PA-Lab Zhang, Qing

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2020
2019

Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer

Kumar, S., Srivastav, R. K., Wilkes, D. W., Ross, T., Kim, S., Kowalski, J., Chatla, S., Zhang, Q., Nayak, A., Guha, M., Fuchs, S. Y., Thomas, C. & Chakrabarti, R., Mar 21 2019, In : Oncogene. 38, 12, p. 2092-2107 16 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth

Cai, W., Su, L., Liao, L., Liu, Z. Z., Langbein, L., Dulaimi, E., Testa, J. R., Uzzo, R. G., Zhong, Z., Jiang, W., Yan, Q., Zhang, Q. & Yang, H., Dec 1 2019, In : Nature communications. 10, 1, 5800.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

Zurlo, G., Liu, X., Takada, M., Fan, C., Simon, J. M., Ptacek, T. S., Rodriguez, J., von Kriegsheim, A., Liu, J., Locasale, J. W., Robinson, A., Zhang, J., Holler, J. M., Kim, B., Zikánová, M., Bierau, J., Xie, L., Chen, X., Li, M., Perou, C. M. & 1 others, Zhang, Q., Dec 1 2019, In : Nature communications. 10, 1, 5177.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Regulation of hypoxiainducible factor 1a during hypoxia by DAP5- induced translation of PHD2

Bryant, J. D., Brown, M. C., Dobrikov, M. I., Dobrikova, E. Y., Gemberling, S. L., Zhang, Q. & Gromeier, M., Jun 1 2018, In : Molecular and cellular biology. 38, 11, e00647-17.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

Zhang, J., Wu, T., Simon, J., Takada, M., Saito, R., Fan, C., Liu, X. D., Jonasch, E., Xie, L., Chen, X., Yao, X., Teh, B. T., Tan, P., Zheng, X., Li, M., Lawrence, C., Fan, J., Geng, J., Liu, X., Hu, L. & 13 others, Wang, J., Liao, C., Hong, K., Zurlo, G., Parker, J. S., Todd Auman, J., Perou, C. M., Kimryn Rathmell, W., Kim, W. Y., Kirschner, M. W., Kaelin, W. G., Baldwin, A. S. & Zhang, Q., Jul 20 2018, In : Science. 361, 6399, p. 290-295 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2017

EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor

Takada, M., Zhuang, M., Inuzuka, H., Zhang, J., Zurlo, G., Zhang, J. & Zhang, Q., Jan 1 2017, In : Oncotarget. 8, 4, p. 6787-6795 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis

Zhang, W., Karpen, G. H. & Zhang, Q., Dec 17 2017, In : Cell Cycle. 16, 24, p. 2323-2325 3 p.

Research output: Contribution to journalArticle

Open Access

FBW7 loss promotes chromosomal instability and tumorigenesis via cyclin E1/CDK2–mediated phosphorylation of CENP-A

Takada, M., Zhang, W., Suzuki, A., Kuroda, T. S., Yu, Z., Inuzuka, H., Gao, D., Wan, L., Zhuang, M., Hu, L., Zhai, B., Fry, C. J., Bloom, K., Li, G., Karpen, G. H., Wei, W. & Zhang, Q., Sep 15 2017, In : Cancer research. 77, 18, p. 4881-4893 13 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner

Di Conza, G., Trusso Cafarello, S., Zheng, X., Zhang, Q. & Mazzone, M., Mar 21 2017, In : Cell Reports. 18, 12, p. 2836-2844 9 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2014

Phosphorylation of ETS1 by src family kinases prevents its recognition by the COP1 tumor suppressor

Lu, G., Zhang, Q., Huang, Y., Song, J., Tomaino, R., Ehrenberger, T., Lim, E., Liu, W., Bronson, R. T., Bowden, M., Brock, J., Krop, I. E., Dillon, D. A., Gygi, S. P., Mills, G. B., Richardson, A. L., Signoretti, S., Yaffe, M. B. & Kaelin, W. G., Aug 11 2014, In : Cancer Cell. 26, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

Zheng, X., Zhai, B., Koivunen, P., Shin, S. J., Lu, G., Liu, J., Geisen, C., Chakraborty, A. A., Moslehi, J. J., Smalley, D. M., Wei, X., Chen, X., Chen, Z., Beres, J. M., Zhang, J., Tsao, J. L., Brenner, M. C., Zhang, Y., Fan, C., DePinho, R. A. & 4 others, Paik, J., Gygi, S. P., Kaelin, W. G. & Zhang, Q., Jul 1 2014, In : Genes and Development. 28, 13, p. 1429-1444 16 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations
2011

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Lin, W., Cao, J., Liu, J., Beshiri, M. L., Fujiwara, Y., Francis, J., Cherniack, A. D., Geisen, C., Blair, L. P., Zou, M. R., Shen, X., Kawamori, D., Liu, Z., Grisanzio, C., Watanabe, H., Minamishima, Y. A., Zhang, Q., Kulkarni, R. N., Signoretti, S., Rodig, S. J. & 7 others, Bronson, R. T., Orkin, S. H., Tuck, D. P., Benevolenskaya, E. V., Meyerson, M., Kaelin, W. G. & Yan, Q., Aug 16 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 33, p. 13379-13386 8 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells

Li, Y., Zhang, Q., Tian, R., Wang, Q., Zhao, J. J., Iglehart, J. D., Wang, Z. C. & Richardson, A. L., Dec 15 2011, In : Cancer Research. 71, 24, p. 7481-7489 9 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations
2010

Phosphorylation by Casein Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase

Inuzuka, H., Tseng, A., Gao, D., Zhai, B., Zhang, Q., Shaik, S., Wan, L., Ang, X. L., Mock, C., Yin, H., Stommel, J. M., Gygi, S., Lahav, G., Asara, J., Xiao, Z. X. J., Kaelin, W. G., Harper, J. W. & Wei, W., Aug 1 2010, In : Cancer Cell. 18, 2, p. 147-159 13 p.

Research output: Contribution to journalArticle

Open Access
132 Scopus citations
2008

Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: Implications for therapy

Wang, J., Seethala, R. R., Zhang, Q., Gooding, W., Van Waes, C., Hasegawa, H. & Ferris, R. L., Apr 2008, In : Journal of the National Cancer Institute. 100, 7, p. 502-512 11 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Combined inhibition of PLCγ-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion

Nozawa, H., Howell, G., Suzuki, S., Zhang, Q., Qi, Y., Klein-Seetharaman, J., Wells, A., Grandis, J. R. & Thomas, S. M., Jul 1 2008, In : Clinical Cancer Research. 14, 13, p. 4336-4344 9 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

Young, A. P., Schisio, S., Minamishima, Y. A., Zhang, Q., Li, L., Grisanzio, C., Signoretti, S. & Kaelin, W. G., Mar 1 2008, In : Nature cell biology. 10, 3, p. 361-369 9 p.

Research output: Contribution to journalArticle

179 Scopus citations
2007

Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer

Zhang, Q., Bhola, N. E., Lui, V. W. Y., Siwak, D. R., Thomas, S. M., Gubish, C. T., Siegfried, J. M., Mills, G. B., Shin, D. & Grandis, J. R., Apr 1 2007, In : Molecular Cancer Therapeutics. 6, 4, p. 1414-1424 11 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations
2006

Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma

Thomas, S. M., Bhola, N. E., Zhang, Q., Contrucci, S. C., Wentzel, A. L., Freilino, M. L., Gooding, W. E., Siegfried, J. M., Chan, D. C. & Grandis, J. R., Dec 15 2006, In : Cancer Research. 66, 24, p. 11831-11839 9 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis

Xi, S., Dyer, K. F., Kimak, M., Zhang, Q., Gooding, W. E., Chaillet, J. R., Chai, R. L., Ferrell, R. E., Zamboni, B., Hunt, J. & Grandis, J. R., Feb 1 2006, In : Journal of the National Cancer Institute. 98, 3, p. 181-189 9 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation

Zhang, Q., Thomas, S. M., Lui, V. W. Y., Xi, S., Siegfried, J. M., Fan, H., Smithgall, T. E., Mills, G. B. & Grandis, J. R., May 2 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 6901-6906 6 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations
2004

Src family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells

Zhang, Q., Thomas, S. M., Xi, S., Smithgall, T. E., Siegfried, J. M., Kamens, J., Gooding, W. E. & Grandis, J. R., Sep 1 2004, In : Cancer Research. 64, 17, p. 6166-6173 8 p.

Research output: Contribution to journalArticle

Open Access
134 Scopus citations
2003

Constitutive Activation of Stat5b Contributes to Carcinogenesis in Vivo

Xi, S., Zhang, Q., Gooding, W. E., Smithgall, T. E. & Grandis, J. R., Oct 15 2003, In : Cancer research. 63, 20, p. 6763-6771 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor

Lui, V. W. Y., Thomas, S. M., Zhang, Q., Wentzel, A. L., Siegfried, J. M., Li, J. Y. & Grandis, J. R., Sep 18 2003, In : Oncogene. 22, 40, p. 6183-6193 11 p.

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

Xi, S., Zhang, Q., Dyer, K. F., Lerner, E. C., Smithgall, T. E., Gooding, W. E., Kamens, J. & Grandis, J. R., Aug 22 2003, In : Journal of Biological Chemistry. 278, 34, p. 31574-31583 10 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations