Pharmacology - Collins Lab – Research output — University of Texas Southwestern Medical Center

2024

Schistosome Infection Impacts Hematopoiesis

Wijshake, T., Rose, J., Wang, J., Zielke, J., Marlar-Pave, M., Chen, W., Collins, J. J. & Agathocleous, M., Feb 1 2024, In: Journal of Immunology. 212, 4, p. 607-616 10 p.

Research output: Contribution to journal › Article › peer-review

2023

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

Caldwell, N., Afshar, R., Baragaña, B., Bustinduy, A. L., Caffrey, C. R., Collins, J. J., Fusco, D., Garba, A., Gardner, M., Gomes, M., Hoffmann, K. F., Hsieh, M., Lo, N. C., McNamara, C. W., Nono, J. K., Padalino, G., Read, K. D., Roestenberg, M., Spangenberg, T., Specht, S., & 1 othersGilbert, I. H., May 12 2023, In: ACS infectious diseases. 9, 5, p. 1046-1055 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2022

A male-derived nonribosomal peptide pheromone controls female schistosome development

Chen, R., Wang, J., Gradinaru, I., Vu, H. S., Geboers, S., Naidoo, J., Ready, J. M., Williams, N. S., DeBerardinis, R. J., Ross, E. M. & Collins, J. J., Apr 28 2022, In: Cell. 185, 9, p. 1506-1520.e17

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Convergent evolution of a genotoxic stress response in a parasite-specific p53 homolog

Wendt, G. R., Shiroor, D. A., Adler, C. E. & Collins, J. J., Sep 13 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 37, e2205201119.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Correction: MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni (PLOS NEGLECTED TROPICAL DISEASES)

Protasio, A. V., Van Dongen, S., Collins, J., Quintais, L., Ribeiro, D. M., Sessler, F., Hunt, M., Rinaldi, G., Collins, J. J., Enright, A. J. & Berriman, M., Jun 2022, In: PLoS neglected tropical diseases. 16, 6, e0010521.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Schistosome Sulfotransferases: Mode of Action, Expression and Localization

Guzman, M. A., Rugel, A., Alwan, S. N., Tarpley, R., Taylor, A. B., Chevalier, F. D., Wendt, G. R., Collins, J. J., Anderson, T. J. C., McHardy, S. F. & Loverde, P. T., Jul 2022, In: Pharmaceutics. 14, 7, 1416.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Single-cell RNA-seq analyses show that long non-coding RNAs are conspicuously expressed in Schistosoma mansoni gamete and tegument progenitor cell populations

Morales-Vicente, D. A., Zhao, L., Silveira, G. O., Tahira, A. C., Amaral, M. S., Collins, J. J. & Verjovski-Almeida, S., Sep 20 2022, In: Frontiers in Genetics. 13, 924877.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

The good, the bad, and the ugly: From planarians to parasites

Rozario, T., Collins, J. J. & Newmark, P. A., Jan 2022, Emerging Model Systems in Developmental Biology. Goldstein, B. & Srivastava, M. (eds.). Academic Press Inc., p. 345-373 29 p. (Current Topics in Developmental Biology; vol. 147).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

2021

Analysis of schistosoma mansoni extracellular vesicles surface glycans reveals potential immune evasion mechanism and new insights on their origins of biogenesis

Dagenais, M., Gerlach, J. Q., Wendt, G. R., Collins, J. J., Atkinson, L. E., Mousley, A., Geary, T. G. & Long, T., Nov 2021, In: Pathogens. 10, 11, 1401.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

SchistoCyte Atlas: A Single-Cell Transcriptome Resource for Adult Schistosomes

Wendt, G. R., Reese, M. L. & Collins, J. J., Jul 2021, In: Trends in Parasitology. 37, 7, p. 585-587 3 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

15 Scopus citations

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function

Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I. W., Fernandez-Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K. F., Mar 2021, In: International Journal for Parasitology. 51, 4, p. 251-261 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3

Romero, A. A., Cobb, S. A., Collins, J. N. R., Kliewer, S. A., Mangelsdorf, D. J. & Collins, J. J., Dec 2021, In: PLoS pathogens. 17, 12, e1010140.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2020

A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding

Wendt, G., Zhao, L., Chen, R., Liu, C., O'Donoghue, A. J., Caffrey, C. R., Reese, M. L. & Collins, J. J., Sep 25 2020, In: Science. 369, 6511, eabb7709.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Labeling of the schistosoma mansoni tegument

Wendt, G. & Collins, J. J., 2020, Methods in Molecular Biology. Humana Press Inc., p. 65-74 10 p. (Methods in Molecular Biology; vol. 2151).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni

Wang, J., Paz, C., Padalino, G., Coghlan, A., Lu, Z., Gradinaru, I., Collins, J. N. R., Berriman, M., Hoffmann, K. F. & Collins, J. J., Sep 25 2020, In: Science. 369, 6511, eabb7699.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

2019

A rotifer-derived paralytic compound prevents transmission of schistosomiasis to a mammalian host

Gao, J., Yang, N., Lewis, F. A., Yau, P., Collins, J. J., Sweedler, J. V. & Newmark, P. A., 2019, In: PLoS biology. 17, 10, e3000485.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni

Wang, J., Chen, R. & Collins, J. J., May 2019, In: PLoS biology. 17, 5, e3000254.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

2018

Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

Wendt, G. R., Collins, J. N., Pei, J., Pearson, M. S., Bennett, H. M., Loukas, A., Berriman, M., Grishin, N. V. & Collins, J. J., Mar 20 2018, In: eLife. 7, e33221.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2017

Methods for studying the germline of the human parasite schistosoma mansoni

Collins, J. N. R. & Collins, J. J., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1463. p. 35-47 13 p. (Methods in Molecular Biology; vol. 1463).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

MiR-277/4989 regulate transcriptional landscape during juvenile to adult transition in the parasitic helminth Schistosoma mansoni

Protasio, A. V., van Dongen, S., Collins, J., Quintais, L., Ribeiro, D. M., Sessler, F., Hunt, M., Rinaldi, G., Collins, J. J., Enright, A. J. & Berriman, M., May 23 2017, In: PLoS neglected tropical diseases. 11, 5, e0005559.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Platyhelminthes

Collins, J. J., Apr 3 2017, In: Current Biology. 27, 7, p. R252-R256

Research output: Contribution to journal › Short survey › peer-review

Open Access

31 Scopus citations

2016

Identification of new markers for the Schistosoma mansoni vitelline lineage

Wang, J. & Collins, J. J., Jun 1 2016, In: International Journal for Parasitology. 46, 7, p. 405-410 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Mass spectrometry imaging and identification of peptides associated with cephalic ganglia regeneration in Schmidtea mediterranea

Ong, T. H., Romanova, E. V., Roberts-Galbraith, R. H., Yang, N., Zimmerman, T. A., Collins, J. J., Lee, J. E., Kelleher, N. L., Newmark, P. A. & Sweedler, J. V., Apr 8 2016, In: Journal of Biological Chemistry. 291, 15, p. 8109-8120 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea

Iyer, H., Collins, J. J. & Newmark, P. A., Jun 2016, In: PLoS genetics. 12, 6, e1006109.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Schistosomiasis as a disease of stem cells

Wendt, G. R. & Collins, J. J., Oct 1 2016, In: Current Opinion in Genetics and Development. 40, p. 95-102 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

25 Scopus citations

Stem cell progeny contribute to the schistosome host-parasite interface

Collins, J. J., Wendt, G. R., Iyer, H. & Newmark, P. A., Mar 22 2016, In: eLife. 5, MARCH2016, e12473.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death In Vivo

Collins, J. N. R. & Collins, J. J., Nov 1 2016, In: PLoS pathogens. 12, 11, e1005963.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2015

Correction to: Genome-Wide Analyses Reveal a Role for Peptide Hormones in Planarian Germline Development(PLoS Biol, (2015), 13,8)

Collins, J. J., Hou, X., Romanova, E. V., Lambrus, B. G., Miller, C. M., Saberi, A., Sweedler, J. V. & Newmark, P. A., Aug 14 2015, In: PLoS biology. 13, 8, e1002234.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

3 Scopus citations

Tryptophan hydroxylase is required for eye melanogenesis in the planarian schmidtea mediterranea

Lambrus, B. G., Cochet-Escartin, O., Gao, J., Newmark, P. A., Collins, E. M. S. & Collins, J. J., May 1 2015, In: PloS one. 10, 5, e0127074.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2014

A lophotrochozoan-specific nuclear hormone receptor is required for reproductive system development in the planarian

Tharp, M. E., Collins, J. J. & Newmark, P. A., Dec 1 2014, In: Developmental Biology. 396, 1, p. 150-157 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2013

Adult somatic stem cells in the human parasite Schistosoma mansoni

Collins, J. J., Wang, B., Lambrus, B. G., Tharp, M. E., Iyer, H. & Newmark, P. A., Feb 28 2013, In: Nature. 494, 7438, p. 476-479 4 p.

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite

Chong, T., Collins, J. J., Brubacher, J. L., Zarkower, D. & Newmark, P. A., 2013, In: Nature communications. 4, 1814.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

Wang, B., Collins, J. J. & Newmark, P. A., Jul 30 2013, In: eLife. 2013, 2, e00768.

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

It's No Fluke: The Planarian as a Model for Understanding Schistosomes

Collins, J. J. & Newmark, P. A., Jul 2013, In: PLoS pathogens. 9, 7, e1003396.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2011

An atlas for schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy

Collins, J. J., King, R. S., Cogswell, A., Williams, D. L. & Newmark, P. A., Mar 2011, PLoS Neglected Tropical Diseases. 3 ed. Vol. 5. e1009

Research output: Chapter in Book/Report/Conference proceeding › Chapter

106 Scopus citations

Whole mount in situ hybridization methodology for Schistosoma mansoni

Cogswell, A. A., Collins, J. J., Newmark, P. A. & Williams, D. L., Jul 2011, In: Molecular and Biochemical Parasitology. 178, 1-2, p. 46-50 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2010

Genome-wide analyses reveal a role for peptide hormones in planarian germline development

Collins, J. J., Hou, X., Romanova, E. V., Lambrus, B. G., Miller, C. M., Saberi, A., Sweedler, J. V. & Newmark, P. A., Oct 2010, In: PLoS biology. 8, 10, e1000509.

Research output: Contribution to journal › Article › peer-review