PA-Lab Zhang, Qing

Research output

Research output per year 2019 2020 2022 2023 2024

• 23 Article
• 8 Review article
• 1 Chapter
• 1 Comment/debate
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells

  Zhu, Z., Lou, G., Teng, X. L., Wang, H., Luo, Y., Shi, W., Yihunie, K., Hao, S., DeGolier, K., Liao, C., Huang, H., Zhang, Q., Fry, T., Wang, T., Yao, C. & Wu, T., Jan 2024, In: Nature immunology. 25, 1, p. 117-128 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chimeric Antigen Receptors 100%
  • T-Lymphocytes 45%
  • CD8 Antigens 22%
  • Transcription Factors 18%
  • Gene Regulatory Networks 17%
  1 Scopus citations

• Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

  Hu, L., Zhang, Y., Guo, L., Zhong, H., Xie, L., Zhou, J., Liao, C., Yao, H., Fang, J., Liu, H., Zhang, C., Zhang, H., Zhu, X., Luo, M., von Kriegsheim, A., Li, B., Luo, W., Zhang, X., Chen, X., Mendell, J. T., & 5 othersXu, L., Kapur, P., Baldwin, A. S., Brugarolas, J. & Zhang, Q., Feb 15 2024, In: Molecular cell. 84, 4, p. 776-790.e5

  Research output: Contribution to journal › Article › peer-review

  • Renal Cell Carcinoma 100%
  • Small Interfering RNA 87%
  • Phosphotransferases 80%
  • Carcinogenesis 14%
  • Growth 9%
• 2023

  FDXR drives primary and endocrine-resistant tumor cell growth in ER+ breast cancer via CPT1A-mediated fatty acid oxidation

  Yan, C., Gao, R., Gao, C., Hong, K., Cheng, M., Liu, X., Zhang, Q. & Zhang, J., 2023, In: Frontiers in Oncology. 13, 1105117.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ferredoxins 100%
  • Estrogen Receptors 61%
  • Oxidoreductases 59%
  • Fatty Acids 55%
  • fatty acid reductase 45%
  2 Scopus citations

• Immature natural killer cells promote progression of triple-negative breast cancer

  Thacker, G., Henry, S., Nandi, A., Debnath, R., Singh, S., Nayak, A., Susnik, B., Boone, M. M., Zhang, Q., Kesmodel, S. B., Gumber, S., Das, G. M., Kambayashi, T., Dos Santos, C. O. & Chakrabarti, R., Mar 8 2023, In: Science translational medicine. 15, 686, eabl4414.

  Research output: Contribution to journal › Article › peer-review

  • Triple Negative Breast Neoplasms 100%
  • Natural Killer Cells 76%
  • Neoplastic Stem Cells 22%
  • LGK974 21%
  • Neoplasms 16%
  13 Scopus citations

• Optimized protocols for chromatin immunoprecipitation of exogenously expressed epitope-tagged proteins

  Fang, W., Liao, C. & Zhang, Q., Mar 17 2023, In: STAR Protocols. 4, 1, 102050.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromatin Immunoprecipitation 100%
  • Epitopes 76%
  • Chromatin 39%
  • Antibodies 37%
  • Protein 37%

• Synthesis of the Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitor, 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977, Belzutifan); Efficient Replication of Established Approaches

  Hamal, K. B., Pavlich, C. I., Carlson, G. J., Ching Wong, Y., Zhao, F., Zhang, Q., Klausmeyer, K. K. & Pinney, K. G., Sep 19 2023, In: Tetrahedron Letters. 128, 154691.

  Research output: Contribution to journal › Article › peer-review

  • endothelial PAS domain-containing protein 1 100%
  • Diastereoselectivity 61%
  • Diastereomer 57%
  • von Hippel-Lindau Disease 42%
  • Patents 37%

• Targeting tumor micro-environmental pathways for cancer therapy

  Zhang, Q. & Wei, W., Feb 2023, In: Seminars in Cancer Biology. 89, p. 99-100 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Tumor hypoxia: From basic knowledge to therapeutic implications

  Liao, C., Liu, X., Zhang, C. & Zhang, Q., Jan 2023, In: Seminars in Cancer Biology. 88, p. 172-186 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Tumor Hypoxia 100%
  • Tumor Microenvironment 78%
  • Hypoxia 59%
  • Neoplasms 18%
  • Immunosuppressive Agents 15%
  24 Scopus citations

• α-Ketoglutarate-dependent Enzymes in Breast Cancer and Therapeutic Implications

  Xiong, J., Yan, C., Zhang, Q. & Zhang, J., Apr 17 2023, In: Endocrinology. 164, 6

  Research output: Contribution to journal › Review article › peer-review

  • Dioxygenases 100%
  • Breast Neoplasms 66%
  • Iron 57%
  • Enzymes 56%
  • Oxygen 49%
• 2022

  An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

  Zhou, J., Simon, J. M., Liao, C., Zhang, C., Hu, L., Zurlo, G., Liu, X., Fan, C., Hepperla, A., Jia, L., Tcheuyap, V. T., Zhong, H., Elias, R., Ye, J., Henne, W. M., Kapur, P., Nijhawan, D., Brugarolas, J. & Zhang, Q., Aug 18 2022, In: Molecular cell. 82, 16, p. 3030-3044.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diacylglycerol O-Acyltransferase 100%
  • Lipid Droplets 74%
  • Renal Cell Carcinoma 60%
  • Epigenomics 55%
  • Carcinogenesis 24%
  14 Scopus citations

• Comprehensive metabolomics expands precision medicine for triple-negative breast cancer

  Xiao, Y., Ma, D., Yang, Y. S., Yang, F., Ding, J. H., Gong, Y., Jiang, L., Ge, L. P., Wu, S. Y., Yu, Q., Zhang, Q., Bertucci, F., Sun, Q., Hu, X., Li, D. Q., Shao, Z. M. & Jiang, Y. Z., May 2022, In: Cell Research. 32, 5, p. 477-490 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Metabolomics 91%
  • Precision Medicine 89%
  • Ceramides 27%
  • Metabolome 26%
  109 Scopus citations

• EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway

  Qiu, Z., Guo, W., Dong, B., Wang, Y., Deng, P., Wang, C., Liu, J., Zhang, Q., Grosschedl, R., Yu, Z., Deng, J. & Wu, Y., Jul 12 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 28, e2119518119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • B-Lymphocyte Subsets 100%
  • Triple Negative Breast Neoplasms 95%
  • Mitophagy 23%
  • Chromosome Mapping 10%
  • Gene Regulatory Networks 9%
  6 Scopus citations

• HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans

  Ma, Y., Joyce, A., Brandenburg, O., Saatchi, F., Stevens, C., Toffessi Tcheuyap, V., Christie, A., Do, Q. N., Fatunde, O., Macchiaroli, A., Wong, S. C., Woolford, L., Yousuf, Q., Miyata, J., Carrillo, D., Onabolu, O., McKenzie, T., Mishra, A., Hardy, T., He, W., & 9 othersLi, D., Ivanishev, A., Zhang, Q., Pedrosa, I., Kapur, P., Schluep, T., Kanner, S. B., Hamilton, J. & Brugarolas, J., Dec 15 2022, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 28, 24, p. 5405-5418 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Interference 100%
  • PT2399 67%
  • Renal Cell Carcinoma 57%
  • Pharmaceutical Preparations 43%
  • Polycythemia 38%
  5 Scopus citations

• Histone H3 proline 16 hydroxylation regulates mammalian gene expression

  Liu, X., Wang, J., Boyer, J. A., Gong, W., Zhao, S., Xie, L., Wu, Q., Zhang, C., Jain, K., Guo, Y., Rodriguez, J., Li, M., Uryu, H., Liao, C., Hu, L., Zhou, J., Shi, X., Tsai, Y. H., Yan, Q., Luo, W., & 7 othersChen, X., Strahl, B. D., von Kriegsheim, A., Zhang, Q., Wang, G. G., Baldwin, A. S. & Zhang, Q., Nov 2022, In: Nature genetics. 54, 11, p. 1721-1735 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydroxylation 100%
  • Proline 92%
  • Histones 81%
  • histone H3 trimethyl Lys4 62%
  • Gene Expression 52%
  16 Scopus citations

• Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

  Liao, C., Glodowski, C. R., Fan, C., Liu, J., Mott, K. R., Kaushik, A., Vu, H., Locasale, J. W., McBrayer, S. K., DeBerardinis, R. J., Perou, C. M. & Zhang, Q., Feb 15 2022, In: Cancer research. 82, 4, p. 665-680 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Breast Neoplasms 92%
  • Heterografts 55%
  • pyrimidine 50%
  • Carbohydrates 36%
  5 Scopus citations

• TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

  Zhang, X., Li, S., He, J., Jin, Y., Zhang, R., Dong, W., Lin, M., Yang, Y., Tian, T., Zhou, Y., Xu, Y., Lei, Q. Y., Zhang, J., Zhang, Q., Xu, Y. & Lv, L., Jun 1 2022, In: Cancer research. 82, 11, p. 2097-2109 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Renal Cell Carcinoma 100%
  • Glycolysis 19%
  • Neoplasms 18%
  • Hepatocyte Nuclear Factor 4 15%
  • Dioxygenases 13%
  13 Scopus citations

• USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer

  Xie, H., Zhou, J., Liu, X., Xu, Y., Hepperla, A. J., Simon, J. M., Wang, T., Yao, H., Liao, C., Baldwin, A. S., Gong, K. & Zhang, Q., Sep 6 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, e2119854119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Homeobox Genes 100%
  • Zinc Fingers 97%
  • Kidney Neoplasms 96%
  • Carcinogenesis 65%
  • Renal Cell Carcinoma 51%
  16 Scopus citations
• 2021

  Hypoxia-driven effects in cancer: Characterization, mechanisms, and therapeutic implications

  Shi, R., Liao, C. & Zhang, Q., Mar 2021, In: Cells. 10, 3, p. 1-26 26 p., 678.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Metabolic 100%
  • Hypoxia 97%
  • Resistance 77%
  • Dioxygen 59%
  • Protein 50%
  55 Scopus citations

• Von Hippel-Lindau tumor suppressor pathways & corresponding therapeutics in kidney cancer

  Shulman, M., Shi, R. & Zhang, Q., Jul 20 2021, In: Journal of Genetics and Genomics. 48, 7, p. 552-559 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Kidney Neoplasms 100%
  • Hypoxia 70%
  • Carcinogenesis 45%
  • Urogenital Neoplasms 44%
  • Synthetic Lethal Mutations 43%
  7 Scopus citations

• ZHX2 prom 1 otes hif1α oncogenic signaling in triple-negative breast cancer

  Fang, W., Liao, C., Shi, R., Simon, J. M., Ptacek, T. S., Zurlo, G., Ye, Y., Han, L., Fan, C., Ortiz, C. L., Lin, H. R., Manocha, U., Luo, W., Peng, Y., Kim, W. Y., Yang, L. W. & Zhang, Q., Nov 2021, In: eLife. 10, e70412.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenic 100%
  • Triple Negative Breast Neoplasms 86%
  • Homeobox Genes 82%
  • Zinc Fingers 80%
  • H3K27Ac 28%
  20 Scopus citations
• 2020

  Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC

  Zurlo, G. & Zhang, Q., Mar 3 2020, In: Molecular and Cellular Oncology. 7, 2, 1707045.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenylosuccinate Lyase 100%
  • Triple Negative Breast Neoplasms 66%
  • Hydroxylation 62%
  • Adenosine 35%
  • Protein Stability 21%
  2 Scopus citations

• BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability

  Liao, C. & Zhang, Q., Nov 1 2020, In: Molecular and Cellular Oncology. 7, 6, 1813526.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • gamma-Butyrobetaine Dioxygenase 100%
  • Triple Negative Breast Neoplasms 61%
  • Inositol 1,4,5-Trisphosphate Receptors 33%
  • Calcium Signaling 30%
  • Energy Metabolism 23%
  3 Scopus citations

• Crosstalk Between the Heart and Cancer: Beyond Drug Toxicity

  Moslehi, J., Zhang, Q. & Moore, K. J., Aug 18 2020, In: Circulation. 142, 7, p. 684-687 4 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  25 Scopus citations

• Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

  Liu, X., Simon, J. M., Xie, H., Hu, L., Wang, J., Zurlo, G., Fan, C., Ptacek, T. S., Herring, L., Tan, X., Li, M., Baldwin, A. S., Kim, W. Y., Wu, T., Kirschner, M. W., Gong, K. & Zhang, Q., Mar 19 2020, In: Molecular cell. 77, 6, p. 1294-1306.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms 100%
  • Genome 72%
  • sphingosine kinase 44%
  • Neoplasms 34%
  • endothelial PAS domain-containing protein 1 24%
  39 Scopus citations

• Hypoxia and oxygen-sensing signaling in gene regulation and cancer progression

  Yang, G., Shi, R. & Zhang, Q., Nov 1 2020, In: International journal of molecular sciences. 21, 21, p. 1-24 24 p., 8162.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • gene expression 100%
  • hypoxia 93%
  • progressions 82%
  • Gene expression 80%
  • Neoplasm Genes 80%
  40 Scopus citations

• Identification of bbox1 as a therapeutic target in triple-negative breast cancer

  Liao, C., Zhang, Y., Fan, C., Herring, L. E., Liu, J., Locasale, J. W., Takada, M., Zhou, J., Zurlo, G., Hu, L., Simon, J. M., Ptacek, T. S., Andrianov, V. G., Loza, E., Peng, Y., Yang, H., Perou, C. M. & Zhang, Q., Nov 2020, In: Cancer discovery. 10, 11, p. 1707-1721 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • gamma-Butyrobetaine Dioxygenase 100%
  • Triple Negative Breast Neoplasms 61%
  • Calcium 8%
  • Inositol 1,4,5-Trisphosphate Receptors 8%
  • Therapeutics 8%
  30 Scopus citations

• TBK1 is a synthetic lethal target in cancer with VHL loss

  Hu, L., Xie, H., Liu, X., Potjewyd, F., James, L. I., Wilkerson, E. M., Herring, L. E., Xie, L., Chen, X., Cabrera, J. C., Hong, K., Liao, C., Tan, X., Baldwin, A. S., Gong, K. & Zhang, Q., Mar 2020, In: Cancer discovery. 10, 3, p. 460-475 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphotransferases 100%
  • Neoplasms 41%
  • Kidney Neoplasms 36%
  • Innate Immunity 29%
  • Hypoxia 16%
  58 Scopus citations

• The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer

  Liu, X., Zurlo, G. & Zhang, Q., 2020, Advances in Experimental Medicine and Biology. Springer, p. 173-186 14 p. (Advances in Experimental Medicine and Biology; vol. 1217).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Cullin Proteins 100%
  • Ubiquitin-Protein Ligases 77%
  • Elongin 59%
  • Protein 28%
  • leucine-rich repeat proteins 26%
  13 Scopus citations

• The von hippel-lindau tumor suppressor gene: Implications and therapeutic opportunities

  Elias, R., Zhang, Q. & Brugarolas, J., Sep 1 2020, In: Cancer Journal. 26, 5, p. 390-398 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Tumor Suppressor Genes 100%
  • Renal Cell Carcinoma 97%
  • Therapeutics 16%
  • Genes 13%
  5 Scopus citations

• Understanding the Oxygen-Sensing Pathway and Its Therapeutic Implications in Diseases

  Liao, C. & Zhang, Q., Aug 2020, In: American Journal of Pathology. 190, 8, p. 1584-1595 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Oxygen 100%
  • Hypoxia 55%
  • Dioxygenases 33%
  • Prolyl Hydroxylases 32%
  • Ubiquitin-Protein Ligases 26%
  34 Scopus citations

• USP37 promotes deubiquitination of HIF2α in kidney cancer

  Hong, K., Hu, L., Liu, X., Simon, J. M., Ptacek, T. S., Zheng, X., Liao, C., Baldwin, A. S. & Zhang, Q., Jun 9 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 23, p. 13023-13032 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin-Specific Proteases 100%
  • Kidney Neoplasms 75%
  • Renal Cell Carcinoma 42%
  • Deubiquitinating Enzymes 30%
  • Carcinogenesis 17%
  23 Scopus citations
• 2019

  Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine

  Zhang, Q., Yan, Q., Yang, H. & Wei, W., Dec 2019, In: Genes and Diseases. 6, 4, p. 328-332 5 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Nobel Prize 100%
  • History 50%
  • Medicine 48%
  • Oxygen 47%
  • Physicians 42%
  39 Scopus citations

• PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth

  Cai, W., Su, L., Liao, L., Liu, Z. Z., Langbein, L., Dulaimi, E., Testa, J. R., Uzzo, R. G., Zhong, Z., Jiang, W., Yan, Q., Zhang, Q. & Yang, H., Dec 1 2019, In: Nature communications. 10, 1, 5800.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • acetylation 100%
  • lysine 82%
  • kidneys 72%
  • readers 66%
  • Kidney Neoplasms 65%
  44 Scopus citations

• Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

  Zurlo, G., Liu, X., Takada, M., Fan, C., Simon, J. M., Ptacek, T. S., Rodriguez, J., von Kriegsheim, A., Liu, J., Locasale, J. W., Robinson, A., Zhang, J., Holler, J. M., Kim, B., Zikánová, M., Bierau, J., Xie, L., Chen, X., Li, M., Perou, C. M., & 1 othersZhang, Q., Dec 1 2019, In: Nature communications. 10, 1, 5177.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenylosuccinate Lyase 100%
  • Oncogenic 76%
  • Prolyl Hydroxylases 76%
  • Triple Negative Breast Neoplasms 66%
  • breast 57%
  23 Scopus citations