Pharmacology - Cobb Lab

Research output

Research output per year 1976 1981 1992 1994 1997 1998 1999 2000 2001 2002 2004 2006 2007 2009 2014 2016 2024

• 253 Article
• 27 Review article
• 8 Comment/debate
• 7 Short survey
• 2 More
  • 1 Conference contribution
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Mimicking Protein Kinase C Phosphorylation Inhibits Arc/Arg3.1 Palmitoylation and Its Interaction with Nucleic Acids

  Barylko, B., Taylor, C. A., Wang, J., Earnest, S., Stippec, S., Binns, D. D., Brautigam, C. A., Jameson, D. M., DeMartino, G. N., Cobb, M. H. & Albanesi, J. P., Jan 2024, In: International journal of molecular sciences. 25, 2, 780.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Palmitoylation 100%
  • Phosphorylation 98%
  • Nucleic acids 89%
  • Lipoylation 87%
  • phosphorylation 85%
• 2023

  Crank up the volume: Osmotic stress induces WNK1 phase separation

  Jung, J. U., Taylor, C. A. & Cobb, M. H., Apr 2023, In: Cell Research. 33, 4, p. 265-266 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  1 Scopus citations

• ERK2 Mutations Affect Interactions, Localization, and Dimerization

  Taylor, C. A., Cormier, K. W., Martin-Vega, A., Earnest, S., Stippec, S., Wichaidit, C. & Cobb, M. H., May 2 2023, In: Biochemistry. 62, 9, p. 1433-1442 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimerization 100%
  • Mutation 74%
  • Aspartic Acid 61%
  • Developmental 53%
  • Dual-Specificity Phosphatases 45%
  2 Scopus citations

• Small molecule glucagon release inhibitors with activity in human islets

  Kalwat, M. A., Rodrigues-dos-Santos, K., Binns, D. D., Wei, S., Zhou, A., Evans, M. R., Posner, B. A., Roth, M. G. & Cobb, M. H., 2023, In: Frontiers in Endocrinology. 14, 1114799.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucagon 100%
  • Human Activities 96%
  • Islets of Langerhans 64%
  • Type 1 Diabetes Mellitus 42%
  • Rodentia 39%
• 2022

  CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling

  Taylor IV, C. A. & Cobb, M. H., Apr 1 2022, In: Molecular Pharmacology. 101, 4, p. 201-212 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Protein Interaction Domains and Motifs 100%
  • Phosphotransferases 53%
  • Proline 41%
  • Alanine 40%
  • Oxidative Stress 28%
  3 Scopus citations

• Nuclear speckle integrity and function require TAO2 kinase

  Gao, S., Esparza, M., Dehghan, I., Aksenova, V., Zhang, K., Batten, K., Ferretti, M. B., Begg, B. E., Cagatay, T., Shay, J. W., Garcıa-Sastre, A., Goldsmith, E. J., Chen, Z. J., Dasso, M., Lynch, K. W., Cobb, M. H. & Fontoura, B. M. A., Jun 21 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 25, e2206046119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphotransferases 100%
  • Messenger RNA 73%
  • RNA Splicing 69%
  • Cell Nucleus Active Transport 60%
  • Viral Proteins 54%
  2 Scopus citations

• Rare pathogenic variants in WNK3 cause X-linked intellectual disability

  Küry, S., Zhang, J., Besnard, T., Caro-Llopis, A., Zeng, X., Robert, S. M., Josiah, S. S., Kiziltug, E., Denommé-Pichon, A. S., Cogné, B., Kundishora, A. J., Hao, L. T., Li, H., Stevenson, R. E., Louie, R. J., Deb, W., Torti, E., Vignard, V., McWalter, K., Raymond, F. L., & 60 othersRajabi, F., Ranza, E., Grozeva, D., Coury, S. A., Blanc, X., Brischoux-Boucher, E., Keren, B., Õunap, K., Reinson, K., Ilves, P., Wentzensen, I. M., Barr, E. E., Guihard, S. H., Charles, P., Seaby, E. G., Monaghan, K. G., Rio, M., van Bever, Y., van Slegtenhorst, M., Chung, W. K., Wilson, A., Quinquis, D., Bréhéret, F., Retterer, K., Lindenbaum, P., Scalais, E., Rhodes, L., Stouffs, K., Pereira, E. M., Berger, S. M., Milla, S. S., Jaykumar, A. B., Cobb, M. H., Panchagnula, S., Duy, P. Q., Vincent, M., Mercier, S., Gilbert-Dussardier, B., Le Guillou, X., Audebert-Bellanger, S., Odent, S., Schmitt, S., Boisseau, P., Bonneau, D., Toutain, A., Colin, E., Pasquier, L., Redon, R., Bouman, A., Rosenfeld, J. A., Friez, M. J., Pérez-Peña, H., Akhtar Rizvi, S. R., Haider, S., Antonarakis, S. E., Schwartz, C. E., Martínez, F., Bézieau, S., Kahle, K. T. & Isidor, B., Sep 2022, In: Genetics in Medicine. 24, 9, p. 1941-1951 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intellectual Disability 100%
  • Prieto X-linked mental retardation syndrome 86%
  • Chlorides 75%
  • Epilepsy 59%
  • potassium-chloride symporters 56%
  5 Scopus citations

• Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function

  Rodrigues-Dos-Santos, K., Roy, G., Binns, D. D., Grzemska, M. G., Barella, L. F., Armoo, F., McCoy, M. K., Huynh, A. V., Yang, J. Z., Posner, B. A., Cobb, M. H. & Kalwat, M. A., Jul 1 2022, In: Endocrinology. 163, 7, bqac081.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endoplasmic Reticulum Stress 100%
  • Insulin 61%
  • Calcium Channels 48%
  • Calcium 30%
  • Islets of Langerhans 30%
  1 Scopus citations

• UBR5 is a novel regulator of WNK1 stability

  Jung, J. U., Ghosh, A., Earnest, S., Deaton, S. L. & Cobb, M. H., Jun 2022, In: American Journal of Physiology - Cell Physiology. 322, 6, p. C1176-C1186

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteolysis 100%
  • Protein Stability 62%
  • Ubiquitin-Protein Ligases 60%
  • Proteasome Endopeptidase Complex 55%
  • Proteins 48%
  1 Scopus citations

• WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis

  Jaykumar, A. B., Plumber, S., Barry, D. M., Binns, D., Wichaidit, C., Grzemska, M., Earnest, S., Goldsmith, E. J., Cleaver, O. & Cobb, M. H., Jul 26 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 30, e2203743119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intercellular Junctions 100%
  • Tight Junctions 94%
  • Phosphotransferases 65%
  • Endothelial Cells 62%
  • Occludin 54%
  7 Scopus citations

• WNK1 in Malignant Behaviors: A Potential Target for Cancer?

  Jung, J. U., Jaykumar, A. B. & Cobb, M. H., Jun 22 2022, In: Frontiers in Cell and Developmental Biology. 10, 935318.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neoplasms 100%
  • Osmoregulation 89%
  • Symporters 84%
  • Protein Kinases 57%
  • Ions 51%
  2 Scopus citations
• 2021

  Beth Levine M.D. Prize in Autophagy Research

  Vitetta, E. S., Cobb, M. H., Hobbs, H. H., Hooper, L., Morrison, S. J., Orth, K., Pfeiffer, J., Rosen, M. K., Takahashi, J. S. & Wang, T., 2021, In: Autophagy. 17, 9, p. 2053 1 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Cholesterol Regulates the Tumor Adaptive Resistance to MAPK Pathway Inhibition

  Wang, X. D., Kim, C., Zhang, Y., Rindhe, S., Cobb, M. H. & Yu, Y., Dec 3 2021, In: Journal of Proteome Research. 20, 12, p. 5379-5391 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pathway Inhibitor 100%
  • Cholesterol 72%
  • Resistance 50%
  • Mutation 34%
  • Anticholesteremic Agent 30%
  4 Scopus citations

• Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase

  Liu, Z., Yoon, J., Wichaidit, C., Jaykumar, A. B., Dbouk, H. A., Embry, A. E., Liu, L., Henderson, J. M., Chang, A. N., Cobb, M. H. & Miller, R. T., Feb 2 2021, In: Frontiers in Cell and Developmental Biology. 8, 618898.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Podocytes 100%
  • Elasticity 92%
  • Capillaries 79%
  • Phosphotransferases 63%
  • Calcineurin Inhibitors 36%
  7 Scopus citations

• The Pancreatic β-cell Response to Secretory Demands and Adaption to Stress

  Kalwat, M. A., Scheuner, D., Rodrigues-Dos-Santos, K., Eizirik, D. L. & Cobb, M. H., Nov 1 2021, In: Endocrinology. 162, 11, bqab173.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Insulin 100%
  • Unfolded Protein Response 91%
  • Protein Biosynthesis 39%
  • Metabolic Networks and Pathways 36%
  • Insulin Secretion 36%
  14 Scopus citations

• WNK1 Enhances Migration and Invasion in Breast Cancer Models

  Jaykumar, A. B., Jung, J. U., Parida, P. K., Dang, T. T., Wichaidit, C., Kannangara, A. R., Earnest, S., Goldsmith, E. J., Pearson, G. W., Malladi, S. & Cobb, M. H., Oct 1 2021, In: Molecular Cancer Therapeutics. 20, 10, p. 1800-1808 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Breast Neoplasms 100%
  • Neoplasm Metastasis 80%
  • Lysine 25%
  • Neoplasms 25%
  • Protein Kinases 24%
  18 Scopus citations
• 2020

  Erratum: Amino acids regulate mTORC1 by an obligate two-step mechanism (J. Biol. Chem. (2016) 291 (22414-22426) DOI: 10.1074/jbc.M116.732511)

  Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Jun 26 2020, In: Journal of Biological Chemistry. 295, 26, p. 8868 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Names 75%
  • Error 59%
  • Amino Acids 55%
  • Acid 27%

• Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

  Hernandez, G., Luo, T., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A. & Mangelsdorf, D. J., Jan 8 2020, In: Science translational medicine. 12, 525, eaay5186.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fibroblast growth factor 21 100%
  • Pancreatitis 66%
  • Exocrine Pancreas 22%
  • Acinar Cells 20%
  • Pancreas 14%
  28 Scopus citations

• α₂-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling

  Kalwat, M. A., Huang, Z., Binns, D. D., McGlynn, K. & Cobb, M. H., Oct 15 2020, In: Frontiers in Cell and Developmental Biology. 8, 576396.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • trkB Receptor 100%
  • Adrenergic Agents 69%
  • Epinephrine 66%
  • Protein-Tyrosine Kinases 65%
  • Brain-Derived Neurotrophic Factor 37%
  3 Scopus citations
• 2019

  Functional divergence caused by mutations in an energetic hotspot in ERK2

  Taylor, C. A., Cormier, K. W., Keenan, S. E., Earnest, S., Stippec, S., Wichaidit, C., Juang, Y. C., Wang, J., Shvartsman, S. Y., Goldsmith, E. J. & Cobb, M. H., Jul 30 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15514-15523 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitogen-Activated Protein Kinase 1 100%
  • Mutation 49%
  • Hot Temperature 13%
  • Dual-Specificity Phosphatases 13%
  • Gain of Function Mutation 11%
  20 Scopus citations

• Measuring relative insulin secretion using a co-secreted luciferase surrogate

  Kalwat, M. & Cobb, M. H., Jun 2019, In: Journal of Visualized Experiments. 2019, 148, e59926.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin 100%
  • Assays 86%
  • Insulin Derivative 76%
  • Insulin Secretion 74%
  • Luciferases 69%
  4 Scopus citations

• Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

  Wang, X. D., Hu, R., Ding, Q., Savage, T. K., Huffman, K. E., Williams, N., Cobb, M. H., Minna, J. D., Johnson, J. E. & Yu, Y., Dec 1 2019, In: Nature communications. 10, 1, 3201.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Cells 100%
  • Neuroendocrine Tumors 89%
  • Small Cell Lung Carcinoma 87%
  • tumors 75%
  • cancer 73%
  22 Scopus citations

• The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (k_cat/ K_m) of CK1α

  Shen, C., Li, B., Astudillo, L., Deutscher, M. P., Cobb, M. H., Capobianco, A. J., Lee, E. & Robbins, D. J., Dec 24 2019, In: Biochemistry. 58, 51, p. 5102-5106 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pyrvinium 100%
  • pyrvinium 85%
  • Casein Kinase I 71%
  • Kcat/Km 57%
  • Catenins 14%
  11 Scopus citations
• 2018

  Chromomycin A₂ potently inhibits glucosestimulated insulin secretion from pancreatic β cells

  Kalwat, M. A., Hwang, I. H., Macho, J., Grzemska, M. G., Yang, J. Z., McGlynn, K., MacMillan, J. B. & Cobb, M. H., Dec 1 2018, In: Journal of General Physiology. 150, 12, p. 1747-1757 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chromomycin A2 100%
  • Insulin Secretion 43%
  • Plicamycin 19%
  • Glucose 9%
  • Insulin 8%
  5 Scopus citations

• Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization

  Thorne, C. A., Chen, I. W., Sanman, L. E., Cobb, M. H., Wu, L. F. & Altschuler, S. J., Mar 12 2018, In: Developmental cell. 44, 5, p. 624-633.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intestinal Mucosa 100%
  • Monolayer 70%
  • Growth 47%
  • Proliferative 42%
  • Epithelium 14%
  109 Scopus citations

• OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant

  Taylor, C. A., An, S. W., Kankanamalage, S. G., Stippec, S., Earnest, S., Trivedi, A. T., Yang, J. Z., Mirzaei, H., Huang, C. L. & Cobb, M. H., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3840-3845 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inwardly Rectifying Potassium Channels 100%
  • Oxidative Stress 52%
  • Phosphotransferases 34%
  • Kir2.1 channel 31%
  • Proline 28%
  14 Scopus citations

• Pulling a MAST1 on Cisplatin Resistance

  Jaykumar, A. B., Karra, A. S. & Cobb, M. H., Aug 13 2018, In: Cancer Cell. 34, 2, p. 183-185 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Cisplatin 100%
  • Phosphotransferases 42%
  • Cell Death 42%
  • Neoplasms 17%
  6 Scopus citations

• The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

  He, M., Liu, S., Gallolu Kankanamalage, S., Borromeo, M. D., Girard, L., Gazdar, A. F., Minna, J. D., Johnson, J. E. & Cobb, M. H., Apr 2018, In: Translational Oncology. 11, 2, p. 292-299 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epithelial Sodium Channels 100%
  • Neuroendocrine Tumors 83%
  • Small Cell Lung Carcinoma 81%
  • Lung 39%
  • Lung Neoplasms 38%
  15 Scopus citations

• WNK pathways in cancer signaling networks 06 Biological Sciences 0601 Biochemistry and Cell Biology

  Gallolu Kankanamalage, S., Karra, A. S. & Cobb, M. H., Nov 3 2018, In: Cell Communication and Signaling. 16, 1, 72.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • PAS domain kinases 100%
  • Biological Science Disciplines 67%
  • Oxidative Stress 53%
  • Lysine 50%
  • Biochemistry 49%
  36 Scopus citations
• 2017

  Assaying protein kinase activity with radiolabeled ATP

  Karra, A. S., Stippec, S. & Cobb, M. H., May 26 2017, In: Journal of Visualized Experiments. 2017, 123, e55504.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pharmacologic Agent 100%
  • Adenosinetriphosphate 89%
  • Assays 80%
  • Protein Kinases 63%
  • Proteins 63%
  11 Scopus citations

• Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors

  Li, B., Orton, D., Neitzel, L. R., Astudillo, L., Shen, C., Long, J., Chen, X., Kirkbride, K. C., Doundoulakis, T., Guerra, M. L., Zaias, J., Fei, D. L., Rodriguez-Blanco, J., Thorne, C., Wang, Z., Jin, K., Nguyen, D. M., Sands, L. R., Marchetti, F., Abreu, M. T., & 4 othersCobb, M. H., Capobianco, A. J., Lee, E. & Robbin, D. J., Jun 27 2017, In: Science signaling. 10, 485, aak9916.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl) benzoic acid 100%
  • Pyrvinium 88%
  • Casein Kinases 62%
  • pyrvinium 30%
  • Pharmacology 26%
  28 Scopus citations

• Mechanisms of the amplifying pathway of insulin secretion in the β cell

  Kalwat, M. A. & Cobb, M. H., Nov 2017, In: Pharmacology and Therapeutics. 179, p. 17-30 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Insulin Secretion 100%
  • Metabolic Networks and Pathways 33%
  • Islets of Langerhans 33%
  • Nutrients 28%
  • Calcium 22%
  93 Scopus citations

• Sucralose activates an ERK1/2–ribosomal protein S6 signaling axis

  Guerra, M. L., Kalwat, M. A., McGlynn, K. & Cobb, M. H., Feb 1 2017, In: FEBS Open Bio. 7, 2, p. 174-186 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • trichlorosucrose 100%
  • Sucralose 97%
  • S 6 79%
  • Sweetening Agents 33%
  • Protein 24%
  8 Scopus citations

• WNK1 is an unexpected autophagy inhibitor

  Gallolu Kankanamalage, S., Lee, A. Y., Wichaidit, C., Lorente-Rodriguez, A., Shah, A. M., Stippec, S., Whitehurst, A. W. & Cobb, M. H., May 4 2017, In: Autophagy. 13, 5, p. 969-970 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Autophagy 100%
  • Autophagy-Related Protein-1 Homolog 36%
  • Ultraviolet Rays 32%
  • AMP-Activated Protein Kinases 24%
  • WNK Lysine-Deficient Protein Kinase 1 23%
  31 Scopus citations
• 2016

  Amino acids regulate mTORC1 by an obligate two-step mechanism

  Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Oct 21 2016, In: Journal of Biological Chemistry. 291, 43, p. 22414-22426 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Amino Acids 55%
  • Acid 27%
  • Aminoacylation 12%
  • L-Asparagine 12%
  53 Scopus citations

• ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

  Borromeo, M. D., Savage, T. K., Kollipara, R. K., He, M., Augustyn, A., Osborne, J. K., Girard, L., Minna, J. D., Gazdar, A. F., Cobb, M. H. & Johnson, J. E., Aug 2 2016, In: Cell Reports. 16, 5, p. 1259-1272 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Tumors 100%
  • Small Cell Lung Carcinoma 98%
  • Heterogeneity 81%
  • Oncogenic 61%
  • Lung 47%
  299 Scopus citations

• Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils

  Zhang, E. R., Liu, S., Wu, L. F., Altschuler, S. J. & Cobb, M. H., Dec 13 2016, In: Science signaling. 9, 458, ra122.

  Research output: Contribution to journal › Article › peer-review

  • Chemoattractant 100%
  • methionyl-leucyl-phenylalanine 96%
  • Chemotactic Factors 76%
  • Neutrophils 53%
  • Phosphotransferases 52%
  22 Scopus citations

• Hypertension: The missing WNKs

  Dbouk, H. A., Huang, C. L. & Cobb, M. H., Jul 1 2016, In: American Journal of Physiology - Renal Physiology. 311, 1, p. F16-F27

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Hypertension 100%
  • Blood Pressure 98%
  • Enzymes 56%
  • Ion Channels 50%
  • Cardiovascular System 50%
  19 Scopus citations

• Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways

  Kalwat, M. A., Wichaidit, C., Nava Garcia, A. Y., McCoy, M. K., McGlynn, K., Hwang, I. H., Macmillan, J. B., Posner, B. A. & Cobb, M. H., Oct 28 2016, In: ACS Sensors. 1, 10, p. 1208-1212 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • insulin 100%
  • secretions 96%
  • Insulin 93%
  • Biosensors 85%
  • Assays 81%
  32 Scopus citations

• Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells

  Kalwat, M. A., Huang, Z., Wichaidit, C., McGlynn, K., Earnest, S., Savoia, C., Dioum, E. M., Schneider, J. W., Hutchison, M. R. & Cobb, M. H., Apr 15 2016, In: ACS chemical biology. 11, 4, p. 1128-1136 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isoxazoles 100%
  • Isoxazole 89%
  • Metabolite 49%
  • Phenotype 41%
  • Gene Expression 41%
  28 Scopus citations

• Multistep regulation of autophagy by WNK1

  Kankanamalage, S. G., Lee, A. Y., Wichaidit, C., Lorente-Rodriguez, A., Shah, A. M., Stippec, S., Whitehurst, A. W. & Cobb, M. H., Dec 13 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14342-14347 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Autophagy 100%
  • Phosphotransferases 80%
  • Autophagy-Related Protein-1 Homolog 72%
  • Starvation 45%
  • Ultraviolet Rays 42%
  36 Scopus citations

• Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding

  McReynolds, A. C., Karra, A. S., Li, Y., Lopez, E. D., Turjanski, A. G., Dioum, E., Lorenz, K., Zaganjor, E., Stippec, S., McGlynn, K., Earnest, S. & Cobb, M. H., Mar 29 2016, In: Biochemistry. 55, 12, p. 1909-1917 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oligonucleotides 100%
  • Oligonucleotide 84%
  • Mutation 81%
  • Phosphorylation 66%
  • Threonine 43%
  11 Scopus citations

• Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II

  Barry, D. M., Koo, Y., Norden, P. R., Wylie, L. A., Xu, K., Wichaidit, C., Azizoglu, D. B., Zheng, Y., Cobb, M. H., Davis, G. E. & Cleaver, O., Sep 16 2016, In: Circulation research. 119, 7, p. 810-826 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myosin Type II 100%
  • ras Proteins 92%
  • rho GTP-Binding Proteins 91%
  • Blood Vessels 42%
  • cdc42 GTP-Binding Protein 35%
  41 Scopus citations

• Small cell lung cancer: Can recent advances in biology and molecular biology be translated into improved outcomes?

  Bunn, P. A., Minna, J. D., Augustyn, A., Gazdar, A. F., Ouadah, Y., Krasnow, M. A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P. P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J. T., Byers, L. A., Wynes, M. W., McFadden, D. G., MacPherson, D., Hann, C. L., & 34 othersFarago, A. F., Dive, C., Teicher, B. A., Peacock, C. D., Johnson, J. E., Cobb, M. H., Wendel, H. G., Spigel, D., Sage, J., Yang, P., Pietanza, M. C., Krug, L. M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C. L., Park, K., Einhorn, L. H., Edelman, M. J., Giaccone, G., Gerber, D. E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D. R., Slotman, B. J., Blackhall, F., Goss, G., Thomas, R., Rudin, C. M. & Hirsch, F. R., 2016, In: Journal of Thoracic Oncology. 11, 4, p. 453-474 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  139 Scopus citations
• 2015

  A Kinase Divided

  Karra, A. S., Taylor, C. A., Thorne, C. A. & Cobb, M. H., Aug 10 2015, In: Cancer Cell. 28, 2, p. 145-147 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Protein Multimerization 100%
  • Dimerization 73%
  • Mitogen-Activated Protein Kinase Kinases 70%
  • Drug Resistance 59%
  • Phosphotransferases 50%
  3 Scopus citations

• Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

  Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In: Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Aminoacylation 43%
  • Amino Acids 41%
  • Nutrients 25%
  • FR900359 20%
  15 Scopus citations

• Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

  Taylor, C. A., Juang, Y. C., Earnest, S., Sengupta, S., Goldsmith, E. J. & Cobb, M. H., Jul 24 2015, In: Biochemistry. 54, 32, p. 5063-5071 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Kinases 100%
  • Phosphotransferases 83%
  • Mutation 45%
  • Protein 44%
  • at-403 41%
  16 Scopus citations
• 2014

  Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK

  Dbouk, H. A., Weil, L. M., Perera, G. K. S., Dellinger, M. T., Pearson, G., Brekken, R. A. & Cobb, M. H., Nov 11 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 45, p. 15999-16004 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proline 100%
  • Alanine 95%
  • Protein Kinases 86%
  • Phosphotransferases 72%
  • Endothelial Cells 69%
  49 Scopus citations

• ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

  Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E. & Minna, J. D., Oct 14 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Oncogenes 100%
  • Lung Neoplasms 83%
  • Non-Small Cell Lung Carcinoma 62%
  • Small Cell Lung Carcinoma 38%
  • Chromatin Immunoprecipitation Sequencing 22%

• ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers

  Augustyn, A., Borromeo, M., Wang, T., Fujimoto, J., Shao, C., Dospoy, P. D., Lee, V., Tan, C., Sullivan, J. P., Larsen, J. E., Girard, L., Behrens, C., Wistuba, I. I., Xie, Y., Cobb, M. H., Gazdar, A. F., Johnson, J. E., Minna, J. D. & Vogt, P. K., Oct 14 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 41, p. 14788-14793 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncogenes 100%
  • Lung Neoplasms 83%
  • Non-Small Cell Lung Carcinoma 62%
  • Small Cell Lung Carcinoma 38%
  • Neuroendocrine Cells 22%
  186 Scopus citations