Pharmacology - E Martinez Lab

Research output

Research output per year 1996 2006 2013 2015 2017 2018 2023

• 56 Article
• 3 Comment/debate
• 3 Review article
• 2 Short survey

Research output per year

Research output per year

Search results

• 2023

  Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer

  Duan, L., Chen, Y. A., Liang, Y., Chen, Z., Lu, J., Fang, Y., Cao, J., Lu, J., Zhao, H., Pong, R. C., Hernandez, E., Kapur, P., Tran, T. A. T., Smith, T., Martinez, E. D., Ahn, J. M., Hsieh, J. T., Luo, J. H. & Liu, Z. P., Feb 2023, In: Biomedicine and Pharmacotherapy. 158, 114077.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Demethylases 100%
  • Castration 76%
  • Prostatic Neoplasms 54%
  • Growth 34%
  • Epigenomics 26%
  2 Scopus citations
• 2022

  Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity

  Cruz-Lorenzo, E., Ramirez, N. G. P., Lee, J., Pandhe, S., Wang, L., Hernandez-Doria, J., Spivak, A. M., Planelles, V., Petersen, T., Jain, M. K., Martinez, E. D. & D’Orso, I., Oct 2022, In: Viruses. 14, 10, 2288.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidation-Reduction 100%
  • HIV-1 90%
  • Transcription Factors 78%
  • Transcription Factor AP-1 49%
  • T-Lymphocytes 27%

• Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival

  Tran, T. A., Zhang, Q. J., Wang, L., Gonzales, C., Girard, L., May, H., Gillette, T., Liu, Z. P. & Martinez, E. D., Feb 1 2022, In: Journal of Biological Chemistry. 298, 2, 101515.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dilated Cardiomyopathy 100%
  • Histone 98%
  • Histone Demethylases 88%
  • histone H3 trimethyl Lys4 87%
  • Histones 86%
  5 Scopus citations

• JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis

  Son, J., Huang, S., Zeng, Q., Bricker, T. L., Case, J. B., Zhou, J., Zang, R., Liu, Z., Chang, X., Darling, T. L., Xu, J., Harastani, H. H., Chen, L., Castro, M. F. G., Zhao, Y., Kohio, H. P., Hou, G., Fan, B., Niu, B., Guo, R., & 11 othersRothlauf, P. W., Bailey, A. L., Wang, X., Shi, P. Y., Martinez, E. D., Brody, S. L., Whelan, S. P. J., Diamond, M. S., Boon, A. C. M., Li, B. & Ding, S., Feb 1 2022, In: mBio. 13, 1, e03377.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • JIB-04 100%
  • SARS Virus 68%
  • Coronavirus 58%
  • Antiviral Agents 39%
  • Coronavirus Infections 16%
  8 Scopus citations
• 2021

  Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma

  Bayo, J., Fiore, E. J., Dominguez, L. M., Cantero, M. J., Ciarlantini, M. S., Malvicini, M., Atorrasagasti, C., Garcia, M. G., Rossi, M., Cavasotto, C., Martinez, E., Comin, J. & Mazzolini, G. D., Jul 1 2021, In: Gut. 70, 7, p. 1362-1374 13 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP Phosphohydrolases 100%
  • Computational Biology 82%
  • Psychological Inhibition 71%
  • Hepatocellular Carcinoma 70%
  • Pharmacology 58%
  18 Scopus citations

• Disruption of the plasmodium falciparum life cycle through transcriptional reprogramming by inhibitors of jumonji demethylases

  Matthews, K. A., Senagbe, K. M., Nötzel, C., Gonzales, C. A., Tong, X., Rijo-Ferreira, F., Bhanu, N. V., Miguel-Blanco, C., Lafuente-Monasterio, M. J., Garcia, B. A., Kafsack, B. F. C. & Martinez, E. D., 2021, In: ACS infectious diseases. 6, 5, p. 1058-1075 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • JIB-04 100%
  • Life Cycle Stages 66%
  • Plasmodium falciparum 65%
  • Parasites 51%
  • Histone Demethylases 22%
  15 Scopus citations

• Epigenetic modulation reveals differentiation state specificity of oncogene addiction

  Khaliq, M., Manikkam, M., Martinez, E. D. & Fallahi-Sichani, M., Dec 1 2021, In: Nature communications. 12, 1, 1536.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • oncogenes 100%
  • Oncogene Addiction 94%
  • inhibitors 65%
  • Plastic Property 65%
  • Histone 60%
  12 Scopus citations
• 2020

  A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

  Swift, R. P., Rajaram, K., Liu, H. B., Dziedzic, A., Jedlicka, A. E., Roberts, A. D., Matthews, K. A., Jhun, H., Bumpus, N. N., Tewari, S. G., Wallqvist, A. & Prigge, S. T., 2020, In: PLoS pathogens. 16, 2, e1008316.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apicoplasts 100%
  • apicoplasts 98%
  • Plastids 93%
  • Mevalonic Acid 80%
  • malaria 61%
  24 Scopus citations

• A UHPLC-MS/MS method for the quantification of JIB-04 in rat plasma: Development, validation and application to pharmacokinetics study

  Wang, Y., Ma, J., Martinez, E. D., Liang, D. & Xie, H., Nov 30 2020, In: Journal of Pharmaceutical and Biomedical Analysis. 191, 113587.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • JIB-04 100%
  • Lysine 44%
  • Pharmacokinetics 35%
  • Oncogenic 32%
  • Plasma 28%
  4 Scopus citations
• 2019

  A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets

  Bayo, J., Fiore, E. J., Dominguez, L. M., Real, A., Malvicini, M., Rizzo, M., Atorrasagasti, C., García, M. G., Argemi, J., Martinez, E. D. & Mazzolini, G. D., Jul 2019, In: Journal of Hepatology. 71, 1, p. 78-90 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenomics 100%
  • Hepatocellular Carcinoma 92%
  • JIB-04 44%
  • Lysine 40%
  • LLY-507 24%
  69 Scopus citations

• Correction: Klotho is a novel marker and cell survival factor in a subset of triple negative breast cancers (Oncotarget (2016) 7 (2611-2628) DOI: 10.18632/oncotarget.6006)

  Trošt, N., Peña-Llopis, S., Koirala, S., Stojan, J., Potts, P. R., Tacer, K. F. & Martinez, E. D., Jan 1 2019, In: Oncotarget. 10, 8, p. 916 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Triple Negative Breast Neoplasms 100%
  • Oncogenes 78%
  • Cell Survival 63%
  • Oxidative Stress 60%
  • Breast Neoplasms 52%
  1 Scopus citations

• Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes

  Zoeller, E. L., Pedro, B., Konen, J., Dwivedi, B., Rupji, M., Sundararaman, N., Wang, L., Horton, J. R., Zhong, C., Barwick, B. G., Cheng, X., Martinez, E. D., Torres, M. P., Kowalski, J., Marcus, A. I. & Vertino, P. M., Oct 9 2019, In: Journal of cell science. 132, 19

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Heterogeneity 100%
  • Drive 87%
  • Phenotype 50%
  • Cooperative Behavior 22%
  • Physiological Adaptation 18%
  17 Scopus citations
• 2018

  Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

  Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M. J., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z-P., Dec 1 2018, In: Nature communications. 9, 1, 5230.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fibrosis 100%
  • Histone Demethylases 96%
  • lysine 93%
  • Cardiomegaly 71%
  • Left Ventricular Hypertrophy 71%
  78 Scopus citations

• Host biotin is required for liver stage development in malaria parasites

  Dellibovi-Ragheb, T. A., Jhun, H., Goodman, C. D., Walters, M. S., Ragheb, D. R. T., Matthews, K. A., Rajaram, K., Mishra, S., McFadden, G. I., Sinnis, P. & Prigge, S. T., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 11, p. E2604-E2613

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biotin 100%
  • Malaria 83%
  • Acetyl-CoA Carboxylase 82%
  • Parasites 75%
  • Liver 46%
  13 Scopus citations

• Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

  Bayo, J., Tran, T. A., Wang, L., Peña-Llopis, S., Das, A. K. & Martinez, E. D., Oct 23 2018, In: Cell Reports. 25, 4, p. 1040-1050.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • H3K4Me3 100%
  • histone H3 trimethyl Lys4 61%
  • Methylation 48%
  • JIB-04 46%
  • DNA Repair 29%
  49 Scopus citations

• Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

  Mender, I., LaRanger, R., Luitel, K., Peyton, M., Girard, L., Lai, T. P., Batten, K., Cornelius, C., Dalvi, M. P., Ramirez, M., Du, W., Wu, L. F., Altschuler, S. J., Brekken, R., Martinez, E. D., Minna, J. D., Wright, W. E. & Shay, J. W., Aug 2018, In: Neoplasia (United States). 20, 8, p. 826-837 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-2'-deoxythioguanosine 100%
  • Telomerase 51%
  • Non-Small Cell Lung Carcinoma 40%
  • Lung Neoplasms 27%
  • Drug Therapy 26%
  41 Scopus citations
• 2017

  A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

  Afanador, G. A., Guerra, A. J., Swift, R. P., Rodriguez, R. E., Bartee, D., Matthews, K. A., Schön, A., Freire, E., Freel Meyers, C. L. & Prigge, S. T., Nov 2017, In: Molecular Microbiology. 106, 3, p. 439-451 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Plasmodium 100%
  • Chlamydia 99%
  • Lipoylation 89%
  • Oxidation-Reduction 80%
  • lipoate activating enzyme 49%
  9 Scopus citations

• Assessing histone demethylase inhibitors in cells: Lessons learned

  Hatch, S. B., Yapp, C., Montenegro, R. C., Savitsky, P., Gamble, V., Tumber, A., Ruda, G. F., Bavetsias, V., Fedorov, O., Atrash, B., Raynaud, F., Lanigan, R., Carmichael, L., Tomlin, K., Burke, R., Westaway, S. M., Brown, J. A., Prinjha, R. K., Martinez, E. D., Oppermann, U., & 7 othersSchofield, C. J., Bountra, C., Kawamura, A., Blagg, J., Brennan, P. E., Rossanese, O. & Müller, S., Mar 1 2017, In: Epigenetics and Chromatin. 10, 1, 9.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Demethylases 100%
  • Histones 38%
  • Methylation 37%
  • Ketoglutaric Acids 36%
  • Fluorescent Antibody Technique 23%
  38 Scopus citations

• JumonjiC demethylase inhibitors show potential for targeting chemotherapy-resistant lung cancers

  Dalvi, M. P. & Martinez, E. D., Sep 3 2017, In: Molecular and Cellular Oncology. 4, 5, e1345352.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • taxane 100%
  • Lung Neoplasms 61%
  • Drug Therapy 45%
  • Non-Small Cell Lung Carcinoma 34%
  • Clone Cells 30%
  1 Scopus citations

• Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

  Dalvi, M. P., Wang, L., Zhong, R., Kollipara, R. K., Park, H., Bayo, J., Yenerall, P., Zhou, Y., Timmons, B. C., Rodriguez-Canales, J., Behrens, C., Mino, B., Villalobos, P., Parra, E. R., Suraokar, M., Pataer, A., Swisher, S. G., Kalhor, N., Bhanu, N. V., Garcia, B. A., & 9 othersHeymach, J. V., Coombes, K., Xie, Y., Girard, L., Gazdar, A. F., Kittler, R., Wistuba, I. I., Minna, J. D. & Martinez, E. D., May 23 2017, In: Cell Reports. 19, 8, p. 1669-1684 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • taxane 100%
  • Hypersensitivity 63%
  • Lung Neoplasms 61%
  • Resistance 48%
  • JIB-04 41%
  72 Scopus citations
• 2016

  Inhibiting the Jumonji family: A potential new clinical approach to targeting aberrant epigenetic mechanisms

  Martinez, E. D. & Gazdar, A. F., Mar 2016, In: Epigenomics. 8, 3, p. 313-316 4 p.

  Research output: Contribution to journal › Review article › peer-review
  4 Scopus citations

• Unique epigenetic gene profiles define human breast cancers with poor prognosis

  Peña-Llopis, S., Wan, Y. & Martinez, E. D., 2016, In: Oncotarget. 7, 52, p. 85819-85831 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenomics 100%
  • Breast Neoplasms 73%
  • Genes 46%
  • Breast 19%
  • Nexus 17%
  11 Scopus citations

• γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

  Trošt, N., Peña-Llopis, S., Koirala, S., Stojan, J., Potts, P. R., Tacer, K. F. & Martinez, E. D., 2016, In: Oncotarget. 7, 3, p. 2611-2628 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Cell Survival 63%
  • klotho protein 27%
  • Oxidative Stress 24%
  • Breast Neoplasms 21%
  10 Scopus citations
• 2015

  2-Benzazolyl-4-Piperazin-1- Ylsulfonylbenzenecarbohydroxamic acids as novel selective histone deacetylase-6 inhibitors with antiproliferative activity

  Wang, L., Kofler, M., Brosch, G., Melesina, J., Sippl, W., Martinez, E. D. & Easmon, J., Dec 1 2015, In: PloS one. 10, 12, e0134556.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Deacetylase 6 100%
  • Histone Deacetylase Inhibitors 72%
  • Hydroxamic Acids 66%
  • Acids 46%
  • Benzoxazoles 37%
  10 Scopus citations

• A subset of nuclear receptors are uniquely expressed in uveal melanoma cells

  Huffman, K., Carstens, R. & Martinez, E. D., 2015, In: Frontiers in Endocrinology. 6, MAY, 93.

  Research output: Contribution to journal › Article › peer-review

  • Uveal melanoma 100%
  • Cytoplasmic and Nuclear Receptors 77%
  • Melanoma 56%
  • Skin 22%
  • Second Primary Neoplasms 7%
  5 Scopus citations

• Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

  Thinnes, C. C., Tumber, A., Yapp, C., Scozzafava, G., Yeh, T., Chan, M. C., Tran, T. A., Hsu, K., Tarhonskaya, H., Walport, L. J., Wilkins, S. E., Martinez, E. D., Müller, S., Pugh, C. W., Ratcliffe, P. J., Brennan, P. E., Kawamura, A. & Schofield, C. J., 2015, In: Chemical Communications. 51, 84, p. 15458-15461 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxygenases 100%
  • Enzymes 27%
  • Histone 25%
  • Iron 21%
  37 Scopus citations

• Erratum: Corrigendum: Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 (Nature Communications 6:8023 DOI:10.1038/ncomms9023)

  Schneider, P., Bayo-Fina, J. M., Singh, R., Dhanyamraju, P. K., Holz, P., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martinez, E. D. & Lauth, M., Oct 26 2015, In: Nature communications. 6, 8741.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  2 Scopus citations

• Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

  Schneider, P., Miguel Bayo-Fina, J., Singh, R., Kumar Dhanyamraju, P., Holz, P., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martinez, E. D. & Lauth, M., Aug 27 2015, In: Nature communications. 6, 8023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Down Syndrome 100%
  • Actins 81%
  • modules 78%
  • proteins 76%
  • Phosphotransferases 74%
  53 Scopus citations

• KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes

  Duan, L., Rai, G., Roggero, C., Zhang, Q. J., Wei, Q., Ma, S. H., Zhou, Y., Santoyo, J., Martinez, E. D., Xiao, G., Raj, G., Jadhav, A., Simeonov, A., Maloney, D. J., Rizo-Rey, J., Hsieh, J-T. & Liu, Z-P., Sep 17 2015, In: Chemistry and Biology. 22, 9, p. 1185-1196 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Demethylases 100%
  • Androgen 86%
  • Androgen Receptors 74%
  • Histone 73%
  • Prostate 57%
  62 Scopus citations

• Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

  Chen, Y., Terajima, M., Yang, Y., Sun, L., Ahn, Y. H., Pankova, D., Puperi, D. S., Watanabe, T., Kim, M. P., Blackmon, S. H., Rodriguez, J., Liu, H., Behrens, C., Wistuba, I. I., Minelli, R., Scott, K. L., Sanchez-Adams, J., Guilak, F., Pati, D., Thilaganathan, N., & 7 othersBurns, A. R., Creighton, C. J., Martinez, E. D., Zal, T., Grande-Allen, K. J., Yamauchi, M. & Kurie, J. M., Mar 2 2015, In: Journal of Clinical Investigation. 125, 3, p. 1147-1162 16 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine 100%
  • Collagen 45%
  • Neoplasms 19%
  • Aldehydes 14%
  • Lysine 11%
  128 Scopus citations

• Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential

  Bayo, J., Dalvi, M. P. & Martinez, E. D., Oct 2015, In: Future Medicinal Chemistry. 7, 16, p. 2243-2261 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Histone 100%
  • Histones 87%
  • Epigenomics 81%
  • Haematological 33%
  • Pipeline 26%
  11 Scopus citations
• 2014

  Identification of small molecule modulators of gene transcription with anticancer activity

  Tran, T. A., Wichterman-Kouznetsova, J., Varghese, D., Huang, R., Huang, W., Becker, M., Austin, C. P., Inglese, J., Johnson, R. L. & Martinez, E. D., Nov 21 2014, In: ACS chemical biology. 9, 11, p. 2603-2611 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Expression Regulation 100%
  • Histone 99%
  • High Throughput Screening 99%
  • Antiproliferative 92%
  • Epigenomics 81%
  3 Scopus citations

• Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

  Afanador, G. A., Matthews, K. A., Bartee, D., Gisselberg, J. E., Walters, M. S., Freel Meyers, C. L. & Prigge, S. T., Oct 1 2014, In: Molecular Microbiology. 94, 1, p. 156-171 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipoylation 100%
  • Mitochondrial Proteins 79%
  • Plasmodium falciparum 73%
  • Oxidation-Reduction 67%
  • Oxidoreductases 64%
  15 Scopus citations
• 2013

  A key role for lipoic acid synthesis during Plasmodium liver stage development

  Falkard, B., Kumar, T. R. S., Hecht, L. S., Matthews, K. A., Henrich, P. P., Gulati, S., Lewis, R. E., Manary, M. J., Winzeler, E. A., Sinnis, P., Prigge, S. T., Heussler, V., Deschermeier, C. & Fidock, D., Sep 2013, In: Cellular Microbiology. 15, 9, p. 1585-1604 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thioctic Acid 100%
  • Plasmodium 89%
  • Parasites 62%
  • Apicoplasts 62%
  • Sporozoites 50%
  27 Scopus citations

• A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

  Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Peña-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., Brekken, R. A., Quinn, A. M., Simeonov, A., Easmon, J. & Martinez, E. D., Jun 24 2013, In: Nature communications. 4, 2035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • JIB-04 100%
  • Histone Demethylases 67%
  • inhibitors 53%
  • Histone 49%
  • tumors 44%
  240 Scopus citations

• Erratum: A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth (Nature Communications (2013) 4 (2035) Doi:10.1038/ncomms3035)

  Wang, L., Chang, J., Varghese, D., Dellinger, M., Kumar, S., Best, A. M., Ruiz, J., Bruick, R., Penã-Llopis, S., Xu, J., Babinski, D. J., Frantz, D. E., Brekken, R. A., Quinn, A. M., Simeonov, A., Easmon, J. & Martinez, E. D., 2013, In: Nature communications. 4, 2639.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Pre-clinical studies of epigenetic therapies targeting histone modifiers in lung cancer

  Huffman, K. & Martinez, E. D., 2013, In: Frontiers in Oncology. 3 SEP, Article 235.

  Research output: Contribution to journal › Short survey › peer-review

  • Histones 100%
  • Epigenomics 93%
  • Lung Neoplasms 84%
  • Clinical Studies 73%
  • Drug Delivery Systems 34%
  14 Scopus citations

• The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites

  Gisselberg, J. E., Dellibovi-Ragheb, T. A., Matthews, K. A., Bosch, G. & Prigge, S. T., Sep 2013, In: PLoS pathogens. 9, 9, e1003655.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apicoplasts 100%
  • apicoplasts 98%
  • Sulfur 71%
  • malaria 61%
  • Malaria 55%
  78 Scopus citations
• 2012

  Anthraquinones from a marine-derived streptomyces spinoverrucosus

  Hu, Y., Martinez, E. D. & MacMillan, J. B., Oct 26 2012, In: Journal of Natural Products. 75, 10, p. 1759-1764 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anthraquinones 100%
  • Streptomyces 87%
  • Anthraquinone 77%
  • Spectroscopic Analysis 69%
  • heparinized hydrophilic polymer 67%
  34 Scopus citations

• Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide

  Chang, J., Varghese, D. S., Gillam, M. C., Peyton, M., Modi, B., Schiltz, R. L., Girard, L. & Martinez, E. D., Jan 3 2012, In: British journal of cancer. 106, 1, p. 116-125 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Depsipeptides 100%
  • trichostatin A 81%
  • Histone Deacetylases 71%
  • apicidin 22%
  • Histone Code 21%
  84 Scopus citations
• 2011

  Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay

  Martinez, E. D., Best, A. M., Chang, J., Dull, A. B. & Beutler, J. A., 2011, In: Journal of Biomedicine and Biotechnology. 2011, 868095.

  Research output: Contribution to journal › Article › peer-review

  • Histone 100%
  • Libraries 82%
  • Epigenomics 81%
  • Histones 58%
  • Histone Deacetylases 36%
  10 Scopus citations

• Plasmodium falciparum apicoplast transit peptides are unstructured in vitro and during apicoplast import

  Gallagher, J. R., Matthews, K. A. & Prigge, S. T., Sep 2011, In: Traffic. 12, 9, p. 1124-1138 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Apicoplasts 100%
  • Plasmodium falciparum 63%
  • Peptides 38%
  • Peptide 34%
  • In Vitro Techniques 26%
  25 Scopus citations
• 2010

  Activation of sterol regulatory element binding proteins in the absence of scap in Drosophila melanogaster

  Matthews, K. A., Ozdemir, C. & Rawson, R. B., May 2010, In: Genetics. 185, 1, p. 189-198 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sterol Regulatory Element Binding Proteins 100%
  • Drosophila melanogaster 72%
  • Diptera 35%
  • Larva 35%
  • Lipids 32%
  10 Scopus citations

• Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions

  Holbeck, S., Chang, J., Best, A. M., Bookout, A. L., Mangelsdorf, D. J. & Martinez, E. D., Jun 2010, In: Molecular Endocrinology. 24, 6, p. 1287-1296 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Receptors 100%
  • Cytoplasmic and Nuclear Receptors 74%
  • Genes 29%
  • Drug Interactions 28%
  • Cell Line 25%
  55 Scopus citations
• 2009

  Activation of sterol regulatory element-binding protein by the caspase drice in Drosophila larvae

  Amarneh, B., Matthews, K. A. & Rawson, R. B., Apr 10 2009, In: Journal of Biological Chemistry. 284, 15, p. 9674-9682 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sterol Regulatory Element Binding Proteins 100%
  • Sterol 72%
  • Diptera 71%
  • Larva 70%
  • Caspases 66%
  18 Scopus citations

• Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster

  Matthews, K. A., Kunte, A. S., Tambe-Ebot, E. & Rawson, R. B., Jan 2009, In: Genetics. 181, 1, p. 119-128 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sterol Regulatory Element Binding Proteins 100%
  • Drosophila melanogaster 72%
  • Drosophila 61%
  • Larva 50%
  • site 1 membrane-bound transcription factor peptidase 34%
  14 Scopus citations
• 2008

  A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression

  Johnson, R. L., Huang, W., Jadhav, A., Austin, C. P., Inglese, J. & Martinez, E. D., Apr 15 2008, In: Analytical biochemistry. 375, 2, p. 237-248 12 p.

  Research output: Contribution to journal › Article › peer-review

  • High Throughput Screening 100%
  • Epigenomics 81%
  • Gene Expression 55%
  • 8-mercaptoquinoline 42%
  • Green Fluorescent Proteins 40%
  29 Scopus citations

• Characterizing heterogeneous cellular responses to perturbations

  Slack, M. D., Martinez, E. D., Wu, L. F. & Altschuler, S. J., Dec 9 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 49, p. 19306-19311 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Pharmaceutical Preparations 100%
  • Phenotype 96%
  • Noise 74%
  • Population 63%
  • Neoplasms 25%
  139 Scopus citations
• 2007

  Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition

  Martinez, E. D., Botos, J., Dohoney, K. M., Geiman, T. M., Kolla, S. S., Olivera, A., Qiu, Y., Rayasam, G. V., Stavreva, D. A. & Cohen-Fix, O., Nov 2007, In: EMBO Reports. 8, 11, p. 977-981 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  133 Scopus citations
• 2006

  Development of Assays for Nuclear Receptor Modulators Using Fluorescently Tagged Proteins

  Martinez, E. D. & Hager, G. L., 2006, In: Methods in Enzymology. 414, p. 37-50 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear Receptor Modulator 100%
  • Receptor Modulator 77%
  • Cytoplasmic and Nuclear Receptors 49%
  • Ligands 34%
  • Retinoic Acid 31%
  7 Scopus citations