Pharmacology - Chook Lab – Research output — University of Texas Southwestern Medical Center

2023

A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1

Korff, A., Yang, X., O'Donovan, K., Gonzalez, A., Teubner, B. J. W., Nakamura, H., Messing, J., Yang, F., Carisey, A. F., Wang, Y. D., Patni, T., Sheppard, H., Zakharenko, S. S., Chook, Y. M., Taylor, J. P. & Kim, H. J., Jul 17 2023, In: Journal of Clinical Investigation. 133, 14, e160309.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders

Gonzalez, A., Kim, H. J., Freibaum, B. D., Fung, H. Y. J., Brautigam, C. A., Taylor, J. P. & Chook, Y. M., Aug 3 2023, In: Structure. 31, 8, p. 924-934.e4

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex

Jiou, J., Shaffer, J. M., Bernades, N. E., Yee Joyce Fung, H., Dias, J. K., Arcy, S. D. & Chook, Y. M., Jul 18 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 29, e2301199120.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9

Shaffer, J. M., Jiou, J., Tripathi, K., Olaluwoye, O. S., Fung, H. Y. J., Chook, Y. M. & D'Arcy, S., Aug 3 2023, In: Structure. 31, 8, p. 903-911.e3

Research output: Contribution to journal › Article › peer-review

2022

Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1

Fung, H. Y. J. & Chook, Y. M., 2022, Methods in Molecular Biology. Humana Press Inc., p. 245-256 12 p. (Methods in Molecular Biology; vol. 2502).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1

Fung, H. Y. J. & Chook, Y. M., 2022, Methods in Molecular Biology. Humana Press Inc., p. 285-297 13 p. (Methods in Molecular Biology; vol. 2502).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Karyopherin-mediated nucleocytoplasmic transport

Wing, C. E., Fung, H. Y. J. & Chook, Y. M., May 2022, In: Nature Reviews Molecular Cell Biology. 23, 5, p. 307-328 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

81 Scopus citations

Structure of IMPORTIN-4 bound to the H3–H4–ASF1 histone–histone chaperone complex

Bernardes, N. E., Fung, H. Y. J., Li, Y., Chen, Z. & Chook, Y. M., Sep 20 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 38, e2207177119.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2021

An update to the CRM1 cargo/NES database NESdb

Fung, H. Y. J., Niesman, A. & Chook, Y. M., Mar 1 2021, In: Molecular biology of the cell. 32, 6, p. 467-469 3 p.

Research output: Contribution to journal › Letter › peer-review

6 Scopus citations

Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X)

Gonzalez, A., Mannen, T., Çağatay, T., Fujiwara, A., Matsumura, H., Niesman, A. B., Brautigam, C. A., Chook, Y. M. & Yoshizawa, T., Dec 2021, In: Scientific reports. 11, 1, 3754.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

Walker, J. S., Hing, Z. A., Harrington, B., Baumhardt, J., Ozer, H. G., Lehman, A., Giacopelli, B., Beaver, L., Williams, K., Skinner, J. N., Cempre, C. B., Sun, Q., Shacham, S., Stromberg, B. R., Summers, M. K., Abruzzo, L. V., Rassenti, L., Kipps, T. J., Parikh, S., Kay, N. E., & 7 othersRogers, K. A., Woyach, J. A., Coppola, V., Chook, Y. M., Oakes, C., Byrd, J. C. & Lapalombella, R., Dec 2021, In: Journal of Hematology and Oncology. 14, 1, 17.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2020

Karyopherins and condensates

Springhower, C. E., Rosen, M. K. & Chook, Y. M., Jun 2020, In: Current Opinion in Cell Biology. 64, p. 112-123 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

32 Scopus citations

Molecular Size Analysis of Recombinant Importin-histone Complexes Using Analytical Ultracentrifugation

Padavannil, A., Brautigam, C. A. & Chook, Y. M., May 10 2020, In: Bio-protocol. 10, 10, e3625.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Nuclear import of histones

Bernardes, N. E. & Chook, Y. M., Dec 2020, In: Biochemical Society Transactions. 48, 6, p. 2753-2767 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

22 Scopus citations

Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

Baumhardt, J. M., Walker, J. S., Lee, Y., Shakya, B., Brautigam, C. A., Lapalombella, R., Grishin, N. & Chook, Y. M., Aug 1 2020, In: Molecular biology of the cell. 31, 17, p. 1879-1891 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2019

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

Padavannil, A., Sarkar, P., Kim, S. J., Cagatay, T., Jiou, J., Brautigam, C. A., Tomchick, D. R., Sali, A., D’Arcy, S. & Chook, Y. M., Mar 2019, In: eLife. 8, e43630.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site

Lee, Y., Pei, J., Baumhardt, J. M., Chook, Y. M. & Grishin, N. V., Dec 1 2019, In: Scientific reports. 9, 1, 6627.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2018

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Pinarbasi, E. S., Caǧatay, T., Fung, H. Y. J., Li, Y. C., Chook, Y. M. & Thomas, P. J., Dec 1 2018, In: Scientific reports. 8, 1, 7083.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

Correlation of CRM1-NES affinity with nuclear export activity

Fu, S. C., Fung, H. Y. J., Caǧatay, T., Baumhardt, J. & Chook, Y. M., Aug 15 2018, In: Molecular biology of the cell. 29, 17, p. 2037-2044 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Günter Blobel 1936-2018

Chook, Y. M., Fontoura, B. M. A. & Rout, M. P., Apr 1 2018, In: Nature structural & molecular biology. 25, 4, p. 297-298 2 p.

Research output: Contribution to journal › Article › peer-review

Karyopherins in cancer

Çağatay, T. & Chook, Y. M., Jun 1 2018, In: Current Opinion in Cell Biology. 52, p. 30-42 13 p.

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Yoshizawa, T., Ali, R., Jiou, J., Fung, H. Y. J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K. & Chook, Y. M., Apr 19 2018, In: Cell. 173, 3, p. 693-705.e22

Research output: Contribution to journal › Article › peer-review

Open Access

218 Scopus citations

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Guo, L., Kim, H. J., Wang, H., Monaghan, J., Freyermuth, F., Sung, J. C., O'Donovan, K., Fare, C. M., Diaz, Z., Singh, N., Zhang, Z. C., Coughlin, M., Sweeny, E. A., DeSantis, M. E., Jackrel, M. E., Rodell, C. B., Burdick, J. A., King, O. D., Gitler, A. D., Lagier-Tourenne, C., & 4 othersPandey, U. B., Chook, Y. M., Taylor, J. P. & Shorter, J., Apr 19 2018, In: Cell. 173, 3, p. 677-692.e20

Research output: Contribution to journal › Article › peer-review

Open Access

319 Scopus citations

Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2017

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

Fung, H. Y. J., Fu, S. C. & Chook, Y. M., Mar 10 2017, In: eLife. 6, e23961.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

2016

Importin 8 mediates m⁷G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

Volpon, L., Culjkovic-Kraljacic, B., Osborne, M. J., Ramteke, A., Sun, Q., Niesman, A., Chook, Y. M. & Borden, K. L. B., May 10 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 19, p. 5263-5268 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif

Soniat, M. & Chook, Y. M., Oct 4 2016, In: Structure. 24, 10, p. 1802-1809 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

Hing, Z. A., Fung, H. Y. J., Ranganathan, P., Mitchell, S., El-Gamal, D., Woyach, J. A., Williams, K., Goettl, V. M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A. M., Lucas, D. M., Baloglu, E., Shacham, S., Kauffman, M. G., Byrd, J. C., Chook, Y. M., & 2 othersGarzon, R. & Lapalombella, R., Dec 1 2016, In: Leukemia. 30, 12, p. 2364-2372 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Recognition elements in the histone H3 and H4 tails for seven different importins

Soniat, M., Caǧatay, T. & Chook, Y. M., Sep 30 2016, In: Journal of Biological Chemistry. 291, 40, p. 21171-21183 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2015

LocNES: A computational tool for locating classical NESs in CRM1 cargo proteins

Xu, D., Marquis, K., Pei, J., Fu, S. C., Caʇatay, T., Grishin, N. V. & Chook, Y. M., May 1 2015, In: Bioinformatics. 31, 9, p. 1357-1365 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

102 Scopus citations

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Haines, J. D., Herbin, O., De La Hera, B., Vidaurre, O. G., Moy, G. A., Sun, Q., Fung, H. Y. J., Albrecht, S., Alexandropoulos, K., McCauley, D., Chook, Y. M., Kuhlmann, T., Kidd, G. J., Shacham, S. & Casaccia, P., Apr 28 2015, In: Nature neuroscience. 18, 4, p. 511-520 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

Nuclear localization signals for four distinct Karyopherin-β nuclear import systems

Soniat, M. & Chook, Y. M., Jun 15 2015, In: Biochemical Journal. 468, 3, p. 353-362 10 p.

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

Fung, H. Y. J., Fu, S. C., Brautigam, C. A. & Chook, Y. M., Sep 8 2015, In: eLife. 4, September 2015, e10034.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

2014

Atomic basis of CRM1-cargo recognition, release and inhibition

Fung, H. Y. J. & Chook, Y. M., Aug 2014, In: Seminars in Cancer Biology. 27, p. 52-61 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

115 Scopus citations

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration

Bernis, C., Swift-Taylor, B., Nord, M., Carmona, S., Chook, Y. M. & Forbes, D. J., Apr 1 2014, In: Molecular biology of the cell. 25, 7, p. 992-1009 18 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2013

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Etchin, J., Sun, Q., Kentsis, A., Farmer, A., Zhang, Z. C., Sanda, T., Mansour, M. R., Barcelo, C., McCauley, D., Kauffman, M., Shacham, S., Christie, A. L., Kung, A. L., Rodig, S. J., Chook, Y. M. & Look, A. T., Jan 2013, In: Leukemia. 27, 1, p. 66-74 9 p.

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2

Soniat, M., Sampathkumar, P., Collett, G., Gizzi, A. S., Banu, R. N., Bhosle, R. C., Chamala, S., Chowdhury, S., Fiser, A., Glenn, A. S., Hammonds, J., Hillerich, B., Khafizov, K., Love, J. D., Matikainen, B., Seidel, R. D., Toro, R., Rajesh Kumar, P., Bonanno, J. B., Chook, Y. M., & 1 othersAlmo, S. C., Jun 2013, In: Journal of Structural and Functional Genomics. 14, 2, p. 31-35 5 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

Sun, Q., Carrasco, Y. P., Hu, Y., Guo, X., Mirzaei, H., MacMillan, J. & Chook, Y. M., Jan 22 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1303-1308 6 p.

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

2012

NESdb: A database of NES-containing CRM1 cargoes

Xu, D., Grishin, N. V. & Chook, Y. M., Sep 15 2012, In: Molecular biology of the cell. 23, 18, p. 3673-3676 4 p.

Research output: Contribution to journal › Review article › peer-review

133 Scopus citations

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Lapalombella, R., Sun, Q., Williams, K., Tangeman, L., Jha, S., Zhong, Y., Goettl, V., Mahoney, E., Berglund, C., Gupta, S., Farmer, A., Mani, R., Johnson, A. J., Lucas, D., Mo, X., Daelemans, D., Sandanayaka, V., Shechter, S., McCauley, D., Shacham, S., & 3 othersKauffman, M., Chook, Y. M. & Byrd, J. C., Nov 29 2012, In: Blood. 120, 23, p. 4621-4634 14 p.

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Sequence and structural analyses of nuclear export signals in the NESdb database

Xu, D., Farmer, A., Collett, G., Grishin, N. V. & Chook, Y. M., Sep 15 2012, In: Molecular biology of the cell. 23, 18, p. 3677-3693 17 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)

Zhang, Z. C. & Chook, Y. M., Jul 24 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. 12017-12021 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Scopus citations

2011

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

Zhang, Z. C., Satterly, N., Fontoura, B. M. A. & Chook, Y. M., Dec 1 2011, In: Molecular biology of the cell. 22, 23, p. 4657-4668 12 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Importin-α protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)

Ge, Q., Nakagawa, T., Max Wynn, R., Chook, Y. M., Miller, B. C. & Uyeda, K., Aug 12 2011, In: Journal of Biological Chemistry. 286, 32, p. 28119-28127 9 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Nuclear import by karyopherin-βs: Recognition and inhibition

Chook, Y. M. & Süel, K. E., Sep 2011, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 9, p. 1593-1606 14 p.

Research output: Contribution to journal › Review article › peer-review

310 Scopus citations

2010

Recognition of nuclear targeting signals by Karyopherin-β proteins

Xu, D., Farmer, A. & Chook, Y. M., Dec 2010, In: Current Opinion in Structural Biology. 20, 6, p. 782-790 9 p.

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

2009

Erratum: Structural basis for leucine-rich nuclear export signal recognition by CRM1 (Nature (2009) 458 (1136-1141))

Dong, X., Biswas, A., Süel, K. E., Jackson, L. K., Martinez, R., Gu, H. & Chook, Y. M., Sep 24 2009, In: Nature. 461, 7263, p. 550 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus

Süel, K. E. & Chook, Y. M., Jun 5 2009, In: Journal of Biological Chemistry. 284, 23, p. 15416-15424 9 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Structural basis for assembly and disassembly of the CRM1 nuclear export complex

Dong, X., Biswas, A. & Chook, Y. M., May 2009, In: Nature Structural and Molecular Biology. 16, 5, p. 558-560 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Structural basis for leucine-rich nuclear export signal recognition by CRM1

Dong, X., Biswas, A., Süel, K. E., Jackson, L. K., Martinez, R., Gu, H. & Chook, Y. M., Apr 30 2009, In: Nature. 458, 7242, p. 1136-1141 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

264 Scopus citations

Pharmacology - Chook Lab

Research output

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