Pharmacology - Goodman Lab

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2017

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

Gao, Q., Binns, D. D., Kinch, L. N., Grishin, N. V., Ortiz, N., Chen, X. & Goodman, J. M., Oct 1 2017, In : Journal of Cell Biology. 216, 10, p. 3199-3217 19 p.

Research output: Contribution to journalArticle

30 Scopus citations

The collaborative work of droplet assembly

Chen, X. & Goodman, J. M., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Arabidopsis SEIPIN proteins modulate triacylglycerol accumulation and influence lipid droplet proliferation

Cai, Y., Goodman, J. M., Pyc, M., Mullen, R. T., Dyer, J. M. & Chapmana, K. D., 2015, In : Plant Cell. 27, 9, p. 2616-2636 21 p.

Research output: Contribution to journalArticle

60 Scopus citations
32 Scopus citations

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

Cartwright, B. R., Binns, D. D., Hilton, C. L., Han, S., Gao, Q. & Goodman, J. M., Feb 15 2015, In : Molecular biology of the cell. 26, 4, p. 726-739 14 p.

Research output: Contribution to journalArticle

70 Scopus citations
2012

Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway

Han, S., Bahmanyar, S., Zhang, P., Grishin, N., Oegema, K., Crooke, R., Graham, M., Reue, K., Dixon, J. E. & Goodman, J. M., Jan 27 2012, In : Journal of Biological Chemistry. 287, 5, p. 3123-3137 15 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

Adeyo, O., Horn, P. J., Lee, S., Binns, D. D., Chandrahas, A., Chapman, K. D. & Goodman, J. M., Mar 21 2011, In : Journal of Cell Biology. 192, 6, p. 1043-1055 13 p.

Research output: Contribution to journalArticle

153 Scopus citations
2010

Seipin is a discrete homooligomer

Binns, D., Lee, S., Hilton, C. L., Jiang, Q. X. & Goodman, J. M., Dec 21 2010, In : Biochemistry. 49, 50, p. 10747-10755 9 p.

Research output: Contribution to journalArticle

78 Scopus citations
2007

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

Szymanski, K. M., Binns, D., Bartz, R., Grishin, N. V., Li, W. P., Agarwal, A. K., Garg, A., Anderson, R. G. W. & Goodman, J. M., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20890-20895 6 p.

Research output: Contribution to journalArticle

355 Scopus citations
2006

An intimate collaboration between peroxisomes and lipid bodies

Binns, D., Januszewski, T., Chen, Y., Hill, J., Markin, V. S., Zhao, Y., Gilpin, C., Chapman, K. D., Anderson, R. G. W. & Goodman, J. M., Jun 5 2006, In : Journal of Cell Biology. 173, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

230 Scopus citations
2004

Multiple Targeting Modules on Peroxisomal Proteins Are Not Redundant: Discrete Functions of Targeting Signals within Pmp47 and Pex8p

Wang, X., McMahon, M. A., Shelton, S. N., Nampaisansuk, M., Ballard, J. L. & Goodman, J. M., Apr 1 2004, In : Molecular biology of the cell. 15, 4, p. 1702-1710 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2003

Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase

Shelton, S. N., Barylko, B., Binns, D. D., Horazdovsky, B. F., Albanesi, J. P. & Goodman, J. M., Apr 15 2003, In : Biochemical Journal. 371, 2, p. 533-540 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2002

Monomeric alcohol oxidase is preferentially digested by a novel protease from Candida boidinii

Stewart, M. Q., Van Dijk, R., Veenhuis, M. & Goodman, J. M., Jan 30 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1542, 1-3, p. 160-172 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2001

Alcohol oxidase and dihydroxyacetone synthase, the abundant peroxisomal proteins of methylotrophic yeasts, assemble in different cellular compartments

Stewart, M. Q., Esposito, R. D., Gowani, J. & Goodman, J. M., Sep 6 2001, In : Journal of cell science. 114, 15, p. 2863-2868 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Discrete Targeting Signals Direct Pmp47 to Oleate-induced Peroxisomes in Saccharomyces cerevisiae

Wang, X., Unruh, M. J. & Goodman, J. M., Apr 6 2001, In : Journal of Biological Chemistry. 276, 14, p. 10897-10905 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
1996

Redox-sensitive homodimerization of Pex11p: A proposed mechanism to regulate peroxisomal division

Marshall, P. A., Dyer, J. M., Quick, M. E. & Goodman, J. M., Oct 1 1996, In : Journal of Cell Biology. 135, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

90 Scopus citations

The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop

Dyer, J. M., McNew, J. A. & Goodman, J. M., Apr 1 1996, In : Journal of Cell Biology. 133, 2, p. 269-280 12 p.

Research output: Contribution to journalArticle

142 Scopus citations

The targeting and assembly of peroxisomal proteins: Some old rules do not apply

McNew, J. A. & Goodman, J. M., Feb 1996, In : Trends in Biochemical Sciences. 21, 2, p. 54-58 5 p.

Research output: Contribution to journalArticle

1995

Pmp27 promotes peroxisomal proliferation

Marshall, P. A., Krimkevich, Y. I., Lark, R. H., Dyer, J. M., Veenhuis, M. & Goodman, J. M., Apr 1995, In : Journal of Cell Biology. 129, 2, p. 345-355 11 p.

Research output: Contribution to journalArticle

Open Access
170 Scopus citations

The Candida boidinii peroxisomal membrane protein Pmp30 has a role in peroxisomal proliferation and is functionally homologous to Pmp27 from Saccharomyces cerevisiae

Sakai, Y., Marshall, P. A., Saiganji, A., Takabe, K., Saiki, H., Kato, N. & Goodman, J. M., Jan 1 1995, In : Journal of bacteriology. 177, 23, p. 6773-6781 9 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations
1994

An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes

McCammon, M. T., McNew, J. A., Willy, P. J. & Goodman, J. M., Mar 1994, In : Journal of Cell Biology. 124, 6, p. 915-925 11 p.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations

An oligomeric protein is imported into peroxisomes in vivo

McNew, J. A. & Goodman, J. M., Dec 1 1994, In : Journal of Cell Biology. 127, 5, p. 1245-1257 13 p.

Research output: Contribution to journalArticle

265 Scopus citations

The peroxisomal membrane proteins of Candida boidinii: Gene isolation and expression

Moreno, M., Lark, R., Campbell, K. L. & Goodman, J. M., Nov 1994, In : Yeast. 10, 11, p. 1447-1457 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
1993

Expression and targeting of a 47 kDa integral peroxisomal membrane protein of Candida boidinii in wild type and a peroxisome-deficient mutant of Hansenula polymorpha

Sulter, G. J., Waterham, H. R., Vrieling, E. G., Goodman, J. M., Harder, W. & Veenhius, M., Jan 11 1993, In : FEBS Letters. 315, 3, p. 211-216 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Specific cross-linking of the proline isomerase cyclophilin to a non-proline-containing peptide

McNew, J. A., Sykes, K. & Goodman, J. M., Jan 1 1993, In : Molecular biology of the cell. 4, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
1992

Chapter 16 Structure and assembly of peroxisomal membrane proteins

Goodman, J. M., Garrard, L. J. & McCammon, M. T., Dec 1 1992, In : New Comprehensive Biochemistry. 22, C, p. 209-220 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Development of multipurpose peroxisomes in Candida boidinii grown in oleic acid-methanol limited continuous cultures

Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W. & Veenhuis, M., Jan 1 1992, In : Journal of bacteriology. 174, 12, p. 4057-4063 7 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
1990

Association of glyoxylate and beta-oxidation enzymes with peroxisomes of Saccharomyces cerevisiae

McCammon, M. T., Veenhuis, M., Trapp, S. B. & Goodman, J. M., Jan 1 1990, In : Journal of bacteriology. 172, 10, p. 5816-5827 12 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations

Immunocytochemical evidence for the acidic nature of peroxisomes in methylotrophic yeasts

Waterham, H. R., Keizer-Gunnink, I., Goodman, J. M., Harder, W. & Veenhuis, M., Mar 12 1990, In : FEBS Letters. 262, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

35 Scopus citations
46 Scopus citations

Peroxisomal protein import is conserved between yeast, plants, insects and mammals

Gould, S. J., Keller, G. A., Schneider, M., Howell, S. H., Garrard, L. J., Goodman, J. M., Distel, B., Tabak, H. & Subramani, S., 1990, In : EMBO Journal. 9, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

215 Scopus citations

Peroxisomes induced in Candida boidinii by methanol, oleic acid and D-alanine vary in metabolic function but share common integral membrane proteins

Goodman, J. M., Trapp, S. B., Hwang, H. & Veenhuis, M., Dec 1 1990, In : Journal of cell science. 97, 1, p. 193-204 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Proliferation and metabolic significance of peroxisomes in Candida boidinii during growth on d-alanine or oleic acid as the sole carbon source

Sulter, G. J., Waterham, H. R., Goodman, J. M. & Veenhuis, M., Apr 1990, In : Archives of Microbiology. 153, 5, p. 485-489 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae

McCammon, M. T., Dowds, C. A., Orth, K., Moomaw, C. R., Slaughter, C. A. & Goodman, J. M., Dec 18 1990, In : Journal of Biological Chemistry. 265, 33, p. 20099-20105 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
1989

Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii

Garrard, L. J. & Goodman, J. M., Jan 1 1989, In : Journal of Biological Chemistry. 264, 23, p. 13929-13937 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
1987

Proton ionophores prevent assembly of a peroxisomal protein

Bellion, E. & Goodman, J. M., Jan 16 1987, In : Cell. 48, 1, p. 165-173 9 p.

Research output: Contribution to journalArticle

73 Scopus citations
1986

The membrane proteins of the methanol-induced peroxisome of Candida boidinii. Initial characterization and generation of monoclonal antibodies

Goodman, J. M., Maher, J., Silver, P. A., Pacifico, A. & Sanders, D., 1986, In : Journal of Biological Chemistry. 261, 7, p. 3464-3468 5 p.

Research output: Contribution to journalArticle

41 Scopus citations
1985
38 Scopus citations
1984

Alcohol oxidase assembles post-translationally into the peroxisome of Candida boidinii

Goodman, J. M., Scott, C. W., Donahue, P. N. & Atherton, J. P., Jan 1 1984, In : Journal of Biological Chemistry. 259, 13, p. 8485-8493 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Assembly of alcohol oxidase into the yeast peroxisome

Goodman, J. M., Jan 1 1984, In : Federation Proceedings. 43, 6, p. no. 1746

Research output: Contribution to journalArticle

1983

Analysis of M13 Procoat Assembly into Membranes in Vitro

Watts, C., Goodman, J. M., Silver, P. & Wickner, W., Jan 1 1983, In : Methods in Enzymology. 97, C, p. 130-138 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
1981

Membrane assembly: Posttranslational insertion of M13 procoat protein into E. coli membranes and its proteolytic conversion to coat protein in vitro

Goodman, J. M., Watts, C. & Wickner, W., May 1981, In : Cell. 24, 2, p. 437-441 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Stimulation of glucose oxidation and transport in isolated rat adipocytes by riboflavin and visible light

Goodman, J. M. & Hochstein, P., May 1981, In : Archives of Biochemistry and Biophysics. 208, 2, p. 380-387 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
1980
Open Access
94 Scopus citations