky, D. K. & Wong, J. M., Jun 19 2014, In : PLoS One. 9, 6, e100515.

Research output: Contribution to journalArticle

Intestinal Perforation
Crohn disease
Crohn Disease
Genes
genes
2013
2 Citations (Scopus)

Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships.

Fordtran, J. S., Goyal, R. K., Feldman, M., Soll, A. H., Trier, J. S., Ockner, R. K., Larusso, N. F., Podolsky, D. K., Brenner, D. A., Rustgi, A. K. & Omary, M. B., Jul 2013, In : Gastroenterology. 145, 1, p. 16-31 16 p.

Research output: Contribution to journalArticle

Gastroenterology
Personality
22 Citations (Scopus)

Increased T-helper 2 cytokines in bile from patients with IgG4-related cholangitis disrupt the tight junction-associated biliary epithelial cell barrier

Müller, T., Beutler, C., Picó, A. H., Otten, M., Dürr, A., Al-Abadi, H., Guckelberger, O., Meyer Zum Büschenfelde, D., Jöhrens, K., Volkmann, M., Lankisch, T., Voigtländer, T., Anders, M., Shibolet, O., Jefferson, D. M., Podolsky, D. K., Fischer, A., Veltzke-Schlieker, W., Adler, A., Baumgart, D. C. & 4 others, Sturm, A., Wiedenmann, B., Schott, E. & Berg, T., May 2013, In : Gastroenterology. 144, 5, p. 1116-1128 13 p.

Research output: Contribution to journalArticle

Cholangitis
Tight Junctions
Bile
Immunoglobulin G
Epithelial Cells

Kenji Fujiwara, MD, PhD.

Sugano, K., Podolsky, D. K., Brenner, D. A., Michalopoulos, G. & Tsukamoto, H., Apr 2013, In : Gastroenterology. 144, 4, p. 661-663 3 p.

Research output: Contribution to journalArticle

21st Century History
Gastroenterology
Japan
34 Citations (Scopus)

Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis

Ey, B., Eyking, A., Klepak, M., Salzman, N. H., Göthert, J. R., Run̈zi, M., Schmid, K. W., Gerken, G., Podolsky, D. K. & Cario, E., Jun 1 2013, In : Journal of Immunology. 190, 11, p. 5676-5688 13 p.

Research output: Contribution to journalArticle

Colitis
Ulcerative Colitis
Interleukin-1
Interleukin 1 Receptor Antagonist Protein
Caspase 1
2012

Foreword

Podolsky, D. K., Jan 1 2012, In : Unknown Journal. p. v-vi

Research output: Contribution to journalArticle

Forward

Podolsky, D. K., Jan 4 2012, In : Unknown Journal.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling

Wei, S. C., Rosenberg, I. M., Cao, Z., Huett, A. S., Xavier, R. J. & Podolsky, D. K., May 2012, In : Inflammatory Bowel Diseases. 18, 5, p. 877-888 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 5
NF-kappa B
Toll-Like Receptors
Inflammatory Bowel Diseases
Phosphotransferases
2011
246 Citations (Scopus)

Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: Meta-analysis of individual patient data

Mathurin, P., O'Grady, J., Carithers, R. L., Phillips, M., Louvet, A., Mendenhall, C. L., Ramond, M. J., Naveau, S., Maddrey, W. C. & Morgan, T. R., Feb 2011, In : Gut. 60, 2, p. 255-260 6 p.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Meta-Analysis
Adrenal Cortex Hormones
Survival
Randomized Controlled Trials
50 Citations (Scopus)

Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis

Mueller, T., Beutler, C., Picó, A. H., Shibolet, O., Pratt, D. S., Pascher, A., Neuhaus, P., Wiedenmann, B., Berg, T. & Podolsky, D. K., Nov 2011, In : Liver International. 31, 10, p. 1574-1588 15 p.

Research output: Contribution to journalArticle

Cholangitis
Endotoxins
Epithelial Cells
Pattern Recognition Receptors
Sclerosing Cholangitis
80 Citations (Scopus)

Evaluation of drug-induced serious hepatotoxicity (eDISH): Application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery

Watkins, P. B., Desai, M., Berkowitz, S. D., Peters, G., Horsmans, Y., Larrey, D. & Maddrey, W., 2011, In : Drug Safety. 34, 3, p. 243-252 10 p.

Research output: Contribution to journalArticle

Knee prostheses
Knee Replacement Arthroplasties
Phase III Clinical Trials
Drug Evaluation
Hip Replacement Arthroplasties
1 Citation (Scopus)

Preface

Schiff, E. R., Maddrey, W. C. & Sorrell, M. F., Oct 31 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer

Eyking, A., Ey, B., Rünzi, M., Roig, A. I., Reis, H., Schmid, K. W., Gerken, G., Podolsky, D. K. & Cario, E., Dec 2011, In : Gastroenterology. 141, 6, p. 2154-2165 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Caco-2 Cells
Colonic Neoplasms
Epithelial Cells
Heterografts
2010
2 Citations (Scopus)

Activity 1: Overview of the viral hepatitis problem

Lok, A. S. F., Kim, W. R., El-Serag, H. B. & Maddrey, W. C., Apr 2010, In : Journal of Family Practice. 59, SUPPL. 4

Research output: Contribution to journalArticle

Carrier State
Mass Screening
Cost of Illness
Chronic Hepatitis B
Chronic Hepatitis C
17 Citations (Scopus)

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3

Beck, P. L., Ihara, E., Hirota, S. A., MacDonald, J. A., Meng, D., Nanthakumar, N. N., Podolsky, D. K. & Xavier, R. J., Jul 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 1

Research output: Contribution to journalArticle

galactoside 3-fucosyltransferase
Fucosyltransferases
Dextran Sulfate
Leukocytes
Colitis
119 Citations (Scopus)

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

Surolia, I., Pirnie, S. P., Chellappa, V., Taylor, K. N., Cariappa, A., Moya, J., Liu, H., Bell, D. W., Driscoll, D. R., Diederichs, S., Haider, K., Netravali, I., Le, S., Elia, R., Dow, E., Lee, A., Freudenberg, J., De Jager, P. L., Chretien, Y., Varki, A. & 13 others, MacDonald, M. E., Gillis, T., Behrens, T. W., Bloch, D., Collier, D., Korzenik, J., Podolsky, D. K., Hafler, D., Murali, M., Sands, B., Stone, J. H., Gregersen, P. K. & Pillai, S., Jul 8 2010, In : Nature. 466, 7303, p. 243-247 5 p.

Research output: Contribution to journalArticle

Acetylesterase
N-Acetylneuraminic Acid
Autoimmunity
Antigen Receptors
Type 1 Diabetes Mellitus
27 Citations (Scopus)

Identification of Drosophila yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters

Charrière, G. M., Ip, W. K. E., Dejardin, S., Boyer, L., Sokolovska, A., Cappillino, M. P., Cherayil, B. J., Podolsky, D. K., Kobayashi, K. S., Silverman, N., Lacy-Hulbert, A. & Stuart, L. M., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20147-20154 8 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Phagosomes
Oligomerization
Drosophila
Nucleotides
23 Citations (Scopus)

In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase

Xue, L., Aihara, E., Podolsky, D. K., Wang, T. C. & Montrose, M. H., 2010, In : Gut. 59, 9, p. 1184-1191 8 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Stomach
Lasers
Epithelium
Indomethacin
179 Citations (Scopus)

LRRK2 is involved in the IFN-γ response and host response to pathogens

Gardet, A., Benita, Y., Li, C., Sands, B. E., Ballester, I., Stevens, C., Korzenik, J. R., Rioux, J. D., Daly, M. J., Xavier, R. J. & Podolsky, D. K., Nov 1 2010, In : Journal of Immunology. 185, 9, p. 5577-5585 9 p.

Research output: Contribution to journalArticle

Crohn Disease
Phagocytosis
Dendritic Cells
Genes
Parkinson Disease
20 Citations (Scopus)

MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function

Yamamoto-Furusho, J. K., Barnich, N., Hisamatsu, T. & Podolsky, D. K., 2010, In : Inflammatory Bowel Diseases. 16, 5, p. 736-742 7 p.

Research output: Contribution to journalArticle

Defensins
Epithelial Cells
Salmonella typhimurium
Small Interfering RNA
Renilla Luciferases
14 Citations (Scopus)

Synthesis of biologically active biotinylated muramyl dipeptides

Grimes, C. L., Podolsky, D. K. & O'Shea, E. K., Oct 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 20, p. 6061-6063 3 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Isomers
Assays
Molecules
40 Citations (Scopus)

The ribavirin pregnancy registry: Findings after 5 years of enrollment, 2003-2009

Roberts, S. S., Miller, R. K., Jones, J. K., Lindsay, K. L., Greene, M. F., Maddrey, W. C., Williams, I. T., Liu, J. & Spiegel, R. J., Jul 2010, In : Birth Defects Research Part A - Clinical and Molecular Teratology. 88, 7, p. 551-559 9 p.

Research output: Contribution to journalArticle

Ribavirin
Registries
Pregnancy
Live Birth
Interferons
2009
40 Citations (Scopus)

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy

Huett, A., Ng, A., Cao, Z., Kuballa, P., Komatsu, M., Daly, M. J., Podolsky, D. K. & Xavier, R. J., Apr 15 2009, In : Journal of Immunology. 182, 8, p. 4917-4930 14 p.

Research output: Contribution to journalArticle

Autophagy
Carrier Proteins
Yeasts
Salmonella enterica
Fungal Proteins
8 Citations (Scopus)

Beyond tumor necrosis factor: Next-generation biologic therapy for inflammatory bowel disease

Podolsky, D. K., 2009, In : Digestive Diseases. 27, 3, p. 366-369 4 p.

Research output: Contribution to journalArticle

Biological Therapy
Biological Products
Inflammatory Bowel Diseases
Tumor Necrosis Factor-alpha
Cytokines
137 Citations (Scopus)

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

Podolsky, D. K., Gerken, G., Eyking, A. & Cario, E., Jul 2009, In : Gastroenterology. 137, 1, p. 209-220 12 p.

Research output: Contribution to journalArticle

Goblet Cells
Colitis
Dextran Sulfate
Ulcerative Colitis
Toll-Like Receptor 2

Editorial introductions

Podolsky, D. K., Cohen, M. & Bresalier, R., Jan 2009, In : Current Opinion in Gastroenterology. 25, 1

Research output: Contribution to journalArticle

12 Citations (Scopus)

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements

Huett, A., Leong, J. M., Podolsky, D. K. & Xavier, R. J., Jul 15 2009, In : Experimental Cell Research. 315, 12, p. 2001-2011 11 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Actins
Salmonella typhimurium
Epithelial Cells
PDZ Domains
75 Citations (Scopus)

TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury

Ey, B., Eyking, A., Gerken, G., Podolsky, D. K. & Cario, E., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22332-22343 12 p.

Research output: Contribution to journalArticle

Connexin 43
Communication
Wounds and Injuries
Epithelial Cells
Tissue homeostasis
2008

Editorial introductions

Podolsky, D. K., Boedeker, E. C. & Bresalier, R. S., Jan 2008, In : Current Opinion in Gastroenterology. 24, 1

Research output: Contribution to journalArticle

45 Citations (Scopus)

Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds

Paulsen, F. P., Woon, C. W., Varoga, D., Jansen, A., Garreis, F., Jäger, K., Amm, M., Podolsky, D. K., Steven, P., Barker, N. P. & Sel, S., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 13418-13427 10 p.

Research output: Contribution to journalArticle

Re-Epithelialization
Wound Healing
Wounds and Injuries
Alkalies
Cornea
40 Citations (Scopus)

TNF Receptor Type I-Dependent Activation of Innate Responses to Reduce Intestinal Damage-Associated Mortality

Mizoguchi, E., Hachiya, Y., Kawada, M., Nagatani, K., Ogawa, A., Sugimoto, K., Mizoguchi, A. & Podolsky, D. K., Feb 2008, In : Gastroenterology. 134, 2, p. 470-480 11 p.

Research output: Contribution to journalArticle

RAG-1 Genes
Receptors, Tumor Necrosis Factor, Type I
Tumor Necrosis Factor Receptors
Epithelial Cells
Mortality
2007
37 Citations (Scopus)

AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling

Shibolet, O., Giallourakis, C., Rosenberg, I., Mueller, T., Xavier, R. J. & Podolsky, D. K., Nov 30 2007, In : Journal of Biological Chemistry. 282, 48, p. 35308-35317 10 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Guanine
Toll-Like Receptors
Chemical activation
Ligands

Editorial introductions

Podolsky, D. K., Boedeker, E. C. & Bresalier, R. S., Jan 2007, In : Current Opinion in Gastroenterology. 23, 1

Research output: Contribution to journalArticle

37 Citations (Scopus)

Hepatitis B virus infection in 6,130 unvaccinated Korean-Americans surveyed between 1988 and 1990

Hann, H. W. L., Hann, R. S. & Maddrey, W. C., Apr 2007, In : American Journal of Gastroenterology. 102, 4, p. 767-772 6 p.

Research output: Contribution to journalArticle

Asian Americans
Virus Diseases
Hepatitis B virus
Hepatitis B Surface Antigens
Hepatitis B e Antigens
2 Citations (Scopus)

Inadequate numbers [2]

Lindsay, K. L., Greene, M. F., Jones, J. K., Maddrey, W. C. & Miller, R. K., Mar 2007, In : Canadian Family Physician. 53, 3, p. 401 1 p.

Research output: Contribution to journalArticle

interferon alfa-2b
Drug-Induced Abnormalities
Paternal Exposure
Teratogens
Ribavirin
65 Citations (Scopus)

Innate immunity in inflammatory bowel disease

Yamamoto-Furusho, J. K. & Podolsky, D. K., Nov 14 2007, In : World Journal of Gastroenterology. 13, 42, p. 5577-5580 4 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Innate Immunity
Bacteria
Toll-Like Receptors
Adaptive Immunity
112 Citations (Scopus)

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

De Jager, P. L., Franchimont, D., Waliszewska, A., Bitton, A., Cohen, A., Langelier, D., Belaiche, J., Vermeire, S., Farwell, L., Goris, A., Libioulle, C., Jani, N., Dassopoulos, T., Bromfield, G. P., Dubois, B., Cho, J. H., Brant, S. R., Duerr, R. H., Yang, H., Rotter, J. I. & 7 others, Silverberg, M. S., Steinhart, A. H., Daly, M. J., Podolsky, D. K., Louis, E., Hafler, D. A. & Rioux, J. D., Jul 2007, In : Genes and Immunity. 8, 5, p. 387-397 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Toll-Like Receptors
Odds Ratio
Confidence Intervals
Alleles
164 Citations (Scopus)
Toll-Like Receptors
Homeostasis
Peroxisome Proliferator-Activated Receptors
Adaptive Immunity
Antigen-Presenting Cells
421 Citations (Scopus)

Toll-Like Receptor 2 Controls Mucosal Inflammation by Regulating Epithelial Barrier Function

Cario, E., Gerken, G. & Podolsky, D. K., Apr 2007, In : Gastroenterology. 132, 4, p. 1359-1374 16 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Tight Junctions
Inflammation
Epithelial Cells
Colitis
2492 Citations (Scopus)

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J. & Podolsky, D. K., Jul 26 2007, In : Nature. 448, 7152, p. 427-434 8 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Bacteria
Adaptive Immunity
Ulcerative Colitis
Innate Immunity
2006
18 Citations (Scopus)

Case 8-2006: A 71-year-old woman with Crohn's disease and altered mental status

Podolsky, D. K., Gonzalez, R. G., Hasserjian, R. P., Harris, N. L. & Hochberg, E. P., Mar 16 2006, In : New England Journal of Medicine. 354, 11, p. 1178-1184 7 p.

Research output: Contribution to journalArticle

6-Mercaptopurine
Epstein-Barr Virus Infections
X Ray Computed Tomography
Fatal Outcome
Unconsciousness