Pharmacology - Goodman Lab

Research Output 1980 2019

2019
Open Access
Phosphoric Monoester Hydrolases
Lipids
Phosphatidate Phosphatase
Confusion
Fungal Proteins

Spatial compartmentalization of lipid droplet biogenesis

Henne, M., Goodman, J. M. & Hariri, H., Jan 1 2019, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalReview article

Organelles
Endoplasmic Reticulum
Lipids
Lipid Droplets
Membrane Proteins
2018
22 Citations (Scopus)

The assembly of lipid droplets and their roles in challenged cells

Henne, W. M., Reese, M. L. & Goodman, J. M., Jun 15 2018, In : EMBO Journal. 37, 12, e98947.

Research output: Contribution to journalReview article

Starvation
Organelles
Prokaryotic Cells
Lipids
Cytoplasm
2 Citations (Scopus)

Understanding the Lipid Droplet Proteome and Protein Targeting

Goodman, J. M., Jan 8 2018, In : Developmental Cell. 44, 1, p. 1-2 2 p.

Research output: Contribution to journalShort survey

Protein Transport
Proteome
Organelles
Technology
Lipids
2017
23 Citations (Scopus)

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

Gao, Q., Binns, D. D., Kinch, L. N., Grishin, N. V., Ortiz, N., Chen, X. & Goodman, J. M., Oct 1 2017, In : Journal of Cell Biology. 216, 10, p. 3199-3217 19 p.

Research output: Contribution to journalArticle

Triglycerides
Yeasts
Diacylglycerol O-Acyltransferase
Fungal Proteins
Oleic Acid
16 Citations (Scopus)

The collaborative work of droplet assembly

Chen, X. & Goodman, J. M., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalArticle

Proteins
Lipid Droplets
Perilipin-1
2015
54 Citations (Scopus)

Arabidopsis SEIPIN proteins modulate triacylglycerol accumulation and influence lipid droplet proliferation

Cai, Y., Goodman, J. M., Pyc, M., Mullen, R. T., Dyer, J. M. & Chapmana, K. D., 2015, In : Plant Cell. 27, 9, p. 2616-2636 21 p.

Research output: Contribution to journalArticle

Arabidopsis Proteins
droplets
Arabidopsis
Triglycerides
triacylglycerols
28 Citations (Scopus)
Phosphatidic Acids
Endoplasmic Reticulum
Triglycerides
Enzymes
Esters
60 Citations (Scopus)

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

Cartwright, B. R., Binns, D. D., Hilton, C. L., Han, S., Gao, Q. & Goodman, J. M., Feb 15 2015, In : Molecular Biology of the Cell. 26, 4, p. 726-739 14 p.

Research output: Contribution to journalArticle

Adipogenesis
Inositol
Membrane Lipids
Endoplasmic Reticulum
Saccharomyces cerevisiae
75 Citations (Scopus)

The life cycle of lipid droplets

Hashemi, H. F. & Goodman, J. M., Apr 1 2015, In : Current Opinion in Cell Biology. 33, p. 119-124 6 p.

Research output: Contribution to journalArticle

Life Cycle Stages
Protein Transport
Lipid Metabolism
Organelles
Proteomics
84 Citations (Scopus)

The lipid droplet-a well-connected organelle

Gao, Q. & Goodman, J. M., Aug 12 2015, In : Frontiers in Cell and Developmental Biology. 3, AUG, 49.

Research output: Contribution to journalReview article

Open Access
Cellular Structures
Starvation
Organelles
Proteomics
Buffers
2012
45 Citations (Scopus)

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway

Han, S., Bahmanyar, S., Zhang, P., Grishin, N., Oegema, K., Crooke, R., Graham, M., Reue, K., Dixon, J. E. & Goodman, J. M., Jan 27 2012, In : Journal of Biological Chemistry. 287, 5, p. 3123-3137 15 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Phosphoric Monoester Hydrolases
Chemical activation
Membranes
Yeast
70 Citations (Scopus)
Lipid Metabolism
Metabolism
Yeast
Congenital Generalized Lipodystrophy
Yeasts
2011
143 Citations (Scopus)

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

Adeyo, O., Horn, P. J., Lee, S., Binns, D. D., Chandrahas, A., Chapman, K. D. & Goodman, J. M., Mar 21 2011, In : Journal of Cell Biology. 192, 6, p. 1043-1055 13 p.

Research output: Contribution to journalArticle

Yeasts
Diglycerides
Lipids
Endoplasmic Reticulum
Phosphatidate Phosphatase
2010
69 Citations (Scopus)

Seipin is a discrete homooligomer

Binns, D., Lee, S., Hilton, C. L., Jiang, Q. X. & Goodman, J. M., Dec 21 2010, In : Biochemistry. 49, 50, p. 10747-10755 9 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Yeasts
Yeast
Detergents
Proteins
2009
84 Citations (Scopus)

Demonstrated and inferred metabolism associated with cytosolic lipid droplets

Goodman, J. M., 2009, In : Journal of Lipid Research. 50, 11, p. 2148-2156 9 p.

Research output: Contribution to journalArticle

Metabolism
Proteomics
Fatty Acids
Lipids
Membranes
2008
182 Citations (Scopus)

The gregarious lipid droplet

Goodman, J. M., Oct 17 2008, In : Journal of Biological Chemistry. 283, 42, p. 28005-28009 5 p.

Research output: Contribution to journalArticle

Biological Transport
Biological Models
NIH 3T3 Cells
Adipose Tissue
Mitochondria
2007
328 Citations (Scopus)

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

Szymanski, K. M., Binns, D., Bartz, R., Grishin, N. V., Li, W. P., Agarwal, A. K., Garg, A., Anderson, R. G. W. & Goodman, J. M., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20890-20895 6 p.

Research output: Contribution to journalArticle

Lipodystrophy
Endoplasmic Reticulum
Yeasts
Proteins
Genes
2006
215 Citations (Scopus)

An intimate collaboration between peroxisomes and lipid bodies

Binns, D., Januszewski, T., Chen, Y., Hill, J., Markin, V. S., Zhao, Y., Gilpin, C., Chapman, K. D., Anderson, R. G. W. & Goodman, J. M., Jun 5 2006, In : Journal of Cell Biology. 173, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

Peroxisomes
Fatty Acids
Lipid Droplets
Lipolysis
Oleic Acid
82 Citations (Scopus)
Peroxisomes
Organelles
Proteins
Protein Transport
Chloroplasts
2004
16 Citations (Scopus)

Multiple Targeting Modules on Peroxisomal Proteins Are Not Redundant: Discrete Functions of Targeting Signals within Pmp47 and Pex8p

Wang, X., McMahon, M. A., Shelton, S. N., Nampaisansuk, M., Ballard, J. L. & Goodman, J. M., Apr 2004, In : Molecular Biology of the Cell. 15, 4, p. 1702-1710 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Proteins
Saccharomyces cerevisiae
Population
Adenosine Triphosphate
2003
30 Citations (Scopus)

Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase

Shelton, S. N., Barylko, B., Binns, D. D., Horazdovsky, B. F., Albanesi, J. P. & Goodman, J. M., Apr 15 2003, In : Biochemical Journal. 371, 2, p. 533-540 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Yeast
Saccharomyces cerevisiae
Phosphotransferases
2002
10 Citations (Scopus)

Monomeric alcohol oxidase is preferentially digested by a novel protease from Candida boidinii

Stewart, M. Q., Van Dijk, R., Veenhuis, M. & Goodman, J. M., Jan 30 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1542, 1-3, p. 160-172 13 p.

Research output: Contribution to journalArticle

alcohol oxidase
Candida
Peptide Hydrolases
Peroxisomes
Chymotrypsin
2001
44 Citations (Scopus)

Alcohol oxidase and dihydroxyacetone synthase, the abundant peroxisomal proteins of methylotrophic yeasts, assemble in different cellular compartments

Stewart, M. Q., Esposito, R. D., Gowani, J. & Goodman, J. M., 2001, In : Journal of Cell Science. 114, 15, p. 2863-2868 6 p.

Research output: Contribution to journalArticle

formaldehyde transketolase
alcohol oxidase
Fungal Proteins
Peroxisomes
Proteins
46 Citations (Scopus)

Discrete Targeting Signals Direct Pmp47 to Oleate-induced Peroxisomes in Saccharomyces cerevisiae

Wang, X., Unruh, M. J. & Goodman, J. M., Apr 6 2001, In : Journal of Biological Chemistry. 276, 14, p. 10897-10905 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Oleic Acid
Yeast
Saccharomyces cerevisiae
Membrane Proteins
1996
287 Citations (Scopus)

A unified nomenclature for peroxisome biogenesis factors

Distel, B., Erdmann, R., Gould, S. J., Blobel, G., Crane, D. I., Cregg, J. M., Dodt, G., Fujiki, Y., Goodman, J. M., Just, W. W., Kiel, J. A. K. W., Kunau, W. H., Lazarow, P. B., Mannaerts, G. P., Moser, H. W., Osumi, T., Rachubinski, R. A., Roscher, A., Subramani, S., Tabak, H. F. & 5 others, Tsukamoto, T., Valle, D., Van Der Klei, I., Van Veldhoven, P. P. & Veenhuis, M., Oct 1996, In : Journal of Cell Biology. 135, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Microbodies
Peroxisomes
Fungal Proteins
Terminology
Proteins
90 Citations (Scopus)

Redox-sensitive homodimerization of Pex11p: A proposed mechanism to regulate peroxisomal division

Marshall, P. A., Dyer, J. M., Quick, M. E. & Goodman, J. M., Oct 1996, In : Journal of Cell Biology. 135, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

Peroxisomes
Oxidation-Reduction
Organelles
Oleic Acid
Cysteine
141 Citations (Scopus)

The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop

Dyer, J. M., McNew, J. A. & Goodman, J. M., Apr 1996, In : Journal of Cell Biology. 133, 2, p. 269-280 12 p.

Research output: Contribution to journalArticle

Membrane Proteins
Amino Acids
Basic Amino Acids
Chloramphenicol O-Acetyltransferase
Peroxisomes
145 Citations (Scopus)

The targeting and assembly of peroxisomal proteins: Some old rules do not apply

McNew, J. A. & Goodman, J. M., Jan 1 1996, In : Trends in Biochemical Sciences. 21, 2, p. 54-58 5 p.

Research output: Contribution to journalReview article

Organelles
Proteins
Peroxisomes
Protein Folding
Endoplasmic Reticulum

The targeting and assembly of peroxisomal proteins: Some old rules do not apply

McNew, J. A. & Goodman, J. M., Feb 1996, In : Trends in Biochemical Sciences. 21, 2, p. 54-58 5 p.

Research output: Contribution to journalArticle

Organelles
Proteins
Peroxisomes
Protein Folding
Endoplasmic Reticulum
1995
171 Citations (Scopus)

Pmp27 promotes peroxisomal proliferation

Marshall, P. A., Krimkevich, Y. I., Lark, R. H., Dyer, J. M., Veenhuis, M. & Goodman, J. M., 1995, In : Journal of Cell Biology. 129, 2, p. 345-355 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Oleic Acid
Proteins
Eukaryotic Cells
Enzymes
53 Citations (Scopus)

The Candida boidinii peroxisomal membrane protein Pmp30 has a role in peroxisomal proliferation and is functionally homologous to Pmp27 from Saccharomyces cerevisiae

Sakai, Y., Marshall, P. A., Saiganji, A., Takabe, K., Saiki, H., Kato, N. & Goodman, J. M., 1995, In : Journal of Bacteriology. 177, 23, p. 6773-6781 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Candida
Saccharomyces cerevisiae
Organelle Size
Membrane Proteins
1994
70 Citations (Scopus)

An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes

McCammon, M. T., McNew, J. A., Willy, P. J. & Goodman, J. M., Mar 1994, In : Journal of Cell Biology. 124, 6, p. 915-925 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Tetrahydrofolate Dehydrogenase
Membrane Proteins
Amino Acids
Mitochondrial Proteins
259 Citations (Scopus)

An oligomeric protein is imported into peroxisomes in vivo

McNew, J. A. & Goodman, J. M., Dec 1994, In : Journal of Cell Biology. 127, 5, p. 1245-1257 13 p.

Research output: Contribution to journalArticle

Chloramphenicol O-Acetyltransferase
Peroxisomes
Proteins
Membranes
Immunoelectron Microscopy
15 Citations (Scopus)

The peroxisomal membrane proteins of Candida boidinii: Gene isolation and expression

Moreno, M., Lark, R., Campbell, K. L. & Goodman, J. M., 1994, In : Yeast. 10, 11, p. 1447-1457 11 p.

Research output: Contribution to journalArticle

Candida boidinii
Candida
Oleic Acid
membrane proteins
Alanine
1993
10 Citations (Scopus)

Expression and targeting of a 47 kDa integral peroxisomal membrane protein of Candida boidinii in wild type and a peroxisome-deficient mutant of Hansenula polymorpha

Sulter, G. J., Waterham, H. R., Vrieling, E. G., Goodman, J. M., Harder, W. & Veenhius, M., Jan 11 1993, In : FEBS Letters. 315, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

Peroxisomes
Pichia
Candida
Membrane Proteins
Mitochondria
13 Citations (Scopus)

Specific cross-linking of the proline isomerase cyclophilin to a non-proline-containing peptide

McNew, J. A., Sykes, K. & Goodman, J. M., 1993, In : Molecular Biology of the Cell. 4, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
Cyclophilins
Peptides
Proteins
Fungal Proteins
1992
2 Citations (Scopus)

Chapter 16 Structure and assembly of peroxisomal membrane proteins

Goodman, J. M., Garrard, L. J. & McCammon, M. T., 1992, In : New Comprehensive Biochemistry. 22, C, p. 209-220 12 p.

Research output: Contribution to journalArticle

Membrane Proteins
Peroxisomes
formaldehyde transketolase
alcohol oxidase
Membranes
29 Citations (Scopus)

Development of multipurpose peroxisomes in Candida boidinii grown in oleic acid-methanol limited continuous cultures

Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W. & Veenhuis, M., 1992, In : Journal of Bacteriology. 174, 12, p. 4057-4063 7 p.

Research output: Contribution to journalArticle

Peroxisomes
Oleic Acid
Candida
Methanol
formaldehyde transketolase
1990
106 Citations (Scopus)

Association of glyoxylate and beta-oxidation enzymes with peroxisomes of Saccharomyces cerevisiae

McCammon, M. T., Veenhuis, M., Trapp, S. B. & Goodman, J. M., 1990, In : Journal of Bacteriology. 172, 10, p. 5816-5827 12 p.

Research output: Contribution to journalArticle

Peroxisomes
Malate Synthase
Saccharomyces cerevisiae
Oleic Acid
Organelles
33 Citations (Scopus)

Immunocytochemical evidence for the acidic nature of peroxisomes in methylotrophic yeasts

Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W. & Veenhuis, M., Mar 12 1990, In : FEBS Letters. 262, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

Peroxisomes
Yeast
Spheroplasts
Labeling
Proton-Motive Force
46 Citations (Scopus)
Peroxisomes
formaldehyde transketolase
Candida
alcohol oxidase
Yeasts
210 Citations (Scopus)

Peroxisomal protein import is conserved between yeast, plants, insects and mammals

Gould, S. J., Keller, G. A., Schneider, M., Howell, S. H., Garrard, L. J., Goodman, J. M., Distel, B., Tabak, H. & Subramani, S., 1990, In : EMBO Journal. 9, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

Mammals
Peroxisomes
Yeast
Firefly Luciferases
Insects
46 Citations (Scopus)

Peroxisomes induced in Candida boidinii by methanol, oleic acid and D-alanine vary in metabolic function but share common integral membrane proteins

Goodman, J. M., Trapp, S. B., Hwang, H. & Veenhuis, M., Sep 1990, In : Journal of Cell Science. 97, 1, p. 193-204 12 p.

Research output: Contribution to journalArticle

Peroxisomes
Oleic Acid
Candida
Alanine
Methanol
20 Citations (Scopus)

Proliferation and metabolic significance of peroxisomes in Candida boidinii during growth on d-alanine or oleic acid as the sole carbon source

Sulter, G. J., Waterham, H. R., Goodman, J. M. & Veenhuis, M., Apr 1990, In : Archives of Microbiology. 153, 5, p. 485-489 5 p.

Research output: Contribution to journalArticle

Peroxisomes
Candida
Oleic Acid
Alanine
Carbon
44 Citations (Scopus)

Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae

McCammon, M. T., Dowds, C. A., Orth, K., Moomaw, C. R., Slaughter, C. A. & Goodman, J. M., Nov 25 1990, In : Journal of Biological Chemistry. 265, 33, p. 20098-20105 8 p.

Research output: Contribution to journalArticle

Candida
Sorting
Yeast
Peroxisomes
Saccharomyces cerevisiae
1989
44 Citations (Scopus)

Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii

Garrard, L. J. & Goodman, J. M., 1989, In : Journal of Biological Chemistry. 264, 23, p. 13929-13937 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Candida
Methanol
Membrane Proteins
Genes
1987
72 Citations (Scopus)

Proton ionophores prevent assembly of a peroxisomal protein

Bellion, E. & Goodman, J. M., Jan 16 1987, In : Cell. 48, 1, p. 165-173 9 p.

Research output: Contribution to journalArticle

alcohol oxidase
Proton Ionophores
Pharmaceutical Preparations
Membranes
Flavoproteins
1986
41 Citations (Scopus)

The membrane proteins of the methanol-induced peroxisome of Candida boidinii. Initial characterization and generation of monoclonal antibodies

Goodman, J. M., Maher, J., Silver, P. A., Pacifico, A. & Sanders, D., 1986, In : Journal of Biological Chemistry. 261, 7, p. 3464-3468 5 p.

Research output: Contribution to journalArticle

Peroxisomes
Candida
Methanol
Membrane Proteins
Monoclonal Antibodies
1985
38 Citations (Scopus)
formaldehyde transketolase
Microbodies
Peroxisomes
Candida
Transferases