Pharmacology - Corey Lab

Research Output 1985 2019

2019

CHAPTER 2: Mechanisms of Antisense Oligonucleotides

Liu, Z. & Corey, D. R., Jan 1 2019, Therapies for Retinal Degeneration: Targeting Common Processes. Agrawal, S. & Gait, M. J. (eds.). 68 ed. Royal Society of Chemistry, p. 22-31 10 p. (RSC Drug Discovery Series; vol. 2019-January, no. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

Antisense Oligonucleotides
RNA Cleavage
Ribonuclease H
Alternative Splicing
Protein Biosynthesis
1 Citation (Scopus)

Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs' Endothelial Corneal Dystrophy

Hu, J., Shen, X., Rigo, F., Prakash, T. P., Mootha, V. & Corey, D. R., Apr 1 2019, In : Nucleic Acid Therapeutics. 29, 2, p. 73-81 9 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Antisense Oligonucleotides
RNA Interference
RNA
Eye Diseases

Efficient electroporation of neuronal cells using synthetic oligonucleotides: Identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression

Shen, X., Beasley, S., Putman, J. N., Li, Y., Prakash, T. P., Rigo, F., Napierala, M. & Corey, D. R., Jan 1 2019, In : RNA. 25, 9, p. 1118-1129 12 p.

Research output: Contribution to journalArticle

Open Access
Artificial Cells
Electroporation
Antisense Oligonucleotides
Oligonucleotides
RNA

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs

Gagnon, K. T. & Corey, D. R., Jun 1 2019, In : Nucleic Acid Therapeutics. 29, 3, p. 116-122 7 p.

Research output: Contribution to journalArticle

Open Access
Double-Stranded RNA
Antisense Oligonucleotides
Nucleic Acids
Guidelines
Untranslated RNA
Open Access
Corneal Endothelium
RNA
Endothelial Cells
Fuchs' Endothelial Dystrophy
Nuclear RNA
2018
5 Citations (Scopus)

Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion

Shen, X., Kilikevicius, A., O'Reilly, D., Prakash, T. P., Damha, M. J., Rigo, F. & Corey, D. R., Sep 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 17, p. 2850-2855 6 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Friedreich Ataxia
Inborn Genetic Diseases
Mitochondrial Proteins
RNA
13 Citations (Scopus)

Activation of frataxin protein expression by antisense oligonucleotides targeting the mutant expanded repeat

Li, L., Shen, X., Liu, Z., Norrbom, M., Prakash, T. P., O'Reilly, D., Sharma, V. K., Damha, M. J., Watts, J. K., Rigo, F. & Corey, D. R., Feb 1 2018, In : Nucleic Acid Therapeutics. 28, 1, p. 23-33 11 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Friedreich Ataxia
Chemical activation
Proteins
Chemical modification
104 Citations (Scopus)

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

Shen, X. & Corey, D. R., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1584-1600 17 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
RNA
Oligonucleotides
Nucleic Acids
Clinical Trials

Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics

Stoddard, B. L., Khvorova, A., Corey, D. R., Dynan, W. S. & Fox, K. R., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1563-1564 2 p.

Research output: Contribution to journalEditorial

Nucleic Acids
Research
Therapeutics
10 Citations (Scopus)

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy

Hu, J., Rong, Z., Gong, X., Zhou, Z., Sharma, V. K., Xing, C., Watts, J. K., Corey, D. R. & Mootha, V., Mar 15 2018, In : Human Molecular Genetics. 27, 6, p. 1015-1026 12 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Trinucleotide Repeats
Oligonucleotides
RNA
Antisense Oligonucleotides
1 Citation (Scopus)

The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing

Liu, J., Liu, Z. & Corey, D. R., Sep 4 2018, In : Biochemistry. 57, 35, p. 5247-5256 10 p.

Research output: Contribution to journalArticle

Transcription
Proteins
MicroRNAs
Transcriptional Activation
Chemical activation
2017
15 Citations (Scopus)

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA

Liu, J., Hu, J., Ludlow, A. T., Pham, J. T., Shay, J. W., Rothstein, J. D. & Corey, D. R., Feb 16 2017, In : Cell Chemical Biology. 24, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Chromosomes
Open Reading Frames
RNA
Molecules
9 Citations (Scopus)

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription

Hicks, J. A., Li, L., Matsui, M., Chu, Y., Volkov, O., Johnson, K. C. & Corey, D. R., Aug 15 2017, In : Cell Reports. 20, 7, p. 1543-1552 10 p.

Research output: Contribution to journalArticle

Transcription
RNA
RNA Interference
Transcriptional Activation
Mediator Complex
66 Citations (Scopus)

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy

Corey, D. R., Feb 13 2017, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

Spinal Muscular Atrophy
Antisense Oligonucleotides
Pharmaceutical Preparations
8 Citations (Scopus)

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs

Hu, J., Rigo, F., Prakash, T. P. & Corey, D. R., Apr 1 2017, In : Nucleic Acid Therapeutics. 27, 2, p. 87-94 8 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Chromosomes
RNA Interference
Open Reading Frames
Antisense Oligonucleotides
2 Citations (Scopus)

RNA-mediated gene activation: Identifying a candidate RNA for preclinical development

Corey, D. R., 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 983. p. 161-171 11 p. (Advances in Experimental Medicine and Biology; vol. 983).

Research output: Chapter in Book/Report/Conference proceedingChapter

Transcriptional Activation
Genes
Chemical activation
RNA
Gene Expression
2016
40 Citations (Scopus)

Activating frataxin expression by repeat-targeted nucleic acids

Li, L., Matsui, M. & Corey, D. R., Feb 4 2016, In : Nature Communications. 7, 10606.

Research output: Contribution to journalArticle

nucleic acids
Nucleic Acids
proteins
complementary DNA
ataxia
13 Citations (Scopus)

Argonaute 2-dependent regulation of gene expression by single-stranded miRNA mimics

Matsui, M., Prakash, T. P. & Corey, D. R., May 1 2016, In : Molecular Therapy. 24, 5, p. 946-955 10 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
MicroRNAs
RNA Interference
Gene Silencing
Gene Expression

Doubts about therapy for neurological diseases with antisense oligonucleotides-reply

Corey, D. R., 2016, In : JAMA Neurology. 73, 12, p. 1502-1503 2 p.

Research output: Contribution to journalLetter

Antisense Oligonucleotides
Therapeutics
12 Citations (Scopus)

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Liu, H., Liang, C., Kollipara, R. K., Matsui, M., Ke, X., Jeong, B. C., Wang, Z., Yoo, K. S., Yadav, G. P., Kinch, L. N., Grishin, N. V., Nam, Y., Corey, D. R., Kittler, R. & Liu, Q., Feb 8 2016, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

MicroRNAs
Chromatin
Microcomputers
Histones
Proteins
139 Citations (Scopus)

Non-coding RNAs as drug targets

Matsui, M. & Corey, D. R., Jul 22 2016, (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to journalArticle

Untranslated RNA
RNA
Long Noncoding RNA
Pharmaceutical Preparations
Human Genome
12 Citations (Scopus)

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C: C Mismatches

Dodd, D. W., Tomchick, D. R., Corey, D. R. & Gagnon, K. T., Mar 8 2016, In : Biochemistry. 55, 9, p. 1283-1286 4 p.

Research output: Contribution to journalArticle

Antisense RNA
RNA
Amyotrophic Lateral Sclerosis
Molecular Pathology
Introns
43 Citations (Scopus)

Regulation of mammalian transcription and splicing by Nuclear RNAi

Kalantari, R., Chiang, C. M. & Corey, D. R., Jan 29 2016, In : Nucleic Acids Research. 44, 2, p. 524-537 14 p.

Research output: Contribution to journalArticle

Nuclear RNA
RNA Interference
Cell Nucleus
Ribonucleoproteins
Protein Biosynthesis
8 Citations (Scopus)

Synthetic nucleic acids and treatment of neurological diseases

Corey, D. R., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1238-1242 5 p.

Research output: Contribution to journalReview article

Antisense Oligonucleotides
Nucleic Acids
Mutant Proteins
Friedreich Ataxia
Gene Expression
2015
32 Citations (Scopus)

Design and bioinformatics analysis of genome-wide CLIP experiments

Wang, T., Xiao, G., Chu, Y., Zhang, M. Q., Corey, D. R. & Xie, Y., Apr 23 2015, In : Nucleic Acids Research. 43, 11, p. 5263-5274 12 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Computational Biology
Genome
RNA
Technology
10 Citations (Scopus)

Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus

Hu, J., Liu, J., Li, L., Gagnon, K. T. & Corey, D. R., Nov 19 2015, In : Chemistry and Biology. 22, 11, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

RNA
RNA Interference
Frontotemporal Dementia
Genes
Cells

Identification and validation of miRNA target sites within nontraditional miRNA targets

Younger, S. T. & Corey, D. R., 2015, In : Methods in Molecular Biology. 1206, p. 53-67 15 p.

Research output: Contribution to journalArticle

MicroRNAs
RNA
Gene Expression
Complementary RNA
Messenger RNA
7 Citations (Scopus)

Intramolecular circularization increases efficiency of RNA sequencing and enables CLIP-Seq of nuclear RNA from human cells

Chu, Y., Wang, T., Dodd, D., Xie, Y., Janowski, B. A. & Corey, D. R., Jun 23 2015, In : Nucleic Acids Research. 43, 11, p. e75

Research output: Contribution to journalArticle

RNA Sequence Analysis
Nuclear RNA
Immunoprecipitation
RNA
Libraries
7 Citations (Scopus)

Modulation of Splicing by Single-Stranded Silencing RNAs

Liu, J., Hu, J., Hicks, J. A., Prakash, T. P. & Corey, D. R., Jun 1 2015, In : Nucleic Acid Therapeutics. 25, 3, p. 113-120 8 p.

Research output: Contribution to journalArticle

RNA Interference
Modulation
RNA
Oligonucleotides
Protein Isoforms
12 Citations (Scopus)

Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors

Matsui, M., Li, L., Janowski, B. A. & Corey, D. R., Aug 5 2015, In : Scientific Reports. 5, 12855.

Research output: Contribution to journalArticle

RNA Interference
Cell Nucleus
Small Interfering RNA
Cytoplasm
RNA
3 Citations (Scopus)

Stepping toward therapeutic CRISPR

Gagnon, K. T. & Corey, D. R., Dec 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 51, p. 15536-15537 2 p.

Research output: Contribution to journalArticle

2014
17 Citations (Scopus)

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs

Hu, J., Liu, J., Narayanannair, K. J., Lackey, J. G., Kuchimanchi, S., Rajeev, K. G., Manoharan, M., Swayze, E. E., Lima, W. F., Prakash, T. P., Xiang, Q., Martinez, C. & Corey, D. R., Jul 22 2014, In : Biochemistry. 53, 28, p. 4510-4518 9 p.

Research output: Contribution to journalArticle

Alleles
Progressive Myoclonic Epilepsy
Trinucleotide Repeats
Genes
Proteins
57 Citations (Scopus)

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading

Gagnon, K. T., Li, L., Janowski, B. A. & Corey, D. R., 2014, In : Nature Protocols. 9, 9, p. 2045-2060 16 p.

Research output: Contribution to journalArticle

Cell Fractionation
Nuclear RNA
Fractionation
RNA Interference
Cells
1 Citation (Scopus)

Breakthrough articles: Putting science first

Corey, D. R., Wise, J. A., Fox, K. R. & Stoddard, B. L., Sep 12 2014, In : Nucleic Acids Research. 42, 18, p. 11273-11274 2 p.

Research output: Contribution to journalArticle

Journal Impact Factor
Peer Review
Research
1 Citation (Scopus)

Effect of 2'-O-methyl/thiophosphonoacetate-modified antisense oligonucleotides on huntingtin expression in patient-derived cells

Matsui, M., Threlfall, R. N., Caruthers, M. H. & Corey, D. R., Dec 15 2014, In : Artificial DNA, PNA & XNA. 5, 3, p. e1146391

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Oligonucleotides
Oligoribonucleotides
Chemical modification
Oligomers
12 Citations (Scopus)

Exploring the effect of sequence length and composition on allele-selective inhibition of human huntingtin expression by single-stranded silencing RNAs

Hu, J., Liu, J., Yu, D., Aiba, Y., Lee, S., Pendergraff, H., Boubaker, J., Artates, J. W., Lagier-Tourenne, C., Lima, W. F., Swayze, E. E., Prakash, T. P. & Corey, D. R., Jun 1 2014, In : Nucleic Acid Therapeutics. 24, 3, p. 199-209 11 p.

Research output: Contribution to journalArticle

RNA Interference
Alleles
RNA
Chemical modification
Chemical analysis
1 Citation (Scopus)

Identification and validation of miRNA target sites within nontraditional miRNA targets

Younger, S. T. & Corey, D. R., Sep 20 2014, Regulatory Non-Coding RNAs: Methods and Protocols. Springer New York, p. 53-67 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
RNA
Gene expression
Gene Expression
Complementary RNA
174 Citations (Scopus)

RNAi factors are present and active in human cell nuclei

Gagnon, K., Li, L., Chu, Y., Janowski, B. & Corey, D., 2014, In : Cell Reports. 6, 1, p. 211-221 11 p.

Research output: Contribution to journalArticle

RNA Interference
Cell Nucleus
Cells
RNA
MicroRNAs
2013
12 Citations (Scopus)

Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions

Aiba, Y., Hu, J., Liu, J., Xiang, Q., Martinez, C. & Corey, D. R., Dec 23 2013, In : Biochemistry. 52, 51, p. 9329-9338 10 p.

Research output: Contribution to journalArticle

Nucleic Acids
Substitution reactions
Alleles
RNA
Base Pairing
37 Citations (Scopus)

Digital quantitation of potential therapeutic target RNAs

Dodd, D. W., Gagnon, K. T. & Corey, D. R., Jun 1 2013, In : Nucleic Acid Therapeutics. 23, 3, p. 188-194 7 p.

Research output: Contribution to journalArticle

RNA
Polymerase Chain Reaction
Polymerase chain reaction
Therapeutics
Long Noncoding RNA
86 Citations (Scopus)

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Matsui, M., Chu, Y., Zhang, H., Gagnon, K. T., Shaikh, S., Kuchimanchi, S., Corey, D. R. & Janowski, B. A., Dec 2013, In : Nucleic Acids Research. 41, 22, p. 10086-10109 24 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
RNA
Genes
Complementary RNA
RNA Interference
21 Citations (Scopus)

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression

Liu, J., Pendergraff, H., Narayanannair, K. J., Lackey, J. G., Kuchimanchi, S., Rajeev, K. G., Manoharan, M., Hu, J. & Corey, D. R., Oct 2013, In : Nucleic Acids Research. 41, 18, p. 8788-8801 14 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Huntington Disease
RNA Interference
Alleles
RNA
27 Citations (Scopus)

Ss-siRNAs allele selectively inhibit ataxin-3 expression: Multiple mechanisms for an alternative gene silencing strategy

Liu, J., Yu, D., Aiba, Y., Pendergraff, H., Swayze, E. E., Lima, W. F., Hu, J., Prakash, T. P. & Corey, D. R., Nov 2013, In : Nucleic Acids Research. 41, 20, p. 9570-9583 14 p.

Research output: Contribution to journalArticle

Gene Silencing
RNA Interference
Alleles
Machado-Joseph Disease
Antisense Oligonucleotides
18 Citations (Scopus)

Transcriptional silencing by single-stranded RNAs targeting a noncoding rna that overlaps a gene promoter

Matsui, M., Prakash, T. P. & Corey, D. R., Jan 18 2013, In : ACS Chemical Biology. 8, 1, p. 122-126 5 p.

Research output: Contribution to journalArticle

Untranslated RNA
RNA Interference
Genes
RNA
Transcription
2012
23 Citations (Scopus)

Allele-selective inhibition of trinucleotide repeat genes

Matsui, M. & Corey, D. R., May 2012, In : Drug Discovery Today. 17, 9-10, p. 443-450 8 p.

Research output: Contribution to journalArticle

Trinucleotide Repeats
Alleles
Trinucleotide Repeat Expansion
Huntington Disease
Mutant Proteins
38 Citations (Scopus)

Argonaute and the nuclear RNAs: New pathways for RNA-Mediated control of gene expression

Gagnon, K. T. & Corey, D. R., Feb 1 2012, In : Nucleic Acid Therapeutics. 22, 1, p. 3-16 14 p.

Research output: Contribution to journalArticle

Nuclear RNA
Gene expression
RNA
Gene Expression
Argonaute Proteins
44 Citations (Scopus)

Expanding the action of duplex RNAs into the nucleus: Redirecting alternative splicing

Liu, J., Hu, J. & Corey, D. R., Feb 2012, In : Nucleic Acids Research. 40, 3, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Alternative Splicing
RNA
RNA Precursors
Exons
Cytoplasm
21 Citations (Scopus)

Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: Function through the RNAi pathway

Hu, J., Liu, J., Yu, D., Chu, Y. & Corey, D. R., Dec 2012, In : Nucleic Acids Research. 40, 22, p. 11270-11280 11 p.

Research output: Contribution to journalArticle

RNA Interference
Alleles
RNA
Mutant Proteins
MicroRNAs

Non-coding RNAs and cancer: An AACR Special Conference, Miami, FL, USA, January 8-11, 2012

Corey, D., 2012, In : Drugs of the Future. 37, 4, p. 297-299 3 p.

Research output: Contribution to journalArticle

Untranslated RNA
Research
Long Noncoding RNA
Neoplasms
MicroRNAs
76 Citations (Scopus)

RNA sequencing: Platform selection, experimental design, and data interpretation

Chu, Y. & Corey, D. R., Aug 1 2012, In : Nucleic Acid Therapeutics. 22, 4, p. 271-274 4 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Design of experiments
Research Design
RNA
Clinical laboratories