Pharmacology - Cobb Lab

Research Output

2020

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G., Luo, T., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A. & Mangelsdorf, D. J., Jan 8 2020, In : Science translational medicine. 12, 525, eaay5186.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Functional divergence caused by mutations in an energetic hotspot in ERK2

Taylor, C. A., Cormier, K. W., Keenan, S. E., Earnest, S., Stippec, S., Wichaidit, C., Juang, Y. C., Wang, J., Shvartsman, S. Y., Goldsmith, E. J. & Cobb, M. H., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15514-15523 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Measuring relative insulin secretion using a co-secreted luciferase surrogate

Kalwat, M. & Cobb, M. H., Jun 1 2019, In : Journal of Visualized Experiments. 2019, 148, e59926.

Research output: Contribution to journalArticle

Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

Wang, X. D., Hu, R., Ding, Q., Savage, T. K., Huffman, K. E., Williams, N. S., Cobb, M. H., Minna, J. D., Johnson, J. E. & Yu, Y., Dec 1 2019, In : Nature communications. 10, 1, 3201.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/ Km) of CK1α

Shen, C., Li, B., Astudillo, L., Deutscher, M. P., Cobb, M. H., Capobianco, A. J., Lee, E. & Robbins, D. J., Dec 24 2019, In : Biochemistry. 58, 51, p. 5102-5106 5 p.

Research output: Contribution to journalArticle

2018

Chromomycin A2 potently inhibits glucosestimulated insulin secretion from pancreatic β cells

Kalwat, M. A., Hwang, I. H., Macho, J., Grzemska, M. G., Yang, J. Z., McGlynn, K., MacMillan, J. B. & Cobb, M. H., Dec 1 2018, In : Journal of General Physiology. 150, 12, p. 1747-1757 11 p.

Research output: Contribution to journalArticle

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization

Thorne, C. A., Chen, I. W., Sanman, L. E., Cobb, M. H., Wu, L. F. & Altschuler, S. J., Mar 12 2018, In : Developmental Cell. 44, 5, p. 624-633.e4

Research output: Contribution to journalArticle

27 Scopus citations

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant

Taylor, C. A., An, S. W., Kankanamalage, S. G., Stippec, S., Earnest, S., Trivedi, A. T., Yang, J. Z., Mirzaei, H., Huang, C. L. & Cobb, M. H., Jan 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3840-3845 6 p.

Research output: Contribution to journalArticle

Pulling a MAST1 on Cisplatin Resistance

Jaykumar, A. B., Karra, A. S. & Cobb, M. H., Aug 13 2018, In : Cancer Cell. 34, 2, p. 183-185 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M. D., Girard, L., Gazdar, A. F., Minna, J. D., Johnson, J. E. & Cobb, M. H., Apr 1 2018, In : Translational Oncology. 11, 2, p. 292-299 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

Gallolu Kankanamalage, S., Karra, A. S. & Cobb, M. H., Nov 3 2018, In : Cell Communication and Signaling. 16, 1, 72.

Research output: Contribution to journalReview article

7 Scopus citations
2017

Assaying protein kinase activity with radiolabeled ATP

Karra, A. S., Stippec, S. & Cobb, M. H., May 26 2017, In : Journal of Visualized Experiments. 2017, 123, e55504.

Research output: Contribution to journalArticle

4 Scopus citations

Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors

Li, B., Orton, D., Neitzel, L. R., Astudillo, L., Shen, C., Long, J., Chen, X., Kirkbride, K. C., Doundoulakis, T., Guerra, M. L., Zaias, J., Fei, D. L., Rodriguez-Blanco, J., Thorne, C., Wang, Z., Jin, K., Nguyen, D. M., Sands, L. R., Marchetti, F., Abreu, M. T. & 4 others, Cobb, M. H., Capobianco, A. J., Lee, E. & Robbin, D. J., Jun 27 2017, In : Science Signaling. 10, 485, aak9916.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanisms of the amplifying pathway of insulin secretion in the β cell

Kalwat, M. A. & Cobb, M. H., 2017, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

18 Scopus citations

Sucralose activates an ERK1/2–ribosomal protein S6 signaling axis

Guerra, M. L., Kalwat, M. A., McGlynn, K. & Cobb, M. H., Feb 1 2017, In : FEBS Open Bio. 7, 2, p. 174-186 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

WNK1 is an unexpected autophagy inhibitor

Gallolu Kankanamalage, S., Lee, A. Y., Wichaidit, C., Lorente-Rodriguez, A., Shah, A. M., Stippec, S., Whitehurst, A. W. & Cobb, M. H., Mar 9 2017, (Accepted/In press) In : Autophagy. p. 1-2 2 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Amino acids regulate mTORC1 by an obligate two-step mechanism

Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 22414-22426 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In : Cell Reports. 16, 5, p. 1259-1272 14 p.

Research output: Contribution to journalArticle

85 Scopus citations

Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils

Zhang, E. R., Liu, S., Wu, L. F., Altschuler, S. J. & Cobb, M. H., Dec 13 2016, In : Science Signaling. 9, 458, ra122.

Research output: Contribution to journalArticle

10 Scopus citations

Hypertension: The missing WNKs

Dbouk, H. A., Huang, C. L. & Cobb, M. H., Jul 1 2016, In : American Journal of Physiology - Renal Physiology. 311, 1, p. F16-F27

Research output: Contribution to journalReview article

7 Scopus citations

Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways

Kalwat, M. A., Wichaidit, C., Nava Garcia, A. Y., McCoy, M. K., McGlynn, K., Hwang, I. H., Macmillan, J. B., Posner, B. A. & Cobb, M. H., 2016, In : ACS Sensors. 1, 10, p. 1208-1212 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells

Kalwat, M. A., Huang, Z., Wichaidit, C., McGlynn, K., Earnest, S., Savoia, C., Dioum, E. M., Schneider, J. W., Hutchison, M. R. & Cobb, M. H., Apr 15 2016, In : ACS Chemical Biology. 11, 4, p. 1128-1136 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Multistep regulation of autophagy by WNK1

Kankanamalage, S. G., Lee, A. Y., Wichaidit, C., Lorente-Rodriguez, A., Shah, A. M., Stippec, S., Whitehurst, A. W. & Cobb, M. H., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14342-14347 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding

McReynolds, A. C., Karra, A. S., Li, Y., Lopez, E. D., Turjanski, A. G., Dioum, E., Lorenz, K., Zaganjor, E., Stippec, S., McGlynn, K., Earnest, S. & Cobb, M. H., Mar 29 2016, In : Biochemistry. 55, 12, p. 1909-1917 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II

Barry, D. M., Koo, Y., Norden, P. R., Wylie, L. A., Xu, K., Wichaidit, C., Azizoglu, D. B., Zheng, Y., Cobb, M. H., Davis, G. E. & Cleaver, O., Sep 16 2016, In : Circulation Research. 119, 7, p. 810-826 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

Small cell lung cancer: Can recent advances in biology and molecular biology be translated into improved outcomes?

Bunn, P. A., Minna, J. D., Augustyn, A., Gazdar, A. F., Ouadah, Y., Krasnow, M. A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P. P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J. T., Byers, L. A., Wynes, M. W., McFadden, D. G., MacPherson, D., Hann, C. L. & 34 others, Farago, A. F., Dive, C., Teicher, B. A., Peacock, C. D., Johnson, J. E., Cobb, M. H., Wendel, H. G., Spigel, D., Sage, J., Yang, P., Pietanza, M. C., Krug, L. M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C. L., Park, K., Einhorn, L. H., Edelman, M. J., Giaccone, G., Gerber, D. E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D. R., Slotman, B. J., Blackhall, F., Goss, G., Thomas, R., Rudin, C. M. & Hirsch, F. R., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 4, p. 453-474 22 p.

Research output: Contribution to journalReview article

76 Scopus citations
2015

A Kinase Divided

Karra, A. S., Taylor, C. A., Thorne, C. A. & Cobb, M. H., Aug 10 2015, In : Cancer Cell. 28, 2, p. 145-147 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

Taylor, C. A., Juang, Y. C., Earnest, S., Sengupta, S., Goldsmith, E. J. & Cobb, M. H., Jul 24 2015, In : Biochemistry. 54, 32, p. 5063-5071 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014
22 Scopus citations

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E. & Minna, J. D., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

Research output: Contribution to journalArticle

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E., Minna, J. D. & Vogt, P. K., Oct 14 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

Research output: Contribution to journalArticle

Open Access
93 Scopus citations

Chloride sensing by WNK1 involves inhibition of autophosphorylation

Piala, A. T., Moon, T. M., Akella, R., He, H., Cobb, M. H. & Goldsmith, E. J., May 6 2014, In : Science Signaling. 7, 324, ra41.

Research output: Contribution to journalArticle

141 Scopus citations

ERK5 signaling gets XIAPed: A role for ubiquitin in the disassembly of a MAPK cascade

Klein, A. M. & Cobb, M. H., Aug 18 2014, In : EMBO Journal. 33, 16, p. 1735-1736 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

G protein-coupled receptors and the regulation of autophagy

Wauson, E. M., Dbouk, H. A., Ghosh, A. B. & Cobb, M. H., May 2014, In : Trends in Endocrinology and Metabolism. 25, 5, p. 274-282 9 p.

Research output: Contribution to journalReview article

26 Scopus citations

Menin determines K-RAS proliferative outputs in endocrine cells

Chamberlain, C. E., Scheel, D. W., McGlynn, K., Kim, H., Miyatsuka, T., Wang, J., Nguyen, V., Zhao, S., Mavropoulos, A., Abraham, A. G., O'Neill, E., Ku, G. M., Cobb, M. H., Martin, G. R. & German, M. S., Sep 2 2014, In : Journal of Clinical Investigation. 124, 9, p. 4093-4101 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling

Guerra, M. L., Wauson, E. M., McGlynn, K. & Cobb, M. H., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14370-14379 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas

Osborne, J. K., Guerra, M. L., Gonzales, J. X., McMillan, E. A., Minna, J. D. & Cobb, M. H., Jun 1 2014, In : Molecular biology of the cell. 25, 11, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells

Zaganjor, E., Osborne, J. K., Weil, L. M., Diaz-Martinez, L. A., Gonzales, J. X., Singel, S. M., Larsen, J. E., Girard, L., Minna, J. D. & Cobb, M. H., Nov 20 2014, In : Oncogene. 33, 47, p. 5457-5466 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Ras transformation uncouples the kinesin-coordinated cellular nutrient response

Zaganjor, E., Weil, L. M., Gonzales, J. X., Minna, J. D. & Cobb, M. H., Jul 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 29, p. 10568-10573 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3

Wauson, E. M., Zaganjor, E. & Cobb, M. H., Mar 2013, In : Autophagy. 9, 3, p. 418-419 2 p.

Research output: Contribution to journalArticle

21 Scopus citations

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells

Kalwat, M. A., Yoder, S. M., Wang, Z. & Thurmond, D. C., Mar 15 2013, In : Biochemical Pharmacology. 85, 6, p. 808-816 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Chromatin-tethered MAPKs

Klein, A. M., Zaganjor, E. & Cobb, M. H., 2013, In : Current Opinion in Cell Biology. 25, 2, p. 272-277 6 p.

Research output: Contribution to journalReview article

23 Scopus citations

Minireview: Nutrient sensing by G protein-coupled receptors

Wauson, E. M., Lorente-Rodríguez, A. & Cobb, M. H., Aug 1 2013, In : Molecular Endocrinology. 27, 8, p. 1188-1197 10 p.

Research output: Contribution to journalReview article

46 Scopus citations

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM

Osborne, J. K., Larsen, J. E., Shields, M. D., Gonzales, J. X., Shames, D. S., Sato, M., Kulkarni, A., Wistuba, I. I., Girard, L., Minna, J. D. & Cobb, M. H., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6524-6529 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition

Osborne, J. K., Larsen, J. E., Gonzales, J. X., Shames, D. S., Sato, M., Wistuba, I. I., Girard, L., Minna, J. D. & Cobb, M. H., Sep 3 2013, In : Oncogenesis. 2, e63.

Research output: Contribution to journalArticle

9 Scopus citations

Off-target effects of MEK inhibitors

Wauson, E. M., Guerra, M. L., Barylko, B., Albanesi, J. P. & Cobb, M. H., Aug 6 2013, In : Biochemistry. 52, 31, p. 5164-5166 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals

Sengupta, S., Lorente-Rodriguez, A., Earnest, S., Stippec, S., Guo, X., Trudgian, D. C., Mirzaei, H. & Cobb, M. H., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 18826-18831 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells

Kalwat, M. A. & Thurmond, D. C., Aug 16 2013, In : Experimental and Molecular Medicine. 45, 8, e37.

Research output: Contribution to journalReview article

Open Access
56 Scopus citations
2012

Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity

Ramalingam, L., Oh, E., Yoder, S. M., Brozinick, J. T., Kalwat, M. A., Groffen, A. J., Verhage, M. & Thurmond, D. C., Oct 1 2012, In : Diabetes. 61, 10, p. 2424-2432 9 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations